CMT-3 inhibits orthodontic tooth displacement in the rat

Archives of Oral Biology

Volumn 52, Issue 6, 2007, Pages 571-578

  Bildt, M M ^a   Henneman, S ^a   Maltha, J C ^a   Kuijpers Jagtman, A M ^a   Von den Hoff, J W ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Chemically modified tetracyclines; Matrix metalloproteinases; Osteoclasts; Tooth movement

Indexed keywords

GELATINASE B; MATRIX METALLOPROTEINASE; MEMBRANE PROTEIN; TETRACYCLINE CMT 3; TETRACYCLINE CMT-3; TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; CELL COUNT; DRUG ANTAGONISM; DRUG EFFECT; INSTRUMENTATION; JAW; MACROPHAGE; MALE; MONOCYTE; ORTHODONTIC DEVICE; OSTEOCLAST; PATHOLOGY; PERIODONTAL DISEASE; PERIODONTAL LIGAMENT; RAT; TOOTH ROOT; WISTAR RAT;

ALVEOLAR PROCESS; ANIMALS; CELL COUNT; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; MEMBRANE GLYCOPROTEINS; MONOCYTES; ORTHODONTIC APPLIANCES; OSTEOCLASTS; PERIODONTAL LIGAMENT; RATS; RATS, WISTAR; TETRACYCLINES; TOOTH MOVEMENT; TOOTH ROOT;

RATTUS; RATTUS NORVEGICUS;

EID: 34047275136     PISSN: 00039969     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.archoralbio.2006.11.009     Document Type: Article

References (35)

1. Sodek J. Collagen turnover in periodontal ligament. In: Norton L.A., and Burstone C.J. (Eds). The biology of tooth movement (1989), CRC Press, Boca Raton, FL 157-181
2. Lekic P., and McCulloch C.A. Periodontal ligament cell population: the central role of fibroblasts in creating a unique tissue. Anat Rec 245 (1996) 327-341
3. Bumann A., Carvalho R.S., Schwarzer C.L., and Yen E.H. Collagen synthesis from human PDL cells following orthodontic tooth movement. Eur J Orthod 19 (1997) 29-37
4. Nakamura Y., Tanaka T., and Kuwahara Y. New findings in the degenerating tissues of the periodontal ligament during experimental tooth movement. Am J Orthod Dentofacial Orthop 109 (1996) 348-354
5. 2 synthesis. J Bone Miner Res 17 (2002) 210-220
6. Creemers L.B., Jansen I.D., Docherty A.J., Reynolds J.J., Beertsen W., and Everts V. Gelatinase A (MMP-2) and cysteine proteinases are essential for the degradation of collagen in soft connective tissue. Matrix Biol 17 (1998) 35-46
7. Apajalahti S., Sorsa T., Railavo S., and Ingman T. The in vivo levels of matrix metalloproteinase-1 and -8 in gingival crevicular fluid during initial orthodontic tooth movement. J Dent Res 82 (2003) 1018-1022
8. Delaissé J.M., Andersen T.L., Engsig M.T., Hendriksen K., Troen T., and Blavier L. Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities. Microsc Res Tech 61 (2003) 504-513
9. Tervahartiala T., Pirila E., Ceponis A., Maisi P., Salo T., Tuter G., et al. The in vivo expression of the collagenolytic matrix metalloproteinases (MMP-2, -8, -13, and -14) and matrilysin (MMP-7) in adult and localized juvenile periodontitis. J Dent Res 79 (2000) 1969-1977
10. Golub L.M., Lee H.M., Lehrer G., Nemiroff A., McNamara T.F., Kaplan R., et al. Minocycline reduces gingival collagenolytic activity during diabetes. Preliminary observations and a proposed new mechanism of action. J Periodontal Res 18 (1983) 516-526
11. Golub L.M., McNamara T.F., D'Angelo G., Greenwald R.A., and Ramamurthy N.S. A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity. J Dent Res 66 (1987) 1310-1314
12. Acharya M.R., Ventiz J., Figg W.D., and Sparreboom A. Chemically modified tetracyclines as inhibitors of matrix metalloproteinases. Drug Resist Updat 7 (2004) 195-208
13. Sorsa T., Ding Y., Salo T., Lauhio A., Teronen O., Ingman T., et al. Effects of tetracyclines on neutrophil, gingival, and salivary collagenases. A functional and Western-blot assessment with special reference to their cellular sources in periodontal diseases. Ann N Y Acad Sci 732 (1994) 112-131
14. Greenwald R.A., Golub L.M., Ramamurthy N.S., Chowdhury M., Moak S.A., and Sorsa T. In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation. Bone 22 (1998) 33-38
15. Myers S.A., and Wolowacz R.G. Tetracycline-based MMP inhibitors can prevent fibroblast-mediated collagen gel contraction in vitro. Adv Dent Res 12 (1998) 86-93
16. Mäkela M., Sorsa T., Uitto V.J., Salo T., Teronen O., and Larjava H. The effects of chemically modified tetracyclines (CMTs) on human keratinocyte proliferation and migration. Adv Dent Res 12 (1998) 131-135
17. Spessotto P., Rossi F.M., Degan M., Di Francia R., Perris R., Colombatti A., et al. Hyaluronan-DC44 interaction hampers migration of osteoclast-like cells by donw-regulating MMP-9. J Cell Biol 158 (2002) 1133-1144
18. Sasaki T., Ohyori N., Debari K., Ramamurthy N.S., and Golub L.M. Effects of chemically modified tetracycline, CMT-8, on bone loss and osteoclast structure and function in osteoporotic states. Ann N Y Acad Sci 878 (1999) 347-360
19. Holmes S.G., Still K., Buttle D.J., Bishop N.J., and Grabowski P.S. Chemically modified tetracyclines act through multiple mechanisms directly on osteoclast precursors. Bone 35 (2004) 471-478
20. Chang K.M., Ramamurthy N.S., McNamara T.F., Evans R.T., Klausen B., Murray P.A., et al. Tetracyclines inhibit Porphyromonas gingivalis-induced alveolar bone loss in rats by a non-antimicrobial mechanism. J Periodontal Res 29 (1994) 242-249
21. Ramamurthy N.S., Rifkin B.R., Greenwald R.A., Xu J.W., Liu Y., Turner G., et al. Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines. J Periodontol 73 (2002) 726-734
22. Ren Y., Maltha J.C., Van't Hof M.A., and Kuijpers-Jagtman A.M. Age effect on orthodontic tooth movement in rats. J Dent Res 82 (2003) 38-42
23. Damoiseaux J.G., Dopp E.A., Calame W., Chao D., MacPherson G.G., and Dijkstra C.D. Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1. Immunology 83 (1994) 140-147
24. Sminia T., and Dijkstra C.D. The origin of osteoclasts: an immunohistochemical study on macrophages and osteoclasts in embryonic rat bone. Calcif Tissue Int 39 (1986) 263-266
25. Jäger A., Radlanski R., and Gotz W. Demonstration of cells of the mononuclear phagocyte lineage in the periodontium following experimental tooth movement in the rat. An immunohistochemical study using monoclonal antibodies ED1 und ED2 on paraffin-embedded tissues. Histochemistry 100 (1993) 161-166
26. Baroukh B., Cherruau M., Dobigny C., Guez D., and Saffar J.L. Osteoclasts differentiate from resident precursors in an in vivo model of synchronized resorption: a temporal and spatial study in rats. Bone 27 (2000) 627-634
27. Ren Y., Kuijpers-Jagtman A.M., and Maltha J.C. Immunohistochemical evaluation of osteoclast recruitment during experimental tooth movement in young and adult rats. Arch Oral Biol 50 (2005) 1032-1039
28. Holliday L.S., Vakani A., Archer L., and Dolce C. Effects of matrix metalloproteinase inhibitors on bone resorption and orthodontic tooth movement. J Dent Res 82 (2003) 687-691
29. Sicher H., and Weinmann J.P. Bone growth and physiologic tooth movement. Am J Orthod Oral Surg 30 (1944) 109-132
30. Bettany J.T., Peet N.M., Wolowacz R.G., Skerry T.M., and Grabowski P.S. Tetracyclines induce apoptosis in osteoclasts. Bone 27 (2000) 75-80
31. Rifkin B.R., Vernillo A.T., and Golub L.M. Blocking periodontal disease progression by inhibiting tissue-destructive enzymes: a potential therapeutic role for tetracyclines and their chemically-modified analogs. J Periodontol 64 (1993) 819-827
32. Engsig M.T., Chen Q.J., Vu T.H., Pedersen A.C., Therkidsen B., Lund L.R., et al. Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. J Cell Biol 151 (2000) 879-889
33. Meikle M.C., Bord S., Hembry R.M., Compston J., Croucher P.I., and Reynolds J.J. Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in respons to osteotropic hormones and cytokines. J Cell Sci 103 (1992) 1093-1099
34. Holliday L.S., Welgus H.G., Fliszar C.J., Veith G.M., Jeffrey J.J., and Gluck S.L. Initiation of osteoclast bone resorption by interstitial collagenase. J Biol Chem 272 (1997) 22053-22058
35. 2+ receptor" activation. Biosci Rep 13 (1993) 169-174