Mesenchymal stromal cells: Facilitators of successful transplantation?

Cell Stem Cell

Volumn 7, Issue 4, 2010, Pages 431-442

  English, Karen ^a   French, Anna ^a   Wood, Kathryn J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE DISEASE; BONE MARROW CELL; CELL CULTURE; CELL INTERACTION; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; STROMA CELL; T LYMPHOCYTE;

BONE MARROW CELLS; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; STROMAL CELLS;

EID: 77957338676     PISSN: 19345909     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stem.2010.09.009     Document Type: Review

References (118)

1. S. Aggarwal, and M.F. Pittenger Human mesenchymal stem cells modulate allogeneic immune cell responses Blood 105 2005 1815 1822
2. J. Ankrum, and J.M. Karp Mesenchymal stem cell therapy: Two steps forward, one step back Trends Mol. Med. 16 2010 203 209
3. T.L. Arinzeh, S.J. Peter, M.P. Archambault, C. van den Bos, S. Gordon, K. Kraus, A. Smith, and S. Kadiyala Allogeneic mesenchymal stem cells regenerate bone in a critical-sized canine segmental defect J. Bone Joint Surg. Am. 85-A 2003 1927 1935
4. S. Asari, S. Itakura, K. Ferreri, C.P. Liu, Y. Kuroda, F. Kandeel, and Y. Mullen Mesenchymal stem cells suppress B-cell terminal differentiation Exp. Hematol. 37 2009 604 615
5. A. Bartholomew, C. Sturgeon, M. Siatskas, K. Ferrer, K. McIntosh, S. Patil, W. Hardy, S. Devine, D. Ucker, and R. Deans Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo Exp. Hematol. 30 2002 42 48
6. S. Beyth, Z. Borovsky, D. Mevorach, M. Liebergall, Z. Gazit, H. Aslan, E. Galun, and J. Rachmilewitz Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness Blood 105 2005 2214 2219
7. P. Bianco, P.G. Robey, and P.J. Simmons Mesenchymal stem cells: revisiting history, concepts, and assays Cell Stem Cell 2 2008 313 319
8. G.J. Block, S. Ohkouchi, F. Fung, J. Frenkel, C. Gregory, R. Pochampally, G. DiMattia, D.E. Sullivan, and D.J. Prockop Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1 Stem Cells 27 2009 670 681
9. I. Bochev, G. Elmadjian, D. Kyurkchiev, L. Tzvetanov, I. Altankova, P. Tivchev, and S. Kyurkchiev Mesenchymal stem cells from human bone marrow or adipose tissue differently modulate mitogen-stimulated B-cell immunoglobulin production in vitro Cell Biol. Int. 32 2008 384 393
10. A. Briquet, S. Dubois, S. Bekaert, M. Dolhet, Y. Beguin, and A. Gothot Prolonged ex vivo culture of human bone marrow mesenchymal stem cells influences their supportive activity toward NOD/SCID-repopulating cells and committed progenitor cells of B lymphoid and myeloid lineages Haematologica 95 2010 47 56
11. A.I. Caplan Mesenchymal stem cells J. Orthop. Res. 9 1991 641 650
12. A.I. Caplan, and J.E. Dennis Mesenchymal stem cells as trophic mediators J. Cell. Biochem. 98 2006 1076 1084
13. F. Casiraghi, N. Azzollini, P. Cassis, B. Imberti, M. Morigi, D. Cugini, R.A. Cavinato, M. Todeschini, S. Solini, and A. Sonzogni Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells J. Immunol. 181 2008 3933 3946
14. W.K. Chan, A.S.Y. Lau, J.C.B. Li, H.K.W. Law, Y.L. Lau, and G.C.F. Chan MHC expression kinetics and immunogenicity of mesenchymal stromal cells after short-term IFN-gamma challenge Exp. Hematol. 36 2008 1545 1555
15. F.G. Chen, W.J. Zhang, D. Bi, W. Liu, X. Wei, F.F. Chen, L. Zhu, L. Cui, and Y. Cao Clonal analysis of nestin(-) vimentin(+) multipotent fibroblasts isolated from human dermis J. Cell Sci. 120 2007 2875 2883
16. L. Chen, E.E. Tredget, P.Y. Wu, and Y. Wu Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing PLoS One 3 2008 e1886
17. L. Chen, E.E. Tredget, C. Liu, and Y. Wu Analysis of allogenicity of mesenchymal stem cells in engraftment and wound healing in mice PLoS ONE 4 2009 e7119
18. M. Christopeit, M. Schendel, J. Föll, L.P. Müller, G. Keysser, and G. Behre Marked improvement of severe progressive systemic sclerosis after transplantation of mesenchymal stem cells from an allogeneic haploidentical-related donor mediated by ligation of CD137L Leukemia 22 2008 1062 1064
19. R.B. Colvin, and R.N. Smith Antibody-mediated organ-allograft rejection Nat. Rev. Immunol. 5 2005 807 817
20. P. Comoli, F. Ginevri, R. Maccario, M.A. Avanzini, M. Marconi, A. Groff, A. Cometa, M. Cioni, L. Porretti, and W. Barberi Human mesenchymal stem cells inhibit antibody production induced in vitro by allostimulation Nephrol. Dial. Transplant. 23 2008 1196 1202
21. M. Crisan, S. Yap, L. Casteilla, C.W. Chen, M. Corselli, T.S. Park, G. Andriolo, B. Sun, B. Zheng, and L. Zhang A perivascular origin for mesenchymal stem cells in multiple human organs Cell Stem Cell 3 2008 301 313
22. L. da Silva Meirelles, P.C. Chagastelles, and N.B. Nardi Mesenchymal stem cells reside in virtually all post-natal organs and tissues J. Cell Sci. 119 2006 2204 2213
23. W. Dai, S.L. Hale, B.J. Martin, J.Q. Kuang, J.S. Dow, L.E. Wold, and R.A. Kloner Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects Circulation 112 2005 214 223
24. M. Di Nicola, C. Carlo-Stella, M. Magni, M. Milanesi, P.D. Longoni, P. Matteucci, S. Grisanti, and A.M. Gianni Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli Blood 99 2002 3838 3843
25. Y.C. Ding, D.M. Xu, G. Feng, A. Bushell, R.J. Muschel, and K.J. Wood Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9 Diabetes 58 2009 1797 1806
26. Y. Ding, A. Bushell, and K.J. Wood Mesenchymal stem-cell immunosuppressive capabilities: therapeutic implications in islet transplantation Transplantation 89 2010 270 273
27. M. Dominici, K. Le Blanc, I. Mueller, I. Slaper-Cortenbach, F.C. Marini, D.S. Krause, R.J. Deans, A. Keating, Dj. Prockop, and E.M. Horwitz Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement Cytotherapy 8 2006 315 317
28. K. English, F.P. Barry, C.P. Field-Corbett, and B.P. Mahon IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells Immunol. Lett. 110 2007 91 100
29. K. English, F.P. Barry, and B.P. Mahon Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation Immunol. Lett. 115 2008 50 58
30. K. English, J.M. Ryan, L. Tobin, M.J. Murphy, F.P. Barry, and B.P. Mahon Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells Clin. Exp. Immunol. 156 2009 149 160
31. M. Franois, R. Romieu-Mourez, S. Stock-Martineau, M.N. Boivin, J.L. Bramson, and J. Galipeau Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties Blood 114 2009 2632 2638
32. A.J. Friedenstein, I.I. Piatetzky-Shapiro, and K.V. Petrakova Osteogenesis in transplants of bone marrow cells J. Embryol. Exp. Morphol. 16 1966 381 390
33. A.J. Friedenstein, R.K. Chailakhjan, and K.S. Lalykina The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells Cell Tissue Kinet. 3 1970 393 403
34. A.J. Friedenstein, R.K. Chailakhyan, N.V. Latsinik, A.F. Panasyuk, and I.V. Keiliss-Borok Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo Transplantation 17 1974 331 340
35. A.J. Friedenstein, J.F. Gorskaja, and N.N. Kulagina Fibroblast precursors in normal and irradiated mouse hematopoietic organs Exp. Hematol. 4 1976 267 274
36. W. Ge, J. Jiang, M.L. Baroja, J. Arp, R. Zassoko, W. Liu, A. Bartholomew, B. Garcia, and H. Wang Infusion of mesenchymal stem cells and rapamycin synergize to attenuate alloimmune responses and promote cardiac allograft tolerance Am. J. Transplant. 9 2009 1760 1772
37. S. Glennie, I. Soeiro, P.J. Dyson, E.W. Lam, and F. Dazzi Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells Blood 105 2005 2821 2827
38. M.E. Groh, B. Maitra, E. Szekely, and O.N. Ko Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells Exp. Hematol. 33 2005 928 934
39. B.M. Hall, S. Dorsch, and B. Roser The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts J. Exp. Med. 148 1978 878 889 (Pubitemid 9034257)
40. M.A. Haniffa, M.P. Collin, C.D. Buckley, and F. Dazzi Mesenchymal stem cells: the fibroblasts' new clothes? Haematologica 94 2009 258 263
41. H. Harizi, C. Grosset, and N. Gualde Prostaglandin E2 modulates dendritic cell function via EP2 and EP4 receptor subtypes J. Leukoc. Biol. 73 2003 756 763
42. S.E. Haynesworth, M.A. Baber, and A.I. Caplan Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies Bone 13 1992 69 80
43. S.E. Haynesworth, J. Goshima, V.M. Goldberg, and A.I. Caplan Characterization of cells with osteogenic potential from human marrow Bone 13 1992 81 88
44. B. Hegyi, B. Sági, J. Kovács, J. Kiss, V.S. Urbán, G. Mészáros, E. Monostori, and F. Uher Identical, similar or different? Learning about immunomodulatory function of mesenchymal stem cells isolated from various mouse tissues: bone marrow, spleen, thymus and aorta wall Int. Immunol. 22 2010 551 559
45. S. Heidt, D. San, R. Chadha, and K.J. Wood The impact of Th17 cells on transplant rejection and the induction of tolerance Curr. Opin. Organ Transplant. 15 2010 456 461
46. M.J. Hoogduijn, M.J. Crop, S.S. Korevaar, A.M.A. Peeters, M. Eijken, L.P.W.M. Maat, A.H.M.M. Balk, W. Weimar, and C.C. Baan Susceptibility of human mesenchymal stem cells to tacrolimus, mycophenolic acid, and rapamycin Transplantation 86 2008 1283 1291
47. X. Hu, S.P. Yu, J.L. Fraser, Z. Lu, M.E. Ogle, J.A. Wang, and L. Wei Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis J. Thorac. Cardiovasc. Surg. 135 2008 799 808
48. E. Ivanova-Todorova, I. Bochev, M. Mourdjeva, R. Dimitrov, D. Bukarev, S. Kyurkchiev, P. Tivchev, I. Altunkova, and D.S. Kyurkchiev Adipose tissue-derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrow-derived mesenchymal stem cells Immunol. Lett. 126 2009 37 42
49. X.X. Jiang, Y. Zhang, B. Liu, S.X. Zhang, Y. Wu, X.D. Yu, and N. Mao Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells Blood 105 2005 4120 4126
50. H. Karlsson, S. Samarasinghe, L.M. Ball, B. Sundberg, A.C. Lankester, F. Dazzi, M. Uzunel, K. Rao, P. Veys, and K. Le Blanc Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T-cell responses Blood 112 2008 532 541
51. J.M. Karp, and G.S. Leng Teo Mesenchymal stem cell homing: the devil is in the details Cell Stem Cell 4 2009 206 216
52. P. Kebriaei, L. Isola, E. Bahceci, K. Holland, S. Rowley, J. McGuirk, M. Devetten, J. Jansen, R. Herzig, and M. Schuster Adult human mesenchymal stem cells added to corticosteroid therapy for the treatment of acute graft-versus-host disease Biol. Blood Marrow Transplant. 15 2009 804 811
53. S. Kern, H. Eichler, J. Stoeve, H. Klüter, and K. Bieback Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue Stem Cells 24 2006 1294 1301
54. E. Klyushnenkova, J.D. Mosca, V. Zernetkina, M.K. Majumdar, K.J. Beggs, D.W. Simonetti, R.J. Deans, and K.R. McIntosh T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression J. Biomed. Sci. 12 2005 47 57
55. O.N. Ko, J. Day, M. Nieder, S.L. Gerson, H.M. Lazarus, and W. Krivit Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH) Bone Marrow Transplant. 30 2002 215 222
56. G. Kögler, T.F. Radke, A. Lefort, S. Sensken, J. Fischer, R.V. Sorg, and P. Wernet Cytokine production and hematopoiesis supporting activity of cord blood-derived unrestricted somatic stem cells Exp. Hematol. 33 2005 573 583
57. Q.F. Kong, B. Sun, S.S. Bai, D.X. Zhai, G.Y. Wang, Y.M. Liu, S.J. Zhang, R. Li, W. Zhao, and Y.Y. Sun Administration of bone marrow stromal cells ameliorates experimental autoimmune myasthenia gravis by altering the balance of Th1/Th2/Th17/Treg cell subsets through the secretion of TGF-beta J. Neuroimmunol. 207 2009 83 91
58. M. Krampera, S. Glennie, J. Dyson, D. Scott, R. Laylor, E. Simpson, and F. Dazzi Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide Blood 101 2003 3722 3729
59. Y.R. Kuo, S. Goto, H.S. Shih, F.S. Wang, C.C. Lin, C.T. Wang, E.Y. Huang, C.L. Chen, F.C. Wei, X.X. Zheng, and W.P. Lee Mesenchymal stem cells prolong composite tissue allotransplant survival in a swine model Transplantation 87 2009 1769 1777
60. D.F. LaRosa, A.H. Rahman, and L.A. Turka The innate immune system in allograft rejection and tolerance J. Immunol. 178 2007 7503 7509
61. H.M. Lazarus, S.E. Haynesworth, S.L. Gerson, N.S. Rosenthal, and A.I. Caplan Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use Bone Marrow Transplant. 16 1995 557 564
62. H.M. Lazarus, O.N. Koc, S.M. Devine, P. Curtin, R.T. Maziarz, H.K. Holland, E.J. Shpall, P. McCarthy, K. Atkinson, and B.W. Cooper Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients Biol. Blood Marrow Transplant. 11 2005 389 398
63. K. Le Blanc, I. Rasmusson, B. Sundberg, C. Götherström, M. Hassan, M. Uzunel, and O. Ringdén Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells Lancet 363 2004 1439 1441
64. K. Le Blanc, F. Frassoni, L. Ball, F. Locatelli, H. Roelofs, I. Lewis, E. Lanino, B. Sundberg, M.E. Bernardo, M. Remberger Developmental Committee of the European Group for Blood and Marrow Transplantation Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study Lancet 371 2008 1579 1586
65. H. Li, Z.K. Guo, X.X. Jiang, H. Zhu, X.S. Li, and N. Mao Mesenchymal stem cells alter migratory property of T and dendritic cells to delay the development of murine lethal acute graft-versus-host disease Stem Cells 26 2008 2531 2541
66. Y.P. Li, S. Paczesny, E. Lauret, S. Poirault, P. Bordigoni, F. Mekhloufi, O. Hequet, Y. Bertrand, J.P. Ou-Yang, and J.F. Stoltz Human mesenchymal stem cells license adult CD34+ hemopoietic progenitor cells to differentiate into regulatory dendritic cells through activation of the Notch pathway J. Immunol. 180 2008 1598 1608
67. E. Long, and K.J. Wood Regulatory T cells in transplantation: transferring mouse studies to the clinic Transplantation 88 2009 1050 1056
68. M.M. López, J.E. Valenzuela, F.C. Alvarez, M.R. López-Alvarez, G.S. Cecilia, and P.P. Paricio Long-term problems related to immunosuppression Transpl. Immunol. 17 2006 31 35
69. C. Lu, X.Y. Li, Y. Hu, R.G. Rowe, and S.J. Weiss MT1-MMP controls human mesenchymal stem cell trafficking and differentiation Blood 115 2010 221 229
70. M.L. Macmillan, B.R. Blazar, T.E. DeFor, and J.E. Wagner Transplantation of ex-vivo culture-expanded parental haploidentical mesenchymal stem cells to promote engraftment in pediatric recipients of unrelated donor umbilical cord blood: results of a phase I-II clinical trial Bone Marrow Transplant. 43 2009 447 454
71. A. Mahmood, D. Lu, M. Lu, and M. Chopp Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells Neurosurgery 53 2003 697 702, discussion 702-703
72. G.A. McQuibban, J.H. Gong, J.P. Wong, J.L. Wallace, I. Clark-Lewis, and C.M. Overall Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo Blood 100 2002 1160 1167
73. Mills, C.R. (2009). Osiris Therapeutics Announces Preliminary Results for Prochymal Phase III GvHD Trials. (http://investor.osiris.com/releasedetail.cfm? ReleaseID=407404 )
74. M. Miura, Y. Miura, H.M. Padilla-Nash, A.A. Molinolo, B. Fu, V. Patel, B.M. Seo, W. Sonoyama, J.J. Zheng, and C.C. Baker Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation Stem Cells 24 2006 1095 1103
75. M. Mohyeddin Bonab, S. Yazdanbakhsh, J. Lotfi, K. Alimoghaddom, F. Talebian, F. Hooshmand, A. Ghavamzadeh, and B. Nikbin Does mesenchymal stem cell therapy help multiple sclerosis patients? Report of a pilot study Iran. J. Immunol. 4 2007 50 57
76. A. Muraglia, R. Cancedda, and R. Quarto Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model J. Cell Sci. 113 2000 1161 1166
77. K.M. Murphy, and B. Stockinger Effector T cell plasticity: flexibility in the face of changing circumstances Nat. Immunol. 11 2010 674 680
78. J.M. Murphy, D.J. Fink, E.B. Hunziker, and F.P. Barry Stem cell therapy in a caprine model of osteoarthritis Arthritis Rheum. 48 2003 3464 3474
79. S.N. Nadig, J. Wieckiewicz, D.C. Wu, G. Warnecke, W. Zhang, S. Luo, A. Schiopu, D.P. Taggart, and K.J. Wood In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells Nat. Med. 16 2010 809 813
80. M. Najar, R. Rouas, G. Raicevic, H.I. Boufker, P. Lewalle, N. Meuleman, D. Bron, M. Toungouz, P. Martiat, and L. Lagneaux Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: the importance of low cell ratio and role of interleukin-6 Cytotherapy 11 2009 570 583
81. A.J. Nauta, A.B. Kruisselbrink, E. Lurvink, R. Willemze, and W.E. Fibbe Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells J. Immunol. 177 2006 2080 2087
82. A.J. Nauta, G. Westerhuis, A.B. Kruisselbrink, E.G. Lurvink, R. Willemze, and W.E. Fibbe Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting Blood 108 2006 2114 2120
83. K. Németh, A. Leelahavanichkul, P.S.T. Yuen, B. Mayer, A. Parmelee, K. Doi, P.G. Robey, K. Leelahavanichkul, B.H. Koller, and J.M. Brown Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production Nat. Med. 15 2009 42 49
84. M. Owen Marrow stromal stem cells J. Cell Sci. Suppl. 10 1988 63 76
85. M.F. Pittenger, A.M. Mackay, S.C. Beck, R.K. Jaiswal, R. Douglas, J.D. Mosca, M.A. Moorman, D.W. Simonetti, S. Craig, and D.R. Marshak Multilineage potential of adult human mesenchymal stem cells Science 284 1999 143 147
86. D. Polchert, J. Sobinsky, G.W. Douglas, M. Kidd, A. Moadsiri, E. Reina, K. Genrich, S. Mehrotra, S. Setty, B. Smith, and A. Bartholomew IFN-gamma activation of mesenchymal stem cells for treatment and prevention of graft versus host disease Eur. J. Immunol. 38 2008 1745 1755
87. J.A. Potian, H. Aviv, N.M. Ponzio, J.S. Harrison, and P. Rameshwar Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens J. Immunol. 171 2003 3426 3434
88. I. Prigione, F. Benvenuto, P. Bocca, L. Battistini, A. Uccelli, and V. Pistoia Reciprocal interactions between human mesenchymal stem cells and gammadelta T cells or invariant natural killer T cells Stem Cells 27 2009 693 702
89. D.J. Prockop Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms Mol. Ther. 17 2009 939 946
90. M. Rafei, J. Hsieh, S. Fortier, M.Y. Li, S. Yuan, E. Birman, K. Forner, M.N. Boivin, K. Doody, and M. Tremblay Mesenchymal stromal cell-derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction Blood 112 2008 4991 4998
91. M. Rafei, P.M. Campeau, A. Aguilar-Mahecha, M. Buchanan, P. Williams, E. Birman, S. Yuan, Y.K. Young, M.N. Boivin, and K. Forner Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner J. Immunol. 182 2009 5994 6002
92. R. Ramasamy, C.K. Tong, H.F. Seow, S. Vidyadaran, and F. Dazzi The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function Cell. Immunol. 251 2008 131 136
93. I. Rasmusson, M. Uhlin, K. Le Blanc, and V. Levitsky Mesenchymal stem cells fail to trigger effector functions of cytotoxic T lymphocytes J. Leukoc. Biol. 82 2007 887 893
94. G.W. Ren, L.Y. Zhang, X. Zhao, G.W. Xu, Y.Y. Zhang, A.I. Roberts, R.C. Zhao, and Y.F. Shi Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide Cell Stem Cell 2 2008 141 150
95. G.W. Ren, J.J. Su, L.Y. Zhang, X. Zhao, W.F. Ling, A. L'huillie, J.M. Zhang, Y.Q. Lu, A.I. Roberts, and W.Z. Ji Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression Stem Cells 27 2009 1954 1962
96. R. Romieu-Mourez, M. Franois, M.N. Boivin, M. Bouchentouf, D.E. Spaner, and J. Galipeau Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype J. Immunol. 182 2009 7963 7973
97. I. Rosová, M. Dao, B. Capoccia, D. Link, and J.A. Nolta Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells Stem Cells 26 2008 2173 2182
98. J.M. Ryan, F. Barry, J.M. Murphy, and B.P. Mahon Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells Clin. Exp. Immunol. 149 2007 353 363
99. K. Sato, K. Ozaki, I. Oh, A. Meguro, K. Hatanaka, T. Nagai, K. Muroi, and K. Ozawa Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells Blood 109 2007 228 234
100. P. Sbano, A. Cuccia, B. Mazzanti, S. Urbani, B. Giusti, I. Lapini, L. Rossi, R. Abbate, G. Marseglia, and G. Nannetti Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat model Arch. Dermatol. Res. 300 2008 115 124
101. Z. Selmani, A. Naji, I. Zidi, B. Favier, E. Gaiffe, L. Obert, C. Borg, P. Saas, P. Tiberghien, and N. Rouas-Freiss Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells Stem Cells 26 2008 212 222
102. H.M. Sheng, Y. Wang, Y.Q. Jin, Q.Y. Zhang, Y. Zhang, L. Wang, B. Shen, S. Yin, W. Liu, L. Cui, and N. Li A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1 Cell Res. 18 2008 846 857
103. D.A. Shoskes, and K.J. Wood Indirect presentation of MHC antigens in transplantation Immunol. Today 15 1994 32 38
104. E.L. Spaeth, J.L. Dembinski, A.K. Sasser, K. Watson, A. Klopp, B. Hall, M. Andreeff, and F. Marini Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression PLoS ONE 4 2009 e4992
105. G.M. Spaggiari, A. Capobianco, H. Abdelrazik, F. Becchetti, M.C. Mingari, and L. Moretta Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2 Blood 111 2008 1327 1333
106. G.M. Spaggiari, H. Abdelrazik, F. Becchetti, and L. Moretta MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2 Blood 113 2009 6576 6583
107. J. Stagg, S. Pommey, N. Eliopoulos, and J. Galipeau Interferon-gamma- stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell Blood 107 2006 2570 2577
108. F. Tögel, Z. Hu, K. Weiss, J. Isaac, C. Lange, and C. Westenfelder Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms Am. J. Physiol. Renal Physiol. 289 2005 F31 F42
109. W.T. Tse, J.D. Pendleton, W.M. Beyer, M.C. Egalka, and E.C. Guinan Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation Transplantation 75 2003 389 397
110. A. Uccelli, L. Moretta, and V. Pistoia Mesenchymal stem cells in health and disease Nat. Rev. Immunol. 8 2008 726 736
111. W. Wagner, P. Horn, M. Castoldi, A. Diehlmann, S. Bork, R. Saffrich, V. Benes, J. Blake, S. Pfister, V. Eckstein, and A.D. Ho Replicative senescence of mesenchymal stem cells: a continuous and organized process PLoS ONE 3 2008 e2213
112. C. Wan, Q. He, and G. Li Osteoclastogenesis in the nonadherent cell population of human bone marrow is inhibited by rhBMP-2 alone or together with rhVEGF J. Orthop. Res. 24 2006 29 36
113. R. Wehner, D. Wehrum, M. Bornhauser, S.M. Zhao, K. Schakel, M.R. Bachmann, U. Platzbecker, G. Ehninger, E.P. Rieber, and M. Schmitz Mesenchymal stem cells efficiently inhibit the proinflammatory properties of 6-sulfo LacNAc dendritic cells Haematologica. 94 2009 1151 1156
114. K.J. Wood, and S. Sakaguchi Regulatory T cells in transplantation tolerance Nat. Rev. Immunol. 3 2003 199 210
115. G.W. Xu, Y.Y. Zhang, L.Y. Zhang, A.I. Roberts, and Y.F. Shi C/EBPbeta mediates synergistic upregulation of gene expression by interferon-gamma and tumor necrosis factor-alpha in bone marrow-derived mesenchymal stem cells Stem Cells 27 2009 942 948
116. K.H. Yoo, I.K. Jang, M.W. Lee, H.E. Kim, M.S. Yang, Y. Eom, J.E. Lee, Y.J. Kim, S.K. Yang, and H.L. Jung Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues Cell. Immunol. 259 2009 150 156
117. W. Zhang, W. Ge, C. Li, S. You, L. Liao, Q. Han, W. Deng, and R.C. Zhao Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells Stem Cells Dev. 13 2004 263 271
118. B. Zhang, R. Liu, D. Shi, X.X. Liu, Y. Chen, X.W. Dou, X.S. Zhu, C.H. Lu, W. Liang, and L.M. Liao Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population Blood 113 2009 46 57