H 2S-donating sildenafil (ACS6) inhibits superoxide formation and gp91 phox expression in arterial endothelial cells: Role of protein kinases A and G

British Journal of Pharmacology

Volumn 155, Issue 7, 2008, Pages 984-994

  Muzaffar, S ^a,d   Jeremy, J Y ^a,d   Sparatore, A ^b   Del Soldato, P ^c   Angelini, G D ^a   Shukla, N ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF MILAN   (Italy)

^c CTG Pharma SRL   (Italy)

^d BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

cAMP; Endothelial cells; Hydrogen sulphide; NADPH oxidase; Superoxide

Indexed keywords

ACS 6; ADENYLATE CYCLASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; GUANYLATE CYCLASE; GUANYLATE CYCLASE INHIBITOR; HYDROGEN SULFIDE; NITRIC OXIDE; PHOSPHODIESTERASE V; PROTEIN KINASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SILDENAFIL; SODIUM DERIVATIVE; SODIUM HYDROSULFIDE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 1 PIPERAZINEACETIC ACID 4 ((3 (4,7 DIHYDRO 1 METHYL 7 OXO 3 PROPYL 1H PYRAZOLO(4,3 D)PYRIMIDIN 5 YL) 4 ETHOXYPHENYL)SULFONYL) 4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENYL ESTER; 1-PIPERAZINEACETIC ACID 4-((3-(4,7-DIHYDRO-1-METHYL-7-OXO-3-PROPYL-1H-PYRAZOLO(4,3-D)PYRIMIDIN-5-YL)-4-ETHOXYPHENYL)SULFONYL)-4-(3-THIOXO-3H-1,2-DITHIOL-5-YL)PHENYL ESTER; PIPERAZINE DERIVATIVE; SODIUM BISULFIDE; SULFIDE; SULFONE;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ARTERY ENDOTHELIUM; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; IC 50; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; SWINE; UPREGULATION; WESTERN BLOTTING; ANIMAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; PATHOPHYSIOLOGY; TIME;

ADENYLATE CYCLASE; ANIMALS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; GUANYLATE CYCLASE; HYDROGEN SULFIDE; INHIBITORY CONCENTRATION 50; MALE; NADPH OXIDASE; PIPERAZINES; PULMONARY ARTERY; RESPIRATORY DISTRESS SYNDROME, ADULT; SULFIDES; SULFONES; SUPEROXIDES; SWINE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 56749104311     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.326     Document Type: Article

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