Clinical applications of miRNAs in cardiac remodeling and heart failure

Personalized Medicine

Volumn 7, Issue 5, 2010, Pages 531-548

  Topkara, Veli K ^a   Mann, Douglas L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cardiac remodeling; gene silencing; miRNAs; personalized medicine

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MICRORNA; MICRORNA 1; MICRORNA 133; MICRORNA 199A; MICRORNA 208; MICRORNA 21; MICRORNA 29; MICRORNA 320; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; BIOGENESIS; CELL FATE; DISEASE MARKER; DNA POLYMORPHISM; DRUG TARGETING; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; GENE TARGETING; HEART ELECTROPHYSIOLOGY; HEART FAILURE; HEART MUSCLE CELL; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; NONHUMAN; PHARMACOGENOMICS; PRIORITY JOURNAL; PROGNOSIS; REVIEW;

EID: 77957606848     PISSN: 17410541     EISSN: 1744828X     Source Type: Journal    
DOI: 10.2217/pme.10.44     Document Type: Review

References (72)

1. Yang B, Lin H, Xiao J et al.: The musclespecific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat. Med. 13(4), 486-491 (2007). (Pubitemid 46559834)
2. Zhao Y, Ransom JF, Li A et al.: Dysregulation of cardiogenesis, cardiac conduction and cell cycle in mice lacking miRNA-1-2. Cell 129(2), 303-317 (2007). (Pubitemid 46574975)
3. van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN: Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 316, 575-579 (2007). (Pubitemid 46683138)
4. van Rooij E, Sutherland LB, Liu N et al.: A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc. Natl Acad. Sci. USA 103(48), 18255-18260 (2006). • First study to demonstrate role of miRNAs in cardiac hypertrophy and heart failure. (Pubitemid 44871645)
5. Zhao Y, Samal E, Srivastava D: Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 436(7048), 214-220 (2005). (Pubitemid 41021266)
6. Xiao J, Luo X, Lin H et al.: MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts. J. Biol. Chem. 282(17), 12363-12367 (2007). (Pubitemid 47100573)
7. Bartel DP: MicroRNAs, genomics, biogenesis, mechanism and function. Cell 116, 281-297 (2008).
8. Lee RC, Feinbaum RL, Ambros V: The C elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75(5), 843-854 (1993). (Pubitemid 24014542)
9. Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E: Phylogenetic shadowing and computational identification of human microRNA genes. Cell 120(1), 21-24 (2005). (Pubitemid 40094599)
10. Cai X, Hagedorn CH, Cullen BR: Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10(12), 1957-1966 (2004). (Pubitemid 39557833)
11. Yi R, Qin Y, Macara IG, Cullen BR: Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 17(24), 3011-3016 (2003). (Pubitemid 38040764)
12. Schwarz DS, Hutvagner G, Du T, Xu Z, Aronin N, Zamore PD: Asymmetry in the assembly of the RNAi enzyme complex. Cell 115(2), 199-208 (2003). (Pubitemid 37329583)
13. Khvorova A, Reynolds A, Jayasena SD: Functional siRNAs and miRNAs exhibit strand bias. Cell 115(2), 209-216 (2003). (Pubitemid 37329584)
14. Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ: Processing of primary microRNAs by the microprocessor complex. Nature 432(7014), 231-235 (2004). (Pubitemid 39545854)
15. Ambros V: The functions of animal microRNAs. Nature 431(7006), 350-355 (2004). (Pubitemid 39265675)
16. Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R: Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20(5), 515-524 (2006). (Pubitemid 43345317)
17. Lewis BP, Burge CB, Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120(1), 15-20 (2005).
18. Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB: Prediction of mammalian microRNA targets. Cell 115(7), 787-798 (2003).
19. Griffiths-Jones S, Grocock RJ, van DS, Bateman A, Enright AJ: miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 34 (Database issue), D140-D144 (2006).
20. Krek A, Grun D, Poy MN et al.: Combinatorial microRNA target predictions. Nat. Genet. 37(5), 495-500 (2005). (Pubitemid 40617277)
21. Kiriakidou M, Nelson PT, Kouranov A et al: A combined computational-experimental approach predicts human microRNA targets. Genes Dev. 18(10), 1165-1178 (2004). (Pubitemid 38669037)
22. Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M: MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ. Res. 100(3), 416-424 (2007). (Pubitemid 46272414)
23. Cheng YH, Ji RR, Yue JM et al.: MicroRNAs are aberrantly expressed in hypertrophic heart - do they play a role in cardiac hypertrophy? Am. J. Pathol. 170(6), 1831-1840 (2007).
24. Tatsuguchi M, Seok HY, Callis TE et al.: Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J. Mol. Cell Cardiol. 42(6), 1137-1141 (2007). (Pubitemid 46829201)
25. van Rooij E, Sutherland LB, Thatcher JE et al.: Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc. Natl Acad. Sci. USA 105, 13027-13032 (2008).
26. Roy S, Khanna S, Hussain SR et al.: MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. Cardiovasc. Res. 82(1), 21-29 (2009).
27. Care A, Catalucci D, Felicetti F et al.: MicroRNA-133 controls cardiac hypertrophy. Nat. Med. 13(5), 613-618 (2007). (Pubitemid 46828487)
28. Matkovich SJ, van Booven DJ, Youker KA et al.: Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support. Circulation 119(9), 1263-1271 (2009).
29. Naga Prasad SV, Duan ZH, Gupta MK et al.: A unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks. J. Biol. Chem. 284, 27487-27499 (2009).
30. Sucharov C, Bristow MR, Port JD: miRNA expression in the failing human heart: functional correlates. J. Mol. Cell Cardiol. 45(2), 185-192 (2008).
31. Ikeda S, Kong SW, Lu J et al.: Altered microRNA expression in human heart disease. Physiol. Genomics 31(3), 367-373 (2007). (Pubitemid 350127777)
32. Thum T, Galuppo P, Wolf C et al.: MicroRNAs in the human heart - a clue to fetal gene reprogramming in heart failure. Circulation 116(3), 258-267 (2007). (Pubitemid 47196561)
33. Morin RD, O'Connor MD, Griffith M et al.: Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res. 18(4), 610-621 (2008). (Pubitemid 351482785)
34. Willenbrock H, Salomon J, Sokilde R et al.: Quantitative miRNA expression ana lysis: comparing microarrays with next-generation sequencing. RNA 15(11), 2028-2034 (2009).
35. Dash R, Kadambi V, Schmidt AG et al.: Interactions between phospholamban and β-adrenergic drive may lead to cardiomyopathy and early mortality. Circulation 103(6), 889-896 (2001). (Pubitemid 32163890)
36. Urabe Y, Hamada Y, Spinale FG et al.: Cardiocyte contractile performance in experimental biventricular volume-overload hypertrophy. Am. J. Physiol. 264, H1615-H1623 (1993). (Pubitemid 23154152)
37. Anand IS, Liu D, Chugh SS et al.: Isolated myocyte contractile function is normal in postinfarct remodeled rat heart with systolic dysfunction. Circulation 96(11), 3974-3984 (1997). (Pubitemid 27506056)
38. Ikeda S, He A, Kong SW et al.: MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Mol. Cell Biol. 29(8), 2193-2204 (2009).
39. Elia L, Contu R, Quintavalle M et al.: Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions. Circulation 120(23), 2377-2385 (2009).
40. Liu N, Bezprozvannaya S, Williams AH et al.: MicroRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev. 22(23), 3242-3254 (2008).
41. Matkovich SJ, Wang W, Tu Y et al.: MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts. Circ. Res. 106(1), 166-175 (2010). • Demonstrates distinct patterns of miRNA expression before and after left ventricular assist device support.
42. Krichevsky AM, Gabriely G: MiR-21: a small multi-faceted RNA. J. Cell Mol. Med. 13(1), 39-53 (2009).
43. Thum T, Gross C, Fiedler J et al.: MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456(7224), 980-984 (2008).
44. Lin Z, Murtaza I, Wang K, Jiao J, Gao J, Li PF: MiR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy. Proc. Natl Acad. Sci. USA 106(29), 12103-12108 (2009).
45. Wang K, Long B, Zhou J, Li PF: MiR-9 and NFATc3 regulate myocardin in cardiac hypertrophy. J. Biol. Chem. 285(16), 11903-11912 (2010).
46. Nakao K, Minobe W, Roden R, Bristow MR, Leinwand LA: Myosin heavy chain gene expression in human heart failure. J. Clin. Invest. 100, 2362-2370 (1997). (Pubitemid 27500161)
47. Callis TE, Pandya K, Seok HY et al.: MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J. Clin. Invest. 119(9), 2772-2786 (2009).
48. 2-induced injury on cardiac myocytes via its target gene PDCD4. J. Mol. Cell Cardiol. 47(1), 5-14 (2009).
49. Xu C, Lu Y, Pan Z et al: The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. J. Cell Sci. 120(17), 3045-3052 (2007). (Pubitemid 47517087)
50. Rane S, He M, Sayed D et al.: Downregulation of miR-199a derepresses hypoxia-inducible factor-1a and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ. Res. 104(7), 879-886 (2009).
51. Ren XP, Wu J, Wang X et al.: MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Circulation 119(17), 2357-2366 (2009).
52. Divakaran V, Adrogue J, Ishiyama M et al.: Adaptive and maladptive effects of SMAD3 signaling in the adult heart after hemodynamic pressure overloading. Circ. Heart Fail. 2(6), 633-642 (2009).
53. Duisters RF, Tijsen AJ, Schroen B et al.: MiR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ. Res. 104(2), 170-178 (2009).
54. Fernandez-Velasco M, Goren N, Benito G, Blanco-Rivero J, Bosca L, Delgado C: Regional distribution of hyperpolarizationactivated current (If) and hyperpolarizationactivated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts. J. Physiol. 553(2), 395-405 (2003). (Pubitemid 37527543)
55. Luo X, Lin H, Pan Z et al.: Downregulation of miRNA-1/miRNA-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. J. Biol. Chem. 283, 20045-20052 (2008).
56. 2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56α and causing CaMKII-dependent hyperphosphorylation of RyR2. Circ. Res. 104(4), 514-521 (2009).
57. Wang GK, Zhu JQ, Zhang JT et al.: Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur. Heart J. 31(6), 659-666 (2010).
58. Tijsen AJ, Creemers EE, Moerland PD et al.: MiR423-5p as a circulating biomarker for heart failure. Circ. Res. 106(6), 1035-1039 (2010). • Shows that circulating miRNAs can serve as disease biomarkers in patients with heart failure.
59. Schipper ME, van Kuik J, de Jonge N, Dullens HF, de Weger RA: Changes in regulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device support. J. Heart Lung Transplant 27(12), 1282-1285 (2008).
60. Krutzfeldt J, Rajewsky N, Braich R et al.: Silencing of microRNAs in vivo with 'antagomirs'. Nature 438(7068), 685-689 (2005). • First demonstration of mammalian miRNA knockdown using antagomir approach. (Pubitemid 41740580)
61. Esau C, Davis S, Murray SF et al.: MiR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 3(2), 87-98 (2006).
62. Elmen J, Lindow M, Schutz S et al.: LNA-mediated microRNA silencing in non-human primates. Nature 452(7189), 896-899 (2008). (Pubitemid 351550859)
63. Suckau L, Fechner H, Chemaly E et al.: Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy. Circulation 119(9), 1241-1252 (2009).
64. Duan R, Pak C, Jin P: Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA. Hum. Mol. Genet. 16(9), 1124-1131 (2007). (Pubitemid 47062732)
65. Martin MM, Buckenberger JA, Jiang J et al.: The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding. J. Biol. Chem. 282(33), 24262-24269 (2007). (Pubitemid 47328062)
66. Saunders MA, Liang H, Li WH: Human polymorphism at microRNAs and microRNA target sites. Proc. Natl Acad. Sci. USA 104(9), 3300-3305 (2007). (Pubitemid 46364154)
67. Mishra PJ, Mishra PJ, Banerjee D, Bertino JR: MiRSNPs or MiR-polymorphisms, new players in microRNA mediated regulation of the cell: introducing microRNA pharmacogenomics. Cell Cycle 7(7), 853-858 (2008). (Pubitemid 351573776)
68. Mishra PJ, Bertino JR: MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine. Pharmacogenomics 10(3), 399-416 (2009).
69. da Costa Martins PA, Bourajjaj M, Gladka M et al.: Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling. Circulation 118(15), 1567-1576 (2008).
70. Rao PK, Toyama Y, Chiang HR et al.: Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ. Res. 105(6), 585-594 (2009).
71. Mann DL: MicroRNAs and the failing heart. N. Engl. J. Med. 356(25), 2644-2645 (2007).
72. van Rooij E, Olson EN: MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets. J. Clin. Invest. 117(9), 2369-2376 (2007). (Pubitemid 47494334)