Maternal oestrogen/xenoestrogen exposure alters expression of steroidogenic factor-1 (SF-1/Ad4BP) in the fetal rat testis

Molecular and Cellular Endocrinology

Volumn 127, Issue 1, 1997, Pages 91-98

  Majdic, G ^a   Sharpe, R M ^a   Saunders, P T K ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Diethylstilbestrol; Leydig; Octylphenol; Oestrogen receptor; Sertoli

Indexed keywords

DIETHYLSTILBESTROL; ESTROGEN; ESTROGEN DERIVATIVE; PHENOL DERIVATIVE; RIBONUCLEASE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENVIRONMENTAL EXPOSURE; FEMALE; FETUS; GONAD DEVELOPMENT; IMMUNOCYTOCHEMISTRY; LEYDIG CELL; MALE; MATERNAL TREATMENT; MOTHER FETUS RELATIONSHIP; NONHUMAN; OVARY; PHYSIOLOGY; PREGNANCY; PRIORITY JOURNAL; RAT; SERTOLI CELL; STEROIDOGENESIS; TESTIS;

ANIMALS; DIETHYLSTILBESTROL; DNA-BINDING PROTEINS; ESTROGENS, NON-STEROIDAL; FEMALE; FUSHI TARAZU TRANSCRIPTION FACTORS; HOMEODOMAIN PROTEINS; MALE; PHENOLS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; TESTIS; TRANSCRIPTION FACTORS;

EID: 0031002166     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(96)03998-6     Document Type: Article

References (39)

1. Toppari, J., Larsen, J.C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L.J., Jegou, B., Jensen, T.K., Jouannet, P., Keiding, N., Leffers, H., McLachlan, J.A., Meyer, O., Muller, J., Rajpert-De Meyts, E., Scheike, T., Sharpe, R.M., Sumpter, J. and Skakkebaek, N.E. (1996) Male reproductive health and environmental xenoestrogens. Environ. Health Pers. 104, 741-803.
2. Auger, J., Kunstmann, J.M., Czyglik, F. and Jouannet, P. (1995) Decline in semen quality among fertile men in Paris during the past 20 years. New Engl. J. Med. 332, 281-285.
3. Fisch, H. and Goluboff, E.T. (1996) Geographic variations in sperm counts; A potential cause of bias in studies of semen quality. Fertil. Steril. 65, 1044-1046.
4. Vierula, M., Niemi, M., Keiski, A., Saatanen, M., Saarikoski, S. and Suominen, J. (1996) High and unchanged sperm counts of Finnish men. Int. J. Androl. 19, 11-17.
5. Gill, W.B., Schumacher, G.F.B., Bibbo, M., Straus, F.H. and Schoenberg, H.W. (1979) Association of diethystilbestrol exposure in utero with cryptorchidism, testicular hypoplasia and semen abnormalities. J. Urol. 122, 36-39.
6. Sharpe, R.M. and Skakkebaek, N.E. (1993) Are oestrogens involved in falling sperm counts and disorders of the reproductive tract? Lancet 341, 125-126.
7. Stone, R. (1994) Environmental estrogens stir debate. Science 265, 308-310.
8. George, F.W. and Wilson, J.D. (1994) Sex determination and differentiation In: The Physiology of Reproduction (Knobil, E. and Neill, J.D., eds.), Raven Press, New York.
9. Koopman, P., Munsterberg, A., Capel, B., Vivian, N. and Lovell-Badge, R. (1990) Expression of a candidate sex-determining gene during mouse testis differentiation. Nature 348, 450-454.
10. Lee, M.M. and Donahoe, P. (1993) Mullerian inhibiting substance: a gonadal hormone with multiple functions. Endo. Rev. 14, 152-164.
11. Saez, J. (1994) Leydig cells: endocrine, paracrine and autocrine regulation. Endo. Rev. 15, 574-624.
12. Lala, D.S., Rice, D.A. and Parker, K.L. (1992) Steroidogenic factor 1, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I. Mol. Endo. 6, 1249-1258.
13. Morohashi, K., Honda, S., Inomata, Y., Handa, H. and Omura, T. (1992) A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s. J. Biol. Chem. 267, 17913-17919.
14. Morohashi, K., Iida, H., Nomura, M., Hatano, O., Honda, S., Tsukiyama, T., Niwa, O., Hara, T., Takakusu, A., Shibata, Y. and Omura, T. (1994) Functional difference between Ad4BP and ELP, and their distributions in steroidogenic tissues. Mol. Endo. 8, 643-653.
15. Luo, X., Ikeda, Y. and Parker, K.L. (1994) A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77, 481-490.
16. Hatano, O., Takayama, K., Imai, T., Waterman, M.R., Takakusu, A., Omura, T. and Morohashi, K. (1994) Sex-dependent expression of a transcription factor, Ad4BP, regulating steroidogenic P-450 genes in the gonads during prenatal and postnatal rat development. Development 120, 2787-2797.
17. Majdic, G., Sharpe, R.M., O'Shaughnessy, P.J. and Saunders, P.T.K. (1996) Expression of cytochrome P450 17α-hydroxylase/ C17-20 lyase (P450c17) in the fetal rat testis is reduced by maternal exposure to exogenous estrogens. Endocrinology 137, 1063-1070.
18. White, R., Jobling, S., Hoare, S., Sumpter, J. and Parker, M. (1994) Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 135, 175-182.
19. Morohashi, K., Zanger, U.M., Honda, S., Hara, M., Waterman, M.R. and Omura, T. (1993) Activation of CYP11A and CYP11B gene promotors by the steroidogenic cell-specific transcription factor, Ad4BP. Mol. Endo. 7, 1196-1204.
20. Shi, S.-R., Chaiwun, B., Young, L., Cote, R.J. and Taylor, C.R. (1993) Antigen retrieval technique utilizing citrate buffer or urea solution for immunohistochemical demonstration of androgen receptor in formalin-fixed paraffin sections. J. Histochem. Cytochem. 41, 1599-1604.
21. Lynch, J., Lala, D., Peluso, J., Luo, W., Parker, K. and White, B. (1993) Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues. Mol. Endo. 7, 776-786.
22. Majdic, G. and Saunders, P.T.K. (1996) Differential patterns of expression of DAX-1 and steroidogenic factor 1 (SF-1) in the fetal rat testis. Endocrinology 137, 3586-3589.
23. Majdic, G., Millar, M.R. and Saunders, P.T.K. (1995) Immunolocalisation of androgen receptor to interstitial cells in fetal rat testes and to mesenchymal and epithelial cells of associated ducts. J. Endo. 147, 285-293.
24. Zhang, P. and Mellon, S.H. (1996) The orphan nuclear receptor Steroidogenic factor 1 regulates the cyclic adenosine 3′,5′-monophosphate-mediated transcriptional activation of rat cytochrome P450c17 (17α-hydroxylase/c17-20 lyase). Mol. Endo. 10, 147-158.
25. Clemens, J., Lala, D., Parker, K. and Richards, J. (1994) Steroidogenic factor 1 binding and transcriptional activity of the cholesterol side-chain cleavage promoter in rat granulosa cells. Endocrinology 134, 1499-1508.
26. Barnhart, K.M. and Mellon, P.L. (1994) The orphan nuclear receptor, steroidogenic factor 1, regulates the glycoprotein hormone α-subunit gene in pituitary gonadotropes. Mol. Endo. 8, 878-885.
27. Leers-Sucheta, S., Morohashi, K., Mason, J.I. and Melner, M.H. (1996) Synergistic activation of the human type II 3β-hydroxysteroid dehydrogenase/δ5-δ-4 isomerase promotor by the transcription factor steroidogenic factor 1/adrenal 4-binding protein and phorbol ester. J. Biol. Chem. in press.
28. Shen, W., Moore, C.C.D., Ikeda, Y., Parker, K.L. and Ingraham, H.A. (1994) Nuclear receptor steroidogenic factor 1 regulates the Mullerian inhibiting substance gene: a link to the sex determination cascade. Cell 77, 651-661.
29. Ikeda, Y., Swain, A., Weber, T.J., Hentges, K.E., Zanaria, E., Lalli, E., Tamai, K.T., Sassoni-Corsi, P., Lovell-Badge, R., Camerino, G. and Parker, K.L. (1996) Steroidogenic factor 1 and Dax-1 colocalise in multiple cell lineages: potential links with endocrine development. Mol. Endo. 10, 1261-1272.
30. Dorrington, J.H. and Khan, S.A. (1993) Steroid production, metabolism, and release by Sertoli cells In: The Sertoli Cell. (Russell, L. and Griswold, M.), pp 538-549, Cache River Press, Clearwater.
31. Sharpe, R.M., Fisher, J., Millar, M.R., Jobling, S. and Sumpter, J.S. (1995) Gestational and/or neonatal exposure of rats to environmental estrogenic chemicals results in reduced testis size and daily sperm production in adulthood. Environ. Health Pers. 103, 1136-1143.
32. Nomura, M., Bartsch, S., Nawata, H., Omura, T. and Morohashi, K. (1995) An E box element is required for the expression of the ad4bp gene, a mammalian homologue of ftz-f1 gene, which is essential for adrenal and gonadal development. J. Biol. Chem. 270, 7453-7461.
33. Carson-Jurnica, M.A., Schrader, W.T. and O'Malley, B.W. (1990) Steroid receptor superfamily: structure and functions. Endo. Rev. 11, 209-220.
34. Green, S., Wlater, P., Kumar, V., Krust, A., Bornert, J.-M., Argos, P. and Chambon, P. (1986) Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320, 134-139.
35. Koike, S., Sakai, M. and Muramatsu, M. (1987) Molecular cloning and characterization of rat estrogen receptor. Nuc. Acids Res. 15, 2499-2513.
36. Greco, T.L., Furlow, J.D., Duello, T.M. and Gorski, J. (1992) Immunodetection of estrogen receptors in fetal and neonatal male mouse reproductive tracts. Endocrinology 130, 421-429.
37. McLachlan, J.A. and Newbold, R.R. (1975) Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol. Science 190, 991-992.
38. Kuiper, G.G.J.M., Enmark, E., Pelto-Hukko, M., Nilsson, S. and Gustafsson, J.-A. (1996) Cloning of a novel estrogen receptor expressed in rat prostate. Proc.Natl. Acad. USA 93, 5925-5930.
39. Mosselman, S., Polman, J. and Dijkema, R. (1996) ERβ: identification and characterization of a novel human estrogen receptor. FEBS 392, 49-53.