Calcium-activated potassium channels BK and IK1 are functionally expressed in human gliomas but do not regulate cell proliferation

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Abdullaev, Iskandar F ^a   Rudkouskaya, Alena ^a,b   Mongin, Alexander A ^a   Kuo, Yu Hung ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(2 CHLOROPHENYL)DIPHENYLMETHYL] 1H PYRAZOLE; 8,14 DIAZA 1,7 (1,4) DIQUINOLINACYCLOTETRADECAPHANE TRIFLUOROACETATE; CLOTRIMAZOLE; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; PAXILLINE; PENITREM A; POTASSIUM CHANNEL BLOCKING AGENT; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; SMALL INTERFERING RNA; TRAM 34; UCL 1848; UNCLASSIFIED DRUG; MESSENGER RNA; POTASSIUM;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL STRAIN U251; CELL STRAIN U87; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; GENE SILENCING; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; POTASSIUM CURRENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR CELL LINE; AMINO ACID SEQUENCE; DRUG ANTAGONISM; DRUG EFFECT; ELECTRIC CONDUCTIVITY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; PATHOLOGY;

AMINO ACID SEQUENCE; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; ELECTRIC CONDUCTIVITY; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GLIOBLASTOMA; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MOLECULAR SEQUENCE DATA; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; RNA, MESSENGER; RNA, SMALL INTERFERING; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS;

EID: 77957926594     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012304     Document Type: Article

References (54)

1. Wrensch M, Minn Y, Chew T, Bondy M, Berger MS (2002) Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro Oncol 4: 278-299.
2. Schwartzbaum JA, Fisher JL, Aldape KD, Wrensch M (2006) Epidemiology and molecular pathology of glioma. Nat Clin Pract Neurol 2: 494-503.
3. Kleihues P, Burger PC, Scheithauer BW (1993) The new WHO classification of brain tumours. Brain Pathol 3: 255-268.
4. Barnholtz-Sloan JS, Sloan AE, Schwartz AG (2003) Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumor, 1973-1997. J Neurosurg 99: 458-466.
5. Sanai N, Berger MS (2008) Glioma extent of resection and its impact on patient outcome. Neurosurgery 62: 753-764.
6. Bondy ML, Scheurer ME, Malmer B, Barnholtz-Sloan JS, Davis FG, et al. (2008) Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer 113: 1953-1968.
7. Amigorena S, Choquet D, Teillaud JL, Korn H, Fridman WH (1990) Ion channel blockers inhibit B cell activation at a precise stage of the G1 phase of the cell cycle. Possible involvement of K+ channels. J Immunol 144: 2038-2045.
8. Nilius B, Wohlrab W (1992) Potassium channels and regulation of proliferation of human melanoma cells. J Physiol 445: 537-548.
9. Woodfork KA, Wonderlin WF, Peterson VA, Strobl JS (1995) Inhibition of ATP-sensitive potassium channels causes reversible cell-cycle arrest of human breast cancer cells in tissue culture. J Cell Physiol 162: 163-171.
10. Bianchi L, Wible B, Arcangeli A, Taglialatela M, Morra F, et al. (1998) herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells? Cancer Res 58: 815-822.
11. Wonderlin WF, Strobl JS (1996) Potassium channels, proliferation and G1 progression. J Membr Biol 154: 91-107.
12. Blackiston DJ, McLaughlin KA, Levin M (2009) Bioelectric controls of cell proliferation: ion channels, membrane voltage and the cell cycle. Cell Cycle 8: 3519-3528.
13. Lang F, Ritter M, Gamper N, Huber S, Fillon S, et al. (2000) Cell volume in the regulation of cell proliferation and apoptotic cell death. Cell Physiol Biochem 10: 417-428.
14. Wang Z (2004) Roles of K+ channels in regulating tumour cell proliferation and apoptosis. Pflugers Arch 448: 274-286.
15. Vergara C, Latorre R, Marrion NV, Adelman JP (1998) Calcium-activated potassium channels. Curr Opin Neurobiol 8: 321-329.
16. Salkoff L, Butler A, Ferreira G, Santi C, Wei A (2006) High-conductance potassium channels of the SLO family. Nat Rev Neurosci 7: 921-931.
17. Pedarzani P, Stocker M (2008) Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain. Cell Mol Life Sci 65: 3196-3217.
18. Xia XM, Fakler B, Rivard A, Wayman G, Johnson-Pais T, et al. (1998) Mechanism of calcium gating in small-conductance calcium-activated potassium channels. Nature 395: 503-507.
19. + channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A 97: 8151-8156.
20. Basrai D, Kraft R, Bollensdorff C, Liebmann L, Benndorf K, et al. (2002) BK channel blockers inhibit potassium-induced proliferation of human astrocytoma cells. Neuroreport 13: 403-407.
21. Weaver AK, Liu X, Sontheimer H (2004) Role for calcium-activated potassium channels (BK) in growth control of human malignant glioma cells. J Neurosci Res 78: 224-234.
22. Weaver AK, Bomben VC, Sontheimer H (2006) Expression and function of calcium-activated potassium channels in human glioma cells. Glia 54: 223-233.
23. Han X, Wang F, Yao W, Xing H, Weng D, et al. (2007) Heat shock proteins and p53 play a critical role in K+ channel-mediated tumor cell proliferation and apoptosis. Apoptosis 12: 1837-1846.
24. Coiret G, Borowiec AS, Mariot P, Ouadid-Ahidouch H, Matifat F (2007) The antiestrogen tamoxifen activates BK channels and stimulates proliferation of MCF-7 breast cancer cells. Mol Pharmacol 71: 843-851.
25. Bloch M, Ousingsawat J, Simon R, Schraml P, Gasser TC, et al. (2007) KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer. Oncogene 26: 2525-2534.
26. Chin LS, Park CC, Zitnay KM, Sinha M, DiPatri AJ, Jr., et al. (1997) 4- Aminopyridine causes apoptosis and blocks an outward rectifier K+ channel in malignant astrocytoma cell lines. J Neurosci Res 48: 122-127.
27. Ouadid-Ahidouch H, Roudbaraki M, Ahidouch A, Delcourt P, Prevarskaya N (2004) Cell-cycle-dependent expression of the large Ca2+-activated K+ channels in breast cancer cells. Biochem Biophys Res Commun 316: 244-251.
28. Han X, Xi L, Wang H, Huang X, Ma X, et al. (2008) The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. Biochem Biophys Res Commun 375: 205-209.
29. Cambien B, Rezzonico R, Vitale S, Rouzaire-Dubois B, Dubois JM, et al. (2008) Silencing of hSlo potassium channels in human osteosarcoma cells promotes tumorigenesis. Int J Cancer 123: 365-371.
30. Parihar AS, Coghlan MJ, Gopalakrishnan M, Shieh CC (2003) Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation. Eur J Pharmacol 471: 157-164.
31. Jager H, Dreker T, Buck A, Giehl K, Gress T, et al. (2004) Blockage of intermediate-conductance Ca2+-activated K+ channels inhibit human pancreatic cancer cell growth in vitro. Mol Pharmacol 65: 630-638.
32. Ouadid-Ahidouch H, Roudbaraki M, Delcourt P, Ahidouch A, Joury N, et al. (2004) Functional and molecular identification of intermediate-conductance Ca(2+)-activated K(+) channels in breast cancer cells: association with cell cycle progression. Am J Physiol Cell Physiol 287: C125-C134.
33. Grgic I, Eichler I, Heinau P, Si H, Brakemeier S, et al. (2005) Selective blockade of the intermediate-conductance Ca2+-activated K+ channel suppresses proliferation of microvascular and macrovascular endothelial cells and angiogenesis in vivo. Arterioscler Thromb Vasc Biol 25: 704-709.
34. Wang ZH, Shen B, Yao HL, Jia YC, Ren J, et al. (2007) Blockage of intermediate-conductance-Ca(2+) -activated K(+) channels inhibits progression of human endometrial cancer. Oncogene 26: 5107-5114.
35. Tao R, Lau CP, Tse HF, Li GR (2008) Regulation of cell proliferation by intermediate-conductance Ca2+-activated potassium and volume-sensitive chloride channels in mouse mesenchymal stem cells. Am J Physiol Cell Physiol 295: C1409-C1416.
36. Benzaquen LR, Brugnara C, Byers HR, Gatton-Celli S, Halperin JA (1995) Clotrimazole inhibits cell proliferation in vitro and in vivo. Nat Med 1: 534-540.
37. Khalid MH, Shibata S, Hiura T (1999) Effects of clotrimazole on the growth, morphological characteristics, and cisplatin sensitivity of human glioblastoma cells in vitro. J Neurosurg 90: 918-927.
38. Khalid MH, Tokunaga Y, Caputy AJ, Walters E (2005) Inhibition of tumor growth and prolonged survival of rats with intracranial gliomas following administration of clotrimazole. J Neurosurg 103: 79-86.
39. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patchclamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391: 85-100.
40. Ishii N, Maier D, Merlo A, Tada M, Sawamura Y, et al. (1999) Frequent coalterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol 9: 469-479.
41. Camphausen K, Purow B, Sproull M, Scott T, Ozawa T, et al. (2005) Influence of in vivo growth on human glioma cell line gene expression: convergent profiles under orthotopic conditions. Proc Natl Acad Sci U S A 102: 8287-8292.
42. Akimova OA, Mongin AA, Hamet P, Orlov SN (2006) The rapid decline of MTT reduction is not a marker of death signaling in ouabain-treated cells. Cell Mol Biol 52: 71-77.
43. Knaus HG, McManus OB, Lee SH, Schmalhofer WA, Garcia-Calvo M, et al. (1994) Tremorgenic indole alkaloids potently inhibit smooth muscle highconductance calcium-activated potassium channels. Biochemistry 33: 5819-5828.
44. Chen JQ, Galanakis D, Ganellin CR, Dunn PM, Jenkinson DH (2000) bis- Quinolinium cyclophanes: 8,14-diaza-1,7(1, 4)-diquinolinacyclotetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apaminsensitive Ca(2+)-activated K(+) channel. J Med Chem 43: 3478-3481.
45. Gessner G, Schonherr K, Soom M, Hansel A, Asim M, et al. (2005) BKCa channels activating at resting potential without calcium in LNCaP prostate cancer cells. J Membr Biol 208: 229-240.
46. Brismar T, Collins VP (1989) Potassium and sodium channels in human malignant glioma cells. Brain Res 480: 259-267.
47. Brismar T (1995) Physiology of transformed glial cells. Glia 15: 231-243.
48. Liu X, Chang Y, Reinhart PH, Sontheimer H, Chang Y (2002) Cloning and characterization of glioma BK, a novel BK channel isoform highly expressed in human glioma cells. J Neurosci 22: 1840-1849.
49. Fioretti B, Castigli E, Calzuola I, Harper AA, Franciolini F, et al. (2004) NPPB block of the intermediate-conductance Ca2+-activated K+ channel. Eur J Pharmacol 497: 1-6.
50. Fioretti B, Castigli E, Micheli MR, Bova R, Sciaccaluga M, et al. (2006) Expression and modulation of the intermediate- conductance Ca2+-activated K+ channel in glioblastoma GL-15 cells. Cell Physiol Biochem 18: 47-56.
51. Sciaccaluga M, Fioretti B, Catacuzzeno L, Pagani F, Bertollini C, et al. (2010) CXCL12-induced glioblastoma cell migration requires intermediate conductance Ca2+-activated K+ channel activity. Am J Physiol Cell Physiol 299: C175-C184.
52. Wulf A, Schwab A (2002) Regulation of a calcium-sensitive K+ channel (cIK1) by protein kinase C. J Membr Biol 187: 71-79.
53. Hayashi M, Kunii C, Takahata T, Ishikawa T (2004) ATP-dependent regulation of SK4/IK1-like currents in rat submandibular acinar cells: possible role of cAMP-dependent protein kinase. Am J Physiol Cell Physiol 286: C635-C646.
54. Si H, Grgic I, Heyken WT, Maier T, Hoyer J, et al. (2006) Mitogenic modulation of Ca2+ -activated K+ channels in proliferating A7r5 vascular smooth muscle cells. Br J Pharmacol 148: 909-917.