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Volumn 14, Issue 10, 2010, Pages 2404-2414

The zinc finger domain of IKKγ (NEMO) protein in health and disease

Author keywords

Ectodermal dysplasia; Hyper IgM syndrome; IKKgamma; Immune deficiency; NEMO; Ubiquitination; Zinc finger

Indexed keywords

I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; ZINC FINGER PROTEIN;

EID: 77958517570     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2010.01054.x     Document Type: Article
Times cited : (27)

References (89)
  • 1
    • 0032568792 scopus 로고    scopus 로고
    • Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation
    • Yamaoka S, Courtois G, Bessia C, et al Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell. 1998; 93: 1231-40.
    • (1998) Cell. , vol.93 , pp. 1231-1240
    • Yamaoka, S.1    Courtois, G.2    Bessia, C.3
  • 2
    • 0032541657 scopus 로고    scopus 로고
    • IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
    • Rothwarf DM, Zandi E, Natoli G, et al IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature. 1998; 395: 297-300.
    • (1998) Nature. , vol.395 , pp. 297-300
    • Rothwarf, D.M.1    Zandi, E.2    Natoli, G.3
  • 3
    • 0032589935 scopus 로고    scopus 로고
    • IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
    • Mercurio F, Murray BW, Shevchenko A, et al IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol Cell Biol. 1999; 19: 1526-38.
    • (1999) Mol Cell Biol. , vol.19 , pp. 1526-1538
    • Mercurio, F.1    Murray, B.W.2    Shevchenko, A.3
  • 4
    • 0033514445 scopus 로고    scopus 로고
    • Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis
    • Li Y, Kang J, Friedman J, et al Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis. Proc Natl Acad Sci USA. 1999; 96: 1042-7.
    • (1999) Proc Natl Acad Sci USA. , vol.96 , pp. 1042-1047
    • Li, Y.1    Kang, J.2    Friedman, J.3
  • 5
    • 0030610362 scopus 로고    scopus 로고
    • A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
    • DiDonato JA, Hayakawa M, Rothwarf DM, et al A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature. 1997; 388: 548-54.
    • (1997) Nature. , vol.388 , pp. 548-554
    • DiDonato, J.A.1    Hayakawa, M.2    Rothwarf, D.M.3
  • 6
    • 0030685825 scopus 로고    scopus 로고
    • IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation
    • Mercurio F, Zhu H, Murray BW, et al IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science. 1997; 278: 860-6.
    • (1997) Science. , vol.278 , pp. 860-866
    • Mercurio, F.1    Zhu, H.2    Murray, B.W.3
  • 7
    • 0030613551 scopus 로고    scopus 로고
    • The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
    • Zandi E, Rothwarf DM, Delhase M, et al The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell. 1997; 91: 243-52.
    • (1997) Cell. , vol.91 , pp. 243-252
    • Zandi, E.1    Rothwarf, D.M.2    Delhase, M.3
  • 8
    • 0031586174 scopus 로고    scopus 로고
    • Identification and characterization of an IkappaB kinase
    • Regnier CH, Song HY, Gao X, et al Identification and characterization of an IkappaB kinase. Cell. 1997; 90: 373-83.
    • (1997) Cell. , vol.90 , pp. 373-383
    • Regnier, C.H.1    Song, H.Y.2    Gao, X.3
  • 9
    • 0030611595 scopus 로고    scopus 로고
    • IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK
    • Woronicz JD, Gao X, Cao Z, et al IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science. 1997; 278: 866-9.
    • (1997) Science. , vol.278 , pp. 866-869
    • Woronicz, J.D.1    Gao, X.2    Cao, Z.3
  • 10
    • 0030004897 scopus 로고    scopus 로고
    • Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity
    • Chen ZJ, Parent L, Maniatis T. Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. Cell. 1996; 84: 853-62.
    • (1996) Cell. , vol.84 , pp. 853-862
    • Chen, Z.J.1    Parent, L.2    Maniatis, T.3
  • 11
    • 0031897632 scopus 로고    scopus 로고
    • NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
    • Ghosh S, May MJ, Kopp EB. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol. 1998; 16: 225-60.
    • (1998) Annu Rev Immunol. , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 12
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa B and I kappa B proteins: new discoveries and insights
    • Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol. 1996; 14: 649-83.
    • (1996) Annu Rev Immunol. , vol.14 , pp. 649-683
    • Baldwin Jr, A.S.1
  • 13
    • 15044350623 scopus 로고    scopus 로고
    • A beginner's guide to NF-kappaB signaling pathways
    • Delhalle S, Blasius R, Dicato M, et al A beginner's guide to NF-kappaB signaling pathways. Ann N Y Acad Sci. 2004; 1030: 1-13.
    • (2004) Ann N Y Acad Sci. , vol.1030 , pp. 1-13
    • Delhalle, S.1    Blasius, R.2    Dicato, M.3
  • 14
    • 0032848655 scopus 로고    scopus 로고
    • Infection of endothelial cells with Trypanosoma cruzi activates NF-kappaB and induces vascular adhesion molecule expression
    • Huang H, Calderon TM, Berman JW, et al Infection of endothelial cells with Trypanosoma cruzi activates NF-kappaB and induces vascular adhesion molecule expression. Infect Immun. 1999; 67: 5434-40.
    • (1999) Infect Immun. , vol.67 , pp. 5434-5440
    • Huang, H.1    Calderon, T.M.2    Berman, J.W.3
  • 15
    • 0036009909 scopus 로고    scopus 로고
    • NFkappaB-dependent signaling pathways
    • Li X, Stark GR. NFkappaB-dependent signaling pathways. Exp Hematol. 2002; 30: 285-96.
    • (2002) Exp Hematol. , vol.30 , pp. 285-296
    • Li, X.1    Stark, G.R.2
  • 16
    • 0035947608 scopus 로고    scopus 로고
    • Novel NEMO/IkappaB kinase and NF-kappa B target genes at the pre-B to immature B cell transition
    • Li J, Peet GW, Balzarano D, et al Novel NEMO/IkappaB kinase and NF-kappa B target genes at the pre-B to immature B cell transition. J Biol Chem. 2001; 276: 18579-90.
    • (2001) J Biol Chem. , vol.276 , pp. 18579-18590
    • Li, J.1    Peet, G.W.2    Balzarano, D.3
  • 17
    • 33645312379 scopus 로고    scopus 로고
    • Circuitry of nuclear factor kappaB signaling
    • Hoffmann A, Baltimore D. Circuitry of nuclear factor kappaB signaling. Immunol Rev. 2006; 210: 171-86.
    • (2006) Immunol Rev. , vol.210 , pp. 171-186
    • Hoffmann, A.1    Baltimore, D.2
  • 18
    • 18644380147 scopus 로고    scopus 로고
    • The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways
    • Dejardin E, Droin NM, Delhase M, et al The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity. 2002; 17: 525-35.
    • (2002) Immunity. , vol.17 , pp. 525-535
    • Dejardin, E.1    Droin, N.M.2    Delhase, M.3
  • 19
    • 0344441264 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway
    • Eliopoulos AG, Caamano JH, Flavell J, et al Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway. Oncogene. 2003; 22: 7557-69.
    • (2003) Oncogene. , vol.22 , pp. 7557-7569
    • Eliopoulos, A.G.1    Caamano, J.H.2    Flavell, J.3
  • 20
    • 0041967294 scopus 로고    scopus 로고
    • Essential role for IKKgamma/NEMO in TCR-induced IL-2 expression in Jurkat T cells
    • He KL, Ting AT. Essential role for IKKgamma/NEMO in TCR-induced IL-2 expression in Jurkat T cells. Eur J Immunol. 2003; 33: 1917-24.
    • (2003) Eur J Immunol. , vol.33 , pp. 1917-1924
    • He, K.L.1    Ting, A.T.2
  • 21
    • 33749633646 scopus 로고    scopus 로고
    • Finding NEMO by K63-linked polyubiquitin chain
    • Chen F, Bhatia D, Chang Q, et al Finding NEMO by K63-linked polyubiquitin chain. Cell Death Differ. 2006; 13: 1835-8.
    • (2006) Cell Death Differ. , vol.13 , pp. 1835-1838
    • Chen, F.1    Bhatia, D.2    Chang, Q.3
  • 22
    • 59149093017 scopus 로고    scopus 로고
    • The zinc finger of NEMO is a functional ubiquitin-binding domain
    • Cordier F, Grubisha O, Traincard F, et al The zinc finger of NEMO is a functional ubiquitin-binding domain. J Biol Chem. 2009; 284: 2902-7.
    • (2009) J Biol Chem. , vol.284 , pp. 2902-2907
    • Cordier, F.1    Grubisha, O.2    Traincard, F.3
  • 23
    • 59649103156 scopus 로고    scopus 로고
    • Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
    • Tokunaga F, Sakata S, Saeki Y, et al Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol. 2009; 11: 123-32.
    • (2009) Nat Cell Biol. , vol.11 , pp. 123-132
    • Tokunaga, F.1    Sakata, S.2    Saeki, Y.3
  • 24
    • 0033051635 scopus 로고    scopus 로고
    • Isolation of full-length cDNA and chromosomal localization of human NF-kappaB modulator NEMO to Xq28
    • Jin DY, Jeang KT. Isolation of full-length cDNA and chromosomal localization of human NF-kappaB modulator NEMO to Xq28. J Biomed Sci. 1999; 6: 115-20.
    • (1999) J Biomed Sci. , vol.6 , pp. 115-120
    • Jin, D.Y.1    Jeang, K.T.2
  • 25
    • 0033634663 scopus 로고    scopus 로고
    • Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti
    • Makris C, Godfrey VL, Krahn-Senftleben G, et al Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol Cell. 2000; 5: 969-79.
    • (2000) Mol Cell. , vol.5 , pp. 969-979
    • Makris, C.1    Godfrey, V.L.2    Krahn-Senftleben, G.3
  • 26
    • 0034713270 scopus 로고    scopus 로고
    • Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium
    • Smahi A, Courtois G, Vabres P, et al Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium. Nature. 2000; 405: 466-72.
    • (2000) Nature. , vol.405 , pp. 466-472
    • Smahi, A.1    Courtois, G.2    Vabres, P.3
  • 27
    • 33750072932 scopus 로고    scopus 로고
    • Multiple regulatory regions and tissue-specific transcription initiation mediate the expression of NEMO/IKKgamma gene
    • Fusco F, Mercadante V, Miano MG, et al Multiple regulatory regions and tissue-specific transcription initiation mediate the expression of NEMO/IKKgamma gene. Gene. 2006; 383: 99-107.
    • (2006) Gene. , vol.383 , pp. 99-107
    • Fusco, F.1    Mercadante, V.2    Miano, M.G.3
  • 28
    • 0034771886 scopus 로고    scopus 로고
    • A recurrent deletion in the ubiquitously expressed NEMO (IKK-gamma) gene accounts for the vast majority of incontinentia pigmenti mutations
    • Aradhya S, Woffendin H, Jakins T, et al A recurrent deletion in the ubiquitously expressed NEMO (IKK-gamma) gene accounts for the vast majority of incontinentia pigmenti mutations. Hum Mol Genet. 2001; 10: 2171-9.
    • (2001) Hum Mol Genet. , vol.10 , pp. 2171-2179
    • Aradhya, S.1    Woffendin, H.2    Jakins, T.3
  • 29
    • 0034175632 scopus 로고    scopus 로고
    • Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice
    • Rudolph D, Yeh WC, Wakeham A, et al Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev. 2000; 14: 854-62.
    • (2000) Genes Dev. , vol.14 , pp. 854-862
    • Rudolph, D.1    Yeh, W.C.2    Wakeham, A.3
  • 30
    • 0033638970 scopus 로고    scopus 로고
    • NEMO/IKK gamma-deficient mice model incontinentia pigmenti
    • Schmidt-Supprian M, Bloch W, Courtois G, et al NEMO/IKK gamma-deficient mice model incontinentia pigmenti. Mol Cell. 2000; 5: 981-92.
    • (2000) Mol Cell. , vol.5 , pp. 981-992
    • Schmidt-Supprian, M.1    Bloch, W.2    Courtois, G.3
  • 31
    • 0141678951 scopus 로고    scopus 로고
    • Mature T cells depend on signaling through the IKK complex
    • Schmidt-Supprian M, Courtois G, Tian J, et al Mature T cells depend on signaling through the IKK complex. Immunity. 2003; 19: 377-89.
    • (2003) Immunity. , vol.19 , pp. 377-389
    • Schmidt-Supprian, M.1    Courtois, G.2    Tian, J.3
  • 32
    • 2942627117 scopus 로고    scopus 로고
    • X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role for NEMO in human T-cell development and/or survival
    • Nishikomori R, Akutagawa H, Maruyama K, et al X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role for NEMO in human T-cell development and/or survival. Blood. 2004; 103: 4565-72.
    • (2004) Blood. , vol.103 , pp. 4565-4572
    • Nishikomori, R.1    Akutagawa, H.2    Maruyama, K.3
  • 33
    • 0037119628 scopus 로고    scopus 로고
    • IkappaB kinase signaling is essential for maintenance of mature B cells
    • Pasparakis M, Schmidt-Supprian M, Rajewsky K. IkappaB kinase signaling is essential for maintenance of mature B cells. J Exp Med. 2002; 196: 743-52.
    • (2002) J Exp Med. , vol.196 , pp. 743-752
    • Pasparakis, M.1    Schmidt-Supprian, M.2    Rajewsky, K.3
  • 34
    • 0037417885 scopus 로고    scopus 로고
    • The role of nuclear factor-kappaB essential modulator (NEMO) in B cell development and survival
    • Kim S, La Motte-Mohs RN, Rudolph D, et al The role of nuclear factor-kappaB essential modulator (NEMO) in B cell development and survival. Proc Natl Acad Sci USA. 2003; 100: 1203-8.
    • (2003) Proc Natl Acad Sci USA. , vol.100 , pp. 1203-1208
    • Kim, S.1    La Motte-Mohs, R.N.2    Rudolph, D.3
  • 35
    • 0037120656 scopus 로고    scopus 로고
    • Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha
    • Rottenberg S, Schmuckli-Maurer J, Grimm S, et al Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha. Gene. 2002; 299: 293-300.
    • (2002) Gene. , vol.299 , pp. 293-300
    • Rottenberg, S.1    Schmuckli-Maurer, J.2    Grimm, S.3
  • 36
    • 0034737194 scopus 로고    scopus 로고
    • Regulation of the NF-kappaB activation pathway by isolated domains of FIP3/ IKKgamma, a component of the IkappaB-alpha kinase complex
    • Ye J, Xie X, Tarassishin L, et al Regulation of the NF-kappaB activation pathway by isolated domains of FIP3/ IKKgamma, a component of the IkappaB-alpha kinase complex. J Biol Chem. 2000; 275: 9882-9.
    • (2000) J Biol Chem. , vol.275 , pp. 9882-9889
    • Ye, J.1    Xie, X.2    Tarassishin, L.3
  • 37
    • 0034310734 scopus 로고    scopus 로고
    • Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma
    • Sun SC, Harhaj EW, Xiao G, et al Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma. AIDS Res Hum Retroviruses. 2000; 16: 1591-6.
    • (2000) AIDS Res Hum Retroviruses. , vol.16 , pp. 1591-1596
    • Sun, S.C.1    Harhaj, E.W.2    Xiao, G.3
  • 38
    • 0347363826 scopus 로고    scopus 로고
    • Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling
    • Iha H, Kibler KV, Yedavalli VR, et al Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling. Oncogene. 2003; 22: 8912-23.
    • (2003) Oncogene. , vol.22 , pp. 8912-8923
    • Iha, H.1    Kibler, K.V.2    Yedavalli, V.R.3
  • 39
    • 0032589261 scopus 로고    scopus 로고
    • IKKgamma mediates the interaction of cellular IkappaB kinases with the Tax transforming protein of human T cell leukemia virus type 1
    • Chu ZL, Shin YA, Yang JM, et al IKKgamma mediates the interaction of cellular IkappaB kinases with the Tax transforming protein of human T cell leukemia virus type 1. J Biol Chem. 1999; 274: 15297-300.
    • (1999) J Biol Chem. , vol.274 , pp. 15297-15300
    • Chu, Z.L.1    Shin, Y.A.2    Yang, J.M.3
  • 40
    • 0033551607 scopus 로고    scopus 로고
    • IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein
    • Harhaj EW, Sun SC. IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. J Biol Chem. 1999; 274: 22911-4.
    • (1999) J Biol Chem. , vol.274 , pp. 22911-22914
    • Harhaj, E.W.1    Sun, S.C.2
  • 41
    • 0035830885 scopus 로고    scopus 로고
    • Role of IKKgamma/nemo in assembly of the Ikappa B kinase complex
    • Li XH, Fang X, Gaynor RB. Role of IKKgamma/nemo in assembly of the Ikappa B kinase complex. J Biol Chem. 2001; 276: 4494-500.
    • (2001) J Biol Chem. , vol.276 , pp. 4494-4500
    • Li, X.H.1    Fang, X.2    Gaynor, R.B.3
  • 42
    • 33845428995 scopus 로고    scopus 로고
    • Dimerization of the I kappa B kinase-binding domain of NEMO is required for tumor necrosis factor alpha-induced NF-kappa B activity
    • Marienfeld RB, Palkowitsch L, Ghosh S. Dimerization of the I kappa B kinase-binding domain of NEMO is required for tumor necrosis factor alpha-induced NF-kappa B activity. Mol Cell Biol. 2006; 26: 9209-19.
    • (2006) Mol Cell Biol. , vol.26 , pp. 9209-9219
    • Marienfeld, R.B.1    Palkowitsch, L.2    Ghosh, S.3
  • 43
    • 0036771830 scopus 로고    scopus 로고
    • The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes
    • Smahi A, Courtois G, Rabia SH, et al The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes. Hum Mol Genet. 2002; 11: 2371-5.
    • (2002) Hum Mol Genet. , vol.11 , pp. 2371-2375
    • Smahi, A.1    Courtois, G.2    Rabia, S.H.3
  • 44
    • 0036696739 scopus 로고    scopus 로고
    • Incontinentia pigmenti: a review and update on the molecular basis of pathophysiology
    • Berlin AL, Paller AS, Chan LS. Incontinentia pigmenti: a review and update on the molecular basis of pathophysiology. J Am Acad Dermatol. 2002; 47: 169-87.
    • (2002) J Am Acad Dermatol. , vol.47 , pp. 169-187
    • Berlin, A.L.1    Paller, A.S.2    Chan, L.S.3
  • 45
    • 0034798380 scopus 로고    scopus 로고
    • NEMO/IKK gamma: linking NF-kappa B to human disease
    • Courtois G, Smahi A, Israel A. NEMO/IKK gamma: linking NF-kappa B to human disease. Trends Mol Med. 2001; 7: 427-30.
    • (2001) Trends Mol Med. , vol.7 , pp. 427-430
    • Courtois, G.1    Smahi, A.2    Israel, A.3
  • 46
    • 33750454819 scopus 로고    scopus 로고
    • Mutations in the NF-kappaB signaling pathway: implications for human disease
    • Courtois G, Gilmore TD. Mutations in the NF-kappaB signaling pathway: implications for human disease. Oncogene. 2006; 25: 6831-43.
    • (2006) Oncogene. , vol.25 , pp. 6831-6843
    • Courtois, G.1    Gilmore, T.D.2
  • 48
    • 33646528676 scopus 로고    scopus 로고
    • NEMO, NFkappaB signaling and incontinentia pigmenti
    • Nelson DL. NEMO, NFkappaB signaling and incontinentia pigmenti. Curr Opin Genet Dev. 2006; 16: 282-8.
    • (2006) Curr Opin Genet Dev. , vol.16 , pp. 282-288
    • Nelson, D.L.1
  • 49
    • 27944501076 scopus 로고    scopus 로고
    • The range of defects associated with nuclear factor kappaB essential modulator
    • Uzel G. The range of defects associated with nuclear factor kappaB essential modulator. Curr Opin Allergy Clin Immunol. 2005; 5: 513-8.
    • (2005) Curr Opin Allergy Clin Immunol. , vol.5 , pp. 513-518
    • Uzel, G.1
  • 50
    • 33746772796 scopus 로고    scopus 로고
    • Lessons learned from molecular defects in nuclear factor kappaB dependent signaling
    • McDonald DR, Janssen R, Geha R. Lessons learned from molecular defects in nuclear factor kappaB dependent signaling. Microbes Infect. 2006; 8: 1151-6.
    • (2006) Microbes Infect. , vol.8 , pp. 1151-1156
    • McDonald, D.R.1    Janssen, R.2    Geha, R.3
  • 51
    • 0036046564 scopus 로고    scopus 로고
    • Recent advances in understanding of the molecular basis of anhidrotic ectodermal dysplasia: discovery of a ligand, ectodysplasin A and its two receptors
    • Wisniewski SA, Kobielak A, Trzeciak WH, et al Recent advances in understanding of the molecular basis of anhidrotic ectodermal dysplasia: discovery of a ligand, ectodysplasin A and its two receptors. J Appl Genet. 2002; 43: 97-107.
    • (2002) J Appl Genet. , vol.43 , pp. 97-107
    • Wisniewski, S.A.1    Kobielak, A.2    Trzeciak, W.H.3
  • 52
    • 1042278904 scopus 로고    scopus 로고
    • Inherited disorders of NF-kappaB-mediated immunity in man
    • Puel A, Picard C, Ku CL, et al Inherited disorders of NF-kappaB-mediated immunity in man. Curr Opin Immunol. 2004; 16: 34-41.
    • (2004) Curr Opin Immunol. , vol.16 , pp. 34-41
    • Puel, A.1    Picard, C.2    Ku, C.L.3
  • 53
    • 1942500166 scopus 로고    scopus 로고
    • The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation
    • Orange JS, Jain A, Ballas ZK, et al The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation. J Allergy Clin Immunol. 2004; 113: 725-33.
    • (2004) J Allergy Clin Immunol. , vol.113 , pp. 725-733
    • Orange, J.S.1    Jain, A.2    Ballas, Z.K.3
  • 54
    • 0035093630 scopus 로고    scopus 로고
    • X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling
    • Doffinger R, Smahi A, Bessia C, et al X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling. Nat Genet. 2001; 27: 277-85.
    • (2001) Nat Genet. , vol.27 , pp. 277-285
    • Doffinger, R.1    Smahi, A.2    Bessia, C.3
  • 55
    • 0035089759 scopus 로고    scopus 로고
    • Atypical forms of incontinentia pigmenti in male individuals result from mutations of a cytosine tract in exon 10 of NEMO (IKK-gamma)
    • Aradhya S, Courtois G, Rajkovic A, et al Atypical forms of incontinentia pigmenti in male individuals result from mutations of a cytosine tract in exon 10 of NEMO (IKK-gamma). Am J Hum Genet. 2001; 68: 765-71.
    • (2001) Am J Hum Genet. , vol.68 , pp. 765-771
    • Aradhya, S.1    Courtois, G.2    Rajkovic, A.3
  • 56
    • 0033658369 scopus 로고    scopus 로고
    • A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO)
    • Zonana J, Elder ME, Schneider LC, et al A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO). Am J Hum Genet. 2000; 67: 1555-62.
    • (2000) Am J Hum Genet. , vol.67 , pp. 1555-1562
    • Zonana, J.1    Elder, M.E.2    Schneider, L.C.3
  • 57
    • 0035286726 scopus 로고    scopus 로고
    • Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia
    • Jain A, Ma CA, Liu S, et al Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia. Nat Immunol. 2001; 2: 223-8.
    • (2001) Nat Immunol. , vol.2 , pp. 223-228
    • Jain, A.1    Ma, C.A.2    Liu, S.3
  • 58
    • 14944385521 scopus 로고    scopus 로고
    • Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome
    • Lee WI, Torgerson TR, Schumacher MJ, et al Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome. Blood. 2005; 105: 1881-90.
    • (2005) Blood. , vol.105 , pp. 1881-1890
    • Lee, W.I.1    Torgerson, T.R.2    Schumacher, M.J.3
  • 59
    • 0036259559 scopus 로고    scopus 로고
    • Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations
    • Orange JS, Brodeur SR, Jain A, et al Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations. J Clin Invest. 2002; 109: 1501-9.
    • (2002) J Clin Invest. , vol.109 , pp. 1501-1509
    • Orange, J.S.1    Brodeur, S.R.2    Jain, A.3
  • 60
    • 13144261692 scopus 로고    scopus 로고
    • Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation
    • Orange JS, Levy O, Geha RS. Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation. Immunol Rev. 2005; 203: 21-37.
    • (2005) Immunol Rev. , vol.203 , pp. 21-37
    • Orange, J.S.1    Levy, O.2    Geha, R.S.3
  • 61
    • 33646824119 scopus 로고    scopus 로고
    • Transient hemophagocytosis with deficient cellular cytotoxicity, monoclonal immunoglobulin M gammopathy, increased T-cell numbers, and hypomorphic NEMO mutation
    • Schmid JM, Junge SA, Hossle JP, et al Transient hemophagocytosis with deficient cellular cytotoxicity, monoclonal immunoglobulin M gammopathy, increased T-cell numbers, and hypomorphic NEMO mutation. Pediatrics. 2006; 117: e1049-56.
    • (2006) Pediatrics. , vol.117 , pp. 1049-1056
    • Schmid, J.M.1    Junge, S.A.2    Hossle, J.P.3
  • 62
    • 0026563059 scopus 로고
    • Extramedullary hematopoiesis of the cranial dura and anhidrotic ectodermal dysplasia
    • Sitton JE, Reimund EL. Extramedullary hematopoiesis of the cranial dura and anhidrotic ectodermal dysplasia. Neuropediatrics. 1992; 23: 108-10.
    • (1992) Neuropediatrics. , vol.23 , pp. 108-110
    • Sitton, J.E.1    Reimund, E.L.2
  • 63
    • 38349150875 scopus 로고    scopus 로고
    • A male infant with anhidrotic ectodermal dysplasia/immunodeficiency accompanied by incontinentia pigmenti and a mutation in the NEMO pathway
    • Chang TT, Behshad R, Brodell RT, et al A male infant with anhidrotic ectodermal dysplasia/immunodeficiency accompanied by incontinentia pigmenti and a mutation in the NEMO pathway. J Am Acad Dermatol. 2008; 58: 316-20.
    • (2008) J Am Acad Dermatol. , vol.58 , pp. 316-320
    • Chang, T.T.1    Behshad, R.2    Brodell, R.T.3
  • 64
    • 41149102026 scopus 로고    scopus 로고
    • X-linked ectodermal dysplasia with immunodeficiency caused by NEMO mutation: early recognition and diagnosis
    • Mancini AJ, Lawley LP, Uzel G. X-linked ectodermal dysplasia with immunodeficiency caused by NEMO mutation: early recognition and diagnosis. Arch Dermatol. 2008; 144: 342-6.
    • (2008) Arch Dermatol. , vol.144 , pp. 342-346
    • Mancini, A.J.1    Lawley, L.P.2    Uzel, G.3
  • 65
    • 9644281000 scopus 로고    scopus 로고
    • Nuclear factor kappaB essential modulator-deficient child with immunodeficiency yet without anhidrotic ectodermal dysplasia
    • Niehues T, Reichenbach J, Neubert J, et al Nuclear factor kappaB essential modulator-deficient child with immunodeficiency yet without anhidrotic ectodermal dysplasia. J Allergy Clin Immunol. 2004; 114: 1456-62.
    • (2004) J Allergy Clin Immunol. , vol.114 , pp. 1456-1462
    • Niehues, T.1    Reichenbach, J.2    Neubert, J.3
  • 66
    • 30144437157 scopus 로고    scopus 로고
    • Novel splicing mutation in the NEMO (IKK-gamma) gene with severe immunodeficiency and heterogeneity of X-chromosome inactivation
    • Orstavik KH, Kristiansen M, Knudsen, GP, et al Novel splicing mutation in the NEMO (IKK-gamma) gene with severe immunodeficiency and heterogeneity of X-chromosome inactivation. Am J Med Genet A. 2006; 140: 31-9.
    • (2006) Am J Med Genet A. , vol.140 , pp. 31-39
    • Orstavik, K.H.1    Kristiansen, M.2    Knudsen, G.P.3
  • 67
    • 85047693229 scopus 로고    scopus 로고
    • Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation
    • Jain A, Ma CA, Lopez-Granados E, et al Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation. J Clin Invest. 2004; 114: 1593-602.
    • (2004) J Clin Invest. , vol.114 , pp. 1593-1602
    • Jain, A.1    Ma, C.A.2    Lopez-Granados, E.3
  • 68
    • 0040215628 scopus 로고
    • Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes
    • Miller J, McLachlan AD, Klug A. Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J. 1985; 4: 1609-14.
    • (1985) EMBO J. , vol.4 , pp. 1609-1614
    • Miller, J.1    McLachlan, A.D.2    Klug, A.3
  • 69
    • 0034744439 scopus 로고    scopus 로고
    • Three classes of C2H2 zinc finger proteins
    • Iuchi S. Three classes of C2H2 zinc finger proteins. Cell Mol Life Sci. 2001; 58: 625-35.
    • (2001) Cell Mol Life Sci. , vol.58 , pp. 625-635
    • Iuchi, S.1
  • 71
    • 33846707892 scopus 로고    scopus 로고
    • Sticky fingers: zinc-fingers as protein-recognition motifs
    • Gamsjaeger R, Liew CK, Loughlin FE, et al Sticky fingers: zinc-fingers as protein-recognition motifs. Trends Biochem Sci. 2007; 32: 63-70.
    • (2007) Trends Biochem Sci. , vol.32 , pp. 63-70
    • Gamsjaeger, R.1    Liew, C.K.2    Loughlin, F.E.3
  • 72
    • 0035253047 scopus 로고    scopus 로고
    • Zinc finger proteins: new insights into structural and functional diversity
    • Laity JH, Lee BM, Wright PE. Zinc finger proteins: new insights into structural and functional diversity. Curr Opin Struct Biol. 2001; 11: 39-46.
    • (2001) Curr Opin Struct Biol. , vol.11 , pp. 39-46
    • Laity, J.H.1    Lee, B.M.2    Wright, P.E.3
  • 73
    • 0036866596 scopus 로고    scopus 로고
    • Multifunctional zinc finger proteins in development and disease
    • Ladomery M, Dellaire G. Multifunctional zinc finger proteins in development and disease. Ann Hum Genet. 2002; 66: 331-42.
    • (2002) Ann Hum Genet. , vol.66 , pp. 331-342
    • Ladomery, M.1    Dellaire, G.2
  • 74
    • 33749350212 scopus 로고    scopus 로고
    • Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination
    • Temmerman ST, Ma CA, Borges L, et al Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination. Blood. 2006; 108: 2324-31.
    • (2006) Blood. , vol.108 , pp. 2324-2331
    • Temmerman, S.T.1    Ma, C.A.2    Borges, L.3
  • 75
    • 0842321781 scopus 로고    scopus 로고
    • The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop
    • Yang F, Yamashita J, Tang E, et al The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop. J Immunol. 2004; 172: 2446-52.
    • (2004) J Immunol. , vol.172 , pp. 2446-2452
    • Yang, F.1    Yamashita, J.2    Tang, E.3
  • 76
    • 40849140675 scopus 로고    scopus 로고
    • Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation
    • Cordier F, Vinolo E, Veron M, et al Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation. J Mol Biol. 2008; 377: 1419-32.
    • (2008) J Mol Biol. , vol.377 , pp. 1419-1432
    • Cordier, F.1    Vinolo, E.2    Veron, M.3
  • 77
    • 0036315743 scopus 로고    scopus 로고
    • The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors
    • Huang TT, Feinberg SL, Suryanarayanan S, et al The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors. Mol Cell Biol. 2002; 22: 5813-25.
    • (2002) Mol Cell Biol. , vol.22 , pp. 5813-5825
    • Huang, T.T.1    Feinberg, S.L.2    Suryanarayanan, S.3
  • 78
    • 39149094918 scopus 로고    scopus 로고
    • Mutations in the zinc finger domain of IKK gamma block the activation of NF-kappa B and the induction of IL-2 in stimulated T lymphocytes
    • Shifera AS, Horwitz MS. Mutations in the zinc finger domain of IKK gamma block the activation of NF-kappa B and the induction of IL-2 in stimulated T lymphocytes. Mol Immunol. 2008; 45: 1633-45.
    • (2008) Mol Immunol. , vol.45 , pp. 1633-1645
    • Shifera, A.S.1    Horwitz, M.S.2
  • 79
    • 0141621240 scopus 로고    scopus 로고
    • A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha
    • Tang ED, Wang CY, Xiong Y, et al A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem. 2003; 278: 37297-305.
    • (2003) J Biol Chem. , vol.278 , pp. 37297-37305
    • Tang, E.D.1    Wang, C.Y.2    Xiong, Y.3
  • 80
    • 0036724051 scopus 로고    scopus 로고
    • The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation
    • Makris C, Roberts JL, Karin M. The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation. Mol Cell Biol. 2002; 22: 6573-81.
    • (2002) Mol Cell Biol. , vol.22 , pp. 6573-6581
    • Makris, C.1    Roberts, J.L.2    Karin, M.3
  • 81
    • 0035816547 scopus 로고    scopus 로고
    • Persistent activation of NF-kappa B by the Tax transforming protein involves chronic phosphorylation of IkappaB kinase subunits IKKbeta and IKKgamma
    • Carter RS, Geyer BC, Xie M, et al Persistent activation of NF-kappa B by the Tax transforming protein involves chronic phosphorylation of IkappaB kinase subunits IKKbeta and IKKgamma. J Biol Chem. 2001; 276: 24445-8.
    • (2001) J Biol Chem. , vol.276 , pp. 24445-24448
    • Carter, R.S.1    Geyer, B.C.2    Xie, M.3
  • 82
    • 0038143356 scopus 로고    scopus 로고
    • In vivo identification of inducible phosphoacceptors in the IKKgamma/ NEMO subunit of human IkappaB kinase
    • Carter RS, Pennington KN, Ungurait BJ, et al In vivo identification of inducible phosphoacceptors in the IKKgamma/ NEMO subunit of human IkappaB kinase. J Biol Chem. 2003; 278: 19642-8.
    • (2003) J Biol Chem. , vol.278 , pp. 19642-19648
    • Carter, R.S.1    Pennington, K.N.2    Ungurait, B.J.3
  • 83
    • 70350020147 scopus 로고    scopus 로고
    • NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain
    • Laplantine E, Fontan E, Chiaravalli J, et al NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain. EMBO J. 2009; 28: 2885-95.
    • (2009) EMBO J. , vol.28 , pp. 2885-2895
    • Laplantine, E.1    Fontan, E.2    Chiaravalli, J.3
  • 84
    • 62549155321 scopus 로고    scopus 로고
    • Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
    • Rahighi S, Ikeda F, Kawasaki M, et al Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell. 2009; 136: 1098-109.
    • (2009) Cell. , vol.136 , pp. 1098-1109
    • Rahighi, S.1    Ikeda, F.2    Kawasaki, M.3
  • 85
    • 71449095149 scopus 로고    scopus 로고
    • Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain
    • Kulathu Y, Akutsu M, Bremm A, et al Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain. Nat Struct Mol Biol. 2009; 16: 1328-30.
    • (2009) Nat Struct Mol Biol. , vol.16 , pp. 1328-1330
    • Kulathu, Y.1    Akutsu, M.2    Bremm, A.3
  • 86
    • 72449162040 scopus 로고    scopus 로고
    • Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3
    • Sato Y, Yoshikawa A, Yamashita M, et al Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3. EMBO J. 2009; 28: 3903-9.
    • (2009) EMBO J. , vol.28 , pp. 3903-3909
    • Sato, Y.1    Yoshikawa, A.2    Yamashita, M.3
  • 87
    • 33645703930 scopus 로고    scopus 로고
    • Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]
    • Wu CJ, Conze DB, Li T, et al Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]. Nat Cell Biol. 2006; 8: 398-406.
    • (2006) Nat Cell Biol. , vol.8 , pp. 398-406
    • Wu, C.J.1    Conze, D.B.2    Li, T.3
  • 88
    • 33646034316 scopus 로고    scopus 로고
    • Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
    • Ea CK, Deng L, Xia ZP, et al Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell. 2006; 22: 245-57.
    • (2006) Mol Cell. , vol.22 , pp. 245-257
    • Ea, C.K.1    Deng, L.2    Xia, Z.P.3
  • 89
    • 42949098959 scopus 로고    scopus 로고
    • NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation
    • Wu CJ, Ashwell JD. NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation. Proc Natl Acad Sci USA. 2008; 105: 3023-8.
    • (2008) Proc Natl Acad Sci USA. , vol.105 , pp. 3023-3028
    • Wu, C.J.1    Ashwell, J.D.2


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