-
1
-
-
0024504359
-
The natural history of multiple sclerosis: A geographically based study. I. Clinical course and disability
-
Weinshenker BG, Bass B, Rice GP, et al. The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain 1989;112(Pt 1):133-46
-
(1989)
Brain
, vol.112
, Issue.PART 1
, pp. 133-46
-
-
Weinshenker, B.G.1
Bass, B.2
Rice, G.P.3
-
2
-
-
77949885488
-
Continuous long-term immunomodulatory therapy in relapsing multiple sclerosis: Results from the 15-year analysis of the US prospective open-label study of glatiramer acetate
-
Ford C, Goodman AD, Johnson K, et al. Continuous long-term immunomodulatory therapy in relapsing multiple sclerosis: results from the 15-year analysis of the US prospective open-label study of glatiramer acetate. Mult Scler 2010;16(3):342-50
-
(2010)
Mult Scler
, vol.16
, Issue.3
, pp. 342-50
-
-
Ford, C.1
Goodman, A.D.2
Johnson, K.3
-
3
-
-
33744814611
-
A prospective open-label study of glatiramer acetate: Over a decade of continuous use in multiple sclerosis patients
-
Ford CC, Johnson KP, Lisak RP, et al. A prospective open-label study of glatiramer acetate: over a decade of continuous use in multiple sclerosis patients. Mult Scler 2006;12(3):309-20
-
(2006)
Mult Scler
, vol.12
, Issue.3
, pp. 309-20
-
-
Ford, C.C.1
Johnson, K.P.2
Lisak, R.P.3
-
4
-
-
0029082566
-
Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind placebo-controlled trial. The copolymer 1 multiple sclerosis study group
-
Johnson KP, Brooks BR, Cohen JA, et al. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. The Copolymer 1 Multiple Sclerosis Study Group. Neurology 1995;45(7):1268-76
-
(1995)
Neurology
, vol.45
, Issue.7
, pp. 1268-76
-
-
Johnson, K.P.1
Brooks, B.R.2
Cohen, J.A.3
-
5
-
-
6844254570
-
Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability. Copolymer 1 Multiple Sclerosis Study Group
-
Johnson KP, Brooks BR, Cohen JA, et al. Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability. Copolymer 1 Multiple Sclerosis Study Group. Neurology 1998;50(3):701-8
-
(1998)
Neurology
, vol.50
, Issue.3
, pp. 701-8
-
-
Johnson, K.P.1
Brooks, B.R.2
Cohen, J.A.3
-
6
-
-
0033842848
-
Sustained clinical benefits of glatiramer acetate in relapsing multiple sclerosis patients observed for 6 years. Copolymer 1 Multiple Sclerosis Study Group
-
Johnson KP, Brooks BR, Ford CC, et al. Sustained clinical benefits of glatiramer acetate in relapsing multiple sclerosis patients observed for 6 years. Copolymer 1 Multiple Sclerosis Study Group. Mult Scler 2000;6(4):255-66
-
(2000)
Mult Scler
, vol.6
, Issue.4
, pp. 255-66
-
-
Johnson, K.P.1
Brooks, B.R.2
Ford, C.C.3
-
7
-
-
12744273688
-
Neurologic consequence of delaying glatiramer acetate therapy for multiple sclerosis: 8-year data
-
Johnson KP, Ford CC, Lisak RP, Wolinsky JS. Neurologic consequence of delaying glatiramer acetate therapy for multiple sclerosis: 8-year data. Acta Neurol Scand 2005;111(1):42-7
-
(2005)
Acta Neurol Scand
, vol.111
, Issue.1
, pp. 42-7
-
-
Johnson, K.P.1
Ford, C.C.2
Lisak, R.P.3
Wolinsky, J.S.4
-
8
-
-
0038387390
-
The dawning era of polymer therapeutics
-
Duncan R. The dawning era of polymer therapeutics. Nat Rev Drug Discov 2003;2(5):347-60.
-
(2003)
Nat Rev Drug Discov
, vol.2
, Issue.5
, pp. 347-360
-
-
Duncan, R.1
-
9
-
-
0037362655
-
Effect of pegylation on pharmaceuticals
-
Harris JM, Chess RB. Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov 2003;2(3):214-21
-
(2003)
Nat Rev Drug Discov
, vol.2
, Issue.3
, pp. 214-21
-
-
Harris, J.M.1
Chess, R.B.2
-
10
-
-
76149146724
-
Polymeric micelles as a new drug carrier system and their required considerations for clinical trials
-
Yokoyama M. Polymeric micelles as a new drug carrier system and their required considerations for clinical trials. Expert Opin Drug Deliv 2010;7(2):145-58
-
(2010)
Expert Opin Drug Deliv
, vol.7
, Issue.2
, pp. 145-58
-
-
Yokoyama, M.1
-
11
-
-
0032126044
-
Stabilization of substances in circulation
-
Monfardini C, Veronese FM. Stabilization of substances in circulation. Bioconjug Chem 1998;9(4):418-50
-
(1998)
Bioconjug Chem
, vol.9
, Issue.4
, pp. 418-50
-
-
Monfardini, C.1
Veronese, F.M.2
-
12
-
-
0026124772
-
The therapeutic value of poly(ethylene glycol)-modified proteins
-
Nucci M, Shorr R, Abuchowski A. The therapeutic value of poly(ethylene glycol)-modified proteins. Adv Drug Deliv Rev 1991;6(2):133-51
-
(1991)
Adv Drug Deliv Rev
, vol.6
, Issue.2
, pp. 133-51
-
-
Nucci, M.1
Shorr, R.2
Abuchowski, A.3
-
13
-
-
0037124546
-
The origin of pegnology
-
Davis FF. The origin of pegnology. Adv Drug Deliv Rev 2002;54(4):457-8
-
(2002)
Adv Drug Deliv Rev
, vol.54
, Issue.4
, pp. 457-8
-
-
Davis, F.F.1
-
14
-
-
26944452043
-
PEGylation, successful approach to drug delivery
-
Veronese FM, Pasut G. PEGylation, successful approach to drug delivery. Drug Discov Today 2005;10(21):1451-8.
-
(2005)
Drug Discov Today
, vol.10
, Issue.21
, pp. 1451-1458
-
-
Veronese, F.M.1
Pasut, G.2
-
15
-
-
0023813205
-
Adenosine deaminase deficiency with late onset of recurrent infections: Response to treatment with polyethylene glycol-modified adenosine deaminase
-
Levy Y, Hershfield MS, Fernandez-Mejia C, et al. Adenosine deaminase deficiency with late onset of recurrent infections: response to treatment with polyethylene glycol-modified adenosine deaminase. J Pediatr 1988;113(2):312-17
-
(1988)
J Pediatr
, vol.113
, Issue.2
, pp. 312-17
-
-
Levy, Y.1
Hershfield, M.S.2
Fernandez-Mejia, C.3
-
16
-
-
22144481998
-
Eight-year immunogenicity and safety of interferon beta-1a-Avonex treatment in patients with multiple sclerosis
-
Herndon RM, Rudick RA, Munschauer FE III, et al. Eight-year immunogenicity and safety of interferon beta-1a-Avonex treatment in patients with multiple sclerosis. Mult Scler 2005;11(4):409-19
-
(2005)
Mult Scler
, vol.11
, Issue.4
, pp. 409-19
-
-
Herndon, R.M.1
Rudick, R.A.2
Munschauer III, F.E.3
-
17
-
-
77958525759
-
-
Efficacy and Safety Study of BIIB017 (ADVANCE). NIH 2009. Available from Last accessed August 2010
-
Efficacy and Safety Study of BIIB017 (ADVANCE). NIH 2009. Available from: http://clinicaltrials.gov/ct2/show/NCT00906399 [Last accessed August 2010]
-
-
-
-
18
-
-
0036796777
-
Efficacy of a novel PEGylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: A phase II double-blinded, randomized, dose-escalating trial
-
Choy EH, Hazleman B, Smith M, et al. Efficacy of a novel PEGylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: a phase II double-blinded, randomized, dose-escalating trial. Rheumatology (Oxford) 2002;41(10):1133-7
-
(2002)
Rheumatology (Oxford)
, vol.41
, Issue.10
, pp. 1133-7
-
-
Choy, E.H.1
Hazleman, B.2
Smith, M.3
-
19
-
-
24144483087
-
A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease
-
Schreiber S, Rutgeerts P, Fedorak RN, et al. A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease. Gastroenterology 2005;129(3):807-18
-
(2005)
Gastroenterology
, vol.129
, Issue.3
, pp. 807-18
-
-
Schreiber, S.1
Rutgeerts, P.2
Fedorak, R.N.3
-
20
-
-
77953660821
-
Certolizumab pegol
-
Goel N, Stephens S. Certolizumab pegol. MAbs 2010;2(2):137-47
-
(2010)
MAbs
, vol.2
, Issue.2
, pp. 137-47
-
-
Goel, N.1
Stephens, S.2
-
21
-
-
33746995205
-
Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase i trial of subcutaneous PEGylated urate oxidase
-
Ganson NJ, Kelly SJ, Scarlett E, et al. Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase. Arthritis Res Ther 2006;8(1):R12
-
(2006)
Arthritis Res Ther
, vol.8
, Issue.1
-
-
Ganson, N.J.1
Kelly, S.J.2
Scarlett, E.3
-
22
-
-
34248589255
-
Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes
-
Wang X, Ishida T, Kiwada H. Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes. J Control Release 2007;119(2):236-44.
-
(2007)
J Control Release
, vol.119
, Issue.2
, pp. 236-44
-
-
Wang, X.1
Ishida, T.2
Kiwada, H.3
-
23
-
-
58349110811
-
PEG minocycline-liposomes ameliorate CNS autoimmune disease
-
Hu W, Metselaar J, Ben LH, et al. PEG minocycline-liposomes ameliorate CNS autoimmune disease. PLoS One 2009;4(1):e4151
-
(2009)
PLoS One
, vol.4
, Issue.1
-
-
Hu, W.1
Metselaar, J.2
Ben, L.H.3
-
24
-
-
0036182057
-
Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium
-
Horisawa E, Kubota K, Tuboi I, et al. Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium. Pharm Res 2002;19(2):132-9
-
(2002)
Pharm Res
, vol.19
, Issue.2
, pp. 132-9
-
-
Horisawa, E.1
Kubota, K.2
Tuboi, I.3
-
25
-
-
65649115761
-
Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate
-
Ishihara T, Kubota T, Choi T, Higaki M. Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate. J Pharmacol Exp Ther 2009;329(2):412-17
-
(2009)
J Pharmacol Exp Ther
, vol.329
, Issue.2
, pp. 412-17
-
-
Ishihara, T.1
Kubota, T.2
Choi, T.3
Higaki, M.4
-
26
-
-
44649152160
-
A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes
-
Phillips B, Nylander K, Harnaha J, et al. A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes. Diabetes 2008;57(6):1544-55
-
(2008)
Diabetes
, vol.57
, Issue.6
, pp. 1544-55
-
-
Phillips, B.1
Nylander, K.2
Harnaha, J.3
-
27
-
-
42049117138
-
Enhancement of poly (orthoester) microspheres for DNA vaccine delivery by blending with poly(ethylenimine)
-
Nguyen DN, Raghavan SS, Tashima LM, et al. Enhancement of poly (orthoester) microspheres for DNA vaccine delivery by blending with poly(ethylenimine). Biomaterials 2008;29(18):2783-93
-
(2008)
Biomaterials
, vol.29
, Issue.18
, pp. 2783-93
-
-
Nguyen, D.N.1
Raghavan, S.S.2
Tashima, L.M.3
-
29
-
-
0035988896
-
A positive response to infliximab in Crohn disease: Association with a higher systemic inflammation before treatment but not with -308 TNF gene polymorphism
-
Louis E, Vermeire S, Rutgeerts P, et al. A positive response to infliximab in Crohn disease: association with a higher systemic inflammation before treatment but not with -308 TNF gene polymorphism. Scand J Gastroenterol 2002;37(7):818-24
-
(2002)
Scand J Gastroenterol
, vol.37
, Issue.7
, pp. 818-24
-
-
Louis, E.1
Vermeire, S.2
Rutgeerts, P.3
-
30
-
-
70350513538
-
Management of severe psoriasis with TNF antagonists. Adalimumab, etanercept and infliximab
-
Mossner R, Reich K. Management of severe psoriasis with TNF antagonists. Adalimumab, etanercept and infliximab. Curr Probl Dermatol 2009;38:107-36
-
(2009)
Curr Probl Dermatol
, vol.38
, pp. 107-36
-
-
Mossner, R.1
Reich, K.2
-
31
-
-
40749105734
-
Reduction of oxidative stress marker levels by anti-TNF-α antibody, infliximab, in patients with rheumatoid arthritis
-
Kageyama Y, Takahashi M, Ichikawa T, et al. Reduction of oxidative stress marker levels by anti-TNF-alpha antibody, infliximab, in patients with rheumatoid arthritis. Clin Exp Rheumatol 2008;26(1):73-80 (Pubitemid 351385258)
-
(2008)
Clinical and Experimental Rheumatology
, vol.26
, Issue.1
, pp. 73-80
-
-
Kageyama, Y.1
Takahashi, M.2
Ichikawa, T.3
Torikai, E.4
Nagano, A.5
-
32
-
-
67651146891
-
Infliximab therapy decreases the levels of TNF-alpha and IFN-gamma mRNA in colonic mucosa of ulcerative colitis
-
Olsen T, Cui G, Goll R, et al. Infliximab therapy decreases the levels of TNF-alpha and IFN-gamma mRNA in colonic mucosa of ulcerative colitis. Scand J Gastroenterol 2009;44(6):727-35
-
(2009)
Scand J Gastroenterol
, vol.44
, Issue.6
, pp. 727-35
-
-
Olsen, T.1
Cui, G.2
Goll, R.3
-
33
-
-
0038047689
-
Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease
-
Van den Brande JM, Braat H, van den Brink GR, et al. Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease. Gastroenterology 2003;124(7):1774-85
-
(2003)
Gastroenterology
, vol.124
, Issue.7
, pp. 1774-85
-
-
Van Den Brande, J.M.1
Braat, H.2
Van Den Brink, G.R.3
-
34
-
-
0141758337
-
New technologies in therapeutic antibody development
-
Brekke OH, Loset GA. New technologies in therapeutic antibody development. Curr Opin Pharmacol 2003;3(5):544-50
-
(2003)
Curr Opin Pharmacol
, vol.3
, Issue.5
, pp. 544-50
-
-
Brekke, O.H.1
Loset, G.A.2
-
35
-
-
84921706675
-
OKs two new uses for biologic arthritis drug adalimumab
-
FDA
-
FDA. OKs two new uses for biologic arthritis drug adalimumab. Health News 2006;12(1):2
-
(2006)
Health News
, vol.12
, Issue.1
, pp. 2
-
-
-
36
-
-
0031569177
-
CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice
-
Chatenoud L, Primo J, Bach JF. CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice. J Immunol 1997;158(6):2947-54
-
(1997)
J Immunol
, vol.158
, Issue.6
, pp. 2947-54
-
-
Chatenoud, L.1
Primo, J.2
Bach, J.F.3
-
37
-
-
0027958044
-
Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
-
Chatenoud L, Thervet E, Primo J, Bach JF. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci USA 1994;91(1):123-7.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, Issue.1
, pp. 123-7
-
-
Chatenoud, L.1
Thervet, E.2
Primo, J.3
Bach, J.F.4
-
38
-
-
1942451803
-
Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice
-
Makhlouf L, Grey ST, Dong V, et al. Depleting anti-CD4 monoclonal antibody cures new-onset diabetes, prevents recurrent autoimmune diabetes, and delays allograft rejection in nonobese diabetic mice. Transplantation 2004;77(7):990-7
-
(2004)
Transplantation
, vol.77
, Issue.7
, pp. 990-7
-
-
Makhlouf, L.1
Grey, S.T.2
Dong, V.3
-
39
-
-
20044375937
-
A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
-
Herold KC, Gitelman SE, Masharani U, et al. A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 2005;54(6):1763-9
-
(2005)
Diabetes
, vol.54
, Issue.6
, pp. 1763-9
-
-
Herold, K.C.1
Gitelman, S.E.2
Masharani, U.3
-
40
-
-
0032447240
-
Clinical status and optimal use of rituximab for B-cell lymphomas
-
discussion 69-70, 75-7
-
McLaughlin P, White CA, Grillo-Lopez AJ, Maloney DG. Clinical status and optimal use of rituximab for B-cell lymphomas. Oncology (Williston Park) 1998;12(12):1763-9, discussion 69-70, 75-7
-
(1998)
Oncology (Williston Park)
, vol.12
, Issue.12
, pp. 1763-9
-
-
McLaughlin, P.1
White, C.A.2
Grillo-Lopez, A.J.3
Maloney, D.G.4
-
41
-
-
0031957306
-
Rituximab: A new therapeutic monoclonal antibody for non-Hodgkin's lymphoma
-
Scott SD. Rituximab: a new therapeutic monoclonal antibody for non-Hodgkin's lymphoma. Cancer Pract 1998;6(3):195-7
-
(1998)
Cancer Pract
, vol.6
, Issue.3
, pp. 195-7
-
-
Scott, S.D.1
-
42
-
-
2942537697
-
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
-
Edwards JC, Szczepanski L, Szechinski J, et al. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 2004;350(25):2572-81
-
(2004)
N Engl J Med
, vol.350
, Issue.25
, pp. 2572-81
-
-
Edwards, J.C.1
Szczepanski, L.2
Szechinski, J.3
-
43
-
-
59449107122
-
NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
-
Reis EA, Athanazio DA, Lima I, et al. NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis. Rheumatol Int 2009;29(4):469-75
-
(2009)
Rheumatol Int
, vol.29
, Issue.4
, pp. 469-75
-
-
Reis, E.A.1
Athanazio, D.A.2
Lima, I.3
-
44
-
-
58749085559
-
Severe acute thrombotic exacerbation in two cases with anti-phospholipid syndrome after retreatment with rituximab in phase I/II clinical trial for refractory systemic lupus erythematosus
-
Suzuki K, Nagasawa H, Kameda H, et al. Severe acute thrombotic exacerbation in two cases with anti-phospholipid syndrome after retreatment with rituximab in phase I/II clinical trial for refractory systemic lupus erythematosus. Rheumatology (Oxford) 2009;48(2):198-9
-
(2009)
Rheumatology (Oxford)
, vol.48
, Issue.2
, pp. 198-9
-
-
Suzuki, K.1
Nagasawa, H.2
Kameda, H.3
-
45
-
-
39049142995
-
B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
-
Hauser SL, Waubant E, Arnold DL, et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med 2008;358(7):676-88
-
(2008)
N Engl J Med
, vol.358
, Issue.7
, pp. 676-88
-
-
Hauser, S.L.1
Waubant, E.2
Arnold, D.L.3
-
46
-
-
36849027817
-
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice
-
Hu CY, Rodriguez-Pinto D, Du W, et al. Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J Clin Invest 2007;117(12):3857-67
-
(2007)
J Clin Invest
, vol.117
, Issue.12
, pp. 3857-67
-
-
Hu, C.Y.1
Rodriguez-Pinto, D.2
Du, W.3
-
47
-
-
43049171493
-
B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions
-
Xiu Y, Wong CP, Bouaziz JD, et al. B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. J Immunol 2008;180(5):2863-75
-
(2008)
J Immunol
, vol.180
, Issue.5
, pp. 2863-75
-
-
Xiu, Y.1
Wong, C.P.2
Bouaziz, J.D.3
-
48
-
-
0029933309
-
Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
-
Sloan-Lancaster J, Allen PM. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu Rev Immunol 1996;14:1-27
-
(1996)
Annu Rev Immunol
, vol.14
, pp. 1-27
-
-
Sloan-Lancaster, J.1
Allen, P.M.2
-
49
-
-
0035142467
-
A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin
-
Alleva DG, Crowe PD, Jin L, et al. A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin. J Clin Invest 2001;107(2):173-80
-
(2001)
J Clin Invest
, vol.107
, Issue.2
, pp. 173-80
-
-
Alleva, D.G.1
Crowe, P.D.2
Jin, L.3
-
50
-
-
0036300542
-
Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide
-
Alleva DG, Gaur A, Jin L, et al. Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. Diabetes 2002;51(7):2126-34
-
(2002)
Diabetes
, vol.51
, Issue.7
, pp. 2126-34
-
-
Alleva, D.G.1
Gaur, A.2
Jin, L.3
-
51
-
-
0030699338
-
T cell recognition of self and altered self antigens
-
Nicholson LB, Kuchroo VK. T cell recognition of self and altered self antigens. Crit Rev Immunol 1997;17(5-6):449-62
-
(1997)
Crit Rev Immunol
, vol.17
, Issue.5-6
, pp. 449-62
-
-
Nicholson, L.B.1
Kuchroo, V.K.2
-
52
-
-
21344461521
-
Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes
-
Agardh CD, Cilio CM, Lethagen A, et al. Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes. J Diabetes Complications 2005;19(4):238-46
-
(2005)
J Diabetes Complications
, vol.19
, Issue.4
, pp. 238-46
-
-
Agardh, C.D.1
Cilio, C.M.2
Lethagen, A.3
-
53
-
-
34249812097
-
Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: Extension of a randomized, double-blind, phase II trial
-
Raz I, Avron A, Tamir M, et al. Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trial. Diabetes Metab Res Rev 2007;23(4):292-8
-
(2007)
Diabetes Metab Res Rev
, vol.23
, Issue.4
, pp. 292-8
-
-
Raz, I.1
Avron, A.2
Tamir, M.3
-
54
-
-
0035944844
-
Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
-
Raz I, Elias D, Avron A, et al. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 2001;358(9295):1749-53
-
(2001)
Lancet
, vol.358
, Issue.9295
, pp. 1749-53
-
-
Raz, I.1
Elias, D.2
Avron, A.3
-
55
-
-
34249820806
-
Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: A randomised, double-blind phase II study
-
Lazar L, Ofan R, Weintrob N, et al. Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: a randomised, double-blind phase II study. Diabetes Metab Res Rev 2007;23(4):286-91
-
(2007)
Diabetes Metab Res Rev
, vol.23
, Issue.4
, pp. 286-91
-
-
Lazar, L.1
Ofan, R.2
Weintrob, N.3
-
56
-
-
0033012077
-
Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis
-
discussion 1-2
-
Goldenberg MM. Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis. Clin Ther 1999;21(1):75-87, discussion 1-2
-
(1999)
Clin Ther
, vol.21
, Issue.1
, pp. 75-87
-
-
Goldenberg, M.M.1
-
57
-
-
77952504512
-
The effect of anti-tumor necrosis factor (TNF)-alpha therapy with etanercept on endothelial functions in patients with rheumatoid arthritis
-
Tikiz H, Arslan O, Pirildar T, et al. The effect of anti-tumor necrosis factor (TNF)-alpha therapy with etanercept on endothelial functions in patients with rheumatoid arthritis. Anadolu Kardiyol Derg 2010;10(2):98-103
-
(2010)
Anadolu Kardiyol Derg
, vol.10
, Issue.2
, pp. 98-103
-
-
Tikiz, H.1
Arslan, O.2
Pirildar, T.3
-
58
-
-
33645450590
-
Abatacept (Orencia) for rheumatoid arthritis
-
Editor
-
Abramowicz Mark, Editor. Abatacept (Orencia) for rheumatoid arthritis Med Lett Drugs Ther 2006;48(1229):17-18
-
(2006)
Med Lett Drugs Ther
, vol.48
, Issue.1229
, pp. 17-18
-
-
Mark, A.1
-
59
-
-
2942733370
-
CTLA4Ig: A novel inhibitor of costimulation
-
Dall'Era M, Davis J. CTLA4Ig: a novel inhibitor of costimulation. Lupus 2004;13(5):372-6
-
(2004)
Lupus
, vol.13
, Issue.5
, pp. 372-6
-
-
Dall'Era, M.1
Davis, J.2
-
60
-
-
77958592437
-
-
A Study of Abatacept in patients with active ulcerative colitis. NIH 2006. Available from Last accessed August 2010
-
A Study of Abatacept in patients with active ulcerative colitis. NIH 2006. Available from: http://clinicaltrials.gov/ct/show/NCT00410410 [Last accessed August 2010]
-
-
-
-
61
-
-
77958588340
-
-
Intravenous CTLA4-lg treatment in recent onset type 1 diabetes mellitus. 2007. Available from Last accessed August 2010
-
Intravenous CTLA4-lg treatment in recent onset type 1 diabetes mellitus. 2007. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00505375 [Last accessed August 2010]
-
-
-
-
62
-
-
0242353920
-
Targeting cytokines to inflammation sites
-
Adams G, Vessillier S, Dreja H, Chernajovsky Y. Targeting cytokines to inflammation sites. Nat Biotechnol 2003;21(11):1314-20.
-
(2003)
Nat Biotechnol
, vol.21
, Issue.11
, pp. 1314-20
-
-
Adams, G.1
Vessillier, S.2
Dreja, H.3
Chernajovsky, Y.4
-
63
-
-
51549116988
-
A phase II multicenter trial comparing two schedules of lapatinib (LAP) as first or second line monotherapy in subjects with advanced or metastatic non-small cell lung cancer (NSCLC) with either bronchioloalveolar carcinoma (BAC) or no smoking history. 2007 ASCO Annual Meeting Proceedings (Post-Meeting Edition)
-
Smylie M, Blumenschein GR, Dowlati J, et al. A phase II multicenter trial comparing two schedules of lapatinib (LAP) as first or second line monotherapy in subjects with advanced or metastatic non-small cell lung cancer (NSCLC) with either bronchioloalveolar carcinoma (BAC) or no smoking history. 2007 ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol 2007;25(18S):7611
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
, pp. 7611
-
-
Smylie, M.1
Blumenschein, G.R.2
Dowlati, J.3
-
64
-
-
34548176571
-
Protein transduction: Identification, characterization and optimization
-
Tilstra J, Rehman KK, Hennon T, et al. Protein transduction: identification, characterization and optimization. Biochem Soc Trans 2007;35(Pt 4):811-15
-
(2007)
Biochem Soc Trans
, vol.35
, Issue.PART 4
, pp. 811-15
-
-
Tilstra, J.1
Rehman, K.K.2
Hennon, T.3
-
65
-
-
0033678653
-
Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation
-
Rothbard JB, Garlington S, Lin Q, et al. Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation. Nat Med 2000;6(11):1253-7
-
(2000)
Nat Med
, vol.6
, Issue.11
, pp. 1253-7
-
-
Rothbard, J.B.1
Garlington, S.2
Lin, Q.3
-
66
-
-
56049093057
-
Cell-penetrating and cell-targeting peptides in drug delivery
-
Vives E, Schmidt J, Pelegrin A. Cell-penetrating and cell-targeting peptides in drug delivery. Biochim Biophys Acta 2008;1786(2):126-38
-
(2008)
Biochim Biophys Acta
, vol.1786
, Issue.2
, pp. 126-38
-
-
Vives, E.1
Schmidt, J.2
Pelegrin, A.3
-
67
-
-
11144229887
-
Tumor imaging by means of proteolytic activation of cell-penetrating peptides
-
Jiang T, Olson ES, Nguyen QT, et al. Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proc Natl Acad Sci USA 2004;101(51):17867-72
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.51
, pp. 17867-72
-
-
Jiang, T.1
Olson, E.S.2
Nguyen, Q.T.3
-
68
-
-
0042355298
-
Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium
-
Mi Z, Lu X, Mai JC, et al. Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium. Mol Ther 2003;8(2):295-305
-
(2003)
Mol Ther
, vol.8
, Issue.2
, pp. 295-305
-
-
Mi, Z.1
Lu, X.2
Mai, J.C.3
-
69
-
-
0033013888
-
Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein
-
Vocero-Akbani AM, Heyden NV, Lissy NA, et al. Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein. Nat Med 1999;5(1):29-33
-
(1999)
Nat Med
, vol.5
, Issue.1
, pp. 29-33
-
-
Vocero-Akbani, A.M.1
Heyden, N.V.2
Lissy, N.A.3
-
70
-
-
0038485615
-
Vectors for the treatment of autoimmune disease
-
Gould DJ, Favorov P. Vectors for the treatment of autoimmune disease. Gene Ther 2003;10(10):912-27
-
(2003)
Gene Ther
, vol.10
, Issue.10
, pp. 912-27
-
-
Gould, D.J.1
Favorov, P.2
-
71
-
-
0031055468
-
Construction of adenovirus vectors through Cre-lox recombination
-
Hardy S, Kitamura M, Harris-Stansil T, et al. Construction of adenovirus vectors through Cre-lox recombination. J Virol 1997;71(3):1842-9
-
(1997)
J Virol
, vol.71
, Issue.3
, pp. 1842-9
-
-
Hardy, S.1
Kitamura, M.2
Harris-Stansil, T.3
-
72
-
-
0030462599
-
A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal
-
Parks RJ, Chen L, Anton M, et al. A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci USA 1996;93(24):13565-70
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, Issue.24
, pp. 13565-70
-
-
Parks, R.J.1
Chen, L.2
Anton, M.3
-
74
-
-
0032845120
-
Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis
-
Oligino T, Ghivizzani S, Wolfe D, et al. Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis. Gene Ther 1999;6(10):1713-20
-
(1999)
Gene Ther
, vol.6
, Issue.10
, pp. 1713-20
-
-
Oligino, T.1
Ghivizzani, S.2
Wolfe, D.3
-
75
-
-
30544453442
-
Inhibition of experimental autoimmune anterior uveitis by adenovirus-mediated transfer of the interleukin-10 gene
-
Fang IM, Lin CP, Yang CH, et al. Inhibition of experimental autoimmune anterior uveitis by adenovirus-mediated transfer of the interleukin-10 gene. J Ocul Pharmacol Ther 2005;21(6):420-8
-
(2005)
J Ocul Pharmacol Ther
, vol.21
, Issue.6
, pp. 420-8
-
-
Fang, I.M.1
Lin, C.P.2
Yang, C.H.3
-
76
-
-
42549144899
-
Remission of diabetes by beta-cell regeneration in diabetic mice treated with a recombinant adenovirus expressing betacellulin
-
Shin S, Li N, Kobayashi N, et al. Remission of diabetes by beta-cell regeneration in diabetic mice treated with a recombinant adenovirus expressing betacellulin. Mol Ther 2008;16(5):854-61
-
(2008)
Mol Ther
, vol.16
, Issue.5
, pp. 854-61
-
-
Shin, S.1
Li, N.2
Kobayashi, N.3
-
77
-
-
57749175504
-
Intravenous administration of proinsulin 1 or 2-expressing fiber-mutant recombinant adenovirus vector protects against the development of diabetes in NOD mice
-
Yamada K, Moriyama H, Okumachi Y, et al. Intravenous administration of proinsulin 1 or 2-expressing fiber-mutant recombinant adenovirus vector protects against the development of diabetes in NOD mice. Ann NY Acad Sci 2008;1150:183-6
-
(2008)
Ann NY Acad Sci
, vol.1150
, pp. 183-6
-
-
Yamada, K.1
Moriyama, H.2
Okumachi, Y.3
-
78
-
-
28244461329
-
Enhancement of adenovirus-mediated gene delivery to rheumatoid arthritis synoviocytes and synovium by fiber modifications: Role of arginine-glycine- aspartic acid (RGD)- and non-RGD-binding integrins
-
Toh ML, Hong SS, van de Loo F, et al. Enhancement of adenovirus-mediated gene delivery to rheumatoid arthritis synoviocytes and synovium by fiber modifications: role of arginine-glycine-aspartic acid (RGD)- and non-RGD-binding integrins. J Immunol 2005;175(11):7687-98
-
(2005)
J Immunol
, vol.175
, Issue.11
, pp. 7687-98
-
-
Toh, M.L.1
Hong, S.S.2
Van De Loo, F.3
-
79
-
-
37749038350
-
Gene delivery GAD 500 autoantigen by AAV serotype 1 prevented diabetes in NOD mice: Transduction efficiency do not play important roles
-
Han G, Wang R, Chen G, et al. Gene delivery GAD 500 autoantigen by AAV serotype 1 prevented diabetes in NOD mice: transduction efficiency do not play important roles. Immunol Lett 2008;115(2):110-16
-
(2008)
Immunol Lett
, vol.115
, Issue.2
, pp. 110-16
-
-
Han, G.1
Wang, R.2
Chen, G.3
-
80
-
-
34447554585
-
Inflammation-inducible anti-TNF gene expression mediated by intra-articular injection of serotype 5 adeno-associated virus reduces arthritis
-
Khoury M, Adriaansen J, Vervoordeldonk MJ, et al. Inflammation-inducible anti-TNF gene expression mediated by intra-articular injection of serotype 5 adeno-associated virus reduces arthritis. J Gene Med 2007;9(7):596-604
-
(2007)
J Gene Med
, vol.9
, Issue.7
, pp. 596-604
-
-
Khoury, M.1
Adriaansen, J.2
Vervoordeldonk, M.J.3
-
81
-
-
77649121784
-
Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritis
-
Khoury M, Courties G, Fabre S, et al. Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritis. Arthritis Rheum 2010;62(3):765-70
-
(2010)
Arthritis Rheum
, vol.62
, Issue.3
, pp. 765-70
-
-
Khoury, M.1
Courties, G.2
Fabre, S.3
-
83
-
-
0033579358
-
Gene therapy death prompts review of adenovirus vector
-
Marshall E. Gene therapy death prompts review of adenovirus vector. Science 1999;286(5448):2244-5
-
(1999)
Science
, vol.286
, Issue.5448
, pp. 2244-5
-
-
Marshall, E.1
-
84
-
-
0035021177
-
Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis
-
Morita Y, Yang J, Gupta R, et al. Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J Clin Invest 2001;107(10):1275-84
-
(2001)
J Clin Invest
, vol.107
, Issue.10
, pp. 1275-84
-
-
Morita, Y.1
Yang, J.2
Gupta, R.3
-
85
-
-
0035003202
-
Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis
-
Nakajima A, Seroogy CM, Sandora MR, et al. Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis. J Clin Invest 2001;107(10):1293-301
-
(2001)
J Clin Invest
, vol.107
, Issue.10
, pp. 1293-301
-
-
Nakajima, A.1
Seroogy, C.M.2
Sandora, M.R.3
-
86
-
-
41549150638
-
Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice
-
Creusot RJ, Yaghoubi SS, Kodama K, et al. Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice. Clin Immunol 2008;127(2):176-87
-
(2008)
Clin Immunol
, vol.127
, Issue.2
, pp. 176-87
-
-
Creusot, R.J.1
Yaghoubi, S.S.2
Kodama, K.3
-
87
-
-
0035865707
-
A gene therapy approach for treating T-cell-mediated autoimmune diseases
-
Chen C, Rivera A, Ron N, et al. A gene therapy approach for treating T-cell-mediated autoimmune diseases. Blood 2001;97(4):886-94
-
(2001)
Blood
, vol.97
, Issue.4
, pp. 886-94
-
-
Chen, C.1
Rivera, A.2
Ron, N.3
-
88
-
-
0034936846
-
Approaches to enhancing the retroviral transduction of human synoviocytes
-
Del Vecchio MA, Georgescu HI, McCormack JE, et al. Approaches to enhancing the retroviral transduction of human synoviocytes. Arthritis Res 2001;3(4):259-63
-
(2001)
Arthritis Res
, vol.3
, Issue.4
, pp. 259-63
-
-
Vecchio Ma, D.1
Georgescu, H.I.2
McCormack, J.E.3
-
89
-
-
58849159153
-
Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis
-
Wehling P, Reinecke J, Baltzer AA, et al. Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis. Hum Gene Ther 2009;20:97-101
-
(2009)
Hum Gene Ther
, vol.20
, pp. 97-101
-
-
Wehling, P.1
Reinecke, J.2
Baltzer, A.A.3
-
90
-
-
33746578466
-
Safety of extended treatment with anakinra in patients with rheumatoid arthritis
-
Fleischmann RM, Tesser J, Schiff MH, et al. Safety of extended treatment with anakinra in patients with rheumatoid arthritis. Ann Rheum Dis 2006;65(8):1006-12
-
(2006)
Ann Rheum Dis
, vol.65
, Issue.8
, pp. 1006-12
-
-
Fleischmann, R.M.1
Tesser, J.2
Schiff, M.H.3
-
91
-
-
38649091006
-
Case of leukaemia associated with X-linked severe combined immunodeficiency gene therapy trial in London
-
Board of the European Society of Gene and Cell Therapy, Executive Committee of the Clinigene Network of Excellence, Executive of the Consert Integrated Project
-
Board of the European Society of Gene and Cell Therapy, Executive Committee of the Clinigene Network of Excellence, Executive of the Consert Integrated Project. Case of leukaemia associated with X-linked severe combined immunodeficiency gene therapy trial in London. Hum Gene Ther 2008;19(1):3-4
-
(2008)
Hum Gene Ther
, vol.19
, Issue.1
, pp. 3-4
-
-
-
92
-
-
33947726341
-
Moving towards efficient therapies in type 1 diabetes: To combine or not to combine?
-
Bresson D, von Herrath M. Moving towards efficient therapies in type 1 diabetes: to combine or not to combine? Autoimmun Rev 2007;6(5):315-22
-
(2007)
Autoimmun Rev
, vol.6
, Issue.5
, pp. 315-22
-
-
Bresson, D.1
Von Herrath, M.2
-
94
-
-
0036826744
-
The mononuclear phagocyte system revisited
-
Hume DA, Ross IL, Himes SR, et al. The mononuclear phagocyte system revisited. J Leukoc Biol 2002;72(4):621-7
-
(2002)
J Leukoc Biol
, vol.72
, Issue.4
, pp. 621-7
-
-
Hume, D.A.1
Ross, I.L.2
Himes, S.R.3
-
95
-
-
33845898737
-
Steady-state and inflammatory dendritic-cell development
-
Shortman K, Naik SH. Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol 2007;7(1):19-30
-
(2007)
Nat Rev Immunol
, vol.7
, Issue.1
, pp. 19-30
-
-
Shortman, K.1
Naik, S.H.2
-
96
-
-
0029979341
-
Costimulation and its role in organ transplantation
-
Bluestone JA. Costimulation and its role in organ transplantation. Clin Transplant 1996;10(1 Pt 2):104-9
-
(1996)
Clin Transplant
, vol.10
, Issue.1 PART 2
, pp. 104-9
-
-
Bluestone, J.A.1
-
97
-
-
0034028186
-
The role of costimulatory molecules as targets for new immunosuppressives in transplantation
-
Kishimoto K, Dong VM, Sayegh MH. The role of costimulatory molecules as targets for new immunosuppressives in transplantation. Curr Opin Urol 2000;10(2):57-62
-
(2000)
Curr Opin Urol
, vol.10
, Issue.2
, pp. 57-62
-
-
Kishimoto, K.1
Dong, V.M.2
Sayegh, M.H.3
-
98
-
-
25444508245
-
T-cell costimulatory pathways in allograft rejection and tolerance
-
Clarkson MR, Sayegh MH. T-cell costimulatory pathways in allograft rejection and tolerance. Transplantation 2005;80(5):555-63
-
(2005)
Transplantation
, vol.80
, Issue.5
, pp. 555-63
-
-
Clarkson, M.R.1
Sayegh, M.H.2
-
99
-
-
4644297765
-
Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells
-
Machen J, Harnaha J, Lakomy R, et al. Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells. J Immunol 2004;173(7):4331-41
-
(2004)
J Immunol
, vol.173
, Issue.7
, pp. 4331-41
-
-
MacHen, J.1
Harnaha, J.2
Lakomy, R.3
-
100
-
-
33644779794
-
Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells
-
Harnaha J, Machen J, Wright M, et al. Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells. Diabetes 2006;55(1):158-70
-
(2006)
Diabetes
, vol.55
, Issue.1
, pp. 158-70
-
-
Harnaha, J.1
MacHen, J.2
Wright, M.3
|