Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: Selective quinoline derivatives with prednisolone-equivalent functional activity

Journal of Medicinal Chemistry

Volumn 44, Issue 18, 2001, Pages 2879-2885

  Coghlan, M J ^a   Kym, P R ^a   Elmore, S W ^a   Wang, A X ^a   Luly, J R ^a   Wilcox, D ^a   Stashko, M ^a   Lin, C W ^a   Miner, J ^b   Tyree, C ^b   Jacobson, P ^a   Nakane, M ^a   Lane, B C ^a  

^a ABBOTT LABORATORIES   (United States)

^b LIGAND PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; PENAM DERIVATIVE; PREDNISOLONE; QUINOLINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONFORMATION; CONTROLLED STUDY; DERIVATIZATION; HYDROGENATION; NONHUMAN; PROMOTER REGION; PROTEIN ANALYSIS; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR SENSITIVITY; SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOPYRANS; CELL LINE; E-SELECTIN; GENES, REPORTER; HUMANS; LIGANDS; LUCIFERASES; PREDNISOLONE; QUINOLINES; RATS; RECEPTORS, GLUCOCORTICOID; STEREOISOMERISM; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

EID: 0035974689     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010228c     Document Type: Article

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