Influence of apple polyphenols on the intestinal barrier in a colonic cell model

Journal of Applied Botany and Food Quality

Volumn 83, Issue 2, 2010, Pages 110-117

  Rogoll, Dorothee ^a   Bergmann, Hannah ^b   Hellenschmidt, Dorothee ^a   Heinze, Jana ^a   Scheppach, Wolfgang ^a,c   Melcher, Ralph ^a   Richling, Elke ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b University of Koblenz Landau   (Germany)

^c Stiftung Juliusspital   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; DICOTYLEDON; GENE EXPRESSION; GENETIC ANALYSIS; LESION; METABOLITE; PHENOL; PHYSIOLOGICAL RESPONSE; RODENT;

MALUS; MALUS X DOMESTICA; RODENTIA; ROSACEAE;

EID: 77958178364     PISSN: 16139216     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. AMASHEH, M, SCHLICHTER, S., AMASHEH, S., MANKERTZ, J., ZEITZ, M., FROMM, M., SCHULZKE, J.D., 2008: Quercetin enhances epithelial barrier function and increases claudin-4 expression in Cnco-2 cells, J. Nutr. 138, 1067-1073.
2. ANDERBERG, E.K, LINDMARK, T., ARTURSSON, P., 1993: Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route. Pharm. Res. 10, 857-864.
3. BERGMANN, H, ROGOLL, D., SCHEPPACH, W., MELCHER, R., RICHLING, E., 2009: The Ussing type chamber model to study the intestinal transport and modulation of specific tight-junction genes using a colonic cell line. Mol. Nutr. Food Res. 53, 1211-1225.
4. BOYER, J., LIU, R.H., 2004: Apple phytochemicals and their health benefits. Nutr. J. 3, 5.
5. CHRISTENSEN, L. P., KAACK, K., FRETTE, X.C., 2008: Selection of elderberry (Sambucus nigra L.) genotypes best suited for the preparation of elderflower extracts rich in flavonoids and phenolic acids. Eur. Food Res. Technol. 227, 293-305.
6. CLARKE, J.O., MULLIN, G.E., 2008: A review of complementary and alternative approaches to immunomodulation. Nutr. Clin. Pract. 23, 49-62.
7. CLAYBURGH, D.R., SHEN, L., TURNER, J.R., 2004: A porous defense: the leaky epithelial barrier in intestinal disease. Lab. Invest. 84, 282-291,
8. COATES, E.M., POPA, G., GILL, C.I., MCCANN, M.J., MCDOUGALL, G.J., STEWART, D., ROWLAND, I., 2007: Colon-available raspberry polyphenols exhibit anti-cancer effects on in vitro models of colon cancer, J. Carcinog. 6, 4.
9. ERLEJMAN, A.G., FRAGA, C.G., OTEIZA, P.I., 2006: Procyanidins protect Caco-2 cells from bile acid- and oxidant-induced damage, Free Radic. Biol. Med. 41, 1247-1256.
10. FARHADI, A., BANAN, A., FIELDS, J., KESHAVARZIAN, A., 2003: Intestinal barrier: an interface between health and disease. J. Gastroenterol. Hepatol. 18, 479-497.
11. GALLI, V., BARBAS, C., 2004: Capillary electrophoresis for the analysis of short-chain organic acids in coffee. J. Chromatogr, A 1032, 299-304.
12. GONCALVES, B., LANDBO, A.K., KNUDSEN, D., SILVA, A.P., MOUTINHOPEREIRA, J., ROSA, E., MEYER, A S., 2004: Effect of ripeness and postharvest storage on the phenolic profiles of Cherries (Prunus avium L.). J. Agric. Food Chem. 52, 523-530.
13. GONZALEZ-MARISCAL, L., BETANZOS, A., NAVA, P., JARAMILLO, B.E., 2003: Tight junction proteins. Prog. Biophys, Mol. Biol. 81, 1-44.
14. HILT, P., SCHIEBER, A., YILDIRIM, C., ARNOLD, G., KLAIBER, I., CONRAD, J., BEIFUSS, U., CARLE, R., 2003: Detection of phloridzin in strawberries (Fragaria x ananassa Duch.) by HPLC-PDA-MS/MS and NMR spectroscopy. J. Agric. Food Chem. 51, 2896-2899.
15. JUNG, M., TRIEBEL, S., ANKE, T., RICHLING, E., ERKEL, G., 2009: Influence of apple polyphenols on inflammatory gene expression. Mol. Nutr. Food Res. 53, 1263-1280.
16. KAHLE, K., HUEMMER, W., KEMPF, M., SCHEPPACH, W., ERK, T., RICHLINO, E, 2007: Polyphenols are intensively metabolized in the human gastrointestinal tract after apple juice consumption. J. Agric, Food Chem. 55, 10605-10614.
17. KAHLE, K., KRAUS, M., RICHLING, E., 2005a: Polyphenol profiles of apple juices, Mol. Nutr. Food Res. 49, 797-806.
18. KAHLE, K., KRAUS, M , SCHEPPACH, W., RICHLING, E., 2005b: Colonic availability of apple polyphenols - a study in ileostomy subjects. Mol. Nutr. Food Res. 49, 1143-1150.
19. KLAIBER, R.G., BAUR, S., KOBLO, A., CARLE, R., 2005: Influence of washing treatment and storage atmosphere on phenylalanine ammonia-lyase activity and phenolic acid content of minimally processed carrot sticks. J. Agric. Food Chem. 53, 1065-1072.
20. KULISIC-BILUSIC, T., SCHNABELE, K., SCHMOLLER, I., DRAGOVIC-UZELAC, V., KRISKO, A., DEJANOVIC, B., MILOS, M., PIFAT, G., 2009: Antioxidant activity versus cytotoxic and nuclear factor kappa B regulatory activities on HT-29 cells by natural fruit juices. Eur. Food Res. Technol. 228, 417-424.
21. LABIB, S., ERB, A., KRAUS, M., WICKERT, T., RICHLINO, E., 2004: The pig caecum model: a suitable tool to study the intestinal metabolism of flavonoids. Mol. Nutr. Food Res. 48, 326-332.
22. LAUKOETTER, M.G., NAVA, P., NUSRAT, A., 2008: Role of the intestinal barrier in inflammatory bowel disease. World J. Gastroenterol. 14, 401-407.
23. LEE, H.S., WROLSTAD, R.E., 1988: Apple juice composition: sugar, nonvolatile acid, and phenolic profiles. J. Assoc. Off. Anal. Chem. 71, 789-794.
24. MCCANN, M.J., GILL, C.I., O'BRIEN, G., RAO, J.R., MCROBERTS, W.C., HUOHES, P., MCENTEE, R., ROWLAND, I.R., 2007: Anti-cancer properties of phenolics from apple waste on colon carcinogenesis in vitro. Food Chem. Toxicol. 45, 1224-1230.
25. MCGUCKIN, M.A., ERI, R., SIMMS, L.A., FLORIN, T.H., RADFORD-SMITH, G., 2009: Intestinal barrier dysfunction in inflammatory bowel diseases. Inflamm. Bowel Dis. 15, 100-113.
26. MITIC, L.L., VAN ITALLIE, C.M., ANDERSON, J.M., 2000: Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins. Am. J. Physiol. Gastrointest. Liver Physiol. 279, G250-254.
27. OHNO, Y., NAGANUMA, T., OOAWA, T., MURAMOTO, K., 2006: Effect of lectins on the transport of food factors in caco-2 cell monolayers. J. Agric. Food Chem. 54, 548-553.
28. OLTHOF, M.R., HOLLMAN, P.C., BUIJSMAN, M.N., VAN AMELSVOORT, J.M., KATAN, M.B., 2003: Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. J. Nutr. 133, 1806-1814.
29. PATTERSON, M.K., 1979: Measurement of growth and viablity of cells in culture. In: Jacoby, W.B., Pastan, I.H. (eds.), Methods Enzymology, Vol. 58, 150-152. Academic, New York.
30. PERRONE, D., FARAH, A., DONANGELO, C.M., DE PAULIS, T., MARTIN, P.R., 2008: Comprehensive analysis of major and minor chlorogenic acids and lactones in economically relevant Brazilian coffee cultivare. Food Chem. 106, 859-867.
31. POWELL, D.W., 1981: Barrier function of epithelia. Am. J. Physiol. 241, G275-288.
32. PRASAD, S., MINORINO, R., KAUKINEN, K., HAYES, K.L., POWELL, R.M., MACDONALD, T.T., COLLINS, J.E., 2005: Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells. Lab. Invest. 85, 1139-1162.
33. RECHNER, A.R., SMITH, M.A., KUHNLE, G., GIBSON, G.R., DEBNAM, E.S., SRAI, S.K., MOORE, K.P., RICE-EVANS, C.A., 2004: Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products. Free Radie. Biol. Med. 36, 212-225.
34. RUHL, I., HERRMANN, K., 1985: Organic acids in vegetables. I. Brassica, leaf and bulb vegetables as well as carrots and celery. Z. Lebensm. Unters. Forsch. 180, 215-220.
35. SAMBRUY, Y., FERRUZZA, S., RANALDI, G., DE ANCELIS, I., 2001: Intestinal cell culture models: applications in toxicology and pharmacology. Cell Biol. Toxicol. 17, 301-317.
36. SCALBERT, A., MANACH, C., MORAND, C., REMESY, C., JIMENEZ, L., 2005: Dietary polyphenols and the prevention of diseases. Crit, Rev. Food Sci. Nutr. 45, 287-306.
37. SCALBERT, A., WILLIAMSON, G., 2000: Dietary intake and bioavailability of polyphenols. J. Nutr. 130, 2073-2085.
38. SCHAUBER, J., SVANHOLM, C., TERMEN, S., IFFLAND, K., MENZEL, T., SCHEPPACH, W., MELCHER, R., AOERBERTH, B., LUHRS, H., GUDMUNDSSON, G.H., 2003: Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways. Gut 52, 735-741.
39. SCHEPPACH, W., DUSEL, G., KUHN, T., LOGES, C., KARCH, H., BARTRAM, H.P., RICHTER, F., CHRISTL, S.U., KASPER, H., 1996: Effect of L-glutamine and n-butyrnte on the restitution of rat colonic mucosa after acid induced injury. Gut 38, 878-885.
40. SCHNEIDER, H., BLAUT, M., 2000: Anaerobic degradation of flavonoids by Eubacterium ramulus. Arch. Microbiol. 173, 71-75.
41. SCHOEFER, L., MOHAN, R., SCHWIERTZ, A., BRAUNE, A, BLAUT, M, 2003: Anaerobic degradation of flavonoids by Clostridium orbiscindens. Appl. Environ. Microbiol. 69, 5849-5854.
42. SEFKOW, M., 2001: First efficient synthesis of chlorogenic acid. Eur. J. Org. Chem., 1137-1141.
43. SEFKOW, M., KELLING, A , SCHILDE, U., 2001: First efficient syntheses of 1-, 4-, and 5-caffeoylquinic acid. Eur. J. Org. Chem., 2735-2742.
44. SHAPIRO, H., SINGER, P., HALPERN, Z., BRUCK, R., 2007: Polyphenols in the treatment of inflammatory bowel disease and acute pancreatitis. Gut 56, 426-435.
45. SOUSA, C., PEREIRA, D.M., PEREIRA, J.A., BENTO, A., RODRIGUES, M.A., DOPICO-GARCIA, S., VALENTAO, P., LOPES, G., FERRERES, F., SEABRA, R.M., ANDRADE, P.B., 2008: Multivariate analysis of tronchuda cabbage (Brassica oleracea L. var. costata DC) phenolics: influence of fertilizers. J. Agric. Food Chem. 56, 2231-2239.
46. SUZUKI, T., HARA, H., 2009: Quercetin enhances intestinal barrier function through the assembly of zonula occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells. J. Nutr. 139, 965-974.
47. TRUGO, L.C., MACRAE, R., 1984: Chlorogenic Acid Composition of Instant Coffees. Analyst 109, 263-266.
48. TURNER, A., CHEN, S.N., JOIKE, M.K., PENDLAND, S.L., PAULI, G.F., FARNSWORTH, N.R., 2005: Inhibition of uropathogenic Escherichia coli by cranberry juice: a new antiadherencc assay. J. Agric. Food Chem. 53, 8940-8947.
49. WALLON, C., BRAAF, Y., WOLVING, M., OLAISON, G., SODERHOLM, J.D., 2005: Endoscopic biopsies in Ussing chambers evaluated for studies of macromolecular permeability in the human colon. Scand. J. Gastroenterol. 40, 586-595.
50. WILL, F., ZESSNER, H., BECKER, H., DIETRICH, H., 2007: Semi-preparative isolation and physico-chemical characterization of 4-coumaroylquinic acid and phloretin-2-xylogluco side from laccase-oxidized apple juice. LWT-Food Sci. Technol. 40, 1344-1351.
51. WOJDYLO, A., OSZMIANSKI, J., LASKOWSKI, P., 2008: Polyphenolic compounds and antioxidant activity of new and old apple varieties. J. Agric. Food Chem. 56, 6520-6530.