Plant-derived therapeutics for the treatment of metabolic syndrome

Current Opinion in Investigational Drugs

Volumn 11, Issue 10, 2010, Pages 1107-1115

  Graf, B L ^a   Raskin, I ^a   Cefalu, W T ^a   Ribnicky, D M ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Botanical; cardiovascular disease; diabetes; hypertension; insulin resistance; obesity; phytochemical

Indexed keywords

ARTEMISIA DRACUNCULUS EXTRACT; BLUEBERRY EXTRACT; CINNAMON EXTRACT; CRATAEGUS EXTRACT; GRAPE SEED EXTRACT; HERBACEOUS AGENT; HOODIA GORDONII EXTRACT; MOMORDICA CHARANTIA EXTRACT; TRIGONELLA FOENUM GRAECUM EXTRACT; UNCLASSIFIED DRUG;

ARTEMISIA DRACUNCULUS; DRUG EFFECT; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SYNTHESIS; HOODIA GORDONII; HUMAN; MEDICINAL PLANT; METABOLIC SYNDROME X; NONHUMAN; REVIEW; TREATMENT INDICATION;

ABDOMINAL FAT; ANIMALS; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; DYSLIPIDEMIAS; HUMANS; HYPERTENSION; METABOLIC SYNDROME X; MICE; PHYTOTHERAPY; PLANT PREPARATIONS; PLANTS; PLANTS, MEDICINAL; RATS;

EID: 77957573182     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (71)

1. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr: Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation (2009) 120(16):1640-1645.
2. Simmons RK, Alberti KG, Gale EA, Colagiuri S, Tuomilehto J, Qiao Q, Ramachandran A, Tajima N, Brajkovich Mirchov I, Ben-Nakhi A, Reaven G et al: The metabolic syndrome: Useful concept or clinical tool? Report of a WHO expert consultation. Diabetologia (2010) 53(4):600-605.
3. Marles RJ, Farnsworth NR: Antidiabetic plants and their active constituents. Phytomedicine (1995) 2:137-189.
4. Newman DJ, Cragg GM: Natural products as sources of new drugs over the last 25 years. J Nat Prod (2007) 70(3):461-477.
5. Newman DJ, Cragg GM, Snader KM: Natural products as sources of new drugs over the period 1981-2002. J Nat Prod (2003) 66(7):1022-1037.
6. Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ: Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem (2004) 52(1):65-70.
7. Kim SH, Hyun SH, Choung SY: Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol (2006) 104(1-2):119-123.
8. Dugoua JJ, Seely D, Perri D, Cooley K, Forelli T, Mills E, Koren G: From type 2 diabetes to antioxidant activity: A systematic review of the safety and efficacy of common and cassia cinnamon bark. Can J Physiol Pharmacol (2007) 85(9):837-847.
9. Crawford P: Effectiveness of cinnamon for lowering hemoglobin A1c in patients with type 2 diabetes: A randomized, controlled trial. J Am Board Fam Med (2009) 22(5):507-512.
10. Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA: Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care (2003) 26(12):3215-3218.
11. Anderson RA: Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc Nutr Soc (2008) 67(1):48-53.
12. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM: The effect of cinnamon on A1c among adolescents with type 1 diabetes. Diabetes Care (2007) 30(4):813-816.
13. Blevins SM, Leyva MJ, Brown J, Wright J, Scofield RH, Aston CE: Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes. Diabetes Care (2007) 30(9):2236-2237.
14. Preuss HG, Echard B, Polansky MM, Anderson R: Whole cinnamon and aqueous extracts ameliorate sucrose-induced blood pressure elevations in spontaneously hypertensive rats. J Am Coll Nutr (2006) 25(2):144-150.
15. Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J, Anderson RA: Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sports Nutr (2006) 3:45-53.
16. Qin B, Polansky MM, Anderson RA: Cinnamon extract regulates plasma levels of adipose-derived factors and expression of multiple genes related to carbohydrate metabolism and lipogenesis in adipose tissue of fructose-fed rats. Horm Metab Res (2010) 42(3):187-193.
17. Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO, Hahn A: Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest (2006) 36(5):340-344.
18. Ribnicky DM, Poulev A, Watford M, Cefalu WT, Raskin I: Antihyperglycemic activity of tarralin, an ethanolic extract of Artemisia dracunculus L. Phytomedicine (2006) 13(8): 550-557.
19. Logendra S, Ribnicky DM, Yang H, Poulev A, Ma J, Kennelly EJ, Raskin I: Bioassay-guided isolation of aldose reductase inhibitors from Artemisia dracunculus. Phytochemistry (2006) 67(14):1539-1546.
20. Wang ZQ, Ribnicky D, Zhang XH, Raskin I, Yu Y, Cefalu WT: Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle culture. Metabolism (2008) 57(7 Suppl 1):S58-S64.
21. Govorko D, Logendra S, Wang Y, Esposito D, Komarnytsky S, Ribnicky D, Poulev A, Wang Z, Cefalu WT, Raskin I: Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line. Am J Physiol Endocrinol Metab (2007) 293(6):E1503-E1510.
22. Cefalu WT: Inflammation, insulin resistance, and type 2 diabetes: Back to the future? Diabetes (2009) 58(2):307-308.
23. Ribnicky DM, Poulev A, Rood J, Raskin I, Cefalu WT: Plasma bioactives of Artemisia dracunculus L. and insulin sensitivity in obese, insulin-resistant human subjects: A pilot trial. J Complement Alternative Med (2010):in press.
24. DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol (1979) 237(3):E214-E223.
25. Ribnicky DM, Poulev A, O'Neal J, Wnorowski G, Malek DE, Jager R, Raskin I: Toxicological evaluation of the ethanolic extract of Artemisia dracunculus L. for use as a dietary supplement and in functional foods. Food Chem Toxicol (2004) 42(4): 585-598.
26. Leung L, Birtwhistle R, Kotecha J, Hannah S, Cuthbertson S: Anti-diabetic and hypoglycaemic effects of Momordica charantia (bitter melon): A mini review. Br J Nutr (2009) 102(12):1703-1708.
27. Ahmad N, Hassan MR, Halder H, Bennoor KS: Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients. Bangladesh Med Res Counc Bull (1999) 25(1):11-13.
28. Grover JK, Yadav SP: Pharmacological actions and potential uses of Momordica charantia: A review. J Ethnopharmacol (2004) 93(1):123-132.
29. Rathi SS, Grover JK, Vats V: The effect of Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism. Phytother Res (2002) 16(3): 236-243.
30. Grover JK, Vats V, Rathi SS, Dawar R: Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. J Ethnopharmacol (2001) 76(3):233-238.
31. Grover JK, Rathi SS, Vats V: Amelioration of experimental diabetic neuropathy and gastropathy in rats following oral administration of plant (Eugenia jambolana, Mucuna pruriens and Tinospora cordifolia) extracts. Indian J Exp Biol (2002) 40(3):273-276.
32. Rathi SS, Grover JK, Vikrant V, Biswas NR: Prevention of experimental diabetic cataract by Indian ayurvedic plant extracts. Phytother Res (2002) 16(8):774-777.
33. Ahmed I, Lakhani MS, Gillett M, John A, Raza H: Hypo-triglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats. Diabetes Res Clin Pract (2001) 51(3):155-161.
34. Chaturvedi P: Role of Momordica charantia in maintaining the normal levels of lipids and glucose in diabetic rats fed a high-fat and low-carbohydrate diet. Br J Biomed Sci (2005) 62(3):124-126.
35. Fernandes NP, Lagishetty CV, Panda VS, Naik SR: An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC Complement Altern Med (2007) 7:29.
36. Jayasooriya AP, Sakono M, Yukizaki C, Kawano M, Yamamoto K, Fukuda N: Effects of Momordica charantia powder on serum glucose levels and various lipid parameters in rats fed with cholesterol-free and cholesterol-enriched diets. J Ethnopharmacol (2000) 72(1-2):331-336.
37. Senanayake GV, Maruyama M, Shibuya K, Sakono M, Fukuda N, Morishita T, Yukizaki C, Kawano M, Ohta H: The effects of bitter melon (Momordica charantia) on serum and liver triglyceride levels in rats. J Ethnopharmacol (2004) 91(2-3): 257-262.
38. Srinivasan K: Fenugreek (Trigonella foenum-graecum): A review of health beneficial physiological effects. Food Rev Intl (2006) 22(2):203-224.
39. Gopalpura PB, Jayanthi C, Dubey S: Effect of Trigonella foenumgraecum seeds on the glycemic index of food: A clinical evaluation. Int J Diab Dev Countries (2009) 27(2):41-45.
40. Kassaian N, Azadbakht L, Forghani B, Amini M: Effect of fenugreek seeds on blood glucose and lipid profiles in type 2 diabetic patients. Int J Vitam Nutr Res (2009) 79(1): 34-39.
41. Shi J, Yu J, Pohorly JE, Kakuda Y: Polyphenolics in grape seeds-biochemistry and functionality. J Med Food (2003) 6(4):291-299.
42. Watson EM: Some observations on the effect of blueberry leaf extract in diabetes mellitus. Can Med Assoc J (1928) 19(2):166-171.
43. Grace MH, Ribnicky DM, Kuhn P, Poulev A, Logendra S, Yousef GG, Raskin I, Lila MA: Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton. Phytomedicine (2009) 16(5): 406-415.
44. Vuong T, Benhaddou-Andaloussi A, Brault A, Harbilas D, Martineau LC, Vallerand D, Ramassamy C, Matar C, Haddad PS: Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKA(y) mice. Int J Obes (Lond) (2009) 33(10):1166-1173.
45. Prior RL, Wilkes SE, Rogers TR, Khanal RC, Wu X, Howard LR: Purifed blueberry anthocyanins and blueberry juice alter development of obesity in mice fed an obesogenic high-fat diet. J Agric Food Chem (2010) 58(7):3970-3976.
46. Shaughnessy KS, Boswall IA, Scanlan AP, Gottschall-Pass KT, Sweeney MI: Diets containing blueberry extract lower blood pressure in spontaneously hypertensive stroke-prone rats. Nutr Res (2009) 29(2):130-138.
47. Kalea AZ, Clark K, Schuschke DA, Klimis-Zacas DJ: Vascular reactivity is affected by dietary consumption of wild blueberries in the Sprague-Dawley rat. J Med Food (2009) 12(1):21-28.
48. Kalea AZ, Clark K, Schuschke DA, Kristo AS, Klimis-Zacas DJ: Dietary enrichment with wild blueberries (Vaccinium angustifolium) affects the vascular reactivity in the aorta of young spontaneously hypertensive rats. J Nutr Biochem (2010) 21(1):14-22.
49. Lazze MC, Pizzala R, Perucca P, Cazzalini O, Savio M, Forti L, Vannini V, Bianchi L: Anthocyanidins decrease endothelin-1 production and increase endothelial nitric oxide synthase in human endothelial cells. Mol Nutr Food Res (2006) 50(1):44-51.
50. Xu JW, Ikeda K, Yamori Y: Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment. Hypertension (2004) 44(2):217-222. (Pubitemid 39014241)
51. Erlund I, Koli R, Alfthan G, Marniemi J, Puukka P, Mustonen P, Mattila P, Jula A: Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr (2008) 87(2):323-331.
52. Peng N, Clark JT, Prasain J, Kim H, White CR, Wyss JM: Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol (2005) 289(3): R771-R775.
53. Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda T: Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism (2009) 58(12):1743-1746.
54. Jones DW, Hall JE: Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure and evidence from new hypertension trials. Hypertension (2004) 43(1):1-3.
55. Aldini G, Carini M, Piccoli A, Rossoni G, Facino RM: Procyanidins from grape seeds protect endothelial cells from peroxynitrite damage and enhance endothelium-dependent relaxation in human artery: New evidences for cardio-protection. Life Sci (2003) 73(22):2883-2898.
56. Fitzpatrick DF, Bing B, Maggi DA, Fleming RC, O'Malley RM: Vasodilating procyanidins derived from grape seeds. Ann NY Acad Sci (2002) 957:78-89.
57. Fitzpatrick DF, Fleming RC, Bing B, Maggi DA, O'Malley RM: Isolation and characterization of endothelium-dependent vasorelaxing compounds from grape seeds. J Agric Food Chem (2000) 48(12):6384-6390.
58. Quesada H, del Bas JM, Pajuelo D, Díaz S, Fernandez-Larrea J, Pinent M, Arola L, Salvadó MJ, Bladé C: Grape seed proantho-cyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver. Int J Obes (Lond) (2009) 33(9): 1007-1012.
59. Pittler MH, Guo R, Ernst E: Hawthorn extract for treating chronic heart failure. Cochrane Database Syst Rev (2008) (1):CD005312.
60. Asgary S, Naderi GH, Sadeghi M, Kelishadi R, Amiri M: Antihypertensive effect of Iranian Crataegus curvisepala Lind.: A randomized, double-blind study. Drugs Exp Clin Res (2004) 30(5-6):221-225.
61. Walker AF, Marakis G, Simpson E, Hope JL, Robinson PA, Hassanein M, Simpson HC: Hypotensive effects of hawthorn for patients with diabetes taking prescription drugs: A randomised controlled trial. Br J Gen Pract (2006) 56(527):437-443.
62. Brixius K, Willms S, Napp A, Tossios P, Ladage D, Bloch W, Mehlhorn U, Schwinger RH: Crataegus special extract WS 1442 induces an endothelium- dependent, NO-mediated vasorelaxation via eNOS-phosphorylation at serine 1177. Cardiovasc Drugs Ther (2006) 20(3):177-184.
63. Lacaille D, Franck U, Wagner H: Search for potential angiotensin converting enzyme (ACE)-inhibitors from plants. Phytomedicine (2001) 8(1):47-52.
64. Tadić VM, Dobrić S, Marković GM, Dordević SM, Arsić IA, Menković NR, Stević T: Anti-inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities of hawthorn berries ethanol extract. J Agric Food Chem (2008) 56(17):7700-7709.
65. Koçyildiz ZC, Birman H, Olgaç V, Akgün-Dar K, Melikoćlu G, Meriçli AH: Crataegus tanacetifolia leaf extract prevents L-NAME-induced hypertension in rats: A morphological study. Phytother Res (2006) 20(1):66-70.
66. Kim SH, Kang KW, Kim KW, Kim ND: Procyanidins in Crataegus extract evoke endothelium-dependent vasorelaxation in rat aorta. Life Sci (2000) 67(2):121-131.
67. Shanthi S, Parasakthy K, Deepalakshmi PD, Devaraj SN: Hypolipidemic activity of tincture of Crataegus in rats. Indian J Biochem Biophys (1994) 31(2):143-146.
68. Rajendran S, Deepalakshmi PD, Parasakthy K, Devaraj H, Devaraj SN: Effect of tincture of Crataegus on the LDL-receptor activity of hepatic plasma membrane of rats fed an atherogenic diet. Atherosclerosis (1996) 123(1-2): 235-241.
69. MacLean DB, Luo LG: Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: Studies of the anorectic mechanism of a plant steroidal glycoside. Brain Res (2004) 1020(1-2):1-11.
70. Shukla YJ, Pawar RS, Ding Y, Li XC, Ferreira D, Khan IA: Pregnane glycosides from Hoodia gordonii. Phytochemistry (2009) 70(5):675-683.
71. Avula B, Wang YH, Pawar RS, Shukla YJ, Smillie TJ, Khan IA: A rapid method for chemical fingerprint analysis of Hoodia species, related genera, and dietary supplements using UPLC-UV-MS. J Pharm Biomed Anal (2008) 48(3):722-731.