Non-steroidal glucocorticoid agonists-The discovery of aryl pyrazoles as A-ring mimetics

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 17, 2007, Pages 4737-4745

  Clackers, Margaret ^a   Coe, Diane M ^a   Demaine, Derek A ^a   Hardy, George W ^a   Humphreys, Davina ^a   Inglis, Graham G A ^a   Johnston, Michael J ^a   Jones, Haydn T ^a   House, David ^a   Loiseau, Richard ^a   Minick, Doug J ^a   Skone, Philip A ^a   Uings, Iain ^a   McLay, Iain M ^a   Macdonald, Simon J F ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Agonist; Aryl pyrazole; Dissociated; Glucocorticoid; Non steroidal; Tetrahydronaphthalene

Indexed keywords

BENZOXAZINONE DERIVATIVE; CORTIVAZOL; DEXAMETHASONE; FLUTICASONE PROPIONATE; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MIFEPRISTONE; PYRAZOLE DERIVATIVE; TETRALIN DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; SUBSTITUTION REACTION;

AMIDES; BINDING SITES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GLUCOCORTICOIDS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PYRAZOLES; RECEPTORS, GLUCOCORTICOID; STEREOISOMERISM; STEROIDS;

MOUSE MAMMARY TUMOR VIRUS;

EID: 34547531177     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.06.066     Document Type: Article

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