Low-dose radiation risk extrapolation fallacy associated with the linear-no-threshold model

Human and Experimental Toxicology

Volumn 27, Issue 2, 2008, Pages 163-168

  Scott, Bobby R ^a  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

Author keywords

Hormesis; LNT; Radiation; Risk assessment

Indexed keywords

APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CANCER RISK; CELL TRANSFORMATION; DOSE RESPONSE; GAMMA RADIATION; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; LINEAR ENERGY TRANSFER; LOW ENERGY RADIATION; NONHUMAN; PRIORITY JOURNAL; RADIATION ABSORPTION; RADIATION DOSE; RADIATION EXPOSURE; RADIATION HAZARD; RADIOBIOLOGY; RISK REDUCTION; STOCHASTIC MODEL; X RAY; ADAPTATION; BIOLOGICAL MODEL; CELL CULTURE; IONIZING RADIATION; METHODOLOGY; PHYSIOLOGY; RADIATION INJURY; RADIATION RESPONSE; RISK ASSESSMENT; STATISTICS;

ADAPTATION, PHYSIOLOGICAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS, RADIATION-INDUCED; RADIATION TOLERANCE; RADIATION, IONIZING; RISK ASSESSMENT;

EID: 48249085792     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327107083410     Document Type: Article

References (13)

1. Higson DJ The bell tolls for LNT. Oper. Radiat Safety 2004 ; 87(5). S47 - S50.
2. Calabrese EJ, Baldwin LA The hormetic dose- response model is more common than the threshold model in toxicology. Toxicol Sci 2003 ; 71: 246-50.
3. Feinendegen LE Low doses of ionizing radiation: relationship between biological benefit and damage induction. World J Nucl Med 2005 ; 4: 21-34.
4. Azzam EI, de Toledo SM, Little JB Stress signaling from irradiated to non-irradiated cells. Curr Cancer Drug Target 2004 ; 4: 53-64.
5. Scott BR A biological-based model that links genomic instability, bystander effects, and adaptive response. Fundamental and Molecular Mechanisms of Mutagenesis, Mut Res 2004 ; 568: 129-43.
6. Scott BR NEOTRANS3 Model for low-dose-induced stochastic radiobiological effects. Poster presentation given at the Department of Energy, Low Dose Radiation Research Program Workshop V, Hyatt Regency, Bethesda, MD, April 25-27, 2005. Retrieved from http://www.radiation-scott.org/Scott_4C_for_web.pdf
7. Scott BR Low-dose radiation-induced protective process and implications for risk assessment, cancer prevention, and cancer therapy. Dose-Response 2007 ; 5 (2). 131-141.
8. Hooker AM, Bhat M., Day TK, Lane JM, Swinburne SJ, Morley AA, Sykes PJ The linear no-threshold model does 1not hold for low-dose ionizing radiation. Radiat Res 2004 ; 162: 447-52.
9. Redpath JL, Liang D., Taylor TH, James C., Christie E., Elmore E. The shape of the dose-response curve for radiation-induced neoplastic transformation in vitro: evidence for an adaptive response against neoplastic transformation at low doses of low-LET radiation. Radiat Res 2001 ; 156: 700-7.
10. Azzam EI, de Toledo SM, Raaphorst GP, Mitchel RE Low-dose ionizing radiation deceases the frequency of neoplastic transformation to a level below the spontaneous rate in C3H 10T1/2 cells. Radiat Res 1996 ; 146: 369-73.
11. Ko SJ, Liao X. -Y, Molloi S., Elmore E., Redpath JL Neoplastic transformation in vitro after exposure to low doses of mammographic-energy x rays: quantitative and mechanistic aspects. Radiat Res 2004 ; 162: 646-54.
12. Redpath JL, Lu Q., Lao X., Molloi S., Elmore E. Low doses of diagnostic energy x-rays protect against neoplastic transformation in vitro. Int J Radiat Biol 2003 ; 79 (4). 235-40.
13. Chen WL, Luan YC, Shieh MC, Chen ST, Kung HT, Soong KL, Yeh YC, Chou TS, Mong SH, Wu JT, Sun CP, Deng WP, Wu MF, Shen ML Is chronic radiation an effective prophylaxis against cancer ? J Am Phys Surg 2004 ; 9 (1). 6-10.