Mycophenolate mofetil inhibits differentiation, maturation and allostimulatory function of human monocyte-derived dendritic cells

Clinical and Experimental Immunology

Volumn 134, Issue 1, 2003, Pages 63-69

  Čolić, Miodrag ^a   Stojic Vukanic Z ^a,b   Pavlovic B ^a,b   Jandric D ^a   Stefanoska, I ^a  

^a UNIVERSITY OF DEFENCE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Alloreactivity; Cytokine production; Endocytosis; Human dendritic cells; Mycophenolate mofetil; Phenotype

Indexed keywords

B7 ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; LIPOPOLYSACCHARIDE; MANNOSE RECEPTOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TUMOR NECROSIS FACTOR ALPHA;

ALLOIMMUNITY; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL LINE; CELL MATURATION; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG UPTAKE; ENDOCYTOSIS; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 19244387277     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2003.02269.x     Document Type: Article

References (42)

1. Behrend M. Mycophenolate mofetil. Exp Opin Invest Drugs, 1998; 7:1509-19.
2. Platz KP, Sollinger HW, Hullet DA et al. RS-61443-a new, potent immunosuppressive agent. Transplantation, 1991; 51:27-31.
3. Fulton B, Merkham A. Mycophenolate mofetil, a review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in renal transplantation. Drugs, 1996; 51:278-98.
4. Fisher Ra Ham JM, Marcos A et al. A prospective randomized trial of mycophenolate mofetil with neoral or tacrolimus after orthotopic liver transplantation. Transplantation, 1998; 66:1616.
5. Sollinger HW, Belzer OF, Deierhoi MH et al. RS-61443 (mycophenolate mofetil): a multicenter study for refractory kidney transplant rejection. Ann Surg, 1992; 216:513-8.
6. Morris RE, Wang J, Blum JR et al. Immunosuppresive effects of the morpholinoethyl ester of mycophenolic acid (R61443) in rat and non-human primate recipients of heart allografts. Transplant Proc, 1991; 23:19-25.
7. Platz KP, Bechstein WO. Eckhoff DE et al. RS-61443 reverses acute allografts. Transplantation, 1995; 59:460-6.
8. Tanabe M, Todo S, Murase N et al. Combined immunosuppressive therapy with low dose FK 506 and anti-metabolites in rat allogenic heart transplantation. Transplantation, 1994; 58:23-7.
9. Böhm M, Beissert S, Schwarz T et al. Bullous pemphigoid treated with mycophenolate mofetil. Lancet, 1997; 349:541.
10. Haufs MG, Beissert S, Grabbe S et al. Psoriasis vulgaris treated successfully with mycophenolate mofetil. Br J Dermatol, 1998; 138:179-81.
11. Goldblum R. Therapy of rheumatoid arthritis with mycophenolate mofetil. Clin Exp Rheumal, 1993; 11:117-9.
12. Sintchak M, Fleming M, Futer O et al. Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. Cell, 1996; 85:921-30.
13. Natsumeda Y, Carr SF. Human type I and II IMP dehydrogenase as drug targets. Ann NY Acad Sci, 1993; 696:88-93.
14. Allison AC, Eugui EM. Preferential suppression of lymphocyte proliferation by mycophenolic acid and predicted long-term effects of mycophenolate mofetil in transplantation. Trasnplant Proc, 1994; 26:3205-10.
15. Eugui EM, Mirkovich A, Allison AC. Lymphocyte-selective antiproliferative and immunosuppressive activity of mycophenolic acid and its morpholinoethyl ester (RS-61443) in rodents. Transplant Proc, 1991; 23:15-8.
16. Grailer A, Nichols J, Hullet D et al. Inhibition of human Bcell responses in vitro by RS-61443, cyclosporine A and DAB486 Il-2. Transplant Proc, 1991; 23:314-5.
17. Weaver JL, Pine PS, Aszalos A. Comparison of the in vitro and biophysical effect of cyclosporine A, FK-506, and mycophenolic acid on human peripheral blood lymphocytes. Immunopharmacol Immunotoxicol, 1991; 13:563-76.
18. Eugui E, Almquist SJ, Mulle CD et al. Lymphooyte.selective cytostatic and immunosppressive efect of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletion. Scand J Immunol, 1991; 33:161-73.
19. Burlingham WJ, Graileer AP, Hullett DA et al. Inhibition of both MLC and in vitro IgG memory response to tetanus toxoid by RS-61443. Transplantation, 1991; 51:545-7.
20. Rescigno M, Winzler C, Delia D et al. Dendritic cell maturation is required for initiation of the immune response. J Leukocyte Biol, 1997; 61:415-21.
21. Hart NJ. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood, 1997; 90:3245-87.
22. Sayegh M, Turka L. The role of T-cell costimulatory activation pathways in transplant rejection. N Engl J Med, 1998; 338:1813-21.
23. Mehling A, Grabbe S, Voskort M et al. Mycophenolate mofetil impairs the maturation and function of murine dendritic cells. J Immunol, 2000; 165:2374-81.
24. 3 , and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol, 2001; 167:1945-53.
25. Meiser MB, Tacrolimus, MMF. in Heart Transplantation. Adv Immunosuppress, 1999; 7:6.
26. Palucka AK, Taquet N, Sanches-Chapuis F et al. Dendritic Cells at the Terminal Stage of Monocyte Differentiation. J Immunol, 1998; 160:4587-95.
27. Hay H, Cohen J. Studies on the specificity of the L929 cell bioassay for the measurement of the tumor necrosis factor. J Clin Laboratory Immunol, 1989; 29:151-5.
28. Migliorati G, Nicoletti I, Pagliaci MC, D'Adamio L, Riccardi C. Interleukin-4 protects double-negative and CD4 single-positive thymocytes from dexamethasone-induced apoptosis. Blood, 1993; 81:1352-8.
29. Lapteva N, Ide K, Nieda M. al et. Activation and suppression of renin-angiotensis system in human dendritic cells. Biochem Biophys Res Commun, 2002; 296:194-200.
30. Reiser C, Bock G, Klocker H et al. Prostaglandin E2 and tumor necrosis factor alpha cooperate to activate human dendritic cells: synergistic activation of interleukin 12 production. J Exp Med, 1997; 86:1603-8.
31. Foey AD, Parry SL, Williams LM et al. Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: Role of the p38 and 42/44 mitogen-activated protein kinases. J Immunol, 1998; 160:920-8.
32. Ebner S, Neyer S, Hofer S et al. Generation of large numbers of human dendritic cells from whole blood passaged through leucocyte removal filters: an alternative to standard buffy coats. J Immunol Meth, 2001; 252:93-104.
33. Nakanishi K. Regulation of Th1 and Th2 immune responces by IL-18. Kekkaku, 2002; 77:87-93.
34. Seewaldt S, Alferink J, Foster I. Interleukin-10 is crucial for maintenance but not for developmental induction of peripheral T cell tolerance. Eur J Immunol, 2002; 32:3607-16.
35. Durez P, Appelboom T, Pira C et al. Antiinflammatory properties of mycophenolate mofetil in murine endotoxemia: inhibition of TNFα and upregulation of IL-10 release. Int J Immunopharmacol, 1999; 9:581-7.
36. Maksimovic-Ivanic D, Trajkovic V, Miljkovic DJ et al. Down-regulation of multiple low dose streptozotocin-induced diabetes by mycophenolate mofetil. Clin Exp Immunol, 2002; 129:214-23.
37. Lemster B, Woo J, Strednak J, Wang SC et al. Cytokine gene expression in murine lymphocytes activated in the presence of FK 506, brednin, mycophenolic acid, or brequinar sodium. Transplant Proc, 1992; 24:2845-6.
38. Gately MK, Renzetti LM, Magram J et al. The interleukin- 12/interleukin-12 receptor system. Role in normal and pathologic immune responses. Annu Rev Immunol, 1998; 16:495-521.
39. van Parijs I, Perez V, Biuckians A et al. Role of interleukin 12 and costimulators in T cell anergy in vivo. J Exp Med, 1997; 186:1119-28.
40. Piemonti L, Monti P, Allavena P et al. Glucocorticoids increase the endocytic activity of human dendritic cells. Int Immunol, 1999; 11:1519-26.
41. Laurent AF, Dumont S, Poindron P et al. Mycophenolic acid suppresses protein N-linked glycosylation in human monocytes and their adhesion to endothelial cells and to some substrates. Exp Hematol, 1996; 24:59-67.
42. Colic M, Vucevic D, Vasilijic S et al. Proliferation of spleen cells in culture stimulated by 7-thia-8-oxoguanosine: evidence that both B- and T-cells are targets of its action. Meth Find Exp Clin Pharmacol, 1999; 21:83-90.