Down-regulation of PARP-1, but not of Ku80 or DNA-PKcs, results in higher gene targeting efficiency

Cell Biology International

Volumn 30, Issue 4, 2006, Pages 389-393

  Domínguez Bendala, Juan ^a   Masutani, Mitsuko ^b   McWhir, Jim ^c  

^a UNIVERSITY OF MIAMI   (United States)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

DNA PK; ES cells; Gene targeting; Homologous recombination; Ku80; PARP 1

Indexed keywords

ANTIGEN; DEOXYRIBONUCLEIC ACID PROTEIN KINASE; KU80 ANTIGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; EMBRYO; EMBRYONIC STEM CELL; GENE TARGETING; HOMOLOGOUS RECOMBINATION; MOUSE; NONHUMAN;

ANIMALS; ANTIGENS, NUCLEAR; CELLS, CULTURED; DNA REPAIR ENZYMES; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; DOWN-REGULATION; GENE TARGETING; MICE; MICE, KNOCKOUT; POLY(ADP-RIBOSE) POLYMERASES; RECOMBINATION, GENETIC;

EID: 33645990290     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2005.12.005     Document Type: Article

References (42)

1. Burma S., and Chen D.J. Role of DNA-PK in the cellular response to DNA double-strand breaks. DNA Repair (Amst) 3 8-9 (2004) 909-918
2. Chatterjee S., and Berger N.A. Growth-phase-dependent response to DNA damage in poly(ADP-ribose) polymerase deficient cell lines: basis for a new hypothesis describing the role of poly(ADP-ribose) polymerase in DNA replication and repair. Mol Cell Biochem 138 1-2 (1994) 61-69
3. de Murcia J.M., Niedergang C., Trucco C., Ricoul M., Dutrillaux B., Mark M., et al. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A 94 14 (1997) 7303-7307
4. Domínguez-Bendala J., Priddle H., Clarke A., and McWhir J. Elevated expression of exogenous Rad51 leads to identical increases in gene-targeting frequency in murine embryonic stem (ES) cells with both functional and dysfunctional p53 genes. Exp Cell Res 286 2 (2003) 298-307
5. Falck J., Coates J., and Jackson S.P. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434 7033 (2005) 605-611
6. Farzaneh F., Panayotou G.N., Bowler L.D., Hardas B.D., Broom T., Walther C., et al. ADP-ribosylation is involved in the integration of foreign DNA into the mammalian cell genome. Nucleic Acids Res 16 23 (1988) 11319-11326
7. Featherstone C., and Jackson S.P. DNA double-strand break repair. Curr Biol 9 20 (1999) R759-R761
8. Featherstone C., and Jackson S.P. Ku, a DNA repair protein with multiple cellular functions?. Mutat Res 434 1 (1999) 3-15
9. Ferro A.M., and Olivera B.M. Poly(ADP-ribosylation) in vitro. Reaction parameters and enzyme mechanism. J Biol Chem 257 13 (1982) 7808-7813
10. Goedecke W., Eijpe M., Offenberg H.H., van Aalderen M., and Heyting C. Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis. Nat Genet 23 2 (1999) 194-198
11. Guo T.L., Miller M.A., Datar S., Shapiro I.M., and Shenker B.J. Inhibition of poly(ADP-ribose) polymerase rescues human T lymphocytes from methylmercury-induced apoptosis. Toxicol Appl Pharmacol 152 2 (1998) 397-405
12. Haber J.E. The many interfaces of Mre11. Cell 95 5 (1998) 583-586
13. Hamilton A.A., and Thacker J. Gene recombination in X-ray-sensitive hamster cells. Mol Cell Biol 7 4 (1987) 1409-1414
14. Jeggo P.A. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiat Res 150 Suppl. 5 (1998) S80-S91
15. Kraus W.L., and Lis J.T. PARP goes transcription. Cell 113 6 (2003) 677-683
16. Latour I., Leunda-Casi A., Denef J.F., and Buc Calderon P. Activation of poly(ADP-ribose) polymerase in rat hepatocytes does not contribute to their cell death by oxidative stress. Exp Cell Res 254 1 (2000) 173-179
17. Liang F., Romanienko P.J., Weaver D.T., Jeggo P.A., and Jasin M. Chromosomal double-strand break repair in Ku80-deficient cells. Proc Natl Acad Sci U S A 93 17 (1996) 8929-8933
18. Lindahl T., Satoh M.S., Poirier G.G., and Klungland A. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem Sci 20 10 (1995) 405-411
19. Lisby M., and Rothstein R. DNA damage checkpoint and repair centers. Curr Opin Cell Biol 16 3 (2004) 328-334
20. Masutani M., Nozaki T., Nishiyama E., Ochiya T., Nakagama H., Wakabayashi K., et al. Establishment of poly(ADP-ribose) polymerase-deficient mouse embryonic stem cell lines. Proc Jpn Acad Ser 74 B (1998) 233-236
21. Morrison C., Smith G.C., Stingl L., Jackson S.P., Wagner E.F., and Wang Z.Q. Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. Nat Genet 17 4 (1997) 479-482
22. Nozaki T., Fujihara H., Watanabe M., Tsutsumi M., Nakamoto K., Kusuoka O., et al. Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane. Cancer Sci 94 6 (2003) 497-500
23. Ogawa K., Masutani M., Kato K., Tang M., Kamada N., Suzuki H., et al. Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice. Cancer Lett (2005)
24. Oliver F.J., de la Rubia G., Rolli V., Ruiz-Ruiz M.C., de Murcia G., Murcia J.M., et al. Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant. J Biol Chem 273 50 (1998) 33533-33539
25. Park S.D., Kim C.G., and Kim M.G. Inhibitors of poly(ADP-ribose) polymerase enhance DNA strand breaks, excision repair, and sister chromatid exchanges induced by alkylating agents. Environ Mutagen 5 4 (1983) 515-525
26. Parsons C.A., Baumann P., Van Dyck E., and West S.C. Precise binding of single-stranded DNA termini by human RAD52 protein. EMBO J 19 15 (2000) 4175-4181
27. Peng Y., Woods R.G., Beamish H., Ye R., Lees-Miller S.P., Lavin M.F., et al. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res 65 5 (2005) 1670-1677
28. Pierce A.J., Hu P., Han M., Ellis N., and Jasin M. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev 15 24 (2001) 3237-3242
29. Semionov A., Cournoyer D., and Chow T.Y. Inhibition of poly(ADP-ribose) polymerase stimulates extrachromosomal homologous recombination in mouse Ltk-fibroblasts. Nucleic Acids Res 27 22 (1999) 4526-4531
30. Semionov A., Cournoyer D., and Chow T.Y. Transient expression of Saccharomyces cerevisiae endo-exonuclease NUD1 gene increases the frequency of extrachromosomal homologous recombination in mouse Ltk-fibroblasts. Mutat Res 435 2 (1999) 129-139
31. Semionov A., Cournoyer D., and Chow T.Y. 1,5-Isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts. Biochem Cell Biol 81 1 (2003) 17-24
32. Smith-Ravin J., and Jeggo P.A. Use of damaged plasmid to study DNA repair in X-ray sensitive (xrs) strains of Chinese hamster ovary (CHO) cells. Int J Radiat Biol 56 6 (1989) 951-961
33. Smulson M., Istock N., Ding R., and Cherney B. Deletion mutants of poly(ADP-ribose) polymerase support a model of cyclic association and dissociation of enzyme from DNA ends during DNA repair. Biochemistry 33 20 (1994) 6186-6191
34. Takao N., Kato H., Mori R., Morrison C., Sonada E., Sun X., et al. Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation. Oncogene 18 50 (1999) 7002-7009
35. Ueda K., and Hayaishi O. ADP-ribosylation. Annu Rev Biochem 54 (1985) 73-100
36. Van Dyck E., Stasiak A.Z., Stasiak A., and West S.C. Binding of double-strand breaks in DNA by human Rad52 protein. Nature 398 6729 (1999) 728-731
37. Vásquez K.M., Marburger K., Intody Z., and Wilson J.H. Manipulating the mammalian genome by homologous recombination. Proc Natl Acad Sci U S A 98 15 (2001) 8403-8410
38. Waldman A.S., and Waldman B.C. Stimulation of intrachromosomal homologous recombination in mammalian cells by an inhibitor of poly(ADP-ribosylation). Nucleic Acids Res 19 21 (1991) 5943-5947
39. Waldman B.C., and Waldman A.S. Illegitimate and homologous recombination in mammalian cells: differential sensitivity to an inhibitor of poly(ADP-ribosylation). Nucleic Acids Res 18 20 (1990) 5981-5988
40. Wang Z.Q., Stingl L., Morrison C., Jantsch M., Los M., Schulze-Osthoff K., et al. PARP is important for genomic stability but dispensable in apoptosis. Genes Dev 11 18 (1997) 2347-2358
41. Yamaguchi-Iwai Y., Sonoda E., Buerstedde J.M., Bezzubova O., Morrison C., Takata M., et al. Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52. Mol Cell Biol 18 11 (1998) 6430-6435
42. Yang Y.G., Cortes U., Patnaik S., Jasin M., and Wang Z.Q. Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks. Oncogene 23 21 (2004) 3872-3882