Skeletal diversity by sequential one-pot and stepwise routes using morpholine ester scaffolds

Tetrahedron Letters

Volumn 51, Issue 48, 2010, Pages 6282-6285

  Ciofi, Leonardo ^a   Morvillo, Manfredi ^a   Sladojevich, Filippo ^b   Guarna, Antonio ^a   Trabocchi, Andrea ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Amino acids; Chemical diversity; Combinatorial Chemistry; Heterocycles; Peptidomimetics

Indexed keywords

ACETAL DERIVATIVE; AMINO ACID DERIVATIVE; ESTER DERIVATIVE; MORPHOLINE DERIVATIVE; PEPTIDOMIMETIC AGENT; PIPERAZINE DERIVATIVE; PIPERAZINEDIONE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ONE POT SYNTHESIS; SKELETAL DIVERSITY;

EID: 78049366423     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.09.103     Document Type: Article

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43. 3CN (5 mL/mmol) and allowed to react for 2 h at rt. The reaction mixture was then evaporated to obtain a pale brown solid, which was purified by flash chromatography (EtOAc-petroleum ether 3:1), to give the title bicyclic 2-oxopiperazine compounds as dark orange oils.
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