1,25-Dihydroxyvitamin D3 prevented allergic asthma in a rat model by suppressing the expression of inducible nitric oxide synthase

Allergy and Asthma Proceedings

Volumn 29, Issue 3, 2008, Pages 258-267

  Zhou, Yan ^a   Zhou, Xin ^a   Wang, Xiaoqiu ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

1,25 Dihydroxyvitamin D 3; Alveolar macrophages; Asthma; Dexamethasone; Induced nitric oxide synthase; Nitric oxide; Vitamin D3

Indexed keywords

CALCITRIOL; INDUCIBLE NITRIC OXIDE SYNTHASE; OVALBUMIN;

ANIMAL; ARTICLE; ASTHMA; BIOSYNTHESIS; CELL COUNT; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; LUNG; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; METHODOLOGY; PATHOLOGY; RAT; WISTAR RAT;

ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE; CALCITRIOL; CELL COUNT; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNOHISTOCHEMISTRY; LUNG; MACROPHAGES, ALVEOLAR; NITRIC OXIDE SYNTHASE TYPE II; OVALBUMIN; RATS; RATS, WISTAR;

EID: 46649091710     PISSN: 10885412     EISSN: None     Source Type: Journal    
DOI: 10.2500/aap.2008.29.3115     Document Type: Article

References (26)

1. Frieri M. Asthma concepts in the new millennium: Update in asthma pathophysiology. Allergy Asthma Proc 26:83-88, 2005.
2. Nelson HS. Advances in upper airway diseases and allergen immunotherapy. J Allergy Clin Immunol 119:872-880, 2007.
3. Payne DN, Adcock IM, Wilson NM, et al. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone. Am J Respir Crit Care Med 164:1376-1381, 2001.
4. Meurs H, Maarsingh H, and Zaagsma J. Arginase and asthma: Novel insights into nitric oxide homeostasis and airway hyperresponsiveness. Trends Pharmacol Sci 24:450-455, 2003.
5. Ricciardolo FL, Sterk PJ, Gaston B, et al. Nitric oxide in health and disease of the respiratory system. Physiol Rev 84:731-765, 2004.
6. Frieri M. Nitric oxide in allergic rhinitis and asthma. Allergy Asthma Proc 19:349-351, 1998.
7. Moncada S, Palmer RMJ, and Higgs EA. Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol Rev 143:109-142, 1991.
8. Veldman CM, Cantorna MT, and DeLuca HF. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys 374:334-338, 2000.
9. 3. Curr Opin Nephrol Hypertens 4:313-318, 1995.
10. 3 has a direct effect on naive CD4-T cells to enhance the development of Th2 cells. J Immunol 167:4974-4980, 2001.
11. Topilski I, Flaishon L, Naveh Y, et al. The anti-inflammatory effects of 1,25-dihydroxyvitamin D3 on Th2 cells in vivo are due in part to the control of integrin-mediated T lymphocyte homing Eur. Eur J Immunol 34:1068-1076, 2004.
12. Matheu V, Back O, Mondoc E, and Issazadeh-Navikas S. Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: Enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. J Allergy Clin Immunol 112:585-592, 2003.
13. Wittke A, Weaver V, Mahon BD, et al. Vitamin D receptor-deficient mice fail to develop experimental allergic asthma. J Immunol 173:3432-3436, 2004.
14. Chang JM, Kuo MC, Kuo HT, et al. 1-α,25-Dihydroxyvitamin D3 regulates inducible nitric oxide synthase messenger RNA expression and nitric oxide release in macrophage-like RAW 264.7 cells. J Lab Clin Med 143:14-22, 2004.
15. Offer S, Yedgar S, Schwob O, et al. Negative feedback between secretory and cytosolic phospholipase A2 and their opposing roles in ovalbumin-induced bronchoconstriction in rats. Am J Physiol Lung Cell Mol Physiol 288:523-529, 2005.
16. Amdur MO, and Mead J. Mechanics of respiration in unanesthetized guinea pigs. Am J Physiol 192:364-368, 1958.
17. Garcion E, Nataf S, Berod A, et al. 1,25-Dihydroxyvitamin D3 inhibits the expression of inducible nitric oxide synthase in rat central nervous system during experimental allergic encephalomyeliris. Mol Brain Res 45:255-267, 1997.
18. Mansur A, Chu A, Karnik A, and Frieri M. Nitric oxide production and apoptosis by gp 120. Allergy Asthma Proc 21:145-149, 2000.
19. Adams JS, Ren SY, Arbelle JE, et al. Coordinate regulation of nitric oxide and 1,25-Dihydroxyvitamin D production in the avian myelomonocytic cell line HD-11. Endocrinology 136:2262-2269, 1995.
20. Ricciardolo FL. Multiple roles of nitric oxide in the airways. Thorax 58:175-182, 2003.
21. Yates DH, Kharitonov SA, Thomas PS, and Barnes PJ. Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase. Am J Respir Crit Care Med 154:247-250, 1996.
22. Dweik RA. Nitric oxide, hypoxia, and superoxide: The good, the bad, and the ugly! Thorax 60:265-267, 2005.
23. Huang YC, Leyko BT, and Frieri M. Effects of omalizumab and budesonide on markers of inflammation in human bronchial epithelial cells. Ann Allergy Asthma Immunol 95:443-451, 2005.
24. Lane C, Knight D, Burgess S, et al. Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath. Thorax 59:757-760, 2004.
25. Duguet A, Iijima H, Eum SY, et al. Eosinophil peroxidase mediates protein nitration in allergic airway inflammation in mice. Am J Respir Crit Care Med 164:1119-1126, 2001.
26. Batra J, Pratap Singh T, Mabalirajan U, et al. Association of inducible nitric oxide synthase with asthma severity, total serum immunoglobulin E and blood eosinophil levels. Thorax. 62:16-22, 2007.