Discovery of quinolines as selective glucocorticoid receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 19, 2010, Pages 5835-5838

  Jaroch, Stefan ^a   Berger, Markus ^a   Huwe, Christoph ^a   Krolikiewicz, Konrad ^a   Rehwinkel, Hartmut ^a   Schäcke, Heike ^a   Schmees, Norbert ^a   Skuballa, Werner ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Glucocorticoid; Quinoline; SEGRA; Transactivation; Transrepression

Indexed keywords

4 (2,3 DIHYDROBENZOFURAN 7 YL) 2 HYDROXY 3,3 DIMETHYL N (4 METHYL 1 OXO 2,3 BENZOXAZIN 6 YL) 2 TRIFLUOROMETHYLBUTANAMIDE; BENZOXAZINE DERIVATIVE; CORTICOSTEROID; DEXAMETHASONE; METHYLBENZOXAZINE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ASSAY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG BINDING; DRUG INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; TRANSACTIVATION;

ANTI-INFLAMMATORY AGENTS; CELL LINE; DRUG EVALUATION, PRECLINICAL; GENES, REPORTER; HUMANS; QUINOLINES; RECEPTORS, GLUCOCORTICOID; TRANSCRIPTIONAL ACTIVATION;

EID: 77957590330     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.125     Document Type: Article

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