Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450

Archives of Toxicology

Volumn 84, Issue 10, 2010, Pages 751-759

  Konsue, Nattaya ^a   Ioannides, Costas ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Chemoprevention; Cytochrome P450; Isothiocyanates; Mechanism based inhibition; Phenethyl isothiocyanate

Indexed keywords

AROCLOR 1254; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 2B; ETHOXYRESORUFIN; GLUTATHIONE; PENTOXYRESORUFIN; PHENETHYL ISOTHIOCYANATE; PHENOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; CYTOCHROME P450 INHIBITOR; ENZYME INHIBITOR; ISOCYANIC ACID DERIVATIVE; ISOTHIOCYANIC ACID DERIVATIVE;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATALYST; CONTROLLED STUDY; DESULFURIZATION; DRUG MECHANISM; DRUG METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; INCUBATION TIME; LIVER METABOLISM; LIVER MICROSOME; LUNG PARENCHYMA; MALE; METABOLITE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; ANIMAL; DRUG EFFECTS; ENZYMOLOGY; LIVER; LUNG; METABOLISM; MIDDLE AGED; TOXICITY;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; ISOCYANATES; ISOTHIOCYANATES; LIVER; LUNG; MALE; MICROSOMES, LIVER; MIDDLE AGED; RATS; CYTOCHROME P-450 ENZYME INHIBITORS;

RATTUS;

EID: 77957780197     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-010-0522-z     Document Type: Article

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