Paracelsus to parascience: The environmental cancer distraction

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 447, Issue 1, 2000, Pages 3-13

  Ames, Bruce N ^a   Gold, Lois Swirsky ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Animal cancer tests; Cancer mechanism; Cancer prevention; Micronutrients; Mutagens; Natural chemicals

Indexed keywords

CARCINOGEN; CHEMICAL COMPOUND; DRUG; HORMONE; MUTAGENIC AGENT; PESTICIDE; TOXIN; TRACE ELEMENT;

CANCER PREVENTION; CARCINOGENESIS; COFFEE; DNA DAMAGE; GENOTOXICITY; HEALTH CARE PLANNING; HEALTH CARE POLICY; HEREDITY; HUMAN; INFECTION; INFLAMMATION; NONHUMAN; NUTRITION; NUTRITIONAL DEFICIENCY; PRIORITY JOURNAL; PUBLIC HEALTH; RADIATION; REVIEW; SMOKING; TOXICOKINETICS;

ANIMALIA; RODENTIA;

EID: 0033953180     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(99)00194-3     Document Type: Article

References (92)

1. Gold L.S., Manley N.B., Slone T.H., Rohrbach L. Supplement to the Carcinogemic Potency Database (CPDB): results of Animal Bioassays Published in the General Literature in 1993-1994 and by the National Toxicology Program in 1995-1996. Environ. Health Perspect. 107(Suppl. 4):1999;527-600.
2. Ames B.N., Gold L.S. Chemical carcinogenesis: too many rodent carcinogens. Proc. Natl. Acad. Sci. U.S.A. 87:1990;7772-7776.
3. Gold L.S., Zeiger E. Handbook of Carcinogenic Potency and Genotoxicity Databases. 1997;CRC Press, Boca Raton, FL.
4. Heddle J.A. The role of proliferation in the origin of mutations in mammalian cells. Drug Metab. Rev. 30:1998;327-338.
5. Tombolan F., Renault D., Brault D., Guffroy M., Perin F., Thybaud V. Effect of mitogenic or regenerative cell proliferation on lacz mutant frequency in the liver of MutaTMMice treated with 5,9-dimethyldibenzo[c,g]carbazole. Carcinogenesis. 20:1999;1357-1362.
6. Cohen S.M. Cell proliferation and carcinogenesis. Drug Metab. Rev. 30:1998;339-357.
7. Butterworth B.E., Bogdanffy M.S. A comprehensive approach for integration of toxicity and cancer risk assessments. Regul. Toxicol. Pharmacol. 29:1999;23-36.
8. Ames B.N., Shigenaga M.K., Gold L.S. DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis. Environ. Health Perspect. 101(Suppl. 5):1993;35-44.
9. Gold L.S., Slone T.H., Ames B.N. What do animal cancer tests tell us about human cancer risk?: Overview of analyses of the Carcinogenic Potency Database. Drug Metab. Rev. 30:1998;359-404.
10. Ames B.N., Gold L.S. The prevention of cancer. Drug Metab. Rev. 30:1998;201-223.
11. Song K.Y., Lim I.K., Park S.C., Lee S.O., Park H.S., Choi Y.K., Hyun B.H. Effect of nodularin on the expression of glutathione S-transferase placental form and proliferating cell nuclear antigen in N-nitrosodiethylamine initiated hepatocarcinogenesis in the male Fischer 344 rat. Carcinogenesis. 20:1999;1541-1548.
12. Cunningham M.L. Role of increased DNA replication in the carcinogenic risk of nonmutagenic chemical carcinogens. Mutat. Res. 365:1996;59-69.
13. Cunningham M.L., Matthews H.B. Relationship of hepatocarcinogenicity and hepatocellular proliferation induced by mutagenic noncarcinogens vs. carcinogens: II. 1- vs. 2-nitropropane. Toxicol. Appl. Pharmacol. 110:1991;505-513.
14. Cunningham M.L., Foley J., Maronpot R., Matthews H.B. Correlation of hepatocellular proliferation with hepatocarcinogenicity induced by the mutagenic noncarcinogen: carcinogen pair - 2,6- and 2,4-diaminotoluene. Toxicol. Appl. Pharmacol. 107:1991;562-567.
15. Christensen J.G., Goldsworthy T.L., Cattley R.C. Dysregulation of apoptosis by c-myc in transgenic hepatocytes and effects of growth factors and nongenotoxic carcinogens. Mol. Carcinog. 25:1999;273-284.
16. Hill L.L., Ouhtit A., Loughlin S.M., Kripke M.L., Ananthaswamy H.N., Owen-Schaub L.B. Fas ligand: a sensor for DNA damage critical in skin cancer etiology. Science. 285:1999;898-900.
17. Helbock H.J., Beckman K.B., Shigenaga M.K., Walter P., Woodall A.A., Yeo H.C., Ames B.N. DNA oxidation matters: The HPLC-EC assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proc. Natl. Acad. Sci. U.S.A. 95:1998;288-293.
18. Laskin D.L., Pendino K.J. Macrophages and inflammatory mediators in tissue injury. Annu. Rev. Pharmacol. Toxicol. 35:1995;655-677.
19. Wei H., Frenkel K. Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters. Carcinogenesis. 14:1993;1195-1201.
20. Wei L., Wei H., Frenkel K. Sensitivity to tumor promotion of SENCAR and C57BL/6J mice correlates with oxidative events and DNA damage. Carcinogenesis. 14:1993;841-847.
21. Laskin D.L., Robertson F.M., Pilaro A.M., Laskin J.D. Activation of liver macrophages following phenobarbital treatment of rats. Hepatology. 8:1988;1051-1055.
22. Adachi Y., Moore L.E., Bradford B.U., Gao W., Thurman R.G. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology. 108:1995;218-224.
23. Gunawardhana L., Mobley S.A., Sipes I.G. Modulation of 1,2-dichlorobenzene hepatotoxicity in the Fischer-344 rat by a scavenger of superoxide anions and an inhibitor of Kupffer cells. Toxicol. Appl. Pharmacol. 119:1993;205-213.
24. Roberts R.A., Kimber I. Cytokines in non-genotoxic hepatocarcinogenesis. Carcinogenesis. 20:1999;1397-1402.
25. Czaja M.J., Xu J., Ju Y., Alt E., Schmiedeberg P. Lipopolysaccharide-neutralizing antibody reduces hepatocyte injury from acute hepatotoxin administration. Hepatology. 19:1994;1282-1289.
26. Omenn G.S., Stuebbe S., Lave L.B. Predictions of rodent carcinogenicity testing results: interpretation in light of the Lave-Omenn value-of-information model. Mol. Carcinog. 14:1995;37-45.
27. Butterworth B., Conolly R., Morgan K. A strategy for establishing mode of action of chemical carcinogens as a guide for approaches to risk assessment. Cancer Lett. 93:1995;129-146.
28. Gaylor W., Swirsky Gold L. Regulatory cancer risk assessment based on a quick estimate of a benchmark dose derived from the maximum tolerated dose. Regul. Toxicol. Pharmacol. 28:1998;222-225.
29. Munday R., Munday C.M. Low doses of diallyl disulfide, a compound derived from garlic, increase tissue activities of quinone reductase and glutathione transferase in the gastrointestinal tract of the rat. Nutr. Cancer. 34:1999;42-48.
30. Trosko J.E. Hierarchical and cybernetic nature of biologic systems and their relevance to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents. Environ. Health Perspect. 106(Suppl. 1):1998;331-339.
31. Luckey T.D. Nurture with ionizing radiation: a provocative hypothesis. Nutr. Cancer. 34:1999;1-11.
32. Ames B.N., Profet M., Gold L.S. Nature's chemicals and synthetic chemicals: comparative toxicology. Proc. Natl. Acad. Sci. U.S.A. 87:1990;7782-7786.
33. Ames B.N., Profet M., Gold L.S. Dietary pesticides (99.99% all natural). Proc. Natl. Acad. Sci. U.S.A. 87:1990;7777-7781.
34. Gold L.S., Slone T.H., Ames B.N. Prioritization of possible carcinogenic hazards in food. Tennant D. Food Chemical Risk Analysis. 1997;267-295 Chapman & Hall, London.
35. Gold L.S., Slone T.H., Stern B.R., Manley N.B., Ames B.N. Rodent carcinogens: setting priorities. Science. 258:1992;261-265.
36. Ames B.N., Magaw R., Gold L.S. Ranking possible carcinogenic hazards. Science. 236:1987;271-280.
37. Gold L.S., Slone T.H., Ames B.N. Overview and update analyses of the Carcinogenic Potency Database. Gold L.S., Zeiger E. Handbook of Carcinogenic Potency and Genotoxicity Databases. 1997;661-685 CRC Press, Boca Raton, FL.
38. Gold L.S., Garfinkel G.B., Slone T.H. Setting priorities among possible carcinogenic hazards in the workplace. Smith C.M., Christiani D.C., Kelsey K.T. Chemical Risk Assessment and Occupational Health, Current Applications, Limitations, and Future Prospects. 1994;91-103 Greenwood Publishing Group, Westport, CT.
39. Carcinogens and Anticarcinogens in the Human Diet: A Comparison of Naturally Occurring and Synthetic Substances. 1996;National Academy Press, Washington, DC.
40. Ames B.N., Gold L.S., Shigenaga M.K. Cancer prevention, rodent high-dose cancer tests and risk assessment. Risk Anal. 16:1996;613-617.
41. National Academy of Sciences, U.S.A., The Life Sciences: Recent Progress and Application to Human Affairs, the World of Biological Research, Requirement for the Future, Committee on Research in the Life Sciences, Washington, DC, 1970, 526 pp.
42. Gribble G.W. The diversity of natural organochlorines in living organisms. Pure Appl. Chem. 68:1996;1699-1712.
43. Xie B., Tsao S.W., Wong Y.C. Sex hormone-induced mammary carcinogenesis in female noble rats: the role of androgens. Carcinogenesis. 20:1999;1597-1606.
44. Henderson B.E., Ross R.K., Pike M.C. Toward the primary prevention of cancer. Science. 254:1991;1131-1138.
45. Ames B.N. Micronutrients prevent cancer and delay aging. Toxicol. Lett. 102-103:1998;5-18.
46. Ames B.N., Gold L.S., Willett W.C. The causes and prevention of cancer. Proc. Natl. Acad. Sci. U.S.A. 92:1995;5258-5265.
47. Christen S., Hagen T.M., Shigenaga M.K., Ames B.N. Chronic inflammation, mutation, and cancer. Parsonnet J., Hornig S. Microbes and Malignancy: Infection as a Cause of Cancer. 1999;35-88 Oxford Univ. Press, New York.
48. Ames B.N., Shigenaga M.K., Hagen T.M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. U.S.A. 90:1993;7915-7922.
49. Block G., Patterson B., Subar A. Fruit, vegetables and cancer prevention: a review of the epidemiologic evidence. Nutr. Cancer. 18:1992;1-29.
50. Steinmetz K.A., Potter J.D. Vegetables, fruit, and cancer prevention: a review. J. Am. Diet Assoc. 96:1996;1027-1039.
51. Hill M.J., Giacosa A., Caygill C.P.J. Epidemiology of Diet and Cancer, Ellis Horwood Series in Food Science and Technology. 1994;Ellis Horwood, West Sussex, England.
52. Krebs-Smith S.M., Cook A., Subar A.F., Cleveland L., Friday J., Kahle L.L. Fruit and vegetable intakes of children and adolescents in the United States. Arch. Pediatr. 150:1996;81-86.
53. Krebs-Smith S.M., Cook A., Subar A.F., Cleveland L., Friday J. US adults' fruit and vegetable intakes, 1989 to 1991: a revised baseline for the healthy people 2000 objective. Am. J. Public Health. 85:1995;1623-1629.
54. Why eat five? J. Natl. Cancer Inst. 88:1996;1314.
55. Blount B.C., Mack M.M., Wehr C., MacGregor J., Hiatt R., Wang G., Wickramasinghe S.N., Everson R.B., Ames B.N. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc. Natl. Acad. Sci. U.S.A. 94:1997;3290-3295.
56. Fenech M., Aitken C., Rinaldi J. Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis. 19:1998;1163-1171.
57. Giovannucci E., Stampfer M.J., Colditz G.A., Rimm E.B., Trichopoulos D., Rosner B.A., Speizer F.E., Willett W.C. Folate, methionine, and alcohol intake and risk of colorectal adenoma. J. Natl. Cancer Inst. 85:1993;875-884.
58. Mason J.B. Folate and colonic carcinogenesis: searching for a mechanistic understanding. J. Nutr. Biochem. 5:1994;170-175.
59. Giovannucci E., Stampfer M.J., Colditz G.A., Hunger D.J., Fuchs C., Rosner B.A., Speizer F.E., Willett W.C. Multivitamin use, folate, and colon cancer in women in the nurses' health study. Ann. Intern. Med. 129:1998;517-524.
60. Wallock L., Woodall A., Jacob R., Ames B. Nutritional status and positive relation of plasma folate to fertility indices in nonsmoking men [abstract]. FASEB J. 11:1997;A184-A1068.
61. Boushey C.J., Beresford S.A., Omenn G.S., Motulsky A.G. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. J. Am. Med. Assoc. 274:1995;1049-1057.
62. Subar A.F., Block G., James L.D. Folate intake and food sources in the US population. Am. J. Clin. Nutr. 50:1989;508-516.
63. Senti F.R., Pilch S.M. Analysis of folate data from the second National Health and Nutrition Examination Survey (NHANES II). J. Nutr. 115:1985;1398-1402.
64. Bailey L.B., Wagner P.A., Christakis G.J., Araujo P.E., Appledorf H., Davis C.G., Masteryanni J., Dinning J.S. Folacin and iron status and hematological findings in predominately black elderly persons from urban low-income households. Am. J. Clin. Nutr. 32:1979;2346-2353.
65. Bailey L.B., Wagner P.A., Christakis G.J., Davis C.G., Appledorf H., Araujo P.E., Dorsey E., Dinning J.S. Folacin and iron status and hematological findings in black and Spanish-American adolescents from urban low-income households. Am. J. Clin. Nutr. 35:1982;1023-1032.
66. Jacques P.F., Selhub J., Bostom A.G., Wilson P.W., Rosenberg I.H. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N. Engl. J. Med. 340:1999;1449-1454.
67. J.W. Wilson, C.W. Enns, J.D. Goldman, K.S. Tippett, S.J. Mickle, L.E. Cleveland, P.S. Chahil, Data tables: combined results from USDA's 1994 and 1995 continuing survey of food intakes by individuals and 1994 and 1995 diet and health knowledge survey, USDA/ARS Food Surveys Research Group, Beltsville Human Nutrition Research Center, Riverdale, MD, 1997.
68. van Asselt D.Z., de Groot L.C., van Staveren W.A., Wevers B.H.J., Wevers R.A., Biemond I., Hoefnagels W.H. Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects. Am. J. Clin. Nutr. 68:1998;328-334.
69. Oakley G.P. Jr., Adams M.J., Dickinson C.M. More folic acid for everyone, now. J. Nutr. 126:1996;751S-755S.
70. Wickramasinghe S.N., Fida S. Bone marrow cells from vitamin B12- and folate-deficient patients misincorporate uracil into DNA. Blood. 83:1994;1656-1661.
71. Fenech M.F., Dreosti I.E., Rinaldi J.R. Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis. 18:1997;1329-1336.
72. Zhang J.Z., Henning S.M., Swendseid M.E. Poly(ADP-ribose) polymerase activity and DNA strand breaks are affected in tissues of niacin-deficient rats. J. Nutr. 123:1993;1349-1355.
73. Jacobson E.L. Niacin deficiency and cancer in women. J. Am. Coll. Nutr. 12:1993;412-416.
74. Colburn T., Dumanoski D., Myers J.P. Our Stolen Future: Are we Threatening our Fertility, Intelligence, and Survival?: A Scientific Detective Story. 1996;Dutton, New York.
75. Safe S.H. Dietary and environmental estrogens and antiestrogens and their possible role in human disease. Environ. Sci. Pollut. Res. Int. 1:1994;29-33.
76. Safe S.H. Environmental and dietary estrogens and human health: is there a problem? Environ. Health Perspect. 103:1995;346-351.
77. Safe S.H. Is there an association between exposure to environmental estrogens and breast cancer? Environ. Health Perspect. 105(Suppl. 3):1997;675-678.
78. Reinli K., Block G. Phytoestrogen content of foods - a compendium of literature values. Nutr. Cancer. 26:1996;1996.
79. Heinze J. Interregional differences undermine sperm trend conclusions [letter]. Environ. Health Perspect. 106:1998;A369-A370. Discussion A370-1.
80. Orejuela F., Lipshultz L.I., Lamb D.J. Debate about sperm count decline [letter]. Environ. Health Perspect. 106:1998;A370. Discussion A370-1.
81. Swan S.H., Elkin E., Fenster L. A reanalysis of sperm density data [response]. Environ. Health Perspect. 106:1998;A371. Discussion A370-1.
82. R.W. Hahn, Risks, Costs, and Lives Saved: Getting Better Results from Regulation, Oxford Univ. Press, New York and AEI Press, Washington, DC, 1996.
83. Graham J., Wiener J. Risk versus Risk: Tradeoffs in Protecting Health and the Environment. 1995;Harvard Univ. Press, Cambridge, MA.
84. U.S. Environmental Protection Agency, Environmental Investments: The Cost of a Clean Environment, Office of the Administrator, Washington, DC, 1991.
85. Tengs T.O., Adams M.E., Pliskin J.S., Safran D.G., Siegel J.E., Weinstein M.C., Graham J.D. Five-hundred life-saving interventions and their cost-effectiveness. Risk Anal. Prod. Safe Food. 15:1995;369-389.
86. Plenty of gloom: environmental scares - forecasters of scarcity and doom are not only invariably wrong, they think that being wrong proves them right, The Economist, 1997, pp. 19-21.
87. Wildavsky A.B. But is it True?: A Citizen's Guide to Environmental Health and Safety. 1995;Harvard Univ. Press, Cambridge, MA.
88. Ames B.N., Gold L.S. Introduction [foreword]. Marquardt H., Schafer S. Toxicology. 1999;1-7 Academic Press, San Diego.
89. Ames B.N., Gold L.S. Environmental pollution, pesticides, and the prevention of cancer: misconceptions. FASEB J. 11:1997;1041-1052.
90. Innes J.R.M., Ulland B.M., Valerio M.G., Petrucelli L., Fishbein L., Hart E.R., Pallota A.J., Bates R.R., Falk H.L., Gart J.J., Klein M., Mitchell I., Peters J. Bioassay of pesticides and industrial chemicals for tumorigenicity in mice: a preliminary note. J. Natl. Cancer Inst. 42:1969;1101-1114.
91. Davies T.S., Monro A. Marketed human pharmaceuticals reported to be tumorigenic in rodents. J. Am. Coll. Toxicol. 14:1995;90-107.
92. Contrera J., Jacobs A., DeGeorge J. Carcinogenicity testing and the evaluation of regulatory requirements for pharmaceuticals. Regul. Toxicol. Pharmacol. 25:1997;130-145.