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Volumn 18, Issue 21, 2010, Pages 7392-7401

Design, solid-phase synthesis, and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors

(11) Gluszok, Sébastien a Frédérick, Raphaël b Foulon, Catherine a Klupsch, Frédérique a Supuran, Claudiu T c Vullo, Daniela c Scozzafava, Andrea c Goossens, Jean Franois a Masereel, Bernard b Depreux, Patrick a Goossens, Laurence a

a Université de Lille 1 Sciences et Technologies (France)

b UNIVERSITY OF NAMUR (Belgium)

c UNIVERSITY OF FLORENCE (Italy)

Author keywords

Carbonic anhydrase; Lipophilicity; Molecular modeling; Pyrrole; Sulfonamide

Indexed keywords

CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; PYRROLE DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; LIPOPHILICITY; MOLECULAR MODEL; PHYSICAL CHEMISTRY;

ANTIGENS, NEOPLASM; BINDING SITES; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; COMPUTER SIMULATION; DRUG DESIGN; HUMANS; PYRROLES; SOLUBILITY; SULFONAMIDES;

EID: 77958011398 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.09.007 Document Type: Article

Times cited : (18)

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