Hydrogen sulfide and its modulation in arterial hypertension and atherosclerosis

Cardiovascular and Hematological Agents in Medicinal Chemistry

Volumn 8, Issue 4, 2010, Pages 173-186

  Beltowski J ^a   Jamroz Wisniewska A ^a   Tokarzewska, D ^a  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

Arterial hypertension; Atherosclerosis; Homocysteine; Hydrogen sulfide

Indexed keywords

3 MERCAPTOPYRUVIC ACID; ADENOSINE TRIPHOSPHATE; ALLYL SULFIDE; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; CYSTEINE; DIALLYL DISULFIDE; DIALLYL TRISULFIDE; GLUTATHIONE; GYY 4137; HOMOCYSTEINE; HYDROGEN SULFIDE; LOW DENSITY LIPOPROTEIN; MORPHOLIN 4 IUM 4 METHOXYPHENYL(MORPHOLINO)PHOSPHINODITHIOATE; MYELOPEROXIDASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; REACTIVE OXYGEN METABOLITE; SULFUR; SULFURTRANSFERASE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BIOCHEMISTRY; BLOOD LEVEL; BLOOD PRESSURE REGULATION; BLOOD VESSEL TONE; BODY FLUID; BRAIN; CARDIOVASCULAR SYSTEM; CATABOLISM; CELL PROLIFERATION; CELL VIABILITY; CENTRAL NERVOUS SYSTEM; CHEMICAL COMPOSITION; CHEMICAL REACTION; CHEMICAL STRUCTURE; COLORIMETRY; DRUG ACTIVITY; DRUG DECOMPOSITION; DRUG SYNTHESIS; ENDOTHELIUM CELL; ENDOTOXEMIA; FOAM CELL; GARLIC; GLUTATHIONE METABOLISM; HEART INFARCTION; HEART PROTECTION; HUMAN; HYPERTENSION; INFLAMMATION; KIDNEY; KIDNEY FUNCTION; LIVER; MACROPHAGE; MODULATION; NONHUMAN; OXIDATION; PATHOGENESIS; PRECURSOR; PULMONARY HYPERTENSION; REGULATORY MECHANISM; RESTENOSIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SYNTHESIS; TARGET CELL; TISSUE; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION;

ANIMALS; ATHEROSCLEROSIS; BLOOD PRESSURE; BODY FLUIDS; HUMANS; HYDROGEN SULFIDE; HYPERTENSION; MICE; RATS; SIGNAL TRANSDUCTION;

EID: 77958476039     PISSN: 18715257     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152510792481207     Document Type: Article

References (99)

1. Wang, R. The gasotransmitter role of hydrogen sulfide. Antioxid. Redox Signal., 2003, 5, 493-501.
2. Hughes, M.N.; Centelles, M.N., Moore, K.P. Making and working with hydrogen sulfide: The chemistry and generation of hydrogen sulfide in vitro and its measurement in vivo: a review. Free Radic. Biol. Med., 2009, 47, 1346-1353.
3. Reiffenstein, R.J.; Hulbert, W.C.; Roth, S.H. Toxicology of hydrogen sulfide. Annu. Rev. Pharmacol. Toxicol, 1992, 32, 109-134.
4. Goubern, M.; Andriamihaja, M.; Nübel, T.; Blachier, F.; Bouillaud, F. Sulfide, the first inorganic substrate for human cells. FASEB J., 2007, 21, 1699-1706.
5. Leschelle, X.; Goubern, M.; Andriamihaja, M.; Blottière, H.M.; Couplan, E.; Gonzalez-Barroso, M.D.; Petit, C.; Pagniez, A.; Chaumontet, C.; Mignotte, B.; Bouillaud, F.; Blachier, F. Adaptative metabolic response of human colonic epithelial cells to the adverse effects of the luminal compound sulfide. Biochim. Biophys. Acta, 2005, 1725, 201-212.
6. Cooper, C.E.; Brown, G.C. The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance. J. Bioenerg. Biomembr., 2008, 40, 533-539.
7. Koenitzer, J.R.; Isbell, T.S.; Patel, H.D.; Benavides, G.A.; Dickinson, D.A.; Patel, R.P.; Darley-Usmar, V.M.; Lancaster, J.R; Doeller, J.E.; Kraus, D.W. Hydrogen sulfide mediates vasoactivity in an O2-dependent manner. Am. J. Physiol. Heart Circ. Physiol., 2007, 292, H1953-H1960.
8. 2S/sulfide concentration in vertebrate blood and its potential significance in ischemic preconditioning and vascular signaling. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2008, 294, R1930-R1937.
9. Iciek, M.; Bilska, A.; Ksiazek, L.; Srebro, Z.; Włodek, L. Allyl disulfide as donor and cyanide as acceptor of sulfane sulfur in the mouse tissues. Pharmacol. Rep., 2005, 57, 212-218.
10. Ishigami, M.; Hiraki, K.; Umemura, K.; Ogasawara, Y.; Ishii, K.; Kimura, H. A source of hydrogen sulfide and a mechanism of its release in the brain. Antioxid. Redox. Signal, 2009, 11, 205-214.
11. Doeller, J.E.; Isbell, T.S.; Benavides, G.; Koenitzer, J.; Patel, H.; Patel, R.P.; Lancaster, J.R. Polarographic measurement of hydrogen sulfide production and consumption by mammalian tissues. Anal. Biochem., 2005, 341, 40-51.
12. Stipanuk, M.H. Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu. Rev. Nutr., 2004, 24, 539-577.
13. 2S) - the third gas of interest for pharmacologists. Pharmacol. Rep., 2007, 59, 4-24.
14. 2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine. J. Biol. Chem., 2004, 279, 52082-52086.
15. 2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J. Biol. Chem., 2009, 284, 11601-11612.
16. Shibuya, N.; Tanaka, M.; Yoshida, M.; Ogasawara, Y.; Togawa, T.; Ishii, K.; Kimura, H. 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain. Antioxid. Redox Signal., 2009, 11, 703-714.
17. 2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science, 2008, 322, 587-590.
18. 2S as a novel endogenous gaseous KATP channel opener. EMBO J., 2001, 20, 6008-6016.
19. Wang, J.; Dudman, N.P.; Wilcken, D.E.; Lynch, J.F. Homocysteine catabolism: levels of 3 enzymes in cultured human vascular endothelium and their relevance to vascular disease. Atherosclerosis, 1992, 97, 97-106.
20. Wang, R. Hydrogen sulfide: a new EDRF. Kidney Int., 2009, 76, 700-704.
21. Shibuya, N.; Mikami, Y.; Kimura, Y.; Nagahara, N.; Kimura, H. Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide. J. Biochem., 2009, 146, 623-626.
22. 2S in rat tissues. Can. J. Physiol. Pharmacol., 2003, 81, 848-853.
23. Zhong, G.; Chen, F.; Cheng, Y.; Tang, C.; Du, J. The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase. J. Hypertens., 2003, 21, 1879-1885.
24. Ishii, I.; Akahoshi, N.; Yu, X.N.; Kobayashi, Y.; Namekata, K.; Komaki, G.; Kimura, H. Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression. Biochem. J., 2004, 381, 113-123.
25. Li, L.; Bhatia, M.; Zhu, Y.Z.; Zhu, Y.C.; Ramnath, R.D.; Wang, Z.J.; Anuar, F.B.; Whiteman, M.; Salto-Tellez, M.; Moore, P.K. Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. FASEB J., 2005, 19, 1196-1198.
26. Renga, B.; Mencarelli, A.; Migliorati, M.; Distrutti, E.; Fiorucci, S. Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation. World J. Gastroenterol., 2009, 15, 2097-2108.
27. Geng, B.; Chang L.; Pan, C.; Qi, Y.; Zhao, J.; Pang, Y.; Du, J. Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol. Biochem. Biophys. Res. Commun., 2004, 318, 756-763.
28. Yong, Q.C.; Pan, T.T.; Hu, L.F.; Bian, J.S. Negative regulation of beta-adrenergic function by hydrogen sulphide in the rat hearts. J. Mol. Cell. Cardiol., 2008, 44, 701-710.
29. Chang, L.; Geng, B.; Yu, F.; Zhao, J.; Jiang, H.; Du, J.; Tang, C. Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats. Amino Acids, 2008, 34, 573-585.
30. Hildebrandt, T.M.; Grieshaber, M.K. Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria. FEBS J., 2008, 275, 3352-3361.
31. Ramasamy, S.; Singh, S.; Taniere, P.; Langman, M.J.; Eggo, M.C. Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation. Am. J. Physiol. Gastrointest. Liver Physiol., 2006, 291, G288-G296.
32. Kamoun, P. Endogenous production of hydrogen sulfide in mammals. Amino Acids, 2004, 26, 243-254.
33. Belardinelli, M.C.; Chabli, A.; Chadefaux-Vekemans, B.; Kamoun, P. Urinary sulfur compounds in Down syndrome. Clin. Chem., 2001, 47, 1500-1501.
34. Furne, J.; Springfield, J.; Koenig, T.; DeMaster, E.; Levitt, M.D. Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues: a specialized function of the colonic mucosa. Biochem. Pharmacol., 2001, 62, 255-259.
35. Morselli-Labate, A.M.; Fantini, L.; Pezzilli, R. Hydrogen sulfide, nitric oxide and a molecular mass 66 u substance in the exhaled breath of chronic pancreatitis patients. Pancreatology, 2007, 7, 497-504.
36. Abe, K.; Kimura, H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J. Neurosci., 1996, 16, 1066-1071.
37. Cheng, Y.; Ndisang, J.F.; Tang, G.; Cao, K.; Wang, R. Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats. Am. J. Physiol. Heart Circ. Physiol., 2004, 287, H2316-H2323.
38. Tang, G.; Wu, L.; Liang, W.; Wang, R. Direct stimulation of KATP channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells. Mol. Pharmacol., 2005, 68, 1757-1764.
39. 2S generated by heart in rat and its effects on cardiac function. Biochem. Biophys. Res. Commun., 2004, 313, 362-368.
40. Mitsuhashi, H.; Yamashita, S.; Ikeuchi, H.; Kuroiwa, T.; Kaneko, Y.; Hiromura, K.; Ueki, K: Oxidative stress-dependent conversion of hydrogen sulfide to sulfite by activated neutrophils. Shock, 2005, 24, 529-534.
41. Whiteman, M.; Armstrong, J.S.; Chu, S.H.; Jia-Ling, S.; Wong, B.S.; Cheung, N.S.; Halliwell, B. The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'? J. Neurochem., 2004, 90, 765-768.
42. Whiteman, M.; Cheung, N.S.; Zhu, Y.Z.; Chu, S.H.; Siau, J.L.; Wong, B.S.; Armstrong, J.S. Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?. Biochem. Biophys. Res. Commun., 2005, 326, 794-798.
43. Collin, M.; Thiemermann, C. Hydrogen sulfide and sulfite: novel mediators in the pathophysiology of shock and inflammation. Shock, 2005, 24, 595-596.
44. Mitsuhashi, H.; Ikeuchi, H.; Nojima, Y. Is sulfite an antiatherogenic compound in wine? Clin. Chem., 2001, 47, 1872-1873.
45. Whiteman, M.; Li, L.; Kostetski, I.; Chu, S.H.; Siau, J.L. Bhatia M, Moore PK: Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide. Biochem. Biophys. Res. Commun., 2006, 343, 303-310.
46. Kimura, Y.; Dargusch, R.; Schubert, D.; Kimura, H. Hydrogen sulfide protects HT22 neuronal cells from oxidative stress. Antioxid. Redox. Signal., 2006, 8, 661-670.
47. Yan, H.; Du, J.; Tang, C. The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats. Biochem. Biophys. Res. Commun., 2004, 313, 22-27.
48. Mok, Y.Y.; Atan, M.S.; Yoke Ping, C.; Zhong Jing, W.; Bhatia, M.; Moochhala, S. Moore, P.K: Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulfide biosynthesis. Br. J. Pharmacol., 2004, 143, 881-889.
49. 2S-induced vasorelaxation and underlying cellular and molecular mechanisms. Am. J. Physiol. Heart Circ. Physiol., 2002, 283, H474-H480.
50. Muzaffar, S.; Shukla, N.; Bond, M.; Newby, A.C.; Angelini, G.D.; Sparatore, A.; Del Soldato, P.; Jeremy, J.Y. Exogenous hydrogen sulfide inhibits superoxide formation, NOX-1 expression and Rac1 activity in human vascular smooth muscle cells. J. Vasc. Res., 2008, 45, 521-528.
51. Kiss, L.; Deitch, E.A.; Szabó, C. Hydrogen sulfide decreases adenosine triphosphate levels in aortic rings and leads to vasorelaxation via metabolic inhibition. Life Sci., 2008, 83, 589-594.
52. Lee, S.W.; Cheng, Y.; Moore, P.K.; Bian, J.S. Hydrogen sulphide regulates intracellular pH in vascular smooth muscle cells. Biochem. Biophys. Res. Commun., 2007, 358, 1142-1147.
53. Li, X.; Du, J.; Jin, H.; Geng, B.; Tang, C. Sodium hydrosulfide alleviates pulmonary artery collagen remodeling in rats with high pulmonary blood flow. Heart Vessels., 2008, 23, 409-419.
54. Shi, Y.X.; Chen, Y.; Zhu, Y.Z.; Huang, G.Y.; Moore, P.K.; Huang, S.H.; Yao, T.; Zhu, Y.C. Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive rats. Am. J. Physiol. Heart Circ. Physiol., 2007, 293, H2093-H2100.
55. Laggner, H.; Hermann, M.; Esterbauer, H.; Muellner, M.K.; Exner, M.; Gmeiner, B.M.; Kapiotis, S. The novel gaseous vasorelaxant hydrogen sulfide inhibits angiotensin-converting enzyme activity of endothelial cells. J. Hypertens., 2007, 25, 2100-2104.
56. Xiao, L.; Wu, Y.M.; Wang, R.; Liu, Y.X.; Wang, F.W.; He, R.R. Hydrogen sulfide facilitates carotid sinus baroreceptor activity in anesthetized male rats. Chin. Med. J., 2007, 120, 1343-1347.
57. Fang, L.; Zhao, J.; Chen, Y.; Ma, T.; Xu, G.; Tang, C.; Liu, X.; Geng, B. Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator. J. Hypertens., 2009, 27, 2174-2185.
58. Ali, M.Y.; Ping, C.Y.; Mok, Y.Y.; Ling, L.; Whiteman, M.; Bhatia, M.; Moore, P.K: Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide? Br. J. Pharmacol., 2006, 149, 625-634.
59. Kubo, S.; Doe, I.; Kurokawa, Y.; Nishikawa, H.; Kawabata, A. Direct inhibition of endothelial nitric oxide synthase by hydrogen sulfide: contribution to dual modulation of vascular tension. Toxicology, 2007, 232, 138-146.
60. Geng, B.; Cui, Y.; Zhao, J.; Yu, F.; Zhu, Y.; Xu, G.; Zhang, Z.; Tang, C.; Du, J. Hydrogen sulfide downregulates the aortic Larginine/nitric oxide pathway in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2007, 293, R1608-R1618.
61. Kubo, S.; Kurokawa, Y.; Doe, I.; Masuko, T.; Sekiguchi, F.; Kawabata, A. Hydrogen sulfide inhibits activity of three isoforms of recombinant nitric oxide synthase. Toxicology, 2007, 241, 92-97.
62. Lim, J.J.; Liu, Y.H.; Khin, E.S.; Bian, J.S. Vasoconstrictive effect of hydrogen sulfide involves downregulation of cAMP in vascular smooth muscle cells. Am. J. Physiol. Cell Physiol., 2008, 295, C1261-C1270.
63. Webb, G.D.; Lim, L.H.; Oh, V.M.; Yeo, S.B.; Cheong, Y.P.; Ali, M.Y.; El Oakley, R.; Lee, C.N.; Wong, P.S.; Caleb, M.G.; Salto-Tellez, M.; Bhatia, M.; Chan, E.S.; Taylor, E.A.; Moore, P.K. Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery. J. Pharmacol. Exp. Ther., 2008, 324, 876-882.
64. Stipanuk, M.H.; De la Rosa, J.; Hirschberger, L.L. Catabolism of cysteine by rat renal cortical tubules. J. Nutr., 1990, 120, 450-458.
65. Xia, M.; Chen, L.; Muh, R.W.; Li, P.L.; Li, N. Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys. J. Pharmacol. Exp. Ther., 2009, 329, 1056-1062.
66. Chen, L.; Ingrid, S.; Ding, Y.G.; Liu, Y.; Qi, J.G.; Tang, C.S.; Du, J.B. Imbalance of endogenous homocysteine and hydrogen sulfide metabolic pathway in essential hypertensive children. Chin. Med. J., 2007, 120, 389-393.
67. Li, Y.; Zhao, Q.; Liu, X.L.; Wang, L.Y.; Lu, X.F.; Li, H.F.; Chen, S.F.; Huang, J.F.; Gu, D.F. Relationship between cystathionine gamma-lyase gene polymorphism and essential hypertension in Northern Chinese Han population. Chin. Med. J., 2008, 121, 716-720.
68. Du, J.; Hui, Y.; Cheung, Y.; Bin, G.; Jiang, H.; Chen, X.; Tang, C. The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells. Heart Vessels, 2004, 19, 75-80.
69. Yang, G.; Sun, X.; Wang, R. Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3. FASEB J., 2004, 18, 1782-1784.
70. 2S on human aorta smooth muscle cells. FASEB J., 2006, 20, 553-555.
71. Oh, G.S.; Pae, H.O.; Lee, B.S.; Kim, B.N.; Kim, J.M.; Kim, H.R.; Jeon, S.B. Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappa β via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide. Free Radic. Biol. Med., 2006, 41, 106-119.
72. Jeong, S.O.; Pae, H.O.; Oh, G.S.; Jeong, G.S.; Lee, B.S.; Lee, S.; Kim du, Y. Hydrogen sulfide potentiates interleukin-1β-induced nitric oxide production via enhancement of extracellular signal regulated kinase activation in rat vascular smooth muscle cells. Biochem. Biophys. Res. Commun., 2006, 345, 938-944.
73. Laggner, H.; Muellner, M.K.; Schreier, S.; Sturm, B.; Hermann, M.; Exner, M.; Gmeiner, B.M.; Kapiotis S. Hydrogen sulfide: a novel physiological inhibitor of LDL atherogenic modification by HOCl. Free Radic. Res., 2007, 41, 741-747.
74. Nicholls, S.J.; Hazen, S.L. Myeloperoxidase, modified lipoproteins, and atherogenesis. J. Lipid Res., 2009, 50(Suppl), S346-S351.
75. Muellner, M.K.; Schreier, S.M.; Laggner, H.; Hermann, M.; Esterbauer, H.; Exner, M.; Gmeiner, B.M.; Kapiotis, S. Hydrogen sulfide destroys lipid hydroperoxides in oxidized LDL. Biochem. J., 2009, 420, 277-281.
76. 2S). Free Radic. Biol. Med., 2009, 46, 616-623.
77. 2S protects against methionine-induced oxidative stress in brain endothelial cells. Antioxid. Redox Signal., 2009, 11, 25-33.
78. Yan, S.K.; Chang, T.; Wang, H.; Wu, L.; Wang, R.; Meng, Q.H. Effects of hydrogen sulfide on homocysteine-induced oxidative stress in vascular smooth muscle cells. Biochem. Biophys. Res. Commun., 2006, 351, 485-491.
79. Zagli, G.; Patacchini, R.; Trevisani, M.; Abbate, R.; Cinotti, S.; Gensini, G.F.; Masotti, G.; Geppetti, P. Hydrogen sulfide inhibits human platelet aggregation. Eur. J. Pharmacol., 2007, 559, 65-68.
80. Wang, Y.; Zhao, X.; Jin, H.; Wei, H.; Li, W.; Bu, D.; Tang, X.; Ren, Y.; Tang, C.; Du, J. Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice. Arterioscler. Thromb. Vasc. Biol., 2009, 29, 173-179.
81. Wu, S.Y.; Pan, C.S.; Geng, B.; Zhao, J.; Yu, F.; Pang, Y.Z.; Tang, C.S. Hydrogen sulfide ameliorates vascular calcification induced by vitamin D3 plus nicotine in rats. Acta Pharmacol. Sin., 2006, 27, 299-306.
82. Meng, Q.H.; Yang, G.; Yang, W.; Jiang, B.; Wu, L.; Wang, R. Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries. Am. J. Pathol., 2007, 170, 1406-1414.
83. Kamoun, P.; Belardinelli, M.C.; Chabli, A.; Lallouchi, K.; Chadefaux-Vekemans, B. Endogenous hydrogen sulfide overproduction in Down syndrome. Am. J. Med. Genet., 2003, 116, 310-311.
84. Insko, M.A.; Deckwerth, T.L.; Hill, P.; Toombs, C.F.; Szabo, C. Detection of exhaled hydrogen sulfide gas in rats exposed to intravenous sodium sulphide. Br. J. Pharmacol., 2009, 157, 944-951.
85. Li, L.; Whiteman, M.; Guan, Y.Y.; Neo, K.L.; Cheng, Y.; Lee, S.W.; Zhao, Y.; Baskar, R.; Tan, C.H.; Moore, P.K. Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide. Circulation, 2008, 117, 2351-2360.
86. Li, L.; Salto-Tellez, M.; Tan, C.H.; Whiteman, M.; Moore, P.K. GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat. Free Radic. Biol. Med., 2009, 47, 103-113.
87. Chuah, S.C.; Moore, P.K.; Zhu, Y.Z. S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway. Am. J. Physiol. Heart Circ. Physiol., 2007, 293, H2693-H2701.
88. Searcy, D.G.; Lee, S.H. Sulfur reduction by human erythrocytes. J. Exp. Zool., 1998, 282, 310-322.
89. Benavides, G.A.; Squadrito, G.L.; Mills, R.W.; Patel, H.D.; Isbell, T.S.; Patel, R.P.; Darley-Usmar, V.M.; Doeller, J.E.; Kraus, D.W. Hydrogen sulfide mediates the vasoactivity of garlic. Proc. Natl. Acad. Sci. USA, 2007, 104, 17977-17982.
90. 2S-donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: role of protein kinases A and G. Br. J. Pharmacol., 2008, 155, 984-994.
91. Li, L.; Rossoni, G.; Sparatore, A.; Lee, L.C.; Del Soldato, P.; Moore, P.K. Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative. Free Radic. Biol. Med., 2007, 42, 706-719.
92. Fiorucci, S.; Antonelli, E.; Distrutti, E.; Rizzo, G.; Mencarelli, A.; Orlandi, S.; Zanardo, R. Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs. Gastroenterology, 2005, 129, 1210-1224.
93. Rossoni, G.; Sparatore, A.; Tazzari, V.; Manfredi, B.; Del Soldato, P.; Berti, F. The hydrogen sulphide-releasing derivative of diclofenac protects against ischaemia-reperfusion injury in the isolated rabbit heart. Br. J. Pharmacol., 2008, 153, 100-109.
94. Baskar, R.; Sparatore, A.; Del Soldato, P.; Moore, P.K. Effect of Sdiclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferation. Eur. J. Pharmacol., 2008, 594, 1-8.
95. Distrutti, E.; Sediari, L.; Mencarelli, A.; Renga, B.; Orlandi, S.; Russo, G.; Caliendo, G. 5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity. J. Pharmacol. Exp. Ther., 2006, 319, 447-458.
96. Fiorucci, S.; Orlandi, S.; Mencarelli, A.; Caliendo, G.; Santagada, V.; Distrutti, E.; Santucci, L.; Cirino, G.; Wallace, JL. Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis. Br. J. Pharmacol., 2007, 150, 996-1002.
97. 2S-releasing aspirin. Free Radic. Biol. Med., 2009, 46, 586-592.
98. Olson, K.R. Hydrogen sulfide and oxygen sensing in the cardiovascular system. Antioxid. Redox Signal., 2010, 12, 1219-1234.
99. Bełtowski, J. Hypoxia in the renal medulla: Implications for hydrogen sulfide signaling. J. Pharmacol. Exp. Ther., 2010, doi: 10.1124/jpet.110.166637 (in press).