Biological activity of poly(ADP-ribose)polymerase-1;Biologiczna aktywność polimerazy poli(ADP-rybozy)-1

Postepy Higieny i Medycyny Doswiadczalnej

Volumn 64, Issue , 2010, Pages 344-363

  Kiliańska, Zofia M ^a   Zołnierczyk, Jolanta ^a   Wȩsierska Ga̧dek, Józefa ^b  

^a UNIVERSITY OF LODZ   (Poland)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cell death; DNA repair; Domain structure; PARP 1; Posttranslational modifications

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ANIMAL; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; REVIEW;

ANIMALS; HUMANS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN BINDING;

EID: 78049429733     PISSN: 00325449     EISSN: 17322693     Source Type: Journal    
DOI: None     Document Type: Review

References (135)

1. Altmeyer M., Messner S., Hassa P. O., Fey M., Hottiger M. O.: Molecular mechanism of poly (ADP-ribosyl) ation by PARP-1 and identification of lysine residues as ADP-ribose acceptor sites. Nucleic Acids Res., 2009;37:3723-3738
2. Amé J. C., Spenlehauer C., de Murcia G.: The PARP superfamily. Bioessays, 2004;26:882-893 (Pubitemid 39128102)
3. Andrabi S. A., Kim N. S., Yu S. W., Wang H., Koh D. W., Sasaki M., Klaus J. A., Otsuka T., Zhang Z., Koehler R. C., Hurn P. D., Poirier G. G., Dawson V. L., Dawson T. M.: Poly (ADP-ribose) (PAR) polymer is a death signal. Proc. Natl. Acad. Sci. USA, 2006;103:18308-18313 (Pubitemid 44871654)
4. +ADP-ribosyltransferase gene (ADPRT) and two secondary sites to human chromosomal bands 1q42, 13q34, and 14q24. Cytogenet. Cell Genet., 1992;61:172-174
5. Beckert S., Farrahi F., Ghani Q. P., Aslam R., Scheuestuhl H., Coerper S., Königsrainer A., Hunt T. K., Hussain M. Z.: IGF-1-induced VEGF expression in HUVEC involves phosphorylation and inhibition of poly (ADP-ribose) polymerase. Biochem. Biophys. Res. Commun., 2006;341:67-72 (Pubitemid 43117387)
6. Bednarek J., Kiliańska Z. M.: Białka przestrzeni miȩdzybłonowej mitochondriów uczestnicza̧ce w procesie apoptozy. Postepy Biochem., 2005;51:447-458
7. Beneke S.: Poly (ADP-ribose) polymerase activity in different pathologies - the link to inflammation and infarction. Exp. Gerontol., 2008;43:605-614
8. Bernstein C., Bernstein H., Payne CM., Garewal H.: DNA repair/proapoptotic dual-role proteins in five major DNA repair pathways: failsafe protection against carcinogenesis. Mutat. Res., 2002;511:145-178 (Pubitemid 34621252)
9. Bhatia M., Kirkland J. B., Meckling-Gill K. A.: Modulation of poly-(ADP-ribose) polymerase during neutrophilic and monocytic differentiation of promyelocytic (NB4) and myelocytic (HL-60) leukaemia cells. Biochem. J., 1995;308:131-137
10. Bièche L., de Murcia G., Lidereau R.: Poly (ADP-ribose) polymerase gene expression status and genomic instability in human breast cancer. Clin. Cancer Res., 1996;2:1163-1167 (Pubitemid 26238447)
11. Bryant H. E., Petermann E., Schultz N., Jemth A. S., Loseva O., Issaeva N., Johansson F., Fernandez S., McGlynn P., Helleday T.: PARP is activated at stalled forks to mediate Mre 11-dependent replication restart and recombination. EMBO J., 2009;28:2601-2615
12. Bürkle A., Brabeck C., Diefenbach J., Beneke S.: The emerging role of poly (ADP-ribose) polymerase-1 in longevity. Int. J. Biochem. Cell Biol., 2005;37:1043-1053 (Pubitemid 40311745)
13. Burzio L. O., Sáez L., Cornejo R.: Poly (ADP-ribose) synthetase activity in rat testis mitochondria. Biochem. Biophys. Res. Commun., 1981;103:369-375
14. Caiafa P., Guastafierro T., Zampieri M.: Epigenetics: poly (ADP-ribosyl) ation of PARP-1 regulates genomic methylation patterns. FASEB J., 2009;23:672-678
15. Chaitanya G. V., Babu P. P.: Differential PARP cleavage: an indication of heterogeneous forms of cell death and involvement of multiple proteases in the infarct of focal cerebral ischemia in rat. Cell. Mol. Neurobiol., 2009;29:563-573
16. Chambon P., Weill J. D., Mandel P.: Nicotinamide mononucleotide activation of new DNA-dependent polyadenylic acid synthesizing nuclear enzyme. Biochem. Biophys. Res. Commun., 1963;11:39-43
17. Cherney B. W., McBride O. W., Chen D. F., Alkhatib H., Bhatia K., Hensley P., Smulson M. E.: cDNA sequence, protein structure, and chromosomal location of the human gene for poly (ADP-ribose) polymerase. Proc. Natl. Acad. Sci. USA, 1987;84:8370-8374
18. Cipriani G., Rapizzi E., Vannacci A., Rizzuto R., Moroni F., Chiarugi A.: Nuclear poly (ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction. J. Biol. Chem., 2005;280:17227-17234 (Pubitemid 41389190)
19. D'Amours D., Desnoyers S., D'Silva I., Poirier G. G.: Poly (ADP-ribosyl) ation reactions in the regulation of nuclear functions. Biochem. J., 1999;342:249-268 (Pubitemid 29425344)
20. Dawson V. L., Dawson T. M.: Deadly conversations: nuclear-mitochondrial cross-talk. J. Bioenerg. Biomembr., 2004;36:287-294 (Pubitemid 39619828)
21. de Murcia G., Menissier de Murcia J.: Poly (ADP-ribose) polymerase: a molecular nick-sensor. Trends Biochem. Sci., 1994;19:172-176 (Pubitemid 24115433)
22. de Murcia J. M., Niedergang C., Trucco C., Ricoul M., Dutrillaux B., Mark M., Oliver F. J., Masson M., Dierich A., LeMeur M., Waltztinger C., Chambon P., de Murcia G.: Requirement of poly (ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc. Natl. Acad. Sci. USA, 1997;94:7303-7307 (Pubitemid 27345310)
23. Dominguez-Bendala J., Masutani M., McWhir J.: Down-regulation of PARP-1, but not of Ku80 or DNA-PKcs', results in higher gene targeting efficiency. Cell Biol. Int., 2006;30:389-393
24. + depletion and cell death induced by oxidative stress. J. Biol. Chem., 2003;278:18426-18433 (Pubitemid 36799465)
25. Ebralidse K. K., Mirzabekov A. D. One-domain interaction of histone H4 with nucleosomal core DNA is restricted to a narrow DNA segment. FEBS Lett., 1986;194:69-72
26. Eki T.: Poly (ADP-ribose) polymerase inhibits DNA replication by human replicative DNA polymerase a, d and e in vitro. FEBS Lett., 1994;356:261-266 (Pubitemid 24376984)
27. Gagné J. P., Moreel X., Gagné P., Labelle Y., Droit A., Chevalier-Paré M., Bourassa S., McDonald D., Hendzel M. J., Prigent C., Poirier G. G.: Proteomic investigation of phosphorylation sites in poly (ADP-ribose) polymerase-1 and poly (ADP-ribose) glycohydrolase. J. Proteome Res., 2009;8:1014-1029
28. Garnier P., Ying W., Swanson R. A.: Ischemic preconditioning by caspase cleavage of poly (ADP-ribose) polymerase-1. J. Neurosci., 2003;23:7967-7973 (Pubitemid 37082448)
29. Gradwohl G., Mazen A., de Murcia G.: Poly (ADP-ribose) polymerase forms loops with DNA. Biochem. Biophys. Res. Commun., 1987;148:913-919
30. Gradwohl G., Ménissier de Murcia J. M., Molinete M., Simonin F., Koken M., Hoeijmakers J. H., de Murcia G.: The second zinc-fnger domain of poly (ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA. Proc. Natl. Acad. Sci. USA, 1990;87:2990-2994
31. Haince J. F., Kozlov S., Dawson V. L., Dawson T. M., Hendzel M. J., Lavin M. F., Poirier G. G.: Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly (ADP-ribose)-dependent pathway in the early response to DNA-damaging agents. J. Biol. Chem., 2007;282:16441-16453 (Pubitemid 47100334)
32. Hakmé A., Wong H. K., Dantzer F., Schreiber V.: The expanding field of poly (ADP-ribosyl) ation reactions. EMBO Rep., 2008;9:1094-1100
33. Hassa P. O., Buerki C., Lombardi C., Imhof R., Hottiger M. O.: Transcriptional coactivation of nuclear factor-êB-dependent gene expression by p300 is regulated by poly (ADP)-ribose polymerase-1. J. Biol. Chem., 2003;278:45145-45153 (Pubitemid 37432647)
34. Hassa P. O., Haenni S. S., Buerki C., Meier N. I., Lane W. S., Owen H., Gersbach M., Imhof R., Hottiger M. O.: Acetylation of poly (ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-κB-dependent transcription. J. Biol. Chem., 2005;280:40450-40464 (Pubitemid 41780532)
35. Hassa P. O., Haenni S. S., Elser M., Hottiger M. O.: Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and were are we going? Microbiol. Mol. Biol. Rev., 2006;70:789-829 (Pubitemid 44484693)
36. Hassa P. O., Hottiger M. O.: The diverse biological roles of mammalian PARPs, a small but powerful family of poly-ADP-ribose polymerases. Front. Biosci., 2008;13:3046-3082 (Pubitemid 351589219)
37. Hayashi K., Tanaka M., Shimada T., Miwa M., Shimura T.: Size and shape of poly (ADP-ribose): examination by gel filtration, gel electrophoresis and electron microscopy. Biochem. Biophys. Res. Commun., 1983;112:102-107
38. Heeres J. T., Hergenrother P. J.: Poly (ADP-ribose) makes a date with death. Curr. Opin. Chem. Biol., 2007;11:644-653 (Pubitemid 350180567)
39. Hegde M. L., Hazra T. K., Mitra S.: Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells. Cell Res., 2008;18:27-47
40. Hochegger H., Dejsuphong D., Fukushima T., Morrison C., Sonoda E., Schreiber V., Zhao G. Y., Saberi A., Masutani M., Adachi N., Koyama H., de Murcia G., Takeda S.: Parp-1 protects homologous recombination from interference by Ku and ligase IV in vertebrate cells. EMBO J., 2006;25:1305-1314
41. Horton J. K., Wilson S. H.: Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency. DNA Repair, 2007;6:530-543 (Pubitemid 46357055)
42. Huang J. Y., Chen W. H., Chang Y. L., Wang H. T., Chuang W. T., Lee S. C.: Modulation of nucleosome-binding activity of FACT by poly-(ADP-ribosyl) ation. Nucleic Acids Res., 2006;34:2398-2407
43. Ikejima M., Noguchi S., Yamashita R., Ogura T., Sugimura T., Gill D. M., Miwa M.: The zinc fingers of human poly (ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognise intact DNA. J. Biol. Chem., 1990;265:21907-21913 (Pubitemid 120014241)
44. Iliakis G., Wang H., Perrault A. R., Boecker W., Rosidi B., Windhofer F., Wu W., Guan J., Terzoudi G., Pantelias G.: Mechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenet. Genome Res., 2004;104:14-20 (Pubitemid 38721048)
45. Ji Y., Tulin A. V.: Poly (ADP-ribosyl) ation of heterogeneous nuclear ribonucleoproteins modulates splicing. Nucleic Acids Res., 2009;37:3501-3513
46. Kameshita I., Matsuda Z., Taniguchi T., Shizuta Y: Poly (ADP-ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain. J. Biol. Chem., 1984;259:4770-4776 (Pubitemid 14144197)
47. Kaufmann S. H., Desnoyers S., Ottaviano Y., Davidson N. E., Poirier G. G.: Specific proteolytic cleavage of poly (ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res., 1993;53:3976-3985 (Pubitemid 23267698)
48. Kauppinen T. M., Chan W. Y., Suh S. W., Wiggins A. K., Huang E. J., Swanson R. A.: Direct phosphorylation and regulation of poly (ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc. Natl. Acad. Sci. USA, 2006;103:7136-7141
49. +-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1. Cell, 2004;119:803-814 (Pubitemid 40017687)
50. + into a nuclear signal. Genes Dev., 2005;19:1951-1967
51. Kleine H., Poreba E., Lesniewicz K., Hassa P. O., Hottiger M. O., Litchfield D. W., Shilton B. H., Lüscher B.: Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation. Mol. Cell, 2008;32:57-69
52. Klug A., Rhodes D., Smith J., Finch J. T., Thomas J. O.: A low resolution structure for the histone core of the nucleosome. Nature, 1980;287:509-516 (Pubitemid 11232848)
53. Kotova E., Jarnik M., Tulin A. V.: Poly (ADP-ribose) polymerase1 is required for protein localization to Cajal body. PLoS Genet., 2009;5:e1000387
54. Kraus W. L.: Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation. Curr. Opin. Cell Biol., 2008;20:294-302
55. Kraus W. L., Lis J. T.: PARP goes transcription. Cell, 2003;113:677-683 (Pubitemid 36724932)
56. Kun E., Kirsten E., Ordahl C. P.: Coenzymatic activity of randomly broken or intact double-stranded DNAs in auto and histone H1 transpoly (ADP-ribosylation), catalyzed by poly (ADP-ribose) polymerase (PARP1). J. Biol. Chem., 2002;277:39066-39069 (Pubitemid 35190872)
57. Kurosaki T., Ushiro H., Mitsuuchi Y., Suzuki S., Matsuda M., Matsuda Y., Katunuma N., Kangawa K., Matsuo H., Hirose T., Inayama S., Shizuta Y: Primary structure of human poly (ADP-ribose) syntetase as deduced from cDNA sequence. J. Biol. Chem., 1987;262:15990-15997 (Pubitemid 17165199)
58. Lai Y., Chen Y., Watkins S. C., Nathaniel P. D., Guo F., Kochanek P. M., Jenkins L. W., Szabó C., Clark R. S.: Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury. J. Neurochem., 2008;104:1700-1711 (Pubitemid 351316774)
59. Lan S. Y., Smerdon M. J.: A nonuniform distribution of excision repair synthesis in nucleosome core DNA. Biochemistry, 1985;24:7771-7783 (Pubitemid 16140514)
60. Langelier M. F., Servent K. M., Rogers E. E., Pascal J. M.: A third zincbinding domain of human poly (ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation. J. Biol. Chem., 2008;283:4105-4114
61. Levy-Wilson B.: ADP-ribosylation of trout testis chromosomal proteins: distribution of ADP-ribosylated proteins among DNaseI-sensitive and-resistant chromatin domains. Arch. Biochem. Biophys., 1981;208:528-534
62. Lindahl T., Satoh M. S., Poirier G. G., Klungland A.: Post-translational modification of poly (ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem. Sci., 1995;20:405-411
63. Louters L., Chalkley R.: Exchange of histones H1, H2A, and H2B in vivo. Biochemistry, 1985;24:3080-3085 (Pubitemid 15028706)
64. Mahaney B. L., Meek K., Lees-Miller S. P.: Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous endjoining. Biochem. J., 2009;417:639-650
65. Malanga M., Pleschke J. M., Kleczkowska H. E., Althaus F. R.: Poly (ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions. J. Biol. Chem., 1998;273:11839-11843 (Pubitemid 28272089)
66. Maruta H., Matsumura N., Tanuma S.: Role of (ADP-ribose) n catabolism in DNA repair. Biochem. Biophys. Res. Commun., 1997;236:265-269 (Pubitemid 27373281)
67. Maruta H., Okita N., Takasawa R., Uchiumi F., Hatano T., Tanuma S.: The involvement of ATP produced via (ADP-ribose) n in the maintenance of DNA replication apparatus during DNA repair. Biol. Pharm. Bull., 2007;30:447-450 (Pubitemid 46355920)
68. Masson M., Niedergang C., Schreiber V., Muller S., Menissier-de Murcia J., de Murcia G.: XRCC1 is specifically associated with poly (ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol. Cell. Biol., 1998;18:3563-3571 (Pubitemid 28240528)
69. Meder V. S., Boeglin M., de Murcia G., Schreiber V.: PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli. J. Cell Sci., 2005;118:211-222 (Pubitemid 40277117)
70. Messner S., Schuermann D., Altmeyer M., Kassner I., Schmidt D., Schär P., Müller S., Hottiger M. O.: Sumoylation of poly (ADP-ribose) polymerase1 inhibits its acetylation and restrains transcriptional coactivator function. FASEB J., 2009;23:3978-3989
71. Meyer R., Müller M., Beneke S., Küpper J. H., Bürkle A.: Negative regulation of alkylation-induced sister-chromatid exchange by poly-(ADP-ribose) polymerase-1 activity. Int. J. Cancer, 2000;88:351-355
72. Meyer-Ficca M. L., Meyer R. G., Jacobson E. L., Jacobson M. K.: Poly (ADP-ribose) polymerases: managing genome stability. Int. J. Biochem. Cell Biol., 2005;37:920-926 (Pubitemid 40311734)
73. Miwa M., Masutani M.: Poly ADP-ribosylation and cancer. Cancer Sci., 2007;98:1528-1535
74. Mosgoeller W., Steiner M., Hozák P., Penner E., Wȩsierska-Ga̧dek J.: Nuclear architecture and ultrastructural distribution of poly (ADP-ribosyl) transferase, a multifunctional enzyme. J. Cell Sci., 1996;109:409-418
75. Moubarak R. S., Yuste V. J., Artus C., Bouharrour A., Greer P. A., Menissier-de Murcia J., Susin S. A.: Sequential activation of poly-(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol. Cell. Biol., 2007;27:4844-4862 (Pubitemid 47016136)
76. Niere M., Kernstock S., Koch-Nolte F., Ziegler M.: Functional localization of two poly (ADP-ribose)-degrading enzymes to the mitochondrial matrix. Mol. Cell. Biol., 2008;28:814-824
77. Oei S. L., Griesenbeck J., Schweiger M., Ziegler M.: Regulation of RNA polymerase II-dependent transcription by poly (ADP-ribosyl) ation of transcription factors. J. Biol. Chem., 1998;273:31644-31647 (Pubitemid 29177091)
78. Oei S. L., Ziegler M.: ATP for the DNA ligation step in base excision repair is generated from poly (ADP-ribose). J. Biol. Chem., 2000;275:23234-23239 (Pubitemid 30646221)
79. Ogata N., Ueda K., Hayaishi O.: ADP-ribosylation of histone H2B. Identification of glutamic acid residue 2 as the modification site. J. Biol. Chem., 1980;255:7610-7615
80. Ogata N., Ueda K., Kagamiyama H., Hayaishi O.: ADP-ribosylation of histone H1. Identification of glutamic acid residues 2, 14, and the COOH-terminal lysine residue as modification sites. J. Biol. Chem., 1980;255:7616-7620
81. Oka S., Kato J., Moss J.: Identification and characterization of a mammalian 39-kDa poly (ADP-ribose) glycohydrolase. J. Biol. Chem., 2006;281:705-713
82. Otto H., Reche P. A., Bazan F., Dittmar K., Haag F., Koch-Nolte F.: In silico characterization of the family of PARP-like poly (ADP-ribosyl) transferases (pARTs). BMC Genomics, 2005;6:139
83. Perdoni F., Bottone M. G., Soldani C., Veneroni P., Alpini C., Pellicciari C., Scovassi A. I.: Distribution of centromeric proteins and PARP-1 during mitosis and apoptosis. Ann. N Y Acad. Sci., 2009;1171:32-37
84. Pleschke J. M., Kleczkowska H. E., Strohm M., Althaus F. R.: Poly (ADP-ribose) binds to specific domains in DNA damage checkpoint proteins. J. Biol. Chem., 2000;275:40974-40980 (Pubitemid 32054922)
85. Plummer E. R., Calvert H.: Targeting poly (ADP-ribose) polymerase: a two-armed strategy for cancer therapy. Clin. Cancer Res., 2007;13:6252-6256 (Pubitemid 350075012)
86. Poirier G. G., de Murcia G., Jongstra-Bilen J., Niedergang C., Mandel P.: Poly (ADP-ribosyl) ation of polynucleosomes causes relaxation of chromatin structure. Proc. Natl. Acad. Sci. USA, 1982;79:3423-3427 (Pubitemid 12011376)
87. Poitras M. F., Koh D. W., Yu S. W., Andrabi S. A., Mandir A. S., Poirier G. G., Dawson V. L., Dawson T. M.: Spatial and functional relationship between poly (ADP-ribose) polymerase 1 and poly (ADP-ribose) glycohydrolase in the brain. Neuroscience, 2007;148:198-211 (Pubitemid 47224998)
88. Popławski J., Błasiak J.: Naprawa DNA przez rekombinacjȩ homologiczna̧ w komórkach ssaków. Postepy Biochem., 2006;52:180-193
89. Quesada P., Farina B., Jones R.: Poly (ADP-ribosylation) of nuclear proteins in rat testis correlates with active spermatogenesis. Biochim. Biophys. Acta, 1989;1007:167-175 (Pubitemid 19056425)
90. Rajamohan S. B., Pillai V. B., Gupta M., Sundaresan N. R., Birukov K. G., Samant S., Hottiger M. O., Gupta M. P.: SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly (ADP-ribose) polymerase 1. Mol. Cell. Biol., 2009;29:4116-4129
91. Reale A., Matteis G. D., Galleazzi G., Zampieri M., Caiafa P.: Modulation of DNMT1 activity by ADP-ribose polymers. Oncogene, 2005;24:13-19 (Pubitemid 40143860)
92. Rossi M. N., Carbone M., Mostocotto C., Mancone C., Tripodi M., Maione R., Amati P.: Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial DNA integrity. J. Biol. Chem., 2009;284:31616-31624
93. Ruf A., Mennissier de Murcia J., de Murcia G., Schulz G. E.: Structure of the catalytic fragment of poly (ADP-ribose) polymerase from chicken. Proc. Natl. Acad. Sci. USA, 1996;93:7481-7485 (Pubitemid 26277060)
94. Ruscetti T., Lehnert B. E., Halbrook J., Le Trong H., Hoekstra M. F., Chen D. J., Peterson S. R.: Stimulation of the DNA-dependent protein kinase by poly (ADP-ribose) polymerase. J. Biol. Chem., 1998;273:14461-14467 (Pubitemid 28319167)
95. Saberi A., Hochegger H., Szuts D., Lan L., Yasui A., Sale J. E., Taniguchi Y., Murakawa Y., Zeng W., Yokomori K., Helleday T., Teraoka H., Arakawa H., Buerstedde J. M., Takeda S.: RAD18 and poly (ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. Mol. Cell. Biol., 2007;27:2562-2571 (Pubitemid 46581347)
96. Sauermann G., Wȩsierska-Ga̧dek J.: Poly (ADP-ribose) effectively competes with DNA for histone H4 binding. Biochem. Biophys. Res. Commun., 1986;139:523-529 (Pubitemid 16002460)
97. Saxena A., Saffery R., Wong L. H., Kalitsis P., Choo K. H: Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly (ADP-ribose) polymerase-1 protein and are poly (ADP-ribosyl) ated. J. Biol. Chem., 2002;277:26921-26926 (Pubitemid 34951701)
98. Schreiber V., Amé J. C., Dollé P., Schultz I., Rinaldi B., Fraulob V., Ménnissier-de Murcia J., de Murcia G.: Poly (ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. J. Biol. Chem., 2002;277:23028-23036 (Pubitemid 34967289)
99. Schreiber V., Dantzer F., Ame J. C., de Murcia G.: Poly (ADP-ribose): novel functions for an old molecule. Nat. Rev. Mol. Cell Biol., 2006;7:517-528 (Pubitemid 44036457)
100. Schultz N., Lopez E., Saleh-Gohari N., Helleday T.: Poly (ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Res., 2003;31:4959-4964 (Pubitemid 37441861)
101. Scovassi A. I.: Mitochondrial poly (ADP-ribosylation): from old data to new perspectives. FASEB J., 2004;18:1487-1488 (Pubitemid 39336629)
102. Scovassi A. I., Mariani C., Negroni M., Negri C., Bertazzoni U.: ADP-ribosylation of nonhistone proteins in HeLa cells: modification of DNA topoisomerase II. Exp. Cell Res., 1993;206:177-181 (Pubitemid 23194694)
103. Shick V. V., Belyavsky A. V., Bavykin S. G., Mirzabekov A. D. Primary organization of the nucleosome core particles. Sequential arrangement of histones along DNA. J. Mol. Biol., 1980;139:491-517
104. Shieh W. M., Amé J. C., Wilson M. V., Wang Z. Q., Koh D. W., Jacobson M. K., Jacobson E. L.: Poly (ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers. J. Biol. Chem., 1998;273:30069-30072 (Pubitemid 28545464)
105. Shiokawa M., Masutani M., Fujihara H., Ueki K., Nishikawa R., Sugimura T., Kubo H., Nakagama H.: Genetic alteration of poly (ADP-ribose) polymerase in human germ cell tumors. Jpn. J. Clin. Oncol., 2005;35:97-102 (Pubitemid 40567878)
106. Shrivastav M., De Haro L. P., Nickoloff J. A.: Regulation of DNA double-strand break repair pathway choice. Cell Res., 2008;18:134-147
107. Simbulan-Rosenthal CM., Rosenthal D. S., Boulares A. H., Hickey R. J., Malkas L. H., Coll J. M., Smulson M. E.: Regulation of the expression or recruitment of components of the DNA synthesome by poly-(ADP-ribose) polymerase. Biochemistry, 1998;37:9363-9370 (Pubitemid 28307690)
108. Śledziński T.: Polimeraza poli (ADP-rybozy) i jej udział w naprawie DNA. Postepy Biochem., 2003;49:239-249
109. Smith H. M., Grosovsky A. J.: Poly ADP-ribose-mediated regulation of p53 complexed with topoisomerase I following ionizing radiation. Carcinogenesis, 1999;20:1439-1443 (Pubitemid 29385427)
110. Soldani C., Scovassi A. I.: Poly (ADP-ribose) polymerase-1 cleavage during apoptosis: an update. Apoptosis, 2002;7:321-328 (Pubitemid 34832256)
111. Süsse S., Scholz C. J., Bürkle A., Wiesmüller L.: Poly (ADP-ribose) polymerase (PARP-1) and p53 independently function in regulating double-strand break repair in primate cells. Nucleic Acids Res., 2004;32:669-680 (Pubitemid 38263058)
112. Synowiec E., Ksia̧żek D., Błasiak J., Woźniak K.: Rola modyfikacji SUMO w utrzymaniu stabilności genomu. Postepy Biochem., 2008;54:234-241
113. Tao Z., Gao P., Hoffman D. W., Liu H. W.: Domain C of human poly-(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif. Biochemistry, 2008;47:5804-5813 (Pubitemid 351747059)
114. Tao Z., Gao P., Liu H. W.: Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications. J. Am. Chem. Soc. 2009;131:14258-14260
115. Tao Z., Gao P., Liu H. W.: Studies of the expression of human poly-(ADP-ribose) polymerase-1 in Saccharomyses cerevisiae and identifcation of PARP-1 substrates by yeast proteome microarray screening. Biochemistry, 2009;48:11745-11754
116. Thibodeau J., Gradwohl G., Dumas C., Clairoux-Moreau S., Brunet G., Penning C., Poirier G. G., Moreau P.: Cloning of rodent cDNA coding the poly (ADP-ribose) polymerase catalytic domain and analysis of mRNA levels during the cell cycle. Biochem. Cell Biol., 1989;67:653-660 (Pubitemid 19275211)
117. Till S., Diamantara K., Ladurner A. G.: PARP: a transferase by any other name. Nat. Struct. Mol. Biol., 2008;15:1243-1244
118. Wang M., Wu W., Wu W., Rosidi B., Zhang L., Wang H., Iliakis G.: PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res., 2006;34:6170-6182 (Pubitemid 44942738)
119. Wang Y., Dawson V. L., Dawson T. M.: Poly (ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Expt. Neurol., 2009;218:193-202
120. Wang Z. Q., Stingl L., Morrison C., Jantsch M., Los M., Schulze-Osthoff K., Wagner E. F.: PARP is important for genomic stability but dispensable in apoptosis. Genes Dev., 1997;11:2347-2358 (Pubitemid 27408532)
121. Wȩsierska-Ga̧dek J., Bugajska-Schretter A., Cerni C: ADP-ribosylation of p53 tumor suppressor protein: mutant but not wild-type p53 is modified. J. Cell. Biochem., 1996;62:90-101 (Pubitemid 26286285)
122. Wȩsierska-Ga̧dek J., Ranftler C., Schmid G.: Physiological ageing: role of p53 and PARP-1 tumor suppressors in the regulation of terminal senescence. J. Physiol. Pharmacol., 2005;2005(Suppl. 2):77-88 (Pubitemid 44933670)
123. Wȩsierska-Ga̧dek J., Sauermann G.: Modification of nuclear matrix proteins by ADP-ribosylation. Association of nuclear ADP- ribosyltransferase with the nuclear matrix. Eur. J. Biochem., 1985;153:421-428 (Pubitemid 16209845)
124. Wȩsierska-Ga̧dek J., Sauermann G.: The effect of poly (ADP-ribose) on interactions of DNA with histones H1, H3 and H4. Eur. J. Biochem., 1988;173:675-679
125. Wȩsierska-Ga̧dek J., Schmid G., Cerni C: ADP-ribosylation of wildtype p53 in vitro: binding of p53 protein to specific p53 consensus sequence prevents its modification. Biochem. Biophys. Res. Commun., 1996;224:96-102 (Pubitemid 26252417)
126. Woodhouse B. C., Dianov G. L.: Poly ADP-ribose polymerase-1: an international molecule of mystery. DNA Repair, 2008;7:1077-1086
127. Yang Y. G., Cortes U., Patnaik S., Jasin M., Wang Z. Q.: Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks. Oncogene, 2004;23:3872-3882 (Pubitemid 38725700)
128. Yano K., Morotomi-Yano K., Akiyama H.: Cernunnos/XLF: a new player in DNA double-strand break repair. Int. J. Biochem. Cell Biol., 2009;41:1237-1240
129. Yu S. W., Wang H., Poitras M. F., Coombs C., Bowers W. J., Federoff H. J., Poirier G. G., Dawson T. M., Dawson V. L.: Mediation of poly-(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science, 2002;297:259-263 (Pubitemid 34761289)
130. Yu S. W., Wang Y., Frydenlund D. S., Ottersen O. P., Dawson V. L., Dawson T. M.: Outer mitochondrial membrane localization of apoptosis-inducing factor: mechanistic implications for release. ASN Neuro., 2009;1. pii: e00021
131. Zampieri M., Passananti C., Calabrese R., Perilli M., Corbi N., De Cave F., Guastafierro T., Bacalini M. G., Reale A., Amicosante G., Calabrese L., Zlatanova J., Caiafa P.: Parp1 localized within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity. PLoS One, 2009;4:e4717
132. Zaniolo K., Desnoyers S., Leclerc S., Guérin S. L.: Regulation of poly (ADP-ribose) polymerase-1 (PARP-1) gene expression throught the post-translational modification of SP1: a nuclear target protein of PARP-1. BMC Mol. Biol., 2007;8:96
133. Zardo G., Caiafa P.: The unmethylated state of CpG islands in mouse fibroblast depends on the poly (ADP-ribosyl) lation process. J. Biol. Chem., 1998;273:16517-16520 (Pubitemid 28311436)
134. Zardo G., Reale A., Passananti C., Pradhan S., Buontempo S., de Matteis G., Adams R. L., Caiafa P.: Inhibition of poly (ADP-ribosyl) ation induces DNA hypermethylation: a possible molecular mechanism. FASEB J., 2002;16:1319-1321
135. Źródło internetowe: UniProtKB/Swiss-Prot PO9874 (PARP1 HUMAN) Sept 1, 2009, Version BO