Transgenic expression of haem oxygenase-1 in pancreatic beta cells protects non-obese mice used as a model of diabetes from autoimmune destruction and prolongs graft survival following islet transplantation

Diabetologia

Volumn 53, Issue 11, 2010, Pages 2389-2400

  Huang, S H ^a,b   Chu, C H ^b   Yu, J C ^b   Chuang, W C ^a   Lin, G J ^a   Chen, P L ^a   Chou, F C ^a   Chau, L Y ^c   Sytwu, H K ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Heme oxygenase 1; NOD mice; Type 1 diabetes

Indexed keywords

GAMMA INTERFERON; HEME OXYGENASE 1; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC MANIPULATION; GRAFT SURVIVAL; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH1 CELL; TH2 CELL; TRANSGENIC MOUSE;

ANIMALS; DIABETES MELLITUS, TYPE 1; FEMALE; FLOW CYTOMETRY; GRAFT SURVIVAL; HEME OXYGENASE-1; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77957653459     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1858-x     Document Type: Article

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