Human CD14+ leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4

Journal of Leukocyte Biology

Volumn 59, Issue 2, 1996, Pages 208-218

  Kiertscher, Sylvia M ^a   Roth, Michael D ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antigen presentation; B7 1; B7 2; Macrophage; Myeloid

Indexed keywords

CD14 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 4;

ANTIGEN PRESENTING CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; LEUKOCYTE; MACROPHAGE; MORPHOLOGY; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL;

EID: 0029917705     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.59.2.208     Document Type: Article

References (35)

1. King, P.D., Katz, D.R. (1990) Mechanisms of dendritic cell function. Immunol. Today 11, 206-211.
2. Steinman, R. M. (1991) The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271-296.
3. Freudenthal, P. S., Steinman, R. M. (1990) The distinct surface of human blood dendritic cells, as observed after an improved isolation method. Proc. Natl. Acad. Sci. USA 87, 7698-7702.
4. O'Doherty, U., Steinman, R. M., Peng, M., Cameron, P. U., Gezelter S., Kopeloff, I., Swiggard, W. J., Pope, M., Bhardwaj, N. (1993) Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. J Exp. Med. 178, 1067-1076.
5. O'Doherty, U., Peng, M., Gezelter, S., Swiggard, W. J., Betjes, M., Bhardwaj, N., Steinman, R. M. (1994) Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. Immunology 82, 487-493.
6. Thomas, R., Davis, L. S., Lipsky, P. E. (1993) Isolation and characterization of human peripheral blood dendritic cells. J. Immunol. 150, 821-834.
7. Romani, N., Gruber, S., Brang, D., Kampgen, E., Lenz, A., Trockbacher, B., Konwalinka, G., Fritsch, P. O., Steinman, R. M., Schuler, G. (1994) Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180, 83-93.
8. Caux, C., Liu, Y-J., Banchereau, J. (1995) Recent advances in the study of dendritic cells and follicular dendritic cells. Immunol. Today 16, 2-4.
9. Grabbe, S., Beissert, S., Schwarz, T., Granstein, R. D. (1995) Dendritic cells as initiators of tumor immune responses: a possible strategy for tumor immunotherapy? Immunol. Today 16, 117-121.
10. Huang, A., Columbek, P., Ahmadzadeh, M., Jaffe, E., Pardoll, D., Levitsky, H. (1994) Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 264, 961-965.
11. Weissman, D., Yuexia, L., Ananworanich, J., Zhou, L-J., Adelsberger, J., Tedder, T.F., Baseler, M., Fauci, A.S. (1995) Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 92, 826-830.
12. Tsunetsugu-Yokota, Akagawa, K., Kimoto, H., Suzuki, K., Iwasaki, M., Yasuda, S., Hausser, G., Hultgren, C., Meyerhans, A., Takemori, T. (1995) Monocyte-derived cultured dendritic cells are susceptible to human immunodeficiency virus infection and transmit virus to resting T cells in the process of nominal antigen presentation. J. Virol. 69, 4544-4557.
13. Swisher, S. G., Kiertseher, S. M., Golub, S. H., Holmes, E. C., Roth, M. D. (1993) Pulmonary macrophages suppress the proliferation and cytotoxicity of tumor-infiltrating lymphocytes. Am. J. Respir. Cell Mol. Biol. 8, 486-492.
14. Van Voorhis, W. C., Hair, L. S., Steinman, R. M., Kaplan, G. (1982) Human dendritic cells. Enrichment and characterization from peripheral blood. J. Exp. Med. 155, 1172-1187.
15. Chemini, J., Stari, S. E., Kawashima, H., Miller, D. S., Trinchieri, G., Perussia, B., Bandyopadhyay, S. (1989) Dendritic cells and interferon-alpha-producing cells are two functionally distinct non-B, non-monocytic HLA-DR+ cell subsets in human peripheial blood. Immunology 68, 486-490.
16. Thomas, R., Lipsky, P. E. (1994) Human peripheral blood dendritic cell subsets: isolation and characterization of precursor and mature antigen-presenting cells. J. Immunol. 153, 4016-4027.
17. Zhou, L-J., Schwarting, R., Smith, H. M., Tedder, T. F. (1992) A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. J. Immunol. 149, 735-742.
18. Zhou, L-J., Tedder, T. (1995) Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J. Immunol. 154, 3821-3835.
19. Hume, D., Allan, W., Golder, J., Stephens, R. W., Doe, W. F., Warren, H. S. (1985) Preparation and characterization of human bone marrow-derived macrophages. J. Leukoc. Biol. 38, 541-552.
20. Sorg, C. (1991) Macrophages in acute and chronic inflammation. Chest 100, 173S-175S.
21. Roth, M.D. (1994) Interleukin-2 induces the expression of CD45RO and the memory phenotype by CD45RA+ peripheral blood lymphocytes. J. Exp. Med. 179, 857-864.
22. June, C. H., Bluestone, J. A., Nadler, L. M., Thompson, C. B. (1994) The B7 and CD28 receptor families. Immunol. Today 15, 321-331.
23. Young, J. W., Koulova, L., Soergel, S. A., Clark, E. A., Steinman, R. M., Dupont, B. (1992) The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro. J. Clin. Invest. 90, 229-237.
24. Modino, A., Jenkins, M. J. (1994) Surface proteins involved in T cell costimulalion. J. Leukoc. Biol. 55, 805-815.
25. Knight, S. C., Stagg, A. J. (1993) Antigen-presenting cell types. Curr. Opin. Immunol. 5, 374-382.
26. Steinman, R. M., Young, J. W. (1991) Signals arising from antigen presenting cells. Curr. Opin. Immunol. 3, 361-372.
27. Scheeren, R. A., Koopman, G., Van der Baan, S., Meijer, C. J. L. M., Pals, S. T. (1991) Adhesion receptors involved in clustering of blood dendritic cells and T lymphocytes. Eur. J. Immunol. 21, 1101-1105.
28. Inaba, K., Steinman, R.M. (1986) Accessory cell-T lymphocyte interactions: Antigen dependent and independent clustering. J. Exp. Med. 163, 247-261.
29. Caux, C., Massacrier, C., Vanbervliet, B., Dubois, B., Van Kooten, C., Durand, I., Banchereau, J. (1994) Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 180, 1263-1272.
30. Sallusto, F., Cella, M., Danieli, C., Lanzavecchia, A. (1995) Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibilily complex class II compartment: Down-regulation by cytokines and bacterial products. J. Exp. Med. 182, 389-400.
31. Lauener, R.P., Goyert, S.M., Geha, R.S., Vercelli, D. (1990) Interleukin-4 down-regulates the expression of CD14 in normal human monocytes. Eur. J. Immunol. 20, 2375-2381.
32. Peters, J. H., Xu, H., Ruppert, J., Ostermeier, D., Friedrichs, D., Gieseler, R. K. H. (1993) Signals required for differentiating dendritic cells from human monocytes in vitro. Adv. Exp. Med. Biol. 329, 275-280.
33. Lanier, L., O'Fallon, S., Somoza, C., Phillips J., Linsley, P., Okumura, K., Ito, D., Azuma, M. (1995) CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J. Immunol. 154, 97-105.
34. Ruppert, J., Schutt, C., Ostermeier, D., Peters, J. H. (1993) Down-regulation and release of CD14 on human monocytes by IL-4 depends on the presence of serum or GM-CSF. Adv. Exp. Med. Biol. 329, 281-286.
35. Mukherji, B., Chakraborty, N. C., Yamasaki, S., Okino, T., Sporn, J., Kurtzman, S., Yamase, H., Eigin, M. T. (1995) In vivo immunogenicity of MAGE-1 nonapeptide-pulsed autologous macrophages in melanoma patients. Cancer Res. Proceedings 36, 675-676.