Structural Basis for Substrate Recognition and Specificity in Aklavinone-11-Hydroxylase from Rhodomycin Biosynthesis

Journal of Molecular Biology

Volumn 393, Issue 4, 2009, Pages 966-977

  Lindqvist, Ylva ^a   Koskiniemi, Hanna ^a   Jansson, Anna ^a   Sandalova, Tatyana ^a   Schnell, Robert ^a   Liu, Zhanliang ^b   Mäntsälä, Pekka ^b   Niemi, Jarmo ^b   Schneider, Gunter ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

anthracycline; aromatic hydroxylase; flavoenzyme; merohedral twinning; polyketide biosynthesis

Indexed keywords

AKLAVINONE; AKLAVINONE 11 HYDROXYLASE; ANTIBIOTIC AGENT; BACTERIAL ENZYME; FLAVINE ADENINE NUCLEOTIDE; HYDROXYL GROUP; OXYGENASE; PHENYLALANINE; PROTEIN RDME; RHODOMYCIN; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STREPTOMYCES; STREPTOMYCES PURPURASCENS; STRUCTURAL HOMOLOGY; WILD TYPE;

STREPTOMYCES; STREPTOMYCES PURPURASCENS;

AMINO ACID SEQUENCE; ANTHRACYCLINES; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, QUATERNARY; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 70349791995     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.09.003     Document Type: Article

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