Effects of eleven isothiocyanates on P450 2A6- and 2A13-catalyzed coumarin 7-hydroxylation

Chemical Research in Toxicology

Volumn 20, Issue 9, 2007, Pages 1252-1259

  Von Weymarn, Linda B ^a,c   Chun, Jamie A ^a   Knudsen, Gabriel A ^a   Hollenberg, Paul F ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b 2301 Medical Science Research Building III ^*  (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; 1,2 DIPHENYLETHYLISOTHIOCYANATE; 2 BIPHENYLISOTHIOCYANATE; 3 PHENYLPROPYLISOTHIOCYANATE; 6 PHENYLHEXYLISOTHIOCYANATE; BENZYLHYDRYLISOTHIOCYANATE; CROTONYLISOTHIOCYANATE; CYTOCHROME P450 2A13; CYTOCHROME P450 2A6; CYTOCHROME P450 ISOENZYME; ISOBUTYLISOTHIOCYANATE; ISOPROPYLISOTHIOCYANATE; ISOTHIOCYANIC ACID DERIVATIVE; PROPYLISOTHIOCYANATE; TERT BUTYLISOTHIOCYANTE; UMBELLIFERONE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; DRUG HYDROXYLATION; DRUG POTENCY; ENZYME INACTIVATION; ENZYME INHIBITION; INCUBATION TIME; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CATALYSIS; COMPUTER SIMULATION; COUMARINS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; HYDROXYLATION; IMIDAZOLES; ISOTHIOCYANATES; MIXED FUNCTION OXYGENASES; MOLECULAR STRUCTURE;

ANIMALIA;

EID: 35148815019     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx700078v     Document Type: Article

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