Case of leukaemia associated with X-linked severe combined immunodeficiency gene therapy trial in London

Human Gene Therapy

Volumn 19, Issue 1, 2008, Pages 3-4

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS VECTOR;

CANCER CELL; CARCINOGENESIS; CLINICAL TRIAL; DISEASE ASSOCIATION; GENE OVEREXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; LEUKEMIA; NOTE; PROTO ONCOGENE; RISK ASSESSMENT; UNITED KINGDOM; X LINKED SEVERE COMBINED IMMUNODEFICIENCY;

CLINICAL TRIALS AS TOPIC; GENE THERAPY; HUMANS; LEUKEMIA; LONDON; X-LINKED COMBINED IMMUNODEFICIENCY DISEASES;

EID: 38649091006     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2007.1221     Document Type: Note

References (6)

1. CAVAZZANA-CALVO, M. (2007). Gene therapy for SCID-X1. Hum. Gene Ther. 18, 944.
2. CAVAZZANA-CALVO, M., and FISCHER, A. (2007). Gene therapy for severe combined immunodeficiency: Are we there yet? J. Clin. Invest. 117, 1456-1465.
3. HACEIN-BEY-ABINA, S., VON KALLE, C., SCHMIDT, M., MCCORMACK, M.P., WULFFRAAT, N., LEBOULCH, P., LIM, A., OSBORNE, C.S., PAWLIUK, R., MORILLON, E., SORENSEN, R., FORSTER, A., FRASER, P., COHEN, J.I., DE SAINT BASILE, G., ALEXANDER, I., WINTERGERST, U., FREBOURG, T., AURIAS, A., STOPPA-LYONNET, D., ROMANA, S., RADFORD-WEISS, I., GROSS, F., VALENSI, F., DELABESSE, E., MACINTYRE, E., SIGAUX, F., SOULIER, J., LEIVA, L.E., WISSLER, M., PRINZ, C., RABBITTS, T.H., LE DEIST, F., FISCHER, A., and CAVAZZANACALVO, M. (2003). LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302, 415-419.
4. MONTINI, E., CESANA, D., SCHMIDT, M., SANVITO, F., PONZONI, M., BARTHOLOMAE, C., SERGI SERGI, L., BENEDICENTI, F., AMBROSI, A., DI SERIO, C., DOGLIONI, C., VON KALLE, C., and NALDINI, L. (2006). Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat. Biotechnol. 24, 687-696.
5. SCHAMBACH, A., ZYCHLINSKI, D., MODLICH, U., MAETZIG, T., MEYER, J., KNOESS, S., and BAUM, C. (2007). Correlation of enhancer interactions and insertional biosafety of retroviral vectors. Hum. Gene Ther. 18, 972.
6. THRASHER, A., and GASPAR, B. (2007). Press release dated December 18, 2007; available at http://www.esgct.org/upload/ESGCT%20Commentary-UK-SCID- Leukaemia-18DEC2007%20(GDFINAL).pdf (accessed December 2007).