Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes

Journal of Neuroinflammation

Volumn 7, Issue , 2010, Pages

  Spitzer, Philipp ^a,b   Herrmann, Martin ^a   Klafki, Hans Wolfgang ^b   Smirnov, Alexander ^b   Lewczuk, Piotr ^a   Kornhuber, Johannes ^a   Wiltfang, Jens ^b   Maler, Juan M ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[20-40]; AMYLOID PRECURSOR PROTEIN; CD14 ANTIGEN; EDETIC ACID; GLYCOPROTEIN; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN; POLYSTYRENE; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ARTICLE; BLOOD; CELL CULTURE; CELL ISOLATION; CELL SELECTION; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; MONONUCLEAR PHAGOCYTE; PHAGOCYTOSIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN VARIANT; WESTERN BLOTTING; ANALYSIS OF VARIANCE; CYTOLOGY; DRUG EFFECT; METABOLISM; PHAGOCYTE; PHYSIOLOGY;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; BLOTTING, WESTERN; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LIPOPOLYSACCHARIDES; PHAGOCYTES; PHAGOCYTOSIS;

EID: 77957362134     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-7-59     Document Type: Article

References (45)

1. Thal DR, Capetillo-Zarate E, Del TK, Braak H. The development of amyloid beta protein deposits in the aged brain. Sci Aging Knowledge Environ 2006, 2006(6):re1.. 10.1126/sageke.2006.6.re1, 16525193.
2. Dickson DW. The pathogenesis of senile plaques. J Neuropathol Exp Neurol 1997, 56:321-339. 10.1097/00005072-199704000-00001, 9100663.
3. Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001, 81:741-766.
4. Fukumoto H, Asami-Odaka A, Suzuki N, Iwatsubo T. Association of A beta 40-positive senile plaques with microglial cells in the brains of patients with Alzheimer's disease and in non-demented aged individuals. Neurodegeneration 1996, 5:13-17. 10.1006/neur.1996.0002, 8731377.
5. Sasaki A, Nakazato Y, Ogawa A, Sugihara S. The immunophenotype of perivascular cells in the human brain. Pathol Int 1996, 46:15-23. 10.1111/j.1440-1827.1996.tb03528.x, 10846545.
6. Wisniewski HM, Weigel J. Migration of perivascular cells into the neuropil and their involvement in beta-amyloid plaque formation. Acta Neuropathol 1993, 85:586-595. 10.1007/BF00334667, 8337937.
7. Sergeant N, Bombois S, Ghestem A, Drobecq H, Kostanjevecki V, Missiaen C, Wattez A, David JP, Vanmechelen E, Sergheraert C, Delacourte A. Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach. J Neurochem 2003, 85:1581-1591. 10.1046/j.1471-4159.2003.01818.x, 12787077.
8. Güntert A, Döbeli H, Bohrmann B. High sensitivity analysis of amyloid-β peptide composition in amyloid deposits from human and PS2APP mouse brain. Neuroscience 2006, 143:461-475. 10.1016/j.neuroscience.2006.08.027, 17008022.
9. Kuo YM, Emmerling MR, Woods AS, Cotter RJ, Roher AE. Isolation, chemical characterization, and quantitation of Aβ 3-pyroglutamyl peptide from neuritic plaques and vascular amyloid deposits. Biochem Biophys Res Commun 1997, 237:188-191. 10.1006/bbrc.1997.7083, 9266855.
10. Fiala JC. Mechanisms of amyloid plaque pathogenesis. Acta Neuropathol 2007, 114:551-571. 10.1007/s00401-007-0284-8, 17805553.
11. Pasternak SH, Callahan JW, Mahuran DJ. The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective. J Alzheimers Dis 2004, 6:53-65.
12. Mönning U, König G, Banati RB, Mechler H, Czech C, Gehrmann J, Schreiter-Gasser U, Masters CL, Beyreuther K. Alzheimer beta A4-amyloid protein precursor in immunocompetent cells. J Biol Chem 1992, 267:23950-23956.
13. Bauer J, Konig G, Strauss S, Jonas U, Ganter U, Weidemann A, Monning U, Masters CL, Volk B, Berger M. In-vitro matured human macrophages express Alzheimer's beta A4-amyloid precursor protein indicating synthesis in microglial cells. FEBS Lett 1991, 282:335-340. 10.1016/0014-5793(91)80508-Z, 1903718.
14. Ledoux S, Rebai N, Dagenais A, Shaw IT, Nalbantoglu J, Sekaly RP, Cashman NR. Amyloid precursor protein in peripheral mononuclear cells is up-regulated with cell activation. J Immunol 1993, 150:5566-5575.
15. Weidemann A, Konig G, Bunke D, Fischer P, Salbaum JM, Masters CL, Beyreuther K. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 1989, 57:115-126. 10.1016/0092-8674(89)90177-3, 2649245.
16. Pahlsson P, Spitalnik SL. The role of glycosylation in synthesis and secretion of beta-amyloid precursor protein by Chinese hamster ovary cells. Arch Biochem Biophys 1996, 331:177-186. 10.1006/abbi.1996.0296, 8660696.
17. McFarlane I, Georgopoulou N, Coughlan CM, Gillian AM, Breen KC. The role of the protein glycosylation state in the control of cellular transport of the amyloid beta precursor protein. Neuroscience 1999, 90:15-25. 10.1016/S0306-4522(98)00361-3, 10188930.
18. Christie RH, Freeman M, Hyman BT. Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease. Am J Pathol 1996, 148:399-403. 1861668, 8579103.
19. Horiuchi S, Sakamoto Y, Sakai M. Scavenger receptors for oxidized and glycated proteins. Amino Acids 2003, 25:283-292. 10.1007/s00726-003-0029-5, 14661091.
20. Sulahian TH, Imrich A, Deloid G, Winkler AR, Kobzik L. Signaling pathways required for macrophage scavenger receptor-mediated phagocytosis: analysis by scanning cytometry. Respir Res 2008, 9:59-. 10.1186/1465-9921-9-59, 2527561, 18687123.
21. El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD. CD36 mediates the innate host response to beta-amyloid. J Exp Med 2003, 197:1657-1666. 10.1084/jem.20021546, 2193948, 12796468.
22. Paresce DM, Ghosh RN, Maxfield FR. Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor. Neuron 1996, 17:553-565. 10.1016/S0896-6273(00)80187-7, 8816718.
23. Liu Y, Walter S, Stagi M, Cherny D, Letiembre M, Schulz-Schaeffer W, Heine H, Penke B, Neumann H, Fassbender K. LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide. Brain 2005, 128:1778-1789. 10.1093/brain/awh531, 15857927.
24. Maler JM, Spitzer P, Klafki HW, Esselmann H, Bibl M, Lewczuk P, Kornhuber J, Herrmann M, Wiltfang J. Adherence-dependent shifts in the patterns of beta-amyloid peptides secreted by human mononuclear phagocytes. Brain Behav Immun 2008, 22:1044-1048. 10.1016/j.bbi.2008.04.003, 18511234.
25. Wiltfang J, Esselmann H, Bibl M, Smirnov A, Otto M, Paul S, Schmidt B, Klafki HW, Maler M, Dyrks T, Bienert M, Beyermann M, Rüther E, Kornhuber J. Highly conserved and disease-specific patterns of carboxyterminally truncated Aβ peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation. J Neurochem 2002, 81:481-496. 10.1046/j.1471-4159.2002.00818.x, 12065657.
26. Maler JM, Klafki HW, Paul S, Spitzer P, Groemer TW, Henkel AW, Esselmann H, Lewczuk P, Kornhuber J, Wiltfang J. Urea-based two-dimensional electrophoresis of β-amyloid peptides in human plasma: evidence for novel Abeta species. Proteomics 2007, 7:3815-3820. 10.1002/pmic.200700311, 17924594.
27. Wiltfang J, Esselmann H, Cupers P, Neumann M, Kretzschmar H, Beyermann M, Schleuder D, Jahn H, Rüther E, Kornhuber J, Annaert W, De Strooper B, Saftig P. Elevation of β-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells. J Biol Chem 2001, 276:42645-42657. 10.1074/jbc.M102790200, 11526104.
28. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685. 10.1038/227680a0, 5432063.
29. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979, 76:4350-4354. 10.1073/pnas.76.9.4350, 411572, 388439.
30. Reed-Geaghan EG, Savage JC, Hise AG, Landreth GE. CD14 and toll-like receptors 2 and 4 are required for fibrillar Aβ-stimulated microglial activation. J Neurosci 2009, 29:11982-11992. 10.1523/JNEUROSCI.3158-09.2009, 2778845, 19776284.
31. Jung SS, Gauthier S, Cashman NR. Beta-amyloid precursor protein is detectable on monocytes and is increased in Alzheimer's disease. Neurobiol Aging 1999, 20:249-257. 10.1016/S0197-4580(99)00051-2, 10588572.
32. Bitting L, Naidu A, Cordell B, Murphy GM. Beta-amyloid peptide secretion by a microglial cell line is induced by beta-amyloid-(25-35) and lipopolysaccharide. J Biol Chem 1996, 271:16084-16089. 10.1074/jbc.271.27.16084, 8663228.
33. Grilli M, Ribola M, Alberici A, Valerio A, Memo M, Spano P. Identification and characterization of a kappa B/Rel binding site in the regulatory region of the amyloid precursor protein gene. J Biol Chem 1995, 270:26774-26777. 10.1074/jbc.270.45.26774, 7592914.
34. Paris D, Patel N, Quadros A, Linan M, Bakshi P, Ait-Ghezala G, Mullan M. Inhibition of Abeta production by NF-kappaB inhibitors. Neurosci Lett 2007, 415:11-16. 10.1016/j.neulet.2006.12.029, 17223266.
35. Beer J, Masters CL, Beyreuther K. Cells from peripheral tissues that exhibit high APP expression are characterized by their high membrane fusion activity. Neurodegeneration 1995, 4:51-59. 10.1006/neur.1995.0006, 7600184.
36. Booth JW, Trimble WS, Grinstein S. Membrane dynamics in phagocytosis. Semin Immunol 2001, 13:357-364. 10.1006/smim.2001.0332, 11708891.
37. Huynh KK, Kay JG, Stow JL, Grinstein S. Fusion, fission, and secretion during phagocytosis. Physiology (Bethesda) 2007, 22:366-372.
38. Groves E, Dart AE, Covarelli V, Caron E. Molecular mechanisms of phagocytic uptake in mammalian cells. Cell Mol Life Sci 2008, 65:1957-1976. 10.1007/s00018-008-7578-4, 18322649.
39. Simon SI, Schmid-Schonbein GW. Biophysical aspects of microsphere engulfment by human neutrophils. Biophys J 1988, 53:163-173. 10.1016/S0006-3495(88)83078-9, 1330137, 3345329.
40. Sondag CM, Combs CK. Adhesion of monocytes to type I collagen stimulates an APP-dependent proinflammatory signaling response and release of Abeta1-40. J Neuroinflammation 2010, 7:22-. 10.1186/1742-2094-7-22, 2850892, 20302643.
41. Cescato R, Dumermuth E, Spiess M, Paganetti PA. Increased generation of alternatively cleaved beta-amyloid peptides in cells expressing mutants of the amyloid precursor protein defective in endocytosis. J Neurochem 2000, 74:1131-1139. 10.1046/j.1471-4159.2000.741131.x, 10693945.
42. Kalback W, Watson MD, Kokjohn TA, Kuo YM, Weiss N, Luehrs DC, Lopez J, Brune D, Sisodia SS, Staufenbiel M, Emmerling M, Roher AE. APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques. Biochemistry 2002, 41:922-928. 10.1021/bi015685+, 11790115.
43. Pike CJ, Overman MJ, Cotman CW. Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro. J Biol Chem 1995, 270:23895-23898. 10.1074/jbc.270.41.23895, 7592576.
44. Bitan G, Vollers SS, Teplow DB. Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization. J Biol Chem 2003, 278:34882-34889. 10.1074/jbc.M300825200, 12840029.
45. Lorenzen A, Samosh J, Vandewark K, Anborgh PH, Seah C, Magalhaes AC, Cregan SP, Ferguson SS, Pasternak SH. Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway. Mol Brain 2010, 3:11. 10.1186/1756-6606-3-11, 2868040, 20409323.