Effects of in utero exposure to di(n-butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 73, Issue 21-22, 2010, Pages 1544-1559

  Kim, Tae Sung ^a   Jung, Ki Kyung ^a   Kim, Soon Sun ^a   Kang, Il Hyun ^a   Baek, Jung Hee ^a   Nam, Hye Seon ^a   Hong, Soon Keun ^a   Lee, Byung Mu ^c   Hong, Jin Tae ^b   Oh, Ki Wan ^b   Kim, Hyung Sik ^d   Han, Soon Young ^a   Kang, Tae Seok ^a  

^a Korea Food and Drug Administration   (South Korea)

^b Chungbuk National University   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d Pusan National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; DI (N BUTYL) PHTHALATE; ESTROGEN RECEPTOR ALPHA; FLUTAMIDE; PHTHALIC ACID; SONIC HEDGEHOG PROTEIN; STEROID 5ALPHA REDUCTASE 2; STEROIDOGENIC FACTOR 1; TESTOSTERONE; UNCLASSIFIED DRUG; MESSENGER RNA; PHTHALIC ACID DIBUTYL ESTER; PLASTICIZER; SONIC HEDGEHOG PROTEIN, RAT; STEROID 5ALPHA REDUCTASE;

ACCESSORY SEX ORGAN; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; BULBOCAVERNOSUS MUSCLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYPTORCHISM; EPIDIDYMIS; GENE EXPRESSION; GESTATIONAL AGE; GONAD DEVELOPMENT; GONADAL AGENESIS; HISTOPATHOLOGY; HYPOSPADIAS; INCIDENCE; LEVATOR ANI MUSCLE; MALE; MALE GENITAL SYSTEM; NONHUMAN; ORGAN WEIGHT; PENIS; PRIORITY JOURNAL; PROGENY; PROSTATE VENTRAL LOBE; RAT; SEMINAL VESICLE; TESTIS DEVELOPMENT; TESTIS WEIGHT; URETHRA; ANAL CANAL; ANIMAL; ANIMAL EMBRYO; BODY WEIGHT; CHEMICALLY INDUCED; DRUG EFFECTS; ENVIRONMENTAL EXPOSURE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NIPPLE; ORGAN SIZE; PATHOLOGY; PREGNANCY; PRENATAL EXPOSURE; SPRAGUE DAWLEY RAT; TESTIS; TOXICITY;

ANIMALIA; ERINACEIDAE; RATTUS;

3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; ANAL CANAL; ANIMALS; BODY WEIGHT; CRYPTORCHIDISM; DIBUTYL PHTHALATE; EMBRYO, MAMMALIAN; FEMALE; FLUTAMIDE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENITALIA, MALE; HEDGEHOG PROTEINS; HYPOSPADIAS; MALE; MATERNAL EXPOSURE; NIPPLES; ORGAN SIZE; PLASTICIZERS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; RNA, MESSENGER; TESTIS;

EID: 77958173567     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287394.2010.511579     Document Type: Article

References (39)

1. Barlow, J. N., Phillips, S. L., Wallaces, D. G., Sar, M., Gaido, K. W., and Foster, P. M. 2003. Quantitative changes in gene expression in fetal rat testes following exposure to di (nbutyl) phthalate. Toxicol. Sci. 73:431-451.
2. Barqawi, A., Akduman, B., Abouelfadel, Z., Robischon, M., and Crawford, E. D. 2003. The use of flutamide as a single antiandrogen treatment for hormone-refractory prostate cancer. Br. J. Urol. Int. 92:695-698.
3. Barthold, J. S., Kryger, J. V., Derusha, A. M., Duel, B. P., Jednak, R., and Skafar, D. F. 1999. Effects of an environmental endocrine disruptor on fetal development, estrogen receptor a and epidermal growth factor receptor expression in the porcine male genital tract. J. Urol. 162:864-871.
4. Baskin, L. S. 2000. Hypospadias and urethral development. J. Urol. 163:951-956.
5. Baskin, L. S., Erol, A., Jegatheesan, P., Li, Y., Liu, W., and Cunha, G. R. 2001. Urethra seam formation and hypospadias. Cell Tissue Res. 305:379-387.
6. Bentvelsen, F. M., Brinkmann, A. O., van der Schoot, P., van der Linden, J. E., van der Kwast, T. H., Boersma, W. J., Schröder, F. H., and Nijman, J. M. 1995. Developmental pattern and regulation by androgens of androgen receptor expression in the urogenital tract of the rat. Mol. Cell. Endocrinol. 113:245-253.
7. Berman, D. M., Tian, H., and Russell, D. W. 1995. Expression and regulation of steroid 5 alpha-reductase in the urogenital tract of the fetal rat. Mol. Endocrinol. 9:1561-1570.
8. Cain, M. P., Kramer, S. A., Tindall, D. J., and Husmann, D. A. 1994. Epididymal growth factor reverses antiandrogen induced cryptorchidism and epididymal development. J. Urol. 152:770-775.
9. Ema, M., and Miyawaki, E. 2001. Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancy. Reprod. Toxicol. 15:189-194.
10. Ema, M., Harazono, A., Miyawaki, E., and Ogawa, Y. 1997. Developmental effects of di-n-butyl phthalate after a single administration in rats. J. Appl. Toxicol. 17:223-229.
11. Ema, M., Miyawaki, E., and Kawashima, K. 2000. Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy. Toxicol. Lett. 11:271-278.
12. Fisher, J. S. 2004. Environmental antiandrogens and male reproductive health: Focus on phthalates and testicular dysgenesis syndrome. Reproduction 127:305-315.
13. Husmann, D. A., and McPhaul, M. J. 1992. Reversal of flutamide-induced cryptorchidism by prenatal time-specific androgens. Endocrinology 131:1711-1715.
14. Imajima, T., Shono, T., Kai, H., Zakaria, O., and Suita, S. 2001. The biological effect of phthalate esters on transabdominal migration of the testis in fetal rats in comparison with the antiandrogen flutamide. Pediatr. Surg. Int. 17:164-166.
15. Kalloo, N. B., Cearhart, J. P., and Barrack, E. R. 1993. Sexually dimorphic expression of estrogen receptors, but not of androgen receptors in human fetal external genitalia. J. Clin. Endocrinol. Metab. 77:692-698.
16. Kim, H. S., Kim, T. S., Shin, J. H., Moon, H. J., Kang, I. H., Kim, I. Y., Oh, J. Y., and Han, S. Y. 2004. Neonatal exposure to di (n-butyl) phthalate alters male reproductive tract development. J. Toxicol. Environ. Health A 67:2045-2060.
17. Kim, K. S., Liu, W., Cunha, G. R., Russell, D. W., Huang, H., Shapiro, E., and Baskin, L. S. 2002. Expression of the androgen receptor and 5 alpha-reductase type 2 in the developing human fetal penis and urethra. Cell Tissue Res. 307:145-153.
18. Kim, T. S., Yoon, C. Y., Jung, K. K., Kim, S. S., Kang, I. H., Baek, J. H., Jo, M. S., Kim, H. S., and Kang, T. S. 2010. In vitro study of OECD endocrine disruptor screening and testing methods establishment of a recombinant rat androgen receptor binding assay. J. Toxicol. Sci., in press.
19. Lee, B. M., and Koo, H. J. 2007. Hershberger assay for antiandrogenic effects of phthalates. J. Toxicol. Environ. Health. 70:1365-1370.
20. Levine, A. C., Wang, J. P., Ren, M., Elisahvili, E., Russell, D. W., and Kirschenbaum, A. 1996. Immunohistochemical localizaion of steroid 5 alpha-reductase 2 in the human male fetal reproductive tract and adul prostate. J. Clin. Endocrinol. Metab. 81:384-389.
21. Majdic, G., Sharpe, R. M., and Saunders, P. T. 1997. Maternal oestrogen/xenoestrogen exposure alters expression of steroidogenic factor-1 (SF-1/Ad4BP) in the fetal rat testis. Mol. Cell. Endocrinol. 127:91-98.
22. McIntyre, B. S., Barlow, N. J., and Foster, P. M. 2001. Androgen-mediated development in male rat offspring exposed to flutamide in utero: Permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues. Toxicol. Sci. 62:236-249.
23. Mylchreest, E., Sar, M., Cattley, R. C., and Foster, P. M. 1999. Disruption of androgenregulated male reproductive development by di (n-butyl) phthalate during late gestation in rats is different from flutamide. Toxicol. Appl. Pharmacol. 156:81-95.
24. Mylchreest, E., Sar, M., Wallace, D. G., and Foster, P. M. 2002. Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di (nbutyl) phthalate. Reprod. Toxicol. 16:19-28.
25. Nordenskjold, A., Friedman, E., Tapper-Persson, M., Söderhäll, C., Leviav, A., Svensson, J., and Anvret, M. 1999. Screening for mutations in candidate genes for hypospadias. Urol. Res. 27:49-55. (Pubitemid 29145090)
26. Parks, L. G., Ostby, J. S., Lambright, C. R., Abbott, B. D., Klinefelter, G. R., Barlow, N. J., and Gray, L. E., Jr. 2000. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol. Sci. 58:339-349.
27. Perriton, C. L., Powles, N., Chiang, C., Maconochie, M. K., and Cohn, M. J. 2002. Sonic hedgehog signaling from the urethral epithelium controls external genital development. Dev. Biol. 247:26-46.
28. Phillips, K. P., and Tanphaichitr, N. 2008. Human exposure to endocrine disrupters and semen quality. J. Toxicol. Environ. Health B 11:188-230.
29. Prins, G. S., Cooke, P. S., Birch, L., Donjacour, A. A., Yalcinkaya, T. M., Siiteri, P. K., and Cunha, G. R. 1992. Androgen receptor expression and 5 alpha-reductase activity along the proximal-distal axis of the rat prostatic duct. Endocrinology 130:3066-3073.
30. Regadara, J., Martinez-Garcia, F., Gonzalez-Peramato, P., Serrano, A., Nistal, M., and Suárez-Quian, C. 2001. Androgen receptor expression in Sertoli cells as a function of seminiferous tubule maturation in the human cryptorchid testis. J. Clin. Endocrinol. Metab. 86:413-421.
31. Ryu, J. Y., Lee, E., Kim, T. H., Lee, Y. J., Lee, J., Lee, B. M., Kwack, S. J., Jung, K. K., Han, S. Y., Kim, S. H., Kacew, S., and Kim, H. S. 2008. Time-Response Effects of testicular gene expression profiles in Sprague-Dawley male rats treated with di (n-butyl) phthalate. J. Toxicol. Environ. Health A 71:1542-1549.
32. Sharpe, R. M. 2001. Hormone and testis development and the possible adverse effects of environmental chemicals. Toxicol. Lett. 120:221-232.
33. Shultz, V. D., Phillips, S., Sar, M., Foster, P. M., and Gaido, K. W. 2001. Altered gene profiles in fetal rat testes after in utero exposure to di (n-butyl) phthalate. Toxicol. Sci. 64:233-242.
34. Silver, R. I., and Russell, D. W. 1999. 5-Alphareductase type 2 mutations are present in some boys with isolated hypospadias. J. Urol. 162:1142-1145.
35. Spencer, J. R., Torrado, T., Sanchez, R. S., Vaughan, E. D. Jr., and Imperato-McGinley, J. 1991. Effects of flutamide and finasteride on rat testicular descent. Endocrinology 129:741-748.
36. Takeda, H., and Chang, C. 1991. Immunohistochemical and in situ hybridization analysis of androgen receptor expression during the development of the mouse prostate gland. J. Endocrinol. 129:83-89.
37. Tian, H., and Russell, D. W. 1997. Expression and regulation of steroid 5-alpha-reductase in the genital tubercle of the fetal rat. Dev. Dyn. 209:117-126.
38. Tsuji, M., Shima, H., Terada, N., and Cunha, G. R. 1994. 5-Alpha-reductase activity in developing urogenital tracts of fetal and neonatal male mice. Endocrinology 134:2198-2205.
39. Yamada, T., Kunimatsu, T., Sako, H., Yabushita, S., Sukata, T., Okuno, Y., and Matsuo, M. 2000. Comparative evaluation of a 5-day Hershberger assay utilizing mature male rats and a pubertal male assay for detection of flutamide's antiandrogenic activity. Toxicol. Sci. 53:289-296. (Pubitemid 30100146)