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Other less effective Lewis acids surveyed for epoxide ring opening include: Yb(OTf)3, Yb(O-iPr)3, Sc(OTf)3, LiClO4, ZrCl4, Zr(O-iPr)4, Mg-(ClO 4)2, R,R)-Co(Salen, B(C6F5) 3, LiNTf2, NaH, Rh(CO)2Cl]2, SmI2-(THF)2, Aliquat R336, Sm(O-iPr)3, La(O-iPr)3, Bi(OTf)3·H2O, NaOMe, NaI, ZnCl2
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Azido lactones 7a and 7b were initially obtained from the reaction of (R)- and (S)-tosyl lactones with use of sodium azide. However, use of (R)- and (S)-2-azidomethyloxirane in ring openings provided both cis and trans lactones 7 and 9 in excellent yields.
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Azido lactones 7a and 7b were initially obtained from the reaction of (R)- and (S)-tosyl lactones with use of sodium azide. However, use of (R)- and (S)-2-azidomethyloxirane in ring openings provided both cis and trans lactones 7 and 9 in excellent yields.
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The ultility of the arylbromide functionality in building blocks 3 and 6 has been established earlier on our studies of diketopiperazines; see ref 1f
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The ultility of the arylbromide functionality in building blocks 3 and 6 has been established earlier on our studies of diketopiperazines; see ref 1f.
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