The linear no-threshold model does not hold for low-dose ionizing radiation

Radiation Research

Volumn 162, Issue 4, 2004, Pages 447-452

  Hooker, Antony M ^a   Bhat, Madhava ^b   Day, Tanya K ^a   Lane, Joanne M ^a   Swinburne, Sarah J ^a   Morley, Alexander A ^a   Sykes, Pamela J ^a,c  

^a FLINDERS UNIVERSITY   (Australia)

^b ROYAL ADELAIDE HOSPITAL   (Australia)

^c FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CHROMOSOME INVERSION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; IONIZING RADIATION; LINEAR NO THRESHOLD MODEL; LINEAR SYSTEM; LOW ENERGY RADIATION; MODEL; MOUSE; MOUSE STRAIN; NONHUMAN; PKZ1 MOUSE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; TRANSGENIC MOUSE; WHOLE BODY RADIATION; X IRRADIATION;

ANIMALS; BETA-GALACTOSIDASE; CHROMOSOMES; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; LEAD; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; MODELS, GENETIC; MODELS, THEORETICAL; MUTAGENS; RADIATION, IONIZING; RADIOMETRY; SPLEEN; TRANSGENES; X-RAYS;

EID: 6344221296     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3228     Document Type: Article

References (23)

1. M. Polly cove and L. E. Feinendegen, Radiation-induced versus endogenous DNA damage: Possible effect of inducible protective responses in mitigating endogenous damage. Hum. Exp. Toxicol. 22, 290-306 (2003).
2. R. A. Winegar, L. H. Lutze, J. D. Hamer, K. G. O'Loughlin and J. C. Mirsalis, Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice. Mutat. Res. 307, 479-487 (1994).
3. J. A. Gossen, H. J. Martus, J. Y. Wei and J. Vijg, Spontaneous and X-ray-induced deletion mutations in a LacZ plasmid-based transgenic mouse model. Mutat. Res. 331, 89-97 (1995).
4. K. Rothkamm and M. Lobrich, Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses. Proc. Natl. Acad. Sci. USA 100, 5057-5062 (2003).
5. R. H. Schiestl, F. Khogali and N. Carls, Reversion of the mouse pink-eyed unstable mutation induced by low doses of X-rays. Science 266, 1573-1576 (1994).
6. M. Matsuoka, F. Nagawa, K. Okazaki, L. Kingsbury, K. Yoshida, U. Muller, D. T. Larue, J. A. Winer and H. Sakano, Detection of somatic DNA recombination in the transgenic mouse brain. Science 254, 81-86 (1991).
7. P. J. Sykes, A. M. Hooker, A. K. Jacobs, C. S. Harrington, L. Kingsbury and A. A. Morley, Induction of somatic intrachromosomal inversion events by cyclophosphamide in a transgenic mouse model. Mutat. Res. 397, 209-219 (1998).
8. R J. Sykes, A. M. Hooker and A. A. Morley, Inversion due to intrachromosomal recombination produced by carcinogens in a transgenic mouse model. Mutat. Res. 427, 1-9 (1999).
9. P. J. Sykes, B. D. McCallum, M. J. Bangay, A. M. Hooker and A. A. Morley, Effect of exposure to 900 MHz radiofrequency radiation on intrachromosomal recombination in pKZ1 mice. Radiat. Res. 156, 495-502 (2001).
10. A. M. Hooker, A. A. Morley and P. J. Sykes, Dose-dependent increase or decrease of somatic intrachromosomal recombination produced by etoposide. Mutat. Res. 500, 117-124 (2002).
11. A. M. Hooker, A. A. Morley, W. D. Tilley and P. J. Sykes, Cancer-associated genes can affect somatic intrachromosomal recombination early in carcinogenesis. Mutat. Res. 550, 1-10 (2004).
12. S. W. Kohler, G. S. Provost, A. Fieck, P. L. Kretz, W. O. Bullock, D. L. Putman, J. A. Sorge and J. M. Short, Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/locI shuttle vector. Environ. Mol. Mutagen. 18, 318-321 (1991).
13. Institution of Physics and Engineering in Medicine and Biology, The IPEMB code of practice for the determination of absorbed dose for X-rays below 300 kV generating potential (0. 035 mm AL-4 mm Cu HVL; 10-300 kV generating potential). Phys. Med. Biol. 41, 2605-2625 (1996).
14. W. F. Morgan, Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionising radiation? Oncogene 22, 7094-7099 (2003).
15. C. Mothersill and C. Seymour, Radiation-induced bystander effects, carcinogenesis and models. Oncogene 22, 7028-7033 (2003).
16. E. J. Hall and T. K. Hei, Genomic instability and bystander effects induced by high-LET radiation. Oncogene 22, 7034-7042 (2003).
17. E. I. Azzam, S. M. de Toledo and J. B. Little, Oxidative metabolism, gap junctions and the ionising radiation-induced bystander effect. Oncogene 22, 7050-7057 (2003).
18. H. Sakano, K. Hüppi, G. Heinrich and S. Tonegawa, Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature 280, 288-294 (1979).
19. T. T. Paull and M. Gellert, Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev. 13, 1276-1288 (1999).
20. L. H. Thompson and D. Schild, Recombinational DNA repair and human disease. Mutat. Res. 509, 49-78 (2002).
21. E. J. Calabrese and L. A. Baldwin, Special Issue: Scientific foundations of hormesis. Crit. Rev. Toxicol. 31, 349-669 (2001).
22. K. Kant, R. P. Chauhan, G. S. Sharma and S. K. Chakarvarti, Hormesis in humans exposed to low-level ionizing radiation. Int. J. Low Radiat. 1, 76-87 (2003).
23. E. I. Azzam, S. M. de Toledo, G. P. Raaphorat and R. E. J. Mitchel, Low-dose ionizing radiation decreases the frequency of neoplastic transformation to a level below the spontaneous rate in C3H 10T1/2 cells. Radiat. Res. 146, 369-373 (1996).