메뉴 건너뛰기




Volumn 279, Issue 1, 2009, Pages 93-100

Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts

Author keywords

Apoptosis; Colorectal cancer; Guggulsterone; Xenograft

Indexed keywords

CASPASE 3; CASPASE 8; FAS ANTIGEN; GUGGULSTERONE; INHIBITOR OF APOPTOSIS PROTEIN 1; PROTEIN BCL 2; PROTEIN BID; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE;

EID: 67349286984     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.01.026     Document Type: Article
Times cited : (60)

References (37)
  • 1
    • 34548182292 scopus 로고    scopus 로고
    • Cancer incidence, mortality, and associated risk factors among Asian Americans of Chinese, Filipino, Vietnamese, Korean, and Japanese ethnicities
    • McCracken M., Olsen M., Chen Jr. M.S., Jemal A., Thun M., Cokkinides V., Deapen D., and Ward E. Cancer incidence, mortality, and associated risk factors among Asian Americans of Chinese, Filipino, Vietnamese, Korean, and Japanese ethnicities. CA Cancer J. Clin. 57 (2007) 190-205
    • (2007) CA Cancer J. Clin. , vol.57 , pp. 190-205
    • McCracken, M.1    Olsen, M.2    Chen Jr., M.S.3    Jemal, A.4    Thun, M.5    Cokkinides, V.6    Deapen, D.7    Ward, E.8
  • 3
    • 0037029304 scopus 로고    scopus 로고
    • Impact on survival of intensive follow up after curative resection for colorectal cancer: systematic review and meta-analysis of randomised trials
    • Renehan A.G., Egger M., Saunders M.P., and O'Dwyer S.T. Impact on survival of intensive follow up after curative resection for colorectal cancer: systematic review and meta-analysis of randomised trials. BMJ 324 (2002) 813
    • (2002) BMJ , vol.324 , pp. 813
    • Renehan, A.G.1    Egger, M.2    Saunders, M.P.3    O'Dwyer, S.T.4
  • 4
    • 22844443043 scopus 로고    scopus 로고
    • Systemic therapy for metastatic colorectal cancer: current options, current evidence
    • Kelly H., and Goldberg R.M. Systemic therapy for metastatic colorectal cancer: current options, current evidence. J. Clin. Oncol. 23 (2005) 4553-4560
    • (2005) J. Clin. Oncol. , vol.23 , pp. 4553-4560
    • Kelly, H.1    Goldberg, R.M.2
  • 7
    • 0017687334 scopus 로고
    • Comparison of the anti-inflammatory activity of Commiphora mukul (an indigenous drug) with those of phenylbutazone and ibuprofen in experimental arthritis induced by mycobacterial adjuvant
    • Sharma J.N., and Sharma J.N. Comparison of the anti-inflammatory activity of Commiphora mukul (an indigenous drug) with those of phenylbutazone and ibuprofen in experimental arthritis induced by mycobacterial adjuvant. Arzneimittelforschung 27 (1977) 1455-1457
    • (1977) Arzneimittelforschung , vol.27 , pp. 1455-1457
    • Sharma, J.N.1    Sharma, J.N.2
  • 8
    • 0042130513 scopus 로고    scopus 로고
    • GUGULIPID: a natural cholesterol-lowering agent
    • Urizar N.L., and Moore D.D. GUGULIPID: a natural cholesterol-lowering agent. Annu. Rev. Nutr. 23 (2003) 303-313
    • (2003) Annu. Rev. Nutr. , vol.23 , pp. 303-313
    • Urizar, N.L.1    Moore, D.D.2
  • 10
    • 33751577977 scopus 로고    scopus 로고
    • Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis
    • Cheon J.H., Kim J.S., Kim J.M., Kim N., Jung H.C., and Song I.S. Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis. Inflamm. Bowel Dis. 12 (2006) 1152-1161
    • (2006) Inflamm. Bowel Dis. , vol.12 , pp. 1152-1161
    • Cheon, J.H.1    Kim, J.S.2    Kim, J.M.3    Kim, N.4    Jung, H.C.5    Song, I.S.6
  • 11
    • 4544342570 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: the enemy within
    • Aggarwal B.B. Nuclear factor-kappaB: the enemy within. Cancer Cell 6 (2004) 203-208
    • (2004) Cancer Cell , vol.6 , pp. 203-208
    • Aggarwal, B.B.1
  • 12
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    • Beg A.A., and Baltimore D. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 274 (1996) 782-784
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 13
    • 0030298294 scopus 로고    scopus 로고
    • Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
    • Liu Z.G., Hsu H., Goeddel D.V., and Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 87 (1996) 565-576
    • (1996) Cell , vol.87 , pp. 565-576
    • Liu, Z.G.1    Hsu, H.2    Goeddel, D.V.3    Karin, M.4
  • 15
    • 1542357606 scopus 로고    scopus 로고
    • Apoptosis pathways in cancer and cancer therapy
    • Debatin K.M. Apoptosis pathways in cancer and cancer therapy. Cancer Immunol. Immunother. 53 (2004) 153-159
    • (2004) Cancer Immunol. Immunother. , vol.53 , pp. 153-159
    • Debatin, K.M.1
  • 16
    • 8744234076 scopus 로고    scopus 로고
    • Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis
    • Shishodia S., and Aggarwal B.B. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J. Biol. Chem. 279 (2004) 47148-47158
    • (2004) J. Biol. Chem. , vol.279 , pp. 47148-47158
    • Shishodia, S.1    Aggarwal, B.B.2
  • 17
    • 0034921727 scopus 로고    scopus 로고
    • Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs
    • (REVIEWS3009)
    • Verhagen A.M., Coulson E.J., and Vaux D.L. Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs. Genome Biol. 2 (2001) (REVIEWS3009)
    • (2001) Genome Biol. , vol.2
    • Verhagen, A.M.1    Coulson, E.J.2    Vaux, D.L.3
  • 18
    • 0242656497 scopus 로고    scopus 로고
    • Death receptor-induced cell killing
    • Thorburn A. Death receptor-induced cell killing. Cell. Signal. 16 (2004) 139-144
    • (2004) Cell. Signal. , vol.16 , pp. 139-144
    • Thorburn, A.1
  • 20
    • 0031018914 scopus 로고    scopus 로고
    • FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens
    • Muzio M., Salvesen G.S., and Dixit V.M. FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J. Biol. Chem. 272 (1997) 2952-2956
    • (1997) J. Biol. Chem. , vol.272 , pp. 2952-2956
    • Muzio, M.1    Salvesen, G.S.2    Dixit, V.M.3
  • 21
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Li H., Zhu H., Xu C.J., and Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 (1998) 491-501
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 22
    • 28044460494 scopus 로고    scopus 로고
    • Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak
    • Singh S.V., Zeng Y., Xiao D., Vogel V.G., Nelson J.B., Dhir R., and Tripathi Y.B. Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak. Mol. Cancer Ther. 4 (2005) 1747-1754
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 1747-1754
    • Singh, S.V.1    Zeng, Y.2    Xiao, D.3    Vogel, V.G.4    Nelson, J.B.5    Dhir, R.6    Tripathi, Y.B.7
  • 23
    • 34547614631 scopus 로고    scopus 로고
    • Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase
    • Singh S.V., Choi S., Zeng Y., Hahm E.R., and Xiao D. Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase. Cancer Res. 67 (2007) 7439-7449
    • (2007) Cancer Res. , vol.67 , pp. 7439-7449
    • Singh, S.V.1    Choi, S.2    Zeng, Y.3    Hahm, E.R.4    Xiao, D.5
  • 24
    • 34249058341 scopus 로고    scopus 로고
    • Guggulsterone inhibits tumor cell proliferation, Induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products
    • Shishodia S., Sethi G., Ahn K.S., and Aggarwal B.B. Guggulsterone inhibits tumor cell proliferation, Induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. Biochem. Pharmacol. 74 (2007) 118-130
    • (2007) Biochem. Pharmacol. , vol.74 , pp. 118-130
    • Shishodia, S.1    Sethi, G.2    Ahn, K.S.3    Aggarwal, B.B.4
  • 25
    • 30344476414 scopus 로고    scopus 로고
    • Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure
    • Samudio I., Konopleva M., Safe S., McQueen T., and Andreeff M. Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure. Mol. Cancer Ther. 4 (2005) 1982-1992
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 1982-1992
    • Samudio, I.1    Konopleva, M.2    Safe, S.3    McQueen, T.4    Andreeff, M.5
  • 26
    • 38349143690 scopus 로고    scopus 로고
    • z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo
    • Xiao D., and Singh S.V. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol. Cancer Ther. 7 (2008) 171-180
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 171-180
    • Xiao, D.1    Singh, S.V.2
  • 27
    • 31544446372 scopus 로고    scopus 로고
    • Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation
    • Ichikawa H., and Aggarwal B.B. Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation. Clin. Cancer Res. 12 (2006) 662-668
    • (2006) Clin. Cancer Res. , vol.12 , pp. 662-668
    • Ichikawa, H.1    Aggarwal, B.B.2
  • 28
    • 0034676089 scopus 로고    scopus 로고
    • Cross-talk in cell death signaling
    • Roy S., and Nicholson D.W. Cross-talk in cell death signaling. J. Exp. Med. 192 (2000) F21-25
    • (2000) J. Exp. Med. , vol.192
    • Roy, S.1    Nicholson, D.W.2
  • 31
    • 0033215040 scopus 로고    scopus 로고
    • Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases
    • Deveraux Q.L., Leo E., Stennicke H.R., Welsh K., Salvesen G.S., and Reed J.C. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. Embo J. 18 (1999) 5242-5251
    • (1999) Embo J. , vol.18 , pp. 5242-5251
    • Deveraux, Q.L.1    Leo, E.2    Stennicke, H.R.3    Welsh, K.4    Salvesen, G.S.5    Reed, J.C.6
  • 32
    • 0030011398 scopus 로고    scopus 로고
    • Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
    • Boldin M.P., Goncharov T.M., Goltsev Y.V., and Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85 (1996) 803-815
    • (1996) Cell , vol.85 , pp. 803-815
    • Boldin, M.P.1    Goncharov, T.M.2    Goltsev, Y.V.3    Wallach, D.4
  • 34
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross A., McDonnell J.M., and Korsmeyer S.J. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 13 (1999) 1899-1911
    • (1999) Genes Dev. , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 35
    • 0033499801 scopus 로고    scopus 로고
    • BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
    • Yamamoto K., Ichijo H., and Korsmeyer S.J. BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol. Cell. Biol. 19 (1999) 8469-8478
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 8469-8478
    • Yamamoto, K.1    Ichijo, H.2    Korsmeyer, S.J.3
  • 36
    • 0033616709 scopus 로고    scopus 로고
    • Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis
    • Srivastava R.K., Mi Q.S., Hardwick J.M., and Longo D.L. Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis. Proc. Natl. Acad. Sci. USA 96 (1999) 3775-3780
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3775-3780
    • Srivastava, R.K.1    Mi, Q.S.2    Hardwick, J.M.3    Longo, D.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.