Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferation

European Journal of Pharmacology

Volumn 594, Issue 1-3, 2008, Pages 1-8

  Baskar, Rajamanickam ^a,d   Sparatore, Anna ^b   Del Soldato, Piero ^c   Moore, Philip Keith ^d  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

^b UNIVERSITY OF MILAN   (Italy)

^c CTG Pharma   (Italy)

^d Centre for Life Sciences   (Singapore)

Author keywords

Cell cycle; Cell survival; Hydrogen sulfide; p53; S diclofenac

Indexed keywords

DICLOFENAC DERIVATIVE; HYDROGEN SULFIDE; P53 AIP PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; S DICLOFENAC; UNCLASSIFIED DRUG;

ANIMAL CELL; AORTA; APOPTOSIS; ARTICLE; BLOOD VESSEL INJURY; BLOOD VESSEL OCCLUSION; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELL SYNCHRONIZATION; CLONOGENIC ASSAY; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; RESTENOSIS; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DICLOFENAC; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLOW CYTOMETRY; FLUORESCENT DYES; HYDROGEN SULFIDE; INDOLES; MITOTIC INDEX; MYOCYTES, SMOOTH MUSCLE; RATS; THIONES;

EID: 50849114157     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.07.029     Document Type: Article

References (37)

1. Aoki M., Morishita R., Matsushita H., Hayashi S., Nakagami H., Yamamoto K., Moriguchi A., Kaneda Y., Higaki J., and Ogihara T. Inhibition of the p53 tumor suppressor gene results in growth of human aortic vascular smooth muscle cells. Hypertension 34 (1999) 192-200
2. Balajee A.S., Ponnaiya B., Baskar R., and Gerad C.R. Induction of replication protein A in bystander cells. Radiat. Res. 162 (2004) 677-686
3. Baskar R., Li L., and Moore P.K. Hydrogen sulfide-induces DNA damage and changes in apoptotic gene expression in human lung fibroblast cells. FASEB J. 21 (2007) 247-255
4. Baskar R., Balajee A.S., and Geard C.R. Effects of low and high LET radiations on bystander human lung fibroblast cell survival. Int. J. Radiat. Biol. 83 (2007) 551-559
5. Baskar R., Balajee A.S., Geard C.R., and Hande M.P. Isoform-specific activation of protein kinase c in irradiated human fibroblasts and their bystander cells. Int. J. Biochem. Cell Biol. 40 (2008) 125-134
6. Beauchamp Jr. R.O., Bus J.S., Popp J.A., Boreiko C.J., and Andjelkovich D.A. A critical review of the hydrogen sulfide toxicity. Crit. Rev. Toxicol. 13 (1984) 25-97
7. Benavides G.A., Squadrito G.L., Mills R.W., Patel H.D., Isbell T.S., Patel R.P., Darley-Usmar V.M., Doeller J.E., and Kraus D.W. Hydrogen sulfide mediates the vasoactivity of garlic. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 17977-17982
8. Brooks G., Yu X.M., Wang Y., Crabbe M.J.C., Shattock M.J., and Harper J.V. Non-steroidal ant-inflammatory drugs (NSAIDs) inhibit vascular smooth muscle cell proliferation via differential effects on the cell cycle. J. Pharmacy and Pharmacol. 55 (2003) 519-526
9. 2 arrest after DNA damage. Science 282 (1998) 1497-1501
10. Dzau V.J., Braun-Dullaeus R.C., and Sedding D.G. Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat. Med. 8 (2002) 1249-1256
11. Elrod J.W., Calvert J.W., Morrison J., Doeller J.E., Kraus D.W., Tao L., Jiao X., Scalia R., Kiss L., Szabo C., Kimura H., Chow C.W., and Lefer D.J. Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 15560-15565
12. Gizard F., Amant C., Barbier O., Bellosta S., Robillard R., Percevault F., Sevestre H., Krimpenfort P., Corsini A., Rochette J., Glineu C., Fruchart J.C., Torpier G., and Staels B. PPARα inhibits vascular smooth muscle cell proliferation underlying initial hyperplasia by inducing the tumor suppressor p16INK4a. J. Clin. Invest. 115 (2005) 3228-3238
13. Hendzel M.J., Nishioka W.K., Raymond Y., Allis C.D., Bazett-Jones D.P., and Th'ng T.P. Chromatin condensation is not associated with apoptosis. J. Biol. Chem. 273 (1998) 24470-24478
14. Isenberg J.S., Jia Y., Field L., Ridnour L.A., Sparatore A., Del Soldato P., Sowers A.L., Yeh G.C., Moody T.W., Wink D.A., Ramchandran R., and Roberts D.D. Modulation of angiogenesis by dithiolethionemodified NSAIDs and valproic acid. Br. J. Pharmacol. 151 (2007) 63-72
15. Isner J.M., Kearney M., Bortman S., and Passeri J. Apoptosis in human atherosclerosis and restenosis. Circulation 91 (1995) 2703-2711
16. Kamoun P. Endogenous production of hydrogen sulfide in mammals. Amino Acids 26 (2004) 243-254
17. Lane D.P. p53, guardian of the genome. Nature 358 (1992) 15-16
18. Li L., Rossoni G., Lee L.C., Del Soldato P., and Moore P.K. Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative. Free Radical Biol. Med. 42 (2007) 706-719
19. Mayr M., Hu Y., Hainaut H., and Xu Q. Mechanical stress-induced DNA damage and rac p38MAPK signal pathways mediate p53-dependent apoptosis in vascular smooth muscle cells. FASEB J. 16 (2002) 1423-1425
20. Mnjoyan Z.H., Dutta R., Zhang D., Teng B.B., and Fujise K. Paradoxical upregulation of tumor suppressor protein p53 in serum-stimulated vascular smooth muscle cells. Circulation 108 (2003) 464-471
21. Moore P.K., Bhatia M., and Moochhala S.M. Hydrogen sulfide: from the smell of the past to the mediator of the future. Trends Pharmacol. Sci. 24 (2003) 609-611
22. Ross J.S., Stagliano N.E., Donovan M.J., Breitbart R.E., and Ginsburg G.S. Atherosclerosis and cancer: common molecular pathways of disease development and progression. Ann. N. Y. Acad. Sci. 947 (2001) 271-292
23. Rossoni G., Sparatore A., Tazzari V., Manfredi B., Del Soldato P., and Berti F. The hydrogen sulphide-releasing derivative of diclofenac protects against ischaemia-reperfusion injury in the isolated rabbit heart. Br. J. Pharmacol. 153 (2008) 100-109
24. Ryer E.J., Sakakibara K., Wang C., Sarkar D., Fisher P.B., Faries P.L., Kent K.C., and Liu B. Protein kinase C delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38 dependent and independent mechanisms. J. Biol. Chem. 21 (2005) 35310-35317
25. Sidhapuriwala J., Li L., Sparatore A., Bhatia M., and Moore P.K. Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat. Eur. J. Pharmacol. 569 (2007) 149-154
26. Szabo C. Hydrogen sulphide and its therapeutic potential. Nat. Rev. 6 (2007) 917-935
27. 2S be the third endogenous gaseous transmitter?. FASEB J. 16 (2002) 1792-1798
28. Wang R. The gasotransmitter role of hydrogen sulfide. Antioxid. Redox. Signal. 5 (2003) 493-501
29. Wang X., Jin D.Y., Ng R.W.M., Feng H., Wong Y.C., Cheung A.L.M., and Tsao S.W. Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells. Cancer Res. 62 (2002) 1662-1668
30. Wallace J.L., Caliendo G., Santagada V., Cirino G., and Fiorucci S. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology 132 (2007) 261-271
31. Wei G.L., Krasinski K., Kearney M., Isner J.M., Walsh K., and Andres V. Temporally and spatially coordinated expression of cell cycle regulatory factors after angioplasty. Circ. Res. 80 (1997) 418-426
32. Wu J.I., and Crabtree G.R. Cell signaling, nuclear actin as choreographer of cell morphology and transcription. Science 316 (2007) 1710-1711
33. Yoshida T., and Owens G.K. Molecular determinants of vascular smooth muscle cell diversity. Circ. Res. 96 (2005) 280-291
34. Youle R., and Strasser A. The Bcl-2 protein family: opposing activities that mediate cell death. Nature Rev. Mol. Cell Biol. 9 (2008) 47-59
35. Yusuf M., Whiteman M., Mok Y.Y.P., Li L., Kostestski I., Chu S.H., Siau J.L., Cheong Y.P., Bhatia M., and Moore P.K. Effect of hydrogen sulfide and nitric oxide alone and together on rat aortic contractility and blood pressure. Br. J. Pharmacol. 149 (2006) 625-634
36. 2S-induced vasorelaxation and underlying cellular and molecular mechanisms. Am. J. Physiol. Heart. Circ. Physiol. 283 (2002) 474-480
37. 2S as a novel endogenous gaseous KAT channel opener. EMBO J. 20 (2001) 6008-6016