Nonsteroidal selective glucocorticoid modulators: The effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Journal of Medicinal Chemistry

Volumn 44, Issue 25, 2001, Pages 4481-4491

  Elmore, S W ^a   Miner, J N ^b   Jacobson, P B ^a   Wilcox, D M ^a   Lane, B C ^a   Coghlan, M J ^a   Anderson, D D ^a   Pratt, J K ^a   Green, B E ^a   Wang, A X ^a   Stashko, M A ^a   Lin, C W ^a   Tyree, C M ^b  

^a ABBOTT LABORATORIES   (United States)

^b LIGAND PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 DIHYDRO 10 METHOXY 2,2,4 TRIMETHYL 1H [1]BENZOPYRANO[3,4 F]QUINOLINE; 2,5 DIHYDRO 10 METHOXY 5 (2 PROPENYL) 2,2,4 TRIMETHYL 1H [1]BENZOPYRANO[3,4 F]QUINOLINE; 5 CYCLOPENTYL 2,5 DIHYDRO 10 METHOXY 2,2,4 TRIMETHYL 1H [1]BENZOPYRANO[3,4 F]QUINOLINE; A 222977; ALLYL COMPOUND; BUDESONIDE; DEXAMETHASONE; FLUTICASONE; GLUCOCORTICOID RECEPTOR; PREDNISOLONE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GENE REPRESSION; GENETIC TRANSCRIPTION; LOEFFLER PNEUMONIA; MALE; NONHUMAN; PAW EDEMA; RAT; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION;

ANIMALS; BENZOPYRANS; BINDING, COMPETITIVE; CARRAGEENAN; CELL LINE; CERCOPITHECUS AETHIOPS; DEPRESSION, CHEMICAL; E-SELECTIN; EDEMA; EOSINOPHILS; GENES, REPORTER; HUMANS; INSECTS; LUCIFERASES; MALE; NF-KAPPA B; PNEUMONIA; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; RESPONSE ELEMENTS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC;

EID: 0035818924     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010367u     Document Type: Article

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