Vitamin D3 inhibits proinflammatory cytokines and nitric oxide production by the EOC13 microglial cell line

Journal of Neuroscience Research

Volumn 71, Issue 4, 2003, Pages 575-582

  D'Hellencourt, Christian Lefebvre ^a,b   Montero Menei, Claudia N ^a,c   Bernard, Rozenn ^a,d   Couez, Dominique ^a  

^a ANGERS UNIVERSITY HOSPITAL   (France)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c INSERM   (France)

^d SORBONNE UNIVERSITÉ   (France)

Author keywords

IL 6; Microglia; NO; TGF ; TNF; VDR; Vitamin D3

Indexed keywords

COLECALCIFEROL; CYTOKINE; INTERLEUKIN 6; NITRIC OXIDE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; VITAMIN D RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOMODULATION; INFLAMMATION; MICROGLIA; MOUSE; NEUROIMMUNOLOGY; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELL LINE; CHOLECALCIFEROL; CYTOKINES; DOWN-REGULATION; MICE; MICE, INBRED C3H; MICROGLIA; NITRIC OXIDE;

EID: 0037441555     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10491     Document Type: Article

References (53)

1. Aloisi F, Serafini B, Adorini L. 2000. Glia-T cell dialogue. J Neuroimmunol 107:111-117.
2. + T cells by mouse microglia: evidence for a distinct phenotype based on expression of surface-associated and soluble costimulatory molecules. Glia 18:118-128.
3. + T cells as revealed by a panel of microglial cell lines. Immunobiology 195:417-430.
4. Baas D, Prufer K, Ittel ME, Kuchler-Bopp S, Labourdette G, Sarlieve LL, Brachet P. 2000. Rat oligodendrocytes express the vitamin D(3) receptor and respond to 1,25-dihydroxyvitamin D(3). Glia 31:59-68.
5. Brewer LD, Thibault V, Chen KC, Langub MC, Landfield PW, Porter NM. 2001. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. J Neurosci 21:98-108.
6. Cantorna MT, Hayes CE, DeLuca HF. 1996. 1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc Natl Acad Sci USA 93:7861-7864.
7. Cantorna MT, Woodward WD, Hayes CE, DeLuca HF. 1998. 1,25-Dihydroxyvitamin D3 is a positive regulator for the two antiencephalitogenic cytokines TGF-beta 1 and IL-4. J Immunol 160:5314-5319.
8. Carlberg C, Polly P. 1998. Gene regulation by vitamin D3. Crit Rev Eukaryotic Gene Express 8:19-42.
9. Chao CC, Hu S, Close K, Choi CS, Molitor TW, Novick WJ, Peterson PK. 1992a. Cytokine release from microglia: differential inhibition by pentoxifylline and dexamethasone. J Infect Dis 166:847-853.
10. Chao CC, Hu S, Molitor TW, Shaskan EG, Peterson PK. 1992b. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol 149:2736-2741.
11. Chao CC, Hu S, Sheng WS, Tsang M, Peterson PK. 1995. Tumor necrosis factor-alpha mediates the release of bioactive transforming growth factor-beta in murine microglial cell cultures. Clin Immunol Immunopathol 77:358-365.
12. Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
13. Clavreul A, D'Hellencourt CL, Montero-Menei C, Potron G, Couez D. 1998. Vitamin D differentially regulates B7.1 and B7.2 expression on human peripheral blood monocytes. Immunology 95:272-277.
14. Cohen ML, Douvdevani A, Chaimovitz C, Shany S. 2001. Regulation of TNF-alpha by 1alpha,25-dihydroxyvitamin D3 in human macrophages from CAPD patients. Kidney Int 59:69-75.
15. D'Ambrosio D, Cippitelli M, Cocciolo MG, Mazzeo D, Di Lucia P, Lang R, Sinigaglia F, Panina-Bordignon P. 1998. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB down-regulation in transcriptional repression of the p40 gene. J Clin Invest 101:252-262.
16. Danielpour D, Kim KY, Dart LL, Watanabe S, Roberts AB, Sporn MB. 1989. Sandwich enzyme-linked immunosorbent assays (SELISAs) quantitate and distinguish two forms of transforming growth factor-beta (TGF-beta 1 and TGF-beta 2) in complex biological fluids. Growth Factors 2:61-71.
17. Garcion E, Nataf S, Berod A, Darcy F, Brachet P. 1997. 1,25-Dihydroxyvitamin D3 inhibits the expression of inducible nitric oxide synthase in rat central nervous system during experimental allergic encephalomyelitis. Brain Res Mol Brain Res 45:255-267.
18. Garcion E, Sindji L, Montero-Menei C, Andre C, Brachet P, Darcy F. 1998. Expression of inducible nitric oxide synthase during rat brain inflammation: regulation by 1,25-dihydroxyvitamin D3. Glia 22:282-294.
19. Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F, Wion D. 2002. New clues about vitamin D functions in the nervous system. Trends Endocrinol Metab 13:100-105.
20. Gonzalez-Scarano F, Baltuch G. 1999. Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci 22:219-240.
21. Hosseinpour F, Wikvall K. 2000. Porcine microsomal vitamin D(3) 25-hydroxylase (CYP2D25). Catalytic properties, tissue distribution, and comparison with human CYP2D6. J Biol Chem 275:34650-34655.
22. Janabi N, Peudenier S, Heron B, Ng KH, Tardieu M. 1995. Establishment of human microglial cell lines after transfection of primary cultures of embryonic microglial cells with the SV40 large T antigen. Neurosci Lett 195:105-108.
23. Koli K, Keski-Oja J. 1993. Vitamin D3 and calcipotriol enhance the secretion of transforming growth factor-beta 1 and -beta 2 in cultured murine keratinocytes. Growth Factors 8:153-163.
24. Koli K, Keski-Oja J. 1995. 1,25-Dihydroxyvitamin D3 enhances the expression of transforming growth factor beta 1 and its latent form binding protein in cultured breast carcinoma cells. Cancer Res 55:1540-1546.
25. Lefebvre d'Hellencourt C, Diaw L, Cornillet P, Guenounou M. 1996. Inhibition of human TNF alpha and LT in cell-free extracts and in cell culture by antisense oligonucleotides. Biochim Biophys Acta 1317:168-174.
26. Lemire J. 2000. 1,25-Dihydroxyvitamin D3 - a hormone with immunomodulatory properties. Z Rheumatol 59:24-27.
27. Lemire JM, Archer DC, Beck L, Spiegelberg HL. 1995. Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions. J Nutr 125:1704S-1708S.
28. Liu L, Khastgir A, McCauley JM, Dunn ST, Morrissey JH, Christakos S, Hughes MR, Bourdeau JE. 1996. RT-PCR microlocalization of mRNAs for calbindin D28k and vitamin D receptor in the murine nephron. Am J Physiol 270:F677-F681.
29. Lorsbach RB, Murphy WJ, Lowenstein CJ, Snyder SH, Russell SW. 1993. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. J Biol Chem 268:1908-1913.
30. Menendez Iglesias B, Cerase J, Ceracchini C, Levi G, Aloisi F. 1997. Analysis of B7-1 and B7-2 costimulatory ligands in cultured mouse microglia: upregulation by interferon-gamma and lipopolysaccharide and downregulation by interleukin-10, prostaglandin E2 and cyclic AMP-elevating agents. J Neuroimmunol 72:83-93.
31. Muller K, Haahr PM, Diamant M, Rieneck K, Kharazmi A, Bendtzen K. 1992. 1,25-Dihydroxyvitamin D3 inhibits cytokine production by human blood monocytes at the post-transcriptional level. Cytokine 4:506-512.
32. Munoz-Fernandez MA, Fresno M. 1998. The role of tumour necrosis factor, interleukin 6, interferon-gamma and inducible nitric oxide synthase in the development and pathology of the nervous system. Progr Neurobiol 56:307-340.
33. Nashold FE, Miller DJ, Hayes CE. 2000. 1,25-Dihydroxyvitamin D3 treatment decreases macrophage accumulation in the CNS of mice with experimental autoimmune encephalomyelitis. J Neuroimmunol 103:171-179.
34. Nataf S, Garcion E, Darcy F, Chabannes D, Muller JY, Brachet P. 1996. 1,25 Dihydroxyvitamin D3 exerts regional effects in the central nervous system during experimental allergic encephalomyelitis. J Neuropathol Exp Neurol 55:904-914.
35. Neveu I, Naveilhan P, Baudet C, Brachet P, Metsis M. 1994a. 1,25-Dihydroxyvitamin D3 regulates NT-3, NT-4 but not BDNF mRNA in astrocytes. Neuroreport 6:124-126.
36. Neveu I, Naveilhan P, Jehan F, Baudet C, Wion D, De Luca HF, Brachet P. 1994b. 1,25-Dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells. Brain Res Mol Brain Res 24:70-76.
37. Neveu I, Naveilhan P, Menaa C, Wion D, Brachet P, Garabedian M. 1994c. Synthesis of 1,25-dihydroxyvitamin D3 by rat brain macrophages in vitro. J Neurosci Res 38:214-220.
38. Penna G, Adorini L. 2000. 1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 164:2405-2411.
39. Piemonti L, Monti P, Sironi M, Fraticelli P, Leone BE, Dal Cin E, Allavena P, Di Carlo V. 2000. Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells. J Immunol 164: 4443-4451.
40. Prufer K, Veenstra TD, Jirikowski GF, Kumar R. 1999. Distribution of 1,25-dihydroxyvitamin D3 receptor immunoreactivity in the rat brain and spinal cord. J Chem Neuroanat 16:135-145.
41. Ross TK, Moss VE, Prahl JM, DeLuca HF. 1992. A nuclear protein essential for binding of rat 1,25-dihydroxyvitamin D3 receptor to its response elements. Proc Natl Acad Sci USA 89:256-260.
42. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
43. Streit WJ. 2000. Microglial response to brain injury: a brief synopsis. Toxicol Pathol 28:28-30.
44. Streit WJ. 2001. Microglia and macrophages in the developing CNS. Neurotoxicology 22:619-624.
45. Streit WJ, Walter SA, Pennell NA. 1999. Reactive microgliosis. Progr Neurobiol 57:563-581.
46. Suzumura A, Sawada M, Yamamoto H, Marunouchi T. 1993. Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro. J Immunol 151:2150-2158.
47. van der Schoot CE, Jansen P, Poorter M, Wester MR, von dem Borne AE, Aarden LA, van Oers RH. 1989. Interleukin-6 and interleukin-1 production in acute leukemia with monocytoid differentiation. Blood 74: 2081-2087.
48. Veenstra TD, Prufer K, Koenigsberger C, Brimijoin SW, Grande JP, Kumar R. 1998. 1,25-Dihydroxyvitamin D3 receptors in the central nervous system of the rat embryo. Brain Res 804:193-205.
49. Vincent S, Marty L, Fort P. 1993. S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues. Nucleic Acids Res 21:1498.
50. + T cells. J Neuroimmunol 63:163-174.
51. Weinreich T, Landolt M, Booy C, Wuthrich R, Binswanger U. 1999. 1,25-Dihydroxyvitamin D3 stimulates transforming growth factor-beta1 synthesis by mouse renal proximal tubular cells. Kidney Blood Pressure Res 22:99-105.
52. Xu H, Soruri A, Gieseler RK, Peters JH. 1993. 1,25-Dihydroxyvitamin D3 exerts opposing effects to IL-4 on MHC class-II antigen expression, accessory activity, and phagocytosis of human monocytes. Scand J Immunol 38:535-540.
53. Zehnder D, Bland R, Williams MC, McNinch RW, Howie AJ, Stewart PM, Hewison M. 2001. Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab 86:888-894.