Exogenous hydrogen sulfide inhibits superoxide formation, NOX-1 expression and Rac1 activity in human vascular smooth muscle cells

Journal of Vascular Research

Volumn 45, Issue 6, 2008, Pages 521-528

  Muzaffar, Saima ^a,d   Shukla, Nilima ^a   Bond, Mark ^a   Newby, Andrew C ^a   Angelini, Gianni D ^a   Sparatore, Anna ^b   Del Soldato, Piero ^c   Jeremy, Jamie Y ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF MILAN   (Italy)

^c CTG Pharma   (Italy)

^d BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

Hydrogen sulfide; NADPH oxidase; Rac1 protein; Superoxide; Vascular smooth muscle cell

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; HYDROGEN SULFIDE; RAC1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; SUPEROXIDE; THROMBOXANE A2;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ADENYLATE CYCLASE; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLYBURIDE; HUMANS; HYDROGEN SULFIDE; KATP CHANNELS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NADPH OXIDASE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITROSO COMPOUNDS; POTASSIUM CHANNEL BLOCKERS; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SULFIDES; SUPEROXIDES; TIME FACTORS;

EID: 54249148441     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000129686     Document Type: Article

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