Inactivation of cytochrome P450 2B1 by benzyl isothiocyanate, a chemopreventative agent from cruciferous vegetables

Chemical Research in Toxicology

Volumn 13, Issue 12, 2000, Pages 1349-1359

  Goosen, Theunis C ^a,b   Kent, Ute M ^b   Brand, Linda ^a   Hollenberg, Paul F ^b,c  

^a NORTH WEST UNIVERSITY   (South Africa)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c Medical Science Research Bldg III ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYL ISOTHIOCYANATE; COUMARIN DERIVATIVE; PENTOXYRESORUFIN DEALKYLASE; PHENETHYL ISOTHIOCYANATE;

ARTICLE; CARCINOGENESIS; CATALYSIS; CHEMOPROPHYLAXIS; CRUCIFERA; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME KINETICS; PRECIPITATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN MODIFICATION; STOICHIOMETRY; VEGETABLE;

ANIMALS; ANTICARCINOGENIC AGENTS; BRASSICA; CHEMOPREVENTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2B1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ISOTHIOCYANATES; MALE; MICROSOMES, LIVER; RATS; RATS, LONG-EVANS;

BRASSICACEAE;

EID: 0034485496     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000133y     Document Type: Article

References (5)

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4. Silverman, R. B. (1996) Mechanism-based enzyme inactivators. In Contemporary Enzyme Kinetics and Mechanisms (Purich, D. L., Ed.) pp 291-335, Academic Press, San Diego, CA.
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