Developmental effects of di-n-butyl phthalate after a single administration in rats

Journal of Applied Toxicology

Volumn 17, Issue 4, 1997, Pages 223-229

  Ema, Makoto ^a   Harazono, Akira ^a   Miyawaki, Emiko ^a   Ogawa, Yoshiyuki ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Developmental toxicity; Dibutyl phthalate; Embryolethality; Fetal malformation; Phthalic acid ester; rat; Teratogenicity

Indexed keywords

PHTHALIC ACID DIBUTYL ESTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLEFT PALATE; CONTROLLED STUDY; EMBRYO; EMBRYOTOXICITY; FETUS; FETUS MALFORMATION; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETON MALFORMATION; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; BONE AND BONES; DIBUTYL PHTHALATE; DRUG ADMINISTRATION SCHEDULE; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; MALE; PREGNANCY; RATS; RATS, WISTAR; REPRODUCTION;

ANIMALIA;

EID: 0030810420     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199707)17:4<223::AID-JAT433>3.0.CO;2-H     Document Type: Article

References (19)

1. J. Autian, Toxicity and health threats of phthalate esters: Review of the literature Environ. Health Perspect. 4, 3-26 (1973).
2. C. S. Giam, H. S Chan, G. S. Neff and E. L. Atlas, Phthalate ester plasticizers: A new class of marine pollutant. Science 199, 419-421 (1978).
3. CIRC (Cosmetic Ingredient Review Committee), Final report on the safety assessment of butyl benzyl phthalate. J Am. Coll. Toxicol. 11, 1-23 (1992).
4. CIRC (Cosmetic Ingredient Review Committee), Final report on the safety assessment of dibutyl phthalate, dimethyl phthalate, and diethyl phthalate. J. Am. Coll. Toxicol. 4, 267-303 (1985).
5. A. R. Singh, W. H. Lawrence and J. Autian, Teratogenicity of phthalate esters in rats. J. Pharm Sci. 61, 51-55 (1972)
6. M. Nikonorow, H. Mazur and H. Piekacz, Effect of orally administered plasticizers and polyvinyl chloride stabilizers in the rat. Toxicol. Appl. Pharmacol. 26, 253-259 (1973).
7. J. W Peters and R M Cook, Effect of phthalate esters on reproduction in rats. Environ Health Perspect. 3, 91-94 (1973).
8. L. C Lamb, R E Chapin, J Teague, A. D Lawton and J. R Reel, Reproductive effects of four phthalic acid esters in the mouse. Toxicol Appl. Pharmacol. 88, 255-269 (1987).
9. K . Shiota, M J. Chou and H. Nishimura, Embryotoxic effects of di-2-ethylhexyl phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice Environ Res 22, 245-253 (1980).
10. M Ema, H Amano, T Itami and H. Kawasaki, Teratogenic evaluation of di-n-butyl phthalate in rats Toxicol. Lett 69, 197-203 (1993).
11. M. Ema, H Amano and Y. Ogawa, Characterization of the developmental toxicity of di-n-butyl phthalate in rats. Toxicology 86, 163-174 (1994)
12. M. Erna, R Kurosaka, H. Amano and Y. Ogawa, Comparative developmental toxicity of n-butyl benzyl phthalate and di-n-butyl phthalate in rats. Arch. Environ. Contam. Toxicol. 28, 223-228 (1995).
13. S Kawamura, A. Hirohashi, T. Kato and M. Yasuda, Bone-staining technique for fetal rat specimens without skinning and removing adipose tissue. Cong. Anom. 30, 93-95 (1990).
14. J G. Wilson, Methods for administering agents and detecting malformations in experimental animals. In Teratology: Principles and Techniques, ed. by J. G. Wilson and J. Warkany, pp. 262-277. University of Chicago Press, Chicago (1965).
15. P W Albro and B. Moore, Identification of the metabolites of simple phthalate diesters in rat urine. J. Chromatogr. 94, 209-218 (1974).
16. 14C in the rat J Agric. Food Chem. 23, 854-858 (1975).
17. A. Tanaka, A. Matsumoto and T Yamaha, Biochemical studies on phthalic esters III. Metabolism of dibutyl phthalate (DBP) in animals. Toxicology 9, 109-123 (1978).
18. M. Erna, R. Kurosaka, H. Amano and Y. Ogawa, Developmental toxicity evaluation of mono-n-butyl phthalate in rats. Toxicol Lett. 78, 101-106 (1995)
19. M Ema, R. Kurosaka, A. Harazono, H Amano and Y. Ogawa, Phase specificity of developmental toxicity after oral administration of mono-n-butyl phthalate in rats Arch. Environ. Contam. Toxicol 31, 170-176 (1996)