Toxicological evaluation of the ethanolic extract of Artemisia dracunculus L. for use as a dietary supplement and in functional foods

Food and Chemical Toxicology

Volumn 42, Issue 4, 2004, Pages 585-598

  Ribnicky, David M ^a   Poulev, Alexander ^a   O'Neal, Joseph ^a   Wnorowski, Gary ^b   Malek, Dolores E ^b   Jäger, Ralf ^c   Raskin, Ilya ^a  

^a RUTGERS UNIVERSITY   (United States)

^b Product Safety Labs   (United States)

^c EVONIK INDUSTRIES AG   (Germany)

Author keywords

Artemisia dracunculus; Diabetes; Estragole; Extract; Hyperglycemia; Hypoglycemia; Methyl eugenol; No observed adverse effect level; Russian tarragon; Safety

Indexed keywords

ARTEMISIA DRACUNCULUS EXTRACT; PLANT EXTRACT; TARRALIN; UNCLASSIFIED DRUG;

ACUTE TOXICITY; AMES TEST; ARTEMISIA; ARTICLE; AUTOPSY; BIOSAFETY; BLOOD CHEMISTRY; BODY WEIGHT; BRIGHT FIELD MICROSCOPY; DIET SUPPLEMENTATION; DRUG SAFETY; DRUG TOLERABILITY; METABOLIC ACTIVATION; MOTOR ACTIVITY; NONHUMAN; TOXICITY TESTING;

ANIMALS; ARTEMISIA; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; LETHAL DOSE 50; MALE; MUTAGENICITY TESTS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SALMONELLA TYPHIMURIUM;

ARTEMISIA; ARTEMISIA DRACUNCULUS;

EID: 1542346446     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2003.11.002     Document Type: Article

References (23)

1. Anthony A., Caldwell J., Hutt A.J., Smith R.L. Metabolism of estragole in rat and mouse and influence of dose size on excretion of the proximate carcinogen 1′-hydroxyestragole. Fd. Chem. Toxic. 25(11):1987;799-806.
2. Al-Shamaony L., Al-Khazraji S.M., Twaij A.A. Hypoglycaemic effect of Artemisia herba alba. II Effect of a valuable extract on some blood parameters in diabetic animals. Journal of Ethnopharmacology. 43:1994;167-171.
3. Al-Waili Dawood N.S. Treatment of Diabetes Mellitus by Artemisia Herba-Alba extract. preliminary study Clinical and Experimental Pharmacology and Physiology. 13:1986;569-573.
4. Ames B.N., McCann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/Mammalian-Microsome Mutagenicity test. Mutation Research. 31:1975;347-364.
5. Brennan R.J., Kandikonda S., Khrimian A.P., DeMilo A.B., Liquido N.J., Schiestl R.H. Saturated and monofluoro analogs of the oriental fruit fly attractant methyl eugenol show reduced genotoxic activities in yeast. Mutation Research. 369:1996;175-181.
6. Chan V.S.W., Caldwell J. Comparative induction of unscheduled DNA synthesis in cultured rat hepatocytes by allylbenzenes and their 1′-hydroxy metabolites. Fd Chem. Toxic. 30(10):1992;831-836.
7. Drinkwater N.R., Miller E.C., Miller J.A., Pitot H.C. Hepatocarcinogenicity of estragole (1-allyl-4-methoxybenzene) and 1′-hydroxyestragole in the mouse and mutagenicity of 1′- acetoxyestragole in bacteria. J. Natl. Cancer Inst. 57(6):1976;1323-1330.
8. Hylton W.H. The Rodale Herb Book. 1974;Rodale Press, Emmaus PA.
9. Flavor and Extract Manufacturers' Association (FEMA) Scientific Literature Review of Anisole and Derivatives in Flavor Usage. 1978;FEMA, Washington, DC.
10. Leung A.Y. Encyclopaedia of Common Natural Ingredients used in Food, Drugs and Cosmetics. 1980;John Wiley & Sons, New York.
11. Miller E.C., Swanson A.B., Phillips D.H., Fletcher T.L., Lien A., Miller J.A. Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole. Cancer Res. 43:1983;1124-1134.
12. Mueller M.S., Karhagomba I.B., Hirt H.M., Wemaker E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. Journal of Ethnopharmacology. 73(3):2000;487-493.
13. 14C]-labelled trans-anethole, estragole and p-propylanisole in human volunteers. Xenobiotica. 17(10):1987;1223-1232.
14. Schiestl R.H., Chan W.S., Gietz R.D., Mehta R.D., Hastings P.J. Safrole, eugenol and methyleugenol induce intrachromosomal recombination in yeast. Mutation Research. 224:1989;427-436.
15. SCF, 2001a. Opinion of the Scientific Committee on Food on Methyleugenol (4-Allyl-1,2-dimethoxybenzene).
16. SCF, 2001b. Opinion of the Scientific Committee on Food on Estragole (1-Allyl-4-methoxybenzene).
17. Sekizawa J., Shibamoto T. Genotoxicity of safrole-related chemicals in microbial test systems. Mutation Research. 101:1982;127-140.
18. Smith R.L., Adams T.B., Doull J., Feron V.J., Goodman J.I., Marnett L.J., Portoghese P.S., Waddell W.J., Wagner B.M., Rogers A.E., Caldwell J., Sipes I.G. Safety assessment of allyloxybenzene derivatives used as flavouring substances - methyl eugenol and estragole. Food Chem. Toxicol. 40(7):2002;851-870.
19. Swanston-Flatt S.K., Day C., Bailey C.J., Flatt P.R. Evaluation of traditional plant treatments for diabetes. studies in Streprozoticin diabetic mice Acta diabetol. Lat. 26:1989;51-55.
20. Swanston-Flatt S.K., Flatt P.R., Day C., Bailey C.J. Traditional dietary adjuncts for the treatment of Diabetes Mellitus. Proceedings of the Nutrition Society. 50:1991;641-651.
21. Subramoniam S., Pushpangadan P., Rajasekharan S., Evans D.A., Latha P.G., Valsaraj R. Effects of Artemisia pallens Wall. On blood glucose levels in normal and alloxan-induced diabetic rats. Journal of Ehtnopharmacology. 50:1996;13-17.
22. Yazdanparast R., Saee A. Effects of aqueous tarragon, Artemisia dracunculus, extract on lipid and coagulatory parameters in rats. Biomedical Letters. 59:1999;137-141.
23. Zangouras A., Caldwell J., Hutt A.J., Smith R.L. Dose dependent conversion of estragole in the rat and mouse to the carcinogenic metabolite, 1′-hydroxyestragole. Biochemical Pharmacology. 30(11):1981;1383-1386.