Glucuronidation and covalent protein binding of benoxaprofen and flunoxaprofen in sandwich-cultured rat and human hepatocytes

Drug Metabolism and Disposition

Volumn 37, Issue 12, 2009, Pages 2314-2322

  Dong, Jennifer Q ^a   Smith, Philip C ^b  

^a AMGEN INC   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL GLUCURONIDE; BENOXAPROFEN; FLUNOXAPROFEN; GLUCURONIDE; IBUPROFEN; LIVER PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG PROTEIN BINDING; GLUCURONIDATION; HUMAN; HUMAN CELL; LIVER CELL CULTURE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REACTION ANALYSIS;

ADULT; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOXAZOLES; BIOTRANSFORMATION; CELL CULTURE TECHNIQUES; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; FEASIBILITY STUDIES; GLUCURONATES; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HUMANS; IBUPROFEN; KINETICS; LAMININ; MALE; MICROSOMES, LIVER; MODELS, BIOLOGICAL; PROPIONIC ACIDS; PROTEIN BINDING; PROTEOGLYCANS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 71049187283     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.028944     Document Type: Article

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