Production of IL-10 and IL-12 by antigen-presenting cells in periapical lesions

Journal of Oral Pathology and Medicine

Volumn 39, Issue 9, 2010, Pages 690-696

  Colic, Miodrag ^a   Gazivoda, Dragan ^a   Vasilijic, Sasa ^a   Vucevic, Dragana ^a   Lukic, Aleksandra ^b  

^a UNIVERSITY OF DEFENCE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

dendritic cells; interleukin 10; interleukin 12; macrophages; periapical lesions

Indexed keywords

CD14 ANTIGEN; CYTOKINE; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12;

ADOLESCENT; ADULT; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE SYSTEM; IMMUNOASSAY; IMMUNOCYTOCHEMISTRY; INFLAMMATION; MACROPHAGE; MIXED LYMPHOCYTE REACTION; MONONUCLEAR CELL; PRIORITY JOURNAL; TOOTH PULP; TOOTH PULP DISEASE;

ADOLESCENT; ADULT; ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; DENDRITIC CELLS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOPHENOTYPING; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-12; MACROPHAGES; MIDDLE AGED; PERIAPICAL PERIODONTITIS; YOUNG ADULT;

EID: 77957577512     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2010.00925.x     Document Type: Article

References (50)

1. Marton IJ, Kiss C. Protective and destructive immune reactions in apical periodontitis. Oral Microbiol Immunol 2000 15 : 139 150.
2. Nair PN. Pathogenesis of apical periodontitis and the causes of endodontic failures. Crit Rev Oral Biol Med 2004 15 : 348 381.
3. Gao Z, Mackenzie IC, Rittman BR, Korszun AK, Williams DM, Cruchley AT. Immunocytochemical examination of immune cells in periapical granulomata and odontogenic cysts. J Oral Pathol 1988 17 : 84 90.
4. Liapatas S, Nakou M, Rontogianni D. Inflammatory infiltrate of chronic periradicular lesions: an immunohistochemical study. Int Endod J 2003 36 : 464 471.
5. Rodini CO, Lara VS. Study of the expression of CD68 + macrophages and CD8 + T cells in human granulomas and periapical cysts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001 92 : 221 227.
6. Lukic A, Danilovic V, Petrovic R. [Comparative immunohistochemical and quantitative analysis of inflammatory cells in symptomatic and asymptomatic chronic periapical lesions]. Vojnosanit Pregl 2008 65 : 435 440.
7. Banchereau J, Briere F, Caux C, et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000 18 : 767 811.
8. Cutler CW, Jotwani R. Antigen-presentation and the role of dendritic cells in periodontitis. Periodontol 2000 2004 35 : 135 157.
9. Lukic A, Vasilijic S, Majstorovic I, et al. Characterization of antigen-presenting cells in human apical periodontitis lesions by flow cytometry and immunocytochemistry. Int Endod J 2006 39 : 626 636.
10. Metzger Z. Macrophages in periapical lesions. Endod Dent Traumatol 2000 16 : 1 8.
11. Colic M, Gazivoda D, Vucevic D, Vasilijic S, Rudolf R, Lukic A. Proinflammatory and immunoregulatory mechanisms in periapical lesions. Mol Immunol 2009 47 : 101 113.
12. Vernal R, Garcia-Sanz JA. Th17 and Treg cells, two new lymphocyte subpopulations with a key role in the immune response against infection. Infect Disord Drug Targets 2008 8 : 207 220.
13. Kawashima N, Stashenko P. Expression of bone-resorptive and regulatory cytokines in murine periapical inflammation. Arch Oral Biol 1999 44 : 55 66.
14. Stashenko P. Role of immune cytokines in the pathogenesis of periapical lesions. Endod Dent Traumatol 1990 6 : 89 96.
15. Takayanagi H, Ogasawara K, Hida S, et al. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature 2000 408 : 600 605.
16. Horwood NJ, Elliott J, Martin TJ, Gillespie MT. IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro. J Immunol 2001 166 : 4915 4921.
17. Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res 2000 15 : 2 12.
18. Theill LE, Boyle WJ, Penninger JM. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol 2002 20 : 795 823.
19. Szabo SJ, Sullivan BM, Peng SL, Glimcher LH. Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol 2003 21 : 713 758.
20. Brocker T. Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. J Exp Med 1997 186 : 1223 1232.
21. Vasilijic S, Savic D, Vasilev S, et al. Dendritic cells acquire tolerogenic properties at the site of sterile granulomatous inflammation. Cell Immunol 2005 233 : 148 157.
22. De Jong JP, Voerman JS, Leenen PJ, Van Der Sluijs-Gelling AJ, Ploemacher RE. Improved fixation of frozen lympho-haemopoietic tissue sections with hexazotized pararosaniline. Histochem J 1991 23 : 392 401.
23. Colic M, Stojic-Vukanic Z, Pavlovic B, Jandric D, Stefanoska I. Mycophenolate mofetil inhibits differentiation, maturation and allostimulatory function of human monocyte-derived dendritic cells. Clin Exp Immunol 2003 134 : 63 9.
24. Young SH, Antonini JM, Roberts JR, Erdely AD, Zeidler-Erdely PC. Performance evaluation of cytometric bead assays for the measurement of lung cytokines in two rodent models. J Immunol Methods 2008 331 : 59 68.
25. Smits HH, Van Beelen AJ, Hessle C, et al. Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. Eur J Immunol 2004 34 : 1371 1380.
26. Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000 13 : 715 725.
27. Pflanz S, Timans JC, Cheung J, et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 2002 16 : 779 790.
28. Lee E, Trepicchio WL, Oestreicher JL, et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med 2004 199 : 125 130.
29. Honda T, Aoki Y, Takahashi N, et al. Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease. Clin Chim Acta 2008 395 : 137 141.
30. Lester SR, Bain JL, Johnson RB, Serio FG. Gingival concentrations of interleukin-23 and -17 at healthy sites and at sites of clinical attachment loss. J Periodontol 2007 78 : 1545 1550.
31. Sasaki H, Suzuki N, Kent R Jr., Kawashima N, Takeda J, Stashenko P. T cell response mediated by myeloid cell-derived IL-12 is responsible for Porphyromonas gingivalis-induced periodontitis in IL-10-deficient mice. J Immunol 2008 180 : 6193 6198.
32. Fokkema SJ, Loos BG, Van der Velden U. Monocyte-derived RANTES is intrinsically elevated in periodontal disease while MCP-1 levels are related to inflammation and are inversely correlated with IL-12 levels. Clin Exp Immunol 2003 131 : 477 483.
33. Ellis SD, Tucci MA, Serio FG, Johnson RB. Factors for progression of periodontal diseases. J Oral Pathol Med 1998 27 : 101 105.
34. ReicherT S, Machulla HK, Klapproth J, et al. Interferon-gamma and interleukin-12 gene polymorphisms and their relation to aggressive and chronic periodontitis and key periodontal pathogens. J Periodontol 2008 79 : 1434 1443.
35. Kawashima N, Okiji T, Kosaka T, Suda H. Kinetics of macrophages and lymphoid cells during the development of experimentally induced periapical lesions in rat molars: a quantitative immunohistochemical study. J Endod 1996 22 : 311 316.
36. Bildt MM, Henneman S, Maltha JC, Kuijpers-Jagtman AM, Von Den Hoff JW. CMT-3 inhibits orthodontic tooth displacement in the rat. Arch Oral Biol 2007 52 : 571 578.
37. Alhashimi N, Frithiof L, Brudvik P, Bakhiet M. CD40-CD40L expression during orthodontic tooth movement in rats. Angle Orthod 2004 74 : 100 105.
38. Ma J, Chen T, Mandelin J, et al. Regulation of macrophage activation. Cell Mol Life Sci 2003 60 : 2334 2346.
39. Watford WT, Moriguchi M, Morinobu A, O'shea JJ. The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine Growth Factor Rev 2003 14 : 361 368.
40. Cochran DL. Inflammation and bone loss in periodontal disease. J Periodontol 2008 79 : 1569 1576.
41. Nakashima T, Kobayashi Y, Yamasaki S, et al. Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines. Biochem Biophys Res Commun 2000 275 : 768 775.
42. Horwood NJ, Elliott J, Martin TJ, Gillespie MT. IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro. J Immunol 2001 166 : 4915 4921.
43. Takayanagi H, Ogasawara K, Hida S, et al. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature 2000 408 : 600 605.
44. Donnelly RP, Sheikh F, Kotenko SV, Dickensheets H. The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain. J Leukoc Biol 2004 76 : 314 321.
45. Thompson C, Powrie F. Regulatory T cells. Curr Opin Pharmacol 2004 4 : 408 414.
46. Sasaki H, Balto K, Kawashima N, et al. Gamma interferon (IFN-gamma) and IFN-gamma-inducing cytokines interleukin-12 (IL-12) and IL-18 do not augment infection-stimulated bone resorption in vivo. Clin Diagn Lab Immunol 2004 11 : 106 110.
47. Katie FW, David FL, Keiso T, Joyce H, Macdonald DG, Denis FK. Cytokine expression in periapical granulation tissue as assessed by immunohistochemistry. Eur J Oral Sci 2000 108 : 195 201.
48. Baker AH, Edwards DR, Murphy G. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci 2002 115 : 3719 3727.
49. Katagiri T, Takahashi N. Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis 2002 8 : 147 159.
50. Collins DP. Cytokine and cytokine receptor expression as a biological indicator of immune activation: important considerations in the development of in vitro model systems. J Immunol Methods 2000 243 : 125 145.