Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 12, 2008, Pages 3504-3508

  Roach, Steven L ^a   Higuchi, Robert I ^a   Adams, Mark E ^a   Liu, Yan ^a   Karanewsky, Donald S ^a   Marschke, Keith B ^a   Mais, Dale E ^a   Miner, Jeffrey N ^a   Zhi, Lin ^a  

^a LIGAND PHARMACEUTICALS INC   (United States)

Author keywords

E selectin; Glucocorticoid receptor; Inflammation; Prednisolone

Indexed keywords

DEXAMETHASONE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; PREDNISOLONE; PROGESTERONE RECEPTOR; QUINOLINE DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG IDENTIFICATION; DRUG SELECTIVITY; DRUG STRUCTURE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING SITES; DRUG EVALUATION, PRECLINICAL; INDOLES; LIGANDS; MOLECULAR STRUCTURE; QUINOLINES; RECEPTORS, GLUCOCORTICOID; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44649162413     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.029     Document Type: Article

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