Exposure of Tg.AC transgenic mice to benzene suppresses hematopoietic progenitor cells and alters gene expression in critical signaling pathways

Toxicology and Applied Pharmacology

Volumn 196, Issue 1, 2004, Pages 37-46

  Nwosu, Veronica C ^a   Kissling, Grace E ^b   Trempus, Carol S ^b   Honeycutt, Hayden ^b   French, John E ^b  

^a NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Benzene; cDNA array; Hematopoietic progenitor cells; Leukemia; Mouse; Tg.AC

Indexed keywords

BENZENE; COMPLEMENTARY DNA; DNA; DRINKING WATER; I KAPPA B ALPHA; INTERLEUKIN 2; NYLON; PROTEIN BAX; PROTEIN C FOS; PROTEIN P57;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; COLONY FORMING UNIT; COLONY FORMING UNIT GEMM; COLONY FORMING UNIT GM; CONTROLLED STUDY; DNA DAMAGE; ERYTHROCYTE; EXPOSURE; GENE EXPRESSION; HEMATOPOIETIC CELL; HOMOZYGOSITY; INFLAMMATION; MALE; MARKER GENE; MOUSE; NONHUMAN; ONCOGENE C MYC; PROTEIN EXPRESSION; RANK SUM TEST; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; TOXICITY; TRANSGENIC MOUSE;

ANIMALS; BENZENE; COLONY-FORMING UNITS ASSAY; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEMATOPOIETIC STEM CELLS; MALE; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RAS PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSGENES;

MUS MUSCULUS;

EID: 1642279899     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2003.11.010     Document Type: Article

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