Cyclooxygenase inhibition increases interleukin 5 and interleukin 13 production and airway hyperresponsiveness in allergic mice

American Journal of Respiratory and Critical Care Medicine

Volumn 162, Issue 2 I, 2000, Pages 676-681

  Peebles Jr , R Stokes ^a   Dworski, Ryszard ^a   Collins, Robert D ^a   Jarzecka, Kasia ^a   Mitchell, Daphne B ^a   Graham, Barney S ^a   Sheller, James R ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; BETA CHEMOKINE; EOTAXIN; IMMUNOGLOBULIN E; INDOMETACIN; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; METHACHOLINE; MONOCYTE CHEMOTACTIC PROTEIN 1; OVALBUMIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; ENZYME INHIBITION; EOSINOPHILIA; FEMALE; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION;

EID: 0033849141     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.162.2.9911063     Document Type: Article

References (38)

1. The mode of action of aspirin and similar compounds
2. Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines
3. Prostaglandin E2 differentially modulates cytoklne secretion profiles of human T helper lymphocytes
4. Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-gamma and IL-2, but not IL-4 and IL-5
5. Differential modulation of T helper type I (Th1) and T helper type 2 (Th2) cytokine secretion by prostaglandin E2 critically depends oil interleukin-2
6. Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production
7. Pge2-induced immunoregulation mediated by cytokine production from cultures of human peripheral T lymphocytes
8. Regulation of IL-4 and IL-5 secretion by histamine and PGE2
9. The cyclooxygenase-2 theory of atopy and asthma
10. Elevation of interleukin-6 in response to a chronic inflammatory stimulus in mice: Inhibition by indontethacin
11. Allergen-stintulated release of mediators into sheep bronchoalveolar lavage fluid: Effect of cyclooxygenase inhibition
12. Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene
13. Respiratory syncytial virus infection prolongs methacholine-indnced airway hyperresponsiveness in ovalbumin sensitized mice
14. Prostaglandin endopcroxide H synthases-1 and-2
15. Arachidonic acid metabolism: Implications of biological chemistry for lung function and disease
16. Arachidonic acid metabolitcs: Mediators of inflammation in asthma
17. Release of prostaglandin D2 into hulnan airways during acute antigen challenge
18. Specific receptors for prosta-glandins in airways
19. Characterization of contractile prostanoid on human airway smooth muscle
20. Airway and cardiovascular responses to inhaled prostacyclin in normal and asthmatic subjects
21. Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation
22. Cytokines
23. Indomethacin increases the formarion of lipoxygenase products in calcium ionophore stimulated human nemrophils
24. IL-5 increases expression of 5-lipoxygenase-activating protein and translocates 5-lipoxygenase to the nucleus in human blood eosinophils
25. Cysteinyl-leukotrienes partly mediate eotaxin-induced bronchial hyperrcsponsiveness and eosinophilia in IL-5 transgenic mice
26. Eosinophil infiltration precedes development of airway hyperreactivity and mucosal exudation after intranasal administration of interleukin-5 to mice
27. The effect of recombinam human interleukin-5 on cosinephil accumulation and degranulation in human nasal mucosa
28. Chemokines chemotactic cytokines that mediate inflammation
29. Allergic lung responses are increased in prostaglandin H synthase-deficient mice
30. Interleukin-4 is required for the induction of lung Th2 mucosal immunity
31. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma
32. Interleukin 4. but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity
33. Attenuation of allergic airway inflammation in IL-4 deficient mice
34. Importance of interleukin-4 and interleukin-12 in allergen-induced airway changes in mice
35. Requirement for IL-13 independently of IL-4 in experimental asthma
36. Interleukin-13: Central mediator of allergic asthma
37. Characterization of the human cysteinyl leukotrieue CysLTI receptor