4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 15, 2008, Pages 4316-4320

  Alexander, Rikki ^a   Balasundaram, Ahrani ^a   Batchelor, Mark ^a   Brookings, Daniel ^a   Crépy, Karen ^a   Crabbe, Tom ^a   Deltent, Marie France ^b   Driessens, Frank ^b   Gill, Andrew ^a   Harris, Sue ^a   Hutchinson, Gillian ^a   Kulisa, Claire ^a   Merriman, Mark ^a   Mistry, Prakash ^a   Parton, Ted ^a   Turner, James ^a   Whitcombe, Ian ^a   Wright, Sara ^a  

^a UCB Group   (United Kingdom)

^b UCB PHARMA   (Belgium)

Author keywords

Kinase inhibitor; Oncology; PI3K

Indexed keywords

MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; ASTROCYTOMA; CONTROLLED STUDY; DRUG CLEARANCE; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; MOUSE; NONHUMAN; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH; XENOGRAFT;

1-PHOSPHATIDYLINOSITOL 4-KINASE; ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOENZYMES; MICE; MOLECULAR STRUCTURE; MORPHOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 47749100391     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.06.076     Document Type: Article

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