Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding

Journal of Biological Chemistry

Volumn 285, Issue 42, 2010, Pages 32616-32626

  Hong, Weimin C ^a   Amara, Susan G ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTINYLATION ASSAYS; CELL SURFACES; COCAINE BINDING; DETERGENT EXTRACTION; DOPAMINE TRANSPORTERS; ENHANCED REACTIVITY; EXTRACELLULAR; INTEGRAL MEMBRANE PROTEINS; MALEIMIDES; MEMBRANE CHOLESTEROL; MEMBRANE FRACTION; MEMBRANE LIPIDS; RADIOLIGAND BINDING; SULFHYDRYL; TRANS-MEMBRANE DOMAINS; TRANSFECTED CELLS;

ACTIVATION ANALYSIS; AMINO ACIDS; BIOLOGICAL MEMBRANES; BRAIN; CELL MEMBRANES; FACINGS; LIPID BILAYERS; MEMBRANES; PROTEINS; WATER CONTENT; WATER TREATMENT;

CHOLESTEROL;

3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; 3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; BIOTIN; CHOLESTEROL; COCAINE; COCAINE DERIVATIVE; CYSTEINE; DOPAMINE TRANSPORTER; MALEIMIDE; METHYL BETA CYCLODEXTRIN; MUTANT PROTEIN; RADIOLIGAND; THIOL DERIVATIVE; ZINC;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOTINYLATION; BRAIN SYNAPTOSOME; CELL FRACTIONATION; CELL SURFACE; CONTROLLED STUDY; EMBRYO; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIPID ANALYSIS; LIPID BILAYER; LIPID SOLUBILITY; LIQUID LIQUID EXTRACTION; MALE; MEMBRANE PERMEABILITY; NEUROMODULATION; NEUROTRANSMITTER RELEASE; NEUROTRANSMITTER UPTAKE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; RAT; STRIATE CORTEX;

ANIMALS; CELL LINE; CELL MEMBRANE; CHOLESTEROL; COCAINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; SYNAPTOSOMES;

EID: 77957791961     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.150565     Document Type: Article

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