In vitro study of Organization for Economic Co-operation and Development (OECD) endocrine disruptor screening and testing methods- establishment of a recombinant rat androgen receptor (rrAR) binding assay

Journal of Toxicological Sciences

Volumn 35, Issue 2, 2010, Pages 239-243

  Kim, Tae Sung ^a   Yoon, Chang Yong ^a   Jung, Ki Kyung ^a   Kim, Soon Sun ^a   Kang, Il Hyun ^a   Baek, Jung Hee ^a   Jo, Min Soo ^a   Kim, Hyung Sik ^b   Kang, Tae Seok ^a  

^a Health Effects Analysis Team   (South Korea)

^b Pusan National University   (South Korea)

Author keywords

AR binding assay; EDs; Testosterone

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ANDROGEN RECEPTOR; ANDROSTANOLONE; BUTYL PARABEN; ENDOCRINE DISRUPTOR; METHYLTESTOSTERONE; NONYLPHENOL; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PHTHALIC ACID DIBUTYL ESTER; PROPYL PARABEN; TRENBOLONE;

ARTICLE; IN VITRO STUDY; INTERNATIONAL COOPERATION; NONHUMAN; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING;

RATTUS;

EID: 77951664611     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.35.239     Document Type: Article

References (22)

1. Chapin, R.E., Delaney, J., Wang, Y., Lanning, L., Davis, B., Mintz, N. and Wolfe, G. (1999): The effects of 4-nonylphenol in rats: a multigeneration reproduction study. Toxicol. Sci., 52, 80-91.
2. Colborn, T. (1995): Pesticides - how research has succeeded and failed to translate science into policy: endocrinological effects on wildlife. Environ. Health Perspect., 103, 81-85.
3. EDSTAC (1998): EDSTAC Final report. Available via EPA. http://www.epa.gov/scipoly/oscendo/history/finalrpt.htm.
4. Fang, H., Tong, W., Branham, W.S., Moland, C.L., Dial, S.L., Hong, H., Xie, Q., Perkins, R., Owens, W. and Sheehan, D.M. (2003): Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. Chem. Res. Toxicol., 16, 1338-1358.
5. Freyberger, A. and Ahr, H.J. (2004): Development and standardization of a simple binding assay for the detection of compounds with affinity for the androgen receptor. Toxicology, 195, 113-126. (Pubitemid 38125113)
6. Freyberger, A., Weimer, M., Tran, H.S. and Ahr, H.J. (2009): Assessment of a recombinant androgen receptor binding assay: Initial steps towards validation. Reprod. Toxicol. [Epub ahead of print]
7. Gaido, K.W., Leonard, L.S., Lovell, S., Gould, J.C., Babaï, D., Portier, C.J. and McDonnell, D.P. (1997): Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid Hormone Receptor Gene Transcription Assay. Toxicol. Appl. Pharmacol., 143, 205-212.
8. Gelbke, H.P., Kayser, M. and Poole, A. (2004): OECD test strategies and methods for endocrine disruptors. Toxicology, 205, 17-25. (Pubitemid 39349150)
9. ICCVAM/NICEATM Expert panel (2002): Evaluation of the validation status of in vitro test methods for detecting endocrine disruptors: Estrogen and androgen receptor binding and transcriptional activation assays. Expert panel final report. Available via ICCVAM/NICEATM.
10. Kelce, W.R., Gray, L.E. and Wilson, E.M. (1998): Antiandrogens as environmental endocrine disruptors. Reprod. Fertil. Dev., 10, 105-111.
11. Kim, H.S., Han, S.Y., Yoo, S.D., Lee, B.M. and Park, K.L. (2001): Potential estrogenic effects of bisphenol-A estimated by in vitro and in vivo combination assays. J. Toxicol. Sci., 26, 111-118.
12. Krishnan, A.V., Stathis, P., Permuth, S.F., Tokes, L. and Feldman, D. (1993): Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology, 132, 2279-2286. (Pubitemid 23156872)
13. Lee, H.J., Chattopadhyay, S., Gong, E.Y., Ahn, R.S. and Lee, K. (2003): Antiandrogenic effects of bisphenol A and nonylphenol on the function of androgen receptor. Toxicol. Sci., 75, 40-46.
14. Mylchreest, E., Sar, M., Cattley, R.C. and Foster, P.M. (1999): Disruption of androgen- regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide. Toxicol. Appl. Pharmacol., 156, 81-95.
15. OECD (2003): Draft summary report of the sixth meeting of the task force on endocrine disrupters testing and assessment (EDTA 6). Draft as of March 12, 2003.
16. Oishi, S. (2002): Effects of propyl paraben on the male reproductive system. Food Chem. Toxicol., 40, 1807-1813.
17. Pugazhendhi, D., Sadler, A.J. and Darbre, P.D. (2006): Comparison of the global gene expression profiles produced by methylparaben, n-butylparaben and 17beta-oestradiol in MCF7 human breast cancer cells. J. Appl. Toxicol., 27, 67-77.
18. Satoh, K., Nagai, F. and Aoki, N. (2001): Several environmental pollutants have binding affinities for both androgen receptor and estrogen receptor α. J. Health Sci., 47, 495-501. (Pubitemid 33021613)
19. Sultan, C., Balaguer, P., Terouanne, B., Georget, V., Paris, F., Jeandel, C., Lumbroso, S. and Nicolas, J.C. (2001): Environmental xenoestrogens, antiandrogens and disorders of male sexual differentiation. Mol. Cell. Endocrinol., 178, 99-105.
20. Takeyoshi, M., Kuga, N. and Yamasaki, K. (2003): Development of a high-performance reporter plasmid for detection of chemicals with androgenic activity. Arch. Toxicol., 77, 274-279.
21. Wilson, V.S., Lambright, C., Ostby J. and Gray, L.E.Jr. (2002): In vitro and in vivo effects of 17β-trenbolone: a feedlot effluent contaminant. Toxicol. Sci., 70, 202-211.
22. Yamasaki, K., Takeyoshi, M., Sawaki, M., Imatanaka, N., Shinoda, K. and Takatsuki, M. (2003): Immature rat uterotrophic assay of 18 chemicals and Hershberger assay of 30 chemicals. Toxicology, 183, 93-115. (Pubitemid 36005392)