Effect of vitamin D and β-sitosterol on immune function of macrophages

International Immunopharmacology

Volumn 10, Issue 11, 2010, Pages 1390-1396

  Alappat, Lini ^a   Valerio, Michael ^a   Awad, Atif B ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Cell proliferation; Chemokines; Cytokines; NF B; Nitric oxide; P65

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CHEMOKINE; COLECALCIFEROL; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; SITOSTEROL; SYNAPTOTAGMIN I;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; DRUG POTENTIATION; IMMUNOMODULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL LINE; CELL PROLIFERATION; CHOLECALCIFEROL; CYTOKINES; DRUG SYNERGISM; IMMUNOLOGIC FACTORS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; SITOSTEROLS; VITAMINS;

EID: 77958150540     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2010.08.003     Document Type: Article

References (82)

1. Cranney C HT, O'Donnell S, Weiler H, Ooi D, Atkinson S, et al. Effectiveness and safety of vitamin D. Evidence Report/Technology Assessment No. 158 prepared by the University of Ottawa Evidence-based Practice Center under Contract No. 290-02.0021. AHRQ Publication No. 07-E013. Rockville, MD: Agency for Healthcare Research and Quality. 2007.
2. Institute of Medicine FaNBW DC Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride 1997, National Academy Press.
3. van den Berg H. Bioavailability of vitamin D. Eur J Clin Nutr 1997, 51:S76-79.
4. DeLuca H.F. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004, 80:1689S-1696S.
5. Pfeifer M., Begerow B., Minne H.W. Vitamin D and muscle function. Osteoporos Int 2002, 13:187-194.
6. Hayes C.E.H.F., Spach K.M., Pederson L.B. The immunological functions of the vitamin D endocrine system. Cell Mol Biol 2003, 49:277-300.
7. Holick M.F. Evolution and function of vitamin D. Recent results. Cancer Res 2003, 164:3-28.
8. Office of Dietary Supplements NIoH, Bethesda, Maryland. Dietary Supplement Fact Sheet: Vitamin D 2009.
9. Chesney R.W. Vitamin D: can an upper limit be defined?. J Nutr 1989, 119:1825-1828.
10. Favus M.J.C.S. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Lippincott-Raven 1996, Philadelphia. 3rd ed.
11. Jackson R.D.L.A., Gass M., Wallace R.B., Robbins J., Lewis C.E., et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006, 354:669-683.
12. Biser-Rohrbaugh A.H.-M.N. Vitamin D deficiency in breast-fed toddlers. J Pediatr Orthop 2001, 21:508-511.
13. Cohen-Lahav M., Douvdevani A., Chaimovitz C., Shany S. The anti-inflammatory activity of 1, 25-dihydroxyvitamin D3 in macrophages. J Steroid Biochem Mol Biol 2007, 103:558-562.
14. Desai F., Ramanathan M., Fink C.S., Wilding G.E., Weinstock-Guttman B., Awad A.B. Comparison of the immunomodulatory effects of the plant sterol beta-sitosterol to simvastatin in peripheral blood cells from multiple sclerosis patients. Int Immunopharmacol 2009, 9:153-157.
15. Awad A.B., Chan K.C., Downie A.C., Fink C.S. Peanuts as a source of beta-sitosterol, a sterol with anticancer properties. Nutr Cancer 2000, 36:238-241.
16. Kennedy A.R. The evidence for soybean products as cancer preventive agents. J Nutr 1995, 125:733S-743S.
17. Katan M.B., Grundy S.M., Jones P., Law M., Miettinen T., Paoletti R. Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 2003, 78:965-978.
18. Pham T.N., Brown B.L., Dobson P.R., Richardson V.J. Protein kinase C-eta (PKC-eta) is required for the development of inducible nitric oxide synthase (iNOS) positive phenotype in human monocytic cells. Nitric Oxide 2003, 9:123-134.
19. Smith KL. The science of the total environment. 2000;262:185-190.
20. Cohen-Lahav M., Shany S., Tobvin D., Chaimovitz C., Douvdevani A. Vitamin D decreases NFkappaB activity by increasing IkappaBalpha levels. Nephrol Dial Transplant 2006, 21:889-897.
21. C Jer-Ming, Kuo Mei-Chuan, Kuo Hung-Tien, Hwang Shang-Jyh, Tsai Jer-Chia, Chen Hung-Chun, et al. 1-α,25-Dihydroxyvitamin D3 regulates inducible nitric oxide synthase messenger RNA expression and nitric oxide release in macrophage-like RAW 264.7 cells. J Lab Clin Med 2003, 143.
22. Ardizzone S., Cassinotti A., Trabattoni D., Manzionna G., Rainone V., Bevilacqua M., et al. Immunomodulatory effects of 1, 25-dihydroxyvitamin D3 on TH1/TH2 cytokines in inflammatory bowel disease: an in vitro study. Int J Immunopathol Pharmacol 2009, 22:63-71.
23. May E., Asadullah K., Zugel U. Immunoregulation through 1, 25-dihydroxyvitamin D3 and its analogs. Curr Drug Targets Inflamm Allergy 2004, 3:377-393.
24. Shany S., Rapoport J., Zuili I., Gavriel A., Lavi N., Chaimovitz C. Metabolism of 25-OH-vitamin D3 by peritoneal macrophages from CAPD patients. Kidney Int 1991, 39:1005-1011.
25. Schleithoff S.S., Zittermann A., Tenderich G., Berthold H.K., Stehle P., Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2006, 83:754-759.
26. Booij-Vrieling H.E., Tryfonidou M.A., Riemers F.M., Penning L.C., Hazewinkel H.A. Inflammatory cytokines and the nuclear vitamin D receptor are implicated in the pathophysiology of dental resorptive lesions in cats. Vet Immunol Immunopathol 2009.
27. Lefebvre d'Hellencourt C., Montero-Menei C.N., Bernard R., Couez D. Vitamin D3 inhibits proinflammatory cytokines and nitric oxide production by the EOC13 microglial cell line. J Neurosci Res 2003, 71:575-582.
28. Giarratana N., Penna G., Amuchastegui S., Mariani R., Daniel K.C., Adorini L. A vitamin D analog down-regulates proinflammatory chemokine production by pancreatic islets inhibiting T cell recruitment and type 1 diabetes development. J Immunol 2004, 173:2280-2287.
29. Hansdottir S., Monick M.M., Hinde S.L., Lovan N., Look D.C., Hunninghake G.W. Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J Immunol 2008, 181:7090-7099.
30. Zhang Z., Yuan W., Sun L., Szeto F.L., Wong K.E., Li X., et al. 1, 25-Dihydroxyvitamin D3 targeting of NF-kappaB suppresses high glucose-induced MCP-1 expression in mesangial cells. Kidney Int 2007, 72:193-201.
31. Yu X.P., Bellido T., Manolagas S.C. Down-regulation of NF-kappa B protein levels in activated human lymphocytes by 1, 25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 1995, 92:10990-10994.
32. Riis J.L., Johansen C., Gesser B., Moller K., Larsen C.G., Kragballe K., et al. 1alpha, 25(OH)(2)D(3) regulates NF-kappaB DNA binding activity in cultured normal human keratinocytes through an increase in IkappaBalpha expression. Arch Dermatol Res 2004, 296:195-202.
33. Sun J., Kong J., Duan Y., Szeto F.L., Liao A., Madara J.L., et al. Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptor. Am J Physiol Endocrinol Metab 2006, 291:E315-E322.
34. Suzuki Y., Ichiyama T., Ohsaki A., Hasegawa S., Shiraishi M., Furukawa S. Anti-inflammatory effect of 1alpha, 25-dihydroxyvitamin D(3) in human coronary arterial endothelial cells: Implication for the treatment of Kawasaki disease. J Steroid Biochem Mol Biol 2009, 113:134-138.
35. Peterson C.A., Heffernan M.E. Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women. J Inflamm (Lond) 2008, 5:10.
36. Shany S., Levy Y., Lahav-Cohen M. The effects of 1alpha, 24(S)-dihydroxyvitamin D(2) analog on cancer cell proliferation and cytokine expression. Steroids 2001, 66:319-325.
37. Sun X., Zemel M.B. Calcitriol and calcium regulate cytokine production and adipocyte-macrophage cross-talk. J Nutr Biochem 2008, 19:392-399.
38. Hakim I., Bar-Shavit Z. Modulation of TNF-alpha expression in bone marrow macrophages: involvement of vitamin D response element. J Cell Biochem 2003, 88:986-998.
39. Bartels L.E., Jorgensen S.P., Agnholt J., Kelsen J., Hvas C.L., Dahlerup J.F. 1, 25-dihydroxyvitamin D3 and dexamethasone increase interleukin-10 production in CD4+ T cells from patients with Crohn's disease. Int Immunopharmacol 2007, 7:1755-1764.
40. Harant H., Andrew P.J., Reddy G.S., Foglar E., Lindley I.J. 1alpha, 25-dihydroxyvitamin D3 and a variety of its natural metabolites transcriptionally repress nuclear-factor-kappaB-mediated interleukin-8 gene expression. Eur J Biochem 1997, 250:63-71.
41. D'Ambrosio D., Cippitelli M., Cocciolo M.G., Mazzeo D., Di Lucia P., Lang R., et al. Inhibition of IL-12 production by 1, 25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J Clin Invest 1998, 101:252-262.
42. Alroy I., Towers T.L., Freedman L.P. Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Mol Cell Biol 1995, 15:5789-5799.
43. Hayes C.E., Donald Acheson E. A unifying multiple sclerosis etiology linking virus infection, sunlight, and vitamin D, through viral interleukin-10. Med Hypotheses 2008, 71:85-90.
44. Fang F.C. Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity. J Clin Invest 1997, 99:2818-2825.
45. Wheeler M.A., Smith S.D., Garcia-Cardena G., Nathan C.F., Weiss R.M., Sessa W.C. Bacterial infection induces nitric oxide synthase in human neutrophils. J Clin Invest 1997, 99:110-116.
46. Eun J.S., Suh Y.H., Kim D.K., Jeon H. Regulation of cytokine production by exogenous nitric oxide in murine splenocyte and peritoneal macrophage. Arch Pharm Res 2000, 23:531-534.
47. MacMicking J., Xie Q.W., Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol 1997, 15:323-350.
48. Zhou Y., Zhou X., Wang X. 1, 25-Dihydroxyvitamin D3 prevented allergic asthma in a rat model by suppressing the expression of inducible nitric oxide synthase. Allergy Asthma Proc 2008, 29:258-267.
49. Jiao Z.M., Fu Y.H., Fu J., Zhang F., Wang W.Z. 1, 25-dihydroxyvitamin D3 promotes the apoptosis of inflammatory cells in acute experimental autoimmune encephalomyelitis: experiment with rats. Zhonghua Yi Xue Za Zhi 2008, 88:2350-2354.
50. Chan J., Xing Y., Magliozzo R.S., Bloom B.R. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J Exp Med 1992, 175:1111-1122.
51. Rockett K.A., Brookes R., Udalova I., Vidal V., Hill A.V., Kwiatkowski D. 1, 25-Dihydroxyvitamin D3 induces nitric oxide synthase and suppresses growth of Mycobacterium tuberculosis in a human macrophage-like cell line. Infect Immun 1998, 66:5314-5321.
52. Bouic P.J., Lamprecht J.H. Plant sterols and sterolins: a review of their immune-modulating properties. Altern Med Rev 1999, 4:170-177.
53. Bouic P.J., Clark A., Lamprecht J., Freestone M., Pool E.J., Liebenberg R.W., et al. The effects of B-sitosterol (BSS) and B-sitosterol glucoside (BSSG) mixture on selected immune parameters of marathon runners: inhibition of post marathon immune suppression and inflammation. Int J Sports Med 1999, 20:258-262.
54. Bouic P.J., Clark A., Brittle W., Lamprecht J.H., Freestone M., Liebenberg R.W. Plant sterol/sterolin supplement use in a cohort of South African HIV-infected patients-effects on immunological and virological surrogate markers. S Afr Med J 2001, 91:848-850.
55. Bouic P.J. The role of phytosterols and phytosterolins in immune modulation: a review of the past 10years. Curr Opin Clin Nutr Metab Care 2001, 4:471-475.
56. Garcia M.D., Saenz M.T., Gomez M.A., Fernandez M.A. Topical antiinflammatory activity of phytosterols isolated from Eryngium foetidum on chronic and acute inflammation models. Phytother Res 1999, 13:78-80.
57. Ding Y., Nguyen H.T., Kim S.I., Kim H.W., Kim Y.H. The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris. Bioorg Med Chem Lett 2009, 19:3607-3610.
58. Fang S.H., Rao Y.K., Tzeng Y.M. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol 2008, 116:333-340.
59. Aherne S.A., O'Brien N.M. Modulation of cytokine production by plant sterols in stimulated human Jurkat T cells. Mol Nutr Food Res 2008, 52:664-673.
60. Lee J.H., Lee J.Y., Park J.H., Jung H.S., Kim J.S., Kang S.S., et al. Immunoregulatory activity by daucosterol, a beta-sitosterol glycoside, induces protective Th1 immune response against disseminated Candidiasis in mice. Vaccine 2007, 25:3834-3840.
61. Myers L., Bouic P.J.D. Flow cytometric analysis of the TH1-TH2 shift in allergic individuals using ModucareTM (sterols/sterolins). 26th Annual Congress of the Physiology Society of Southern Africa 1998.
62. Moreno J.J. Effect of olive oil minor components on oxidative stress and arachidonic acid mobilization and metabolism by macrophages RAW 264.7. Free Radic Biol Med 2003, 35:1073-1081.
63. Verstuyf A., Segaert S., Verlinden L., Casteels K., Bouillon R., Mathieu C. Recent developments in the use of vitamin D analogues. Curr Opin Nephrol Hypertens 1998, 7:397-403.
64. Wactawski-Wende J., Kotchen J.M., Anderson G.L., Assaf A.R., Brunner R.L., O'Sullivan M.J., et al. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med 2006, 354:684-696.
65. Garland C.F., Garland F.C., Gorham E.D., Lipkin M., Newmark H., Mohr S.B., et al. The role of vitamin D in cancer prevention. Am J Public Health 2006, 96:252-261.
66. Garland C.F., Garland F.C. Do sunlight and vitamin D reduce the likelihood of colon cancer?. Int J Epidemiol 2006, 35:217-220.
67. Giovannucci E., Liu Y., Rimm E.B., Hollis B.W., Fuchs C.S., Stampfer M.J., et al. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst 2006, 98:451-459.
68. Ahonen M.H., Tenkanen L., Teppo L., Hakama M., Tuohimaa P. Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). Cancer Causes Control 2000, 11:847-852.
69. Wu K., Feskanich D., Fuchs C.S., Willett W.C., Hollis B.W., Giovannucci E.L. A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer. J Natl Cancer Inst 2007, 99:1120-1129.
70. Young M.V., Schwartz G.G., Wang L., Jamieson D.P., Whitlatch L.W., Flanagan J.N., et al. The prostate 25-hydroxyvitamin D-1 alpha-hydroxylase is not influenced by parathyroid hormone and calcium: implications for prostate cancer chemoprevention by vitamin D. Carcinogenesis 2004, 25:967-971.
71. van Halteren A.G., Tysma O.M., van Etten E., Mathieu C., Roep B.O. 1alpha, 25-dihydroxyvitamin D3 or analogue treated dendritic cells modulate human autoreactive T cells via the selective induction of apoptosis. J Autoimmun 2004, 23:233-239.
72. Pedersen L.B., Nashold F.E., Spach K.M., Hayes C.E. 1, 25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by inhibiting chemokine synthesis and monocyte trafficking. J Neurosci Res 2007, 85:2480-2490.
73. Stio M., Martinesi M., Bruni S., Treves C., d'Albasio G., Bagnoli S., et al. Interaction among vitamin D(3) analogue KH 1060, TNF-alpha, and vitamin D receptor protein in peripheral blood mononuclear cells of inflammatory bowel disease patients. Int Immunopharmacol 2006, 6:1083-1092.
74. Park C., Moon D.O., Rhu C.H., Choi B.T., Lee W.H., Kim G.Y., et al. Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio. Biol Pharm Bull 2007, 30:1317-1323.
75. Awad A.B., Fink C.S. Phytosterols as anticancer dietary components: evidence and mechanism of action. J Nutr 2000, 130:2127-2130.
76. von Holtz R.L., Fink C.S., Awad A.B. beta-Sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells. Nutr Cancer 1998, 32:8-12.
77. Awad A.B., von Holtz R.L., Cone J.P., Fink C.S., Chen Y.C. beta-Sitosterol inhibits growth of HT-29 human colon cancer cells by activating the sphingomyelin cycle. Anticancer Res 1998, 18:471-473.
78. Awad A.B., Williams H., Fink C.S. Phytosterols reduce in vitro metastatic ability of MDA-MB-231 human breast cancer cells. Nutr Cancer 2001, 40:157-164.
79. Awad A.B., Fink C.S., Williams H., Kim U. In vitro and in vivo (SCID mice) effects of phytosterols on the growth and dissemination of human prostate cancer PC-3 cells. Eur J Cancer Prev 2001, 10:507-513.
80. Awad A.B., Smith A.J., Fink C.S. Plant sterols regulate rat vascular smooth muscle cell growth and prostacyclin release in culture. Prostaglandins Leukot Essent Fatty Acids 2001, 64:323-330.
81. Awad A.B., Roy R., Fink C.S. Beta-sitosterol, a plant sterol, induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells. Oncol Rep 2003, 10:497-500.
82. Jeong S.J., Pise-Masison C.A., Radonovich M.F., Park H.U., Brady J.N. A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity. J Biol Chem 2005, 280:10326-10332.