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Volumn , Issue , 2009, Pages 255-272

Dual Carbonic Anhydrase and Cyclooxygenase-2 Inhibition

Author keywords

Cyclooxygenase inhibition and cardiovascular risks; Dual carbonic anhydrase and cyclooxygenase 2 inhibition; Nanomolar affinity of sulfonamide COX 2 inhibitors celecoxib and valdecoxib for CA II

Indexed keywords


EID: 77958016222     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470508169.ch11     Document Type: Chapter
Times cited : (1)

References (67)
  • 1
    • 27544432733 scopus 로고    scopus 로고
    • Cyclooxygenase variants: the role of alternative splicing
    • Roos, K. L.; Simmons, D. L. Cyclooxygenase variants: the role of alternative splicing. Biochem. Biophys. Res. Commun. 2005, 338, 62-69.
    • (2005) Biochem. Biophys. Res. Commun , vol.338 , pp. 62-69
    • Roos, K.L.1    Simmons, D.L.2
  • 3
    • 17144393290 scopus 로고    scopus 로고
    • Adverse cardiovascular effects of the coxibs
    • Dogné, J.-M.; Supuran, C. T.; Pratico, D. Adverse cardiovascular effects of the coxibs. J. Med. Chem. 2005, 48, 2251-2257.
    • (2005) J. Med. Chem , vol.48 , pp. 2251-2257
    • Dogné, J.-M.1    Supuran, C.T.2    Pratico, D.3
  • 4
    • 0242690224 scopus 로고    scopus 로고
    • COX-2 and beyond: approaches to prostaglandin inhibition in human disease
    • FitzGerald, G. A. COX-2 and beyond: approaches to prostaglandin inhibition in human disease. Nat. Rev. Drug Discov. 2003, 2, 879-890.
    • (2003) Nat. Rev. Drug Discov , vol.2 , pp. 879-890
    • FitzGerald, G.A.1
  • 5
    • 23244445988 scopus 로고    scopus 로고
    • Cyclooxygenase inhibition and cardiovascular risk
    • Antman, E. M.; DeMets, D.; Loscalzo, J. Cyclooxygenase inhibition and cardiovascular risk. Circulation 2005, 111, 759-770.
    • (2005) Circulation , vol.111 , pp. 759-770
    • Antman, E.M.1    DeMets, D.2    Loscalzo, J.3
  • 6
    • 0035833502 scopus 로고    scopus 로고
    • The coxibs, selective inhibitors of cyclooxygenase-2
    • FitzGerald, G. A.; Patrono, C. The coxibs, selective inhibitors of cyclooxygenase-2. N. Engl. J. Med. 2001, 345, 433-442.
    • (2001) N. Engl. J. Med , vol.345 , pp. 433-442
    • FitzGerald, G.A.1    Patrono, C.2
  • 7
    • 33646395681 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition: vascular inflammation and cardiovascular risk
    • Cipollone, F.; Fazia, M. L. Cyclooxygenase-2 inhibition: vascular inflammation and cardiovascular risk. Curr. Atheroscler. Rep. 2006, 8, 245-251.
    • (2006) Curr. Atheroscler. Rep , vol.8 , pp. 245-251
    • Cipollone, F.1    Fazia, M.L.2
  • 8
    • 34547561752 scopus 로고    scopus 로고
    • Cancer chemoprevention by cyclooxygenase 2 (COX-2) blockade: results of case control studies
    • Harris, R. E.; Beebe-Donk, J.; Alshafie, G. A. Cancer chemoprevention by cyclooxygenase 2 (COX-2) blockade: results of case control studies. Subcell. Biochem. 2007, 42, 193-211.
    • (2007) Subcell. Biochem , vol.42 , pp. 193-211
    • Harris, R.E.1    Beebe-Donk, J.2    Alshafie, G.A.3
  • 9
    • 34547557661 scopus 로고    scopus 로고
    • Role of COX-2 in inflammatory and degenerative brain diseases
    • Minghetti, L. Role of COX-2 in inflammatory and degenerative brain diseases. Subcell. Biochem. 2007, 42, 117-141.
    • (2007) Subcell. Biochem , vol.42 , pp. 117-141
    • Minghetti, L.1
  • 10
    • 0037108979 scopus 로고    scopus 로고
    • COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression
    • Chandrasekharan, N. V.; Dai, H.; Roos, K. L.; Evanson, N. K.; Tomsik, J.; Elton, T. S.; Simmons, D. L. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc. Natl. Acad. Sci. USA 2002, 99, 13926-13931.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 13926-13931
    • Chandrasekharan, N.V.1    Dai, H.2    Roos, K.L.3    Evanson, N.K.4    Tomsik, J.5    Elton, T.S.6    Simmons, D.L.7
  • 11
    • 27744529775 scopus 로고    scopus 로고
    • Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention
    • Qin, N.; Zhang, S. P.; Reitz, T. L.; Mei, J. M.; Flores, C. M. Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention. J. Pharmacol. Exp. Ther. 2005, 315, 1198-1305.
    • (2005) J. Pharmacol. Exp. Ther , vol.315 , pp. 1198-1305
    • Qin, N.1    Zhang, S.P.2    Reitz, T.L.3    Mei, J.M.4    Flores, C.M.5
  • 12
    • 39049174710 scopus 로고    scopus 로고
    • Antipyretic analgesics: nonsteroidal antiinflammatory drugs, selective COX-2 inhibitors, paracetamol and pyrazolinones
    • Hinz, B.; Brune, K. Antipyretic analgesics: nonsteroidal antiinflammatory drugs, selective COX-2 inhibitors, paracetamol and pyrazolinones. Handb. Exp. Pharmacol. 2007, 177, 65-93.
    • (2007) Handb. Exp. Pharmacol , vol.177 , pp. 65-93
    • Hinz, B.1    Brune, K.2
  • 13
    • 38949136999 scopus 로고    scopus 로고
    • Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man
    • Hinz, B.; Cheremina, O.; Brune, K. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J. 2008, 22, 383-390.
    • (2008) FASEB J , vol.22 , pp. 383-390
    • Hinz, B.1    Cheremina, O.2    Brune, K.3
  • 14
    • 0037022011 scopus 로고    scopus 로고
    • Role of Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis
    • Huang, J. Q.; Sridhar, S.; Hunt, R. H. Role of Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis. Lancet 2002, 359, 14-22.
    • (2002) Lancet , vol.359 , pp. 14-22
    • Huang, J.Q.1    Sridhar, S.2    Hunt, R.H.3
  • 15
    • 23844526846 scopus 로고    scopus 로고
    • Selective cyclooxygenase-2 inhibitors development in cardiovascular medicine
    • Pratico, D.; Dogné, J.-M. Selective cyclooxygenase-2 inhibitors development in cardiovascular medicine. Circulation 2005, 111, 1073-1079.
    • (2005) Circulation , vol.111 , pp. 1073-1079
    • Pratico, D.1    Dogné, J.-M.2
  • 16
    • 0032700638 scopus 로고    scopus 로고
    • Molecular model of the interaction between nimesulide and human cyclooxygenase-2
    • (Oxford)
    • Garcia-Nieto, R.; Perez, C.; Checa, A.; Gago, F. Molecular model of the interaction between nimesulide and human cyclooxygenase-2. Rheumatology (Oxford) 1999, 38 (Suppl. 1), 14-18.
    • (1999) Rheumatology , vol.38 , Issue.SUPPL. 1 , pp. 14-18
    • Garcia-Nieto, R.1    Perez, C.2    Checa, A.3    Gago, F.4
  • 18
  • 20
    • 0037249213 scopus 로고    scopus 로고
    • The second generation of COX-2 inhibitors: what advantages do the newest offer?
    • Stichtenoth, D. O.; Frolich, J. C. The second generation of COX-2 inhibitors: what advantages do the newest offer? Drugs 2003, 63, 33-45.
    • (2003) Drugs , vol.63 , pp. 33-45
    • Stichtenoth, D.O.1    Frolich, J.C.2
  • 25
    • 4344661128 scopus 로고    scopus 로고
    • Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial
    • Schnitzer, T. J.; Burmester, G. R.; Mysler, E.; Hochberg, M. C.; Doherty, M.; Ehrsam, E.; Gitton, X.; Krammer, G.; Mellein, B.; Matchaba, P.; Gimona, A.; Hawkey, C. J. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial. Lancet 2004, 364, 665-674.
    • (2004) Lancet , vol.364 , pp. 665-674
    • Schnitzer, T.J.1    Burmester, G.R.2    Mysler, E.3    Hochberg, M.C.4    Doherty, M.5    Ehrsam, E.6    Gitton, X.7    Krammer, G.8    Mellein, B.9    Matchaba, P.10    Gimona, A.11    Hawkey, C.J.12
  • 26
    • 33750441189 scopus 로고    scopus 로고
    • Blood pressure effects of COX-2 inhibitors
    • Krum, H.; Aw, T. J.; Liew, D.; Haas, S. Blood pressure effects of COX-2 inhibitors. J. Cardiovasc. Pharmacol. 2006, 47, (Suppl. 1), S43-S48.
    • (2006) J. Cardiovasc. Pharmacol , vol.47 , Issue.SUPPL. 1
    • Krum, H.1    Aw, T.J.2    Liew, D.3    Haas, S.4
  • 28
    • 3242668792 scopus 로고    scopus 로고
    • COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents
    • Supuran, C. T.; Casini, A.; Mastrolorenzo, A.; Scozzafava, A. COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents. Mini Rev. Med. Chem. 2004, 4, 625-632.
    • (2004) Mini Rev. Med. Chem , vol.4 , pp. 625-632
    • Supuran, C.T.1    Casini, A.2    Mastrolorenzo, A.3    Scozzafava, A.4
  • 30
    • 0037103151 scopus 로고    scopus 로고
    • Nonaromatic sulfonamide group as an ideal anchor for potent human carbonic anhydrase inhibitors: role of hydrogen-bonding networks in ligand binding and drug design
    • Abbate, F.; Supuran, C.T.; Scozzafava, A.; Orioli, P.; Stubbs, M. T.; Klebe, G. Nonaromatic sulfonamide group as an ideal anchor for potent human carbonic anhydrase inhibitors: role of hydrogen-bonding networks in ligand binding and drug design. J. Med. Chem. 2002, 45, 3583-3587.
    • (2002) J. Med. Chem , vol.45 , pp. 3583-3587
    • Abbate, F.1    Supuran, C.T.2    Scozzafava, A.3    Orioli, P.4    Stubbs, M.T.5    Klebe, G.6
  • 31
    • 1642540579 scopus 로고    scopus 로고
    • Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib:new pharmacological opportunities due to related binding site recognition
    • Weber, A.; Casini, A.; Heine, A.; Kuhn, D.; Supuran, C. T.; Scozzafava, A.; Klebe, G. Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib:new pharmacological opportunities due to related binding site recognition. J. Med. Chem. 2004, 47, 550-557.
    • (2004) J. Med. Chem , vol.47 , pp. 550-557
    • Weber, A.1    Casini, A.2    Heine, A.3    Kuhn, D.4    Supuran, C.T.5    Scozzafava, A.6    Klebe, G.7
  • 33
    • 27944498514 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II ''selective'' inhibitor celecoxib
    • Di Fiore, A.; Pedone, C.; D'Ambrosio, K.; Scozzafava, A.; De Simone, G.; Supuran, C. T. Carbonic anhydrase inhibitors: valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II ''selective'' inhibitor celecoxib. Bioorg. Med. Chem. Lett. 2006, 16, 437-442.
    • (2006) Bioorg. Med. Chem. Lett , vol.16 , pp. 437-442
    • Di Fiore, A.1    Pedone, C.2    D'Ambrosio, K.3    Scozzafava, A.4    De Simone, G.5    Supuran, C.T.6
  • 34
    • 24744467784 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membraneimpermeant antitumor sulfonamide complexed with isozyme II
    • Menchise, V.; De Simone, G.; Alterio, V.; Di Fiore, A.; Pedone, C.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membraneimpermeant antitumor sulfonamide complexed with isozyme II. J. Med. Chem. 2005, 48, 5721-5727.
    • (2005) J. Med. Chem , vol.48 , pp. 5721-5727
    • Menchise, V.1    De Simone, G.2    Alterio, V.3    Di Fiore, A.4    Pedone, C.5    Scozzafava, A.6    Supuran, C.T.7
  • 35
    • 0035286901 scopus 로고    scopus 로고
    • Cyclooxygenase-2: specific inhibitors and cardiorenal function: a randomized, controlled trial of celecoxib and rofecoxib in older hypertensive osteoarthritis patients
    • Whelton, A.; Fort, J. G.; Puma, J. A.; Normandin, D.; Bello, A. E.; Verburg, K. M. Cyclooxygenase-2: specific inhibitors and cardiorenal function: a randomized, controlled trial of celecoxib and rofecoxib in older hypertensive osteoarthritis patients. Am. J. Ther. 2001, 8, 85-95.
    • (2001) Am. J. Ther , vol.8 , pp. 85-95
    • Whelton, A.1    Fort, J.G.2    Puma, J.A.3    Normandin, D.4    Bello, A.E.5    Verburg, K.M.6
  • 36
    • 0035811229 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition and renal function
    • Whelton, A. Cyclooxygenase-2 inhibition and renal function. Ann. Intern. Med. 2001, 134, 1077-1078.
    • (2001) Ann. Intern. Med , vol.134 , pp. 1077-1078
    • Whelton, A.1
  • 37
    • 0036764153 scopus 로고    scopus 로고
    • COX-2-specific inhibitors and the kidney: effect on hypertension and oedema
    • Whelton, A.COX-2-specific inhibitors and the kidney: effect on hypertension and oedema. J. Hypertens. Suppl. 2002, 20, S31-S35.
    • (2002) J. Hypertens , vol.20 , Issue.SUPPL
    • Whelton, A.1
  • 38
    • 0036830135 scopus 로고    scopus 로고
    • Effects of celecoxib and rofecoxib on blood pressure and edema in patients > or 1/465 years of age with systemic hypertension and osteoarthritis
    • Whelton, A.; White, W. B.; Bello, A. E.; Puma, J. A.; Fort, J. G. Effects of celecoxib and rofecoxib on blood pressure and edema in patients > or 1/465 years of age with systemic hypertension and osteoarthritis. Am. J. Cardiol. 2002, 90, 959-963.
    • (2002) Am. J. Cardiol , vol.90 , pp. 959-963
    • Whelton, A.1    White, W.B.2    Bello, A.E.3    Puma, J.A.4    Fort, J.G.5
  • 39
    • 33745837444 scopus 로고    scopus 로고
    • Effects of the selective cyclooxygenase-2 inhibitor analgesic celecoxib on renal carbonic anhydrase enzyme activity: a randomized, controlled trial
    • Alper,A. B., Jr.; Tomlin, H.; Sadhwani, U.; Whelton, A.; Puschett, J. Effects of the selective cyclooxygenase-2 inhibitor analgesic celecoxib on renal carbonic anhydrase enzyme activity: a randomized, controlled trial. Am. J. Ther. 2006, 13, 229-235.
    • (2006) Am. J. Ther , vol.13 , pp. 229-235
    • Alper Jr, A.B.1    Tomlin, H.2    Sadhwani, U.3    Whelton, A.4    Puschett, J.5
  • 40
    • 33748549323 scopus 로고    scopus 로고
    • Can the blood pressure effects of COX-2 selective inhibitors be explained by changes in plasma aldosterone levels? J
    • Aw, T. J.; Liew, D.; Tofler,G. H.; Schneider,H. G.; Morel-Kopp, M. C.; Billah, B.; Krum, H. Can the blood pressure effects of COX-2 selective inhibitors be explained by changes in plasma aldosterone levels? J. Hypertens. 2006, 24, 1979-1984.
    • (2006) Hypertens , vol.24 , pp. 1979-1984
    • Aw, T.J.1    Liew, D.2    Tofler, G.H.3    Schneider, H.G.4    Morel-Kopp, M.C.5    Billah, B.6    Krum, H.7
  • 41
    • 11144228243 scopus 로고    scopus 로고
    • Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors
    • Julemont, F.; de Leval, X.; Michaux, C.; Renard, J. F.;Winum, J.Y.; Montero, J. L.; Damas, J.; Dogné, J.-M.; Pirotte, B. Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors. J. Med. Chem. 2004, 47, 6749-6759.
    • (2004) J. Med. Chem , vol.47 , pp. 6749-6759
    • Julemont, F.1    De Leval, X.2    Michaux, C.3    Renard, J.F.4    Winum, J.Y.5    Montero, J.L.6    Damas, J.7    Dogné, J.-M.8    Pirotte, B.9
  • 42
    • 0036531924 scopus 로고    scopus 로고
    • Celecoxib exhibits the greatest potency amongst cyclooxygenase (COX) inhibitors for growth inhibition of COX-2-negative hematopoietic and epithelial cell lines
    • Waskewich, C.; Blumenthal, R. D.; Li, H.; Stein, R.; Goldenberg, D. M.; Burton, J. Celecoxib exhibits the greatest potency amongst cyclooxygenase (COX) inhibitors for growth inhibition of COX-2-negative hematopoietic and epithelial cell lines. Cancer Res. 2002, 62, 2029-2033.
    • (2002) Cancer Res , vol.62 , pp. 2029-2033
    • Waskewich, C.1    Blumenthal, R.D.2    Li, H.3    Stein, R.4    Goldenberg, D.M.5    Burton, J.6
  • 43
    • 4544388351 scopus 로고    scopus 로고
    • Cancer-related carbonic anhydrase isozymes and their inhibition
    • Carbonic Anhydrase: Its Inhibitors and Activators; CRC Press: London
    • Pastoreková, S.; Pastorek, J. Cancer-related carbonic anhydrase isozymes and their inhibition. Carbonic Anhydrase: Its Inhibitors and Activators; CRC Press: London, 2004; pp 255-281.
    • (2004) , pp. 255-281
    • Pastoreková, S.1    Pastorek, J.2
  • 44
    • 0033986761 scopus 로고    scopus 로고
    • Causes and consequences of tumour acidity and implications for treatment
    • Stubbs, M.; McSheehy, P. M.; Griffiths, J. R.; Bashford, C. L. Causes and consequences of tumour acidity and implications for treatment. Mol. Med. Today 2000, 6, 15-19.
    • (2000) Mol. Med. Today , vol.6 , pp. 15-19
    • Stubbs, M.1    McSheehy, P.M.2    Griffiths, J.R.3    Bashford, C.L.4
  • 51
    • 0031819881 scopus 로고    scopus 로고
    • Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation
    • Saarnio, J.; Parkkila, S.; Parkkila, A. K.; Haukipuro, K.; Pastorekova, S.; Pastorek, J.; Kairaluoma,M. I.; Karttunen, T. J. Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am. J. Pathol. 1998, 153, 279-285.
    • (1998) Am. J. Pathol , vol.153 , pp. 279-285
    • Saarnio, J.1    Parkkila, S.2    Parkkila, A.K.3    Haukipuro, K.4    Pastorekova, S.5    Pastorek, J.6    Kairaluoma, M.I.7    Karttunen, T.J.8
  • 53
    • 0030972193 scopus 로고    scopus 로고
    • MN antigen expression in normal, preneoplasticneoplastic esophagus: a clinicopathological study of a new cancerassociated biomarker.
    • Turner, J. R.; Odze, R. D.; Crum, C. P.; Resnick, M. B. MN antigen expression in normal, preneoplastic, and neoplastic esophagus: a clinicopathological study of a new cancerassociated biomarker. Hum. Pathol. 1997, 28, 740-744.
    • (1997) Hum. Pathol , vol.28 , pp. 740-744
    • Turner, J.R.1    Odze, R.D.2    Crum, C.P.3    Resnick, M.B.4
  • 54
    • 0030835515 scopus 로고    scopus 로고
    • Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney
    • Liao, S. Y.; Aurelio, O. N.; Jan, K.; Zavada, J.; Stanbridge, E. J. Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney. Cancer Res. 1997, 57, 2827-2831.
    • (1997) Cancer Res , vol.57 , pp. 2827-2831
    • Liao, S.Y.1    Aurelio, O.N.2    Jan, K.3    Zavada, J.4    Stanbridge, E.J.5
  • 56
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects
    • Hockel, M.; Vaupel, P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J. Natl. Cancer Inst. 2001, 93, 266-276.
    • (2001) J. Natl. Cancer Inst , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 58
    • 0035418586 scopus 로고    scopus 로고
    • Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
    • Loncaster, J. A.; Harris, A. L.; Davidson, S. E.; Logue, J. P.; Hunter, R. D.;Wycoff, C. C.; Pastorek, J.; Ratcliffe, P. J.; Stratford, I. J.; West, C. M. Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 2001, 61, 6394-6399.
    • (2001) Cancer Res , vol.61 , pp. 6394-6399
    • Loncaster, J.A.1    Harris, A.L.2    Davidson, S.E.3    Logue, J.P.4    Hunter, R.D.5    Wycoff, C.C.6    Pastorek, J.7    Ratcliffe, P.J.8    Stratford, I.J.9    West, C.M.10
  • 59
    • 0032514685 scopus 로고    scopus 로고
    • Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
    • Ivanov, S. V.; Kuzmin, I.;Wei, M. H.; Pack, S.; Geil, L.; Johnson, B. E.; Stanbridge, E. J.; Lerman, M. I. Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Proc. Natl. Acad. Sci. USA 1998, 95, 11596-11601.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 11596-11601
    • Ivanov, S.V.1    Kuzmin, I.2    Wei, M.H.3    Pack, S.4    Geil, L.5    Johnson, B.E.6    Stanbridge, E.J.7    Lerman, M.I.8
  • 60
    • 0035106202 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: sulfonamides as antitumor agents? Bioorg
    • Supuran, C. T.; Briganti, F.; Tilli, S.; Chegwidden, W. R.; Scozzafava, A. Carbonic anhydrase inhibitors: sulfonamides as antitumor agents? Bioorg. Med. Chem. 2001, 9, 703-714.
    • (2001) Med. Chem , vol.9 , pp. 703-714
    • Supuran, C.T.1    Briganti, F.2    Tilli, S.3    Chegwidden, W.R.4    Scozzafava, A.5
  • 61
    • 16244377468 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides: a new target for the design of antitumor and antiglaucoma drugs?
    • Vullo, D.; Innocenti, A.; Nishimori, I.; Pastorek, J.; Scozzafava, A.; Pastorekova, S.; Supuran, C. T. Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides: a new target for the design of antitumor and antiglaucoma drugs? Bioorg. Med. Chem. Lett. 2005, 15, 963-969.
    • (2005) Bioorg. Med. Chem. Lett , vol.15 , pp. 963-969
    • Vullo, D.1    Innocenti, A.2    Nishimori, I.3    Pastorek, J.4    Scozzafava, A.5    Pastorekova, S.6    Supuran, C.T.7
  • 62
    • 2942599029 scopus 로고    scopus 로고
    • Acetazolamide inhibits aquaporin-1 protein expression and angiogenesis
    • Xiang,Y.; Ma, B.; Li, T.; Gao, J.W.;Yu, H. M.; Li, X. J. Acetazolamide inhibits aquaporin-1 protein expression and angiogenesis. Acta Pharmacol. Sin. 2004, 25, 811-816.
    • (2004) Acta Pharmacol. Sin , vol.25 , pp. 811-816
    • Xiang, Y.1    Ma, B.2    Li, T.3    Gao J.W.4    Yu, H.M.5    Li, X.J.6
  • 63
    • 0030942009 scopus 로고    scopus 로고
    • Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan
    • Vukovic,V.; Tannock, I. F. Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan. Br. J. Cancer 1997, 75, 1167-1172.
    • (1997) Br. J. Cancer , vol.75 , pp. 1167-1172
    • Vukovic, V.1    Tannock, I.F.2
  • 64
    • 33750082400 scopus 로고    scopus 로고
    • Targeting tumor-associated carbonic anhydrase IX in cancer therapy
    • Thiry, A.; Dogné, J.-M.; Masereel, B.; Supuran, C. T. Targeting tumor-associated carbonic anhydrase IX in cancer therapy. Trends Pharmacol. Sci. 2006, 27, 566-573.
    • (2006) Trends Pharmacol. Sci , vol.27 , pp. 566-573
    • Thiry, A.1    Dogné, J.-M.2    Masereel, B.3    Supuran, C.T.4
  • 65
    • 44949190364 scopus 로고    scopus 로고
    • Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs
    • Thiry, A.; Supuran, C. T.; Masereel, B.; Dogné, J.-M. Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. J. Med. Chem. 2008, 51, 3051-3056.
    • (2008) J. Med. Chem , vol.51 , pp. 3051-3056
    • Thiry, A.1    Supuran, C.T.2    Masereel, B.3    Dogné, J.-M.4
  • 66
    • 42549148009 scopus 로고    scopus 로고
    • Carbonic anhydrase IX: a new druggable target for the design of antitumor agents
    • Winum, J.-Y.; Rami, M.; Scozzafava, A.; Montero, J. L.; Supuran, C. Carbonic anhydrase IX: a new druggable target for the design of antitumor agents. Med. Res. Rev. 2008, 28, 445-463.
    • (2008) Med. Res. Rev , vol.28 , pp. 445-463
    • Winum, J.-Y.1    Rami, M.2    Scozzafava, A.3    Montero, J.L.4    Supuran, C.5
  • 67
    • 0037463790 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides
    • Vullo, D.; Franchi, M.; Gallori, E.; Pastorek, J.; Scozzafava, A.; Pastorekova, S.; Supuran, C. T. Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides. Bioorg. Med. Chem. Lett. 2003, 13, 1005-1009.
    • (2003) Bioorg. Med. Chem. Lett , vol.13 , pp. 1005-1009
    • Vullo, D.1    Franchi, M.2    Gallori, E.3    Pastorek, J.4    Scozzafava, A.5    Pastorekova, S.6    Supuran, C.T.7


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